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MX2016004781A - Il-15 humanizada en animales. - Google Patents

Il-15 humanizada en animales.

Info

Publication number
MX2016004781A
MX2016004781A MX2016004781A MX2016004781A MX2016004781A MX 2016004781 A MX2016004781 A MX 2016004781A MX 2016004781 A MX2016004781 A MX 2016004781A MX 2016004781 A MX2016004781 A MX 2016004781A MX 2016004781 A MX2016004781 A MX 2016004781A
Authority
MX
Mexico
Prior art keywords
humanized
animals
human
gene
human animals
Prior art date
Application number
MX2016004781A
Other languages
English (en)
Inventor
Andrew J Murphy
Ka-Man Venus Lai
Jose F Rojas
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016004781A publication Critical patent/MX2016004781A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Animales no humanos modificados genéticamente que comprenden un gen de interleucina 15 humanizada (IL-15). Células, embriones y animales no humanos que comprenden un gen de IL-15 humana. Roedores que expresan la proteína de IL-15 humanizada o humana.
MX2016004781A 2013-10-15 2014-10-15 Il-15 humanizada en animales. MX2016004781A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891013P 2013-10-15 2013-10-15
PCT/US2014/060568 WO2015057758A1 (en) 2013-10-15 2014-10-15 Humanized il-15 animals

Publications (1)

Publication Number Publication Date
MX2016004781A true MX2016004781A (es) 2016-07-26

Family

ID=51830649

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004781A MX2016004781A (es) 2013-10-15 2014-10-15 Il-15 humanizada en animales.

Country Status (27)

Country Link
US (5) US9155290B2 (es)
EP (3) EP2908626B1 (es)
JP (3) JP6492095B2 (es)
KR (1) KR102376041B1 (es)
CN (2) CN105744829B (es)
AU (2) AU2014337526B2 (es)
BR (1) BR112016008175A2 (es)
CA (1) CA2926090C (es)
CY (2) CY1118675T1 (es)
DK (2) DK3138397T3 (es)
ES (2) ES2715949T3 (es)
HR (2) HRP20170380T1 (es)
HU (2) HUE043969T2 (es)
IL (2) IL244525B (es)
LT (2) LT2908626T (es)
MX (1) MX2016004781A (es)
NZ (1) NZ718655A (es)
PL (2) PL3138397T3 (es)
PT (2) PT3138397T (es)
RS (2) RS58465B1 (es)
RU (1) RU2674910C2 (es)
SG (2) SG10201607768YA (es)
SI (2) SI3138397T1 (es)
SM (3) SMT201700024T1 (es)
TR (1) TR201904342T4 (es)
WO (1) WO2015057758A1 (es)
ZA (1) ZA201601676B (es)

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ES2748662T3 (es) 2012-11-05 2020-03-17 Institute For Res In Biomedicine Irb Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos
MX2016004781A (es) 2013-10-15 2016-07-26 Regeneron Pharma Il-15 humanizada en animales.
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Also Published As

Publication number Publication date
CN109090037B (zh) 2021-05-28
PT3138397T (pt) 2019-03-26
SMT201700024T1 (it) 2017-03-08
US20230189772A1 (en) 2023-06-22
JP2019022518A (ja) 2019-02-14
KR102376041B1 (ko) 2022-03-18
DK2908626T3 (en) 2017-03-20
US9155290B2 (en) 2015-10-13
DK3138397T3 (en) 2019-04-15
PL2908626T3 (pl) 2017-05-31
WO2015057758A1 (en) 2015-04-23
RU2016116847A3 (es) 2018-06-07
HUE043969T2 (hu) 2019-09-30
JP6492095B2 (ja) 2019-03-27
HRP20170380T1 (hr) 2017-05-19
JP2019216750A (ja) 2019-12-26
RU2016116847A (ru) 2017-11-21
CY1118675T1 (el) 2018-03-07
AU2020286186B2 (en) 2024-05-23
PL3138397T3 (pl) 2019-06-28
TR201904342T4 (tr) 2019-05-21
ZA201601676B (en) 2019-12-18
EP2908626A1 (en) 2015-08-26
RS58465B1 (sr) 2019-04-30
CY1121405T1 (el) 2020-05-29
US10561125B2 (en) 2020-02-18
LT2908626T (lt) 2017-01-25
SG10201607768YA (en) 2016-11-29
US20200178508A1 (en) 2020-06-11
AU2014337526B2 (en) 2020-09-10
AU2020286186A1 (en) 2021-01-07
EP3138397A1 (en) 2017-03-08
HK1210659A1 (en) 2016-05-06
IL269907B (en) 2020-09-30
CA2926090C (en) 2022-07-05
IL244525B (en) 2019-10-31
HUE033272T2 (en) 2017-11-28
EP3138397B1 (en) 2018-12-26
CA2926090A1 (en) 2015-04-23
RU2674910C2 (ru) 2018-12-13
ES2613379T3 (es) 2017-05-24
SMT201700024B (it) 2017-03-08
NZ718655A (en) 2022-08-26
RS55472B1 (sr) 2017-04-28
IL244525A0 (en) 2016-04-21
HRP20190542T1 (hr) 2019-07-26
US20150106961A1 (en) 2015-04-16
CN105744829B (zh) 2018-08-07
LT3138397T (lt) 2019-04-10
ES2715949T3 (es) 2019-06-07
SI3138397T1 (sl) 2019-04-30
EP2908626B1 (en) 2016-12-07
US20150366175A1 (en) 2015-12-24
SG11201601828XA (en) 2016-04-28
JP6600061B2 (ja) 2019-10-30
US12369570B2 (en) 2025-07-29
EP3461331A1 (en) 2019-04-03
US20180116192A1 (en) 2018-05-03
PT2908626T (pt) 2017-01-09
JP2016533192A (ja) 2016-10-27
KR20160068774A (ko) 2016-06-15
SI2908626T1 (sl) 2017-02-28
CN105744829A (zh) 2016-07-06
CN109090037A (zh) 2018-12-28
US11503813B2 (en) 2022-11-22
SMT201900177T1 (it) 2019-05-10
BR112016008175A2 (pt) 2017-10-03
AU2014337526A1 (en) 2016-04-28

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