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MX376167B - Ratones con complejo principal de histocompatibilidad modificado genéticamente. - Google Patents

Ratones con complejo principal de histocompatibilidad modificado genéticamente.

Info

Publication number
MX376167B
MX376167B MX2017013466A MX2017013466A MX376167B MX 376167 B MX376167 B MX 376167B MX 2017013466 A MX2017013466 A MX 2017013466A MX 2017013466 A MX2017013466 A MX 2017013466A MX 376167 B MX376167 B MX 376167B
Authority
MX
Mexico
Prior art keywords
genetically modified
human
major histocompatibility
histocompatibility complex
modified major
Prior art date
Application number
MX2017013466A
Other languages
English (en)
Inventor
Andrew J Murphy
Cagan Gurer
Faith Harris
John Mcwhirter
Lynn Macdonald
Sean Stevens
Vera Voronina
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX376167B publication Critical patent/MX376167B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención proporciona animales no humanos modificados genéticamente que expresan polipéptido de CPH I humano/no humano quimérico y/o polipéptidos de microglobulina beta2 humano o humanizado, así como embriones no humanos, células y tejidos que comprenden a los mismos. También se proporcionan construcciones para producir animales modificados genéticamente y métodos para la elaboración de los mismos. Se proporcionan métodos de uso de animales modificados genéticamente para estudiar diversos aspectos del sistema inmunitario humano.
MX2017013466A 2011-10-28 2012-10-26 Ratones con complejo principal de histocompatibilidad modificado genéticamente. MX376167B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161552582P 2011-10-28 2011-10-28
US201161552587P 2011-10-28 2011-10-28
US201261700908P 2012-09-14 2012-09-14
PCT/US2012/062042 WO2013063346A1 (en) 2011-10-28 2012-10-26 Genetically modified major histocompatibility complex mice

Publications (1)

Publication Number Publication Date
MX376167B true MX376167B (es) 2025-03-07

Family

ID=47178940

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2020010763A MX391222B (es) 2011-10-28 2012-10-26 Ratones con complejo principal de histocompatibilidad modificado geneticamente
MX2014004895A MX355725B (es) 2011-10-28 2012-10-26 Ratones con complejo principal de histocompatibilidad modificado geneticamente.
MX2017013466A MX376167B (es) 2011-10-28 2012-10-26 Ratones con complejo principal de histocompatibilidad modificado genéticamente.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2020010763A MX391222B (es) 2011-10-28 2012-10-26 Ratones con complejo principal de histocompatibilidad modificado geneticamente
MX2014004895A MX355725B (es) 2011-10-28 2012-10-26 Ratones con complejo principal de histocompatibilidad modificado geneticamente.

Country Status (27)

Country Link
US (3) US9615550B2 (es)
EP (4) EP3563680B1 (es)
JP (4) JP6154391B2 (es)
KR (3) KR102295746B1 (es)
CN (3) CN104039132B9 (es)
AU (3) AU2012324016C1 (es)
BR (1) BR112014009259A2 (es)
CA (2) CA2850387A1 (es)
CY (2) CY1119657T1 (es)
DK (2) DK2770821T3 (es)
ES (3) ES2651517T3 (es)
HK (1) HK1249712B (es)
HR (2) HRP20171761T1 (es)
HU (2) HUE035652T2 (es)
IL (3) IL232097A (es)
LT (2) LT2770821T (es)
MX (3) MX391222B (es)
MY (2) MY164836A (es)
NZ (1) NZ734532A (es)
PL (2) PL2770821T3 (es)
PT (2) PT2770821T (es)
RS (2) RS56656B1 (es)
SG (2) SG10201603188SA (es)
SI (2) SI3262932T1 (es)
SM (2) SMT201700576T1 (es)
WO (1) WO2013063346A1 (es)
ZA (1) ZA201403085B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE033400T2 (en) 2011-10-28 2017-12-28 Regeneron Pharma Humanized IL-6 and IL-6 receptor
US9591835B2 (en) 2011-10-28 2017-03-14 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
JP6444895B2 (ja) * 2013-02-20 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｔ細胞補助受容体を発現するマウス
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
DK2958937T3 (en) * 2013-02-22 2018-11-26 Regeneron Pharma Mice expressing humanized major histocompatibility complex
KR102313053B1 (ko) * 2013-03-11 2021-10-18 리제너론 파아마슈티컬스, 인크. 키메라 주요 조직적합성 복합체(ｍｈｃ) 제ｉ 부류 분자를 발현하는 유전자전이 마우스
KR102407354B1 (ko) 2013-09-23 2022-06-10 리제너론 파마슈티칼스 인코포레이티드 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물
SI2908626T1 (sl) 2013-10-15 2017-02-28 Regeneron Pharmaceuticals, Inc. Humanizirane živali IL-15
JP6236461B2 (ja) * 2013-10-18 2017-11-22 大鵬薬品工業株式会社 Ｈｌａクラスｉ発現非ヒト動物
SG10201900003WA (en) 2013-11-19 2019-02-27 Regeneron Pharma Non-human animals having a humanized b-cell activating factor gene
AU2014353347B2 (en) 2013-11-19 2020-07-02 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized a proliferation-inducing ligand gene
SG11201604886WA (en) 2014-04-08 2016-07-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
SG11201608696RA (en) 2014-05-05 2016-11-29 Regeneron Pharma Humanized c5 and c3 animals
NO2785538T3 (es) 2014-05-07 2018-08-04
BR112016029650A2 (pt) 2014-06-19 2017-10-24 Regeneron Pharma roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor?
CA2959428A1 (en) 2014-09-19 2016-03-24 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors
MX2017006802A (es) 2014-11-24 2018-01-30 Regeneron Pharma Animales no humanos que expresan el complejo cd3 humanizado.
WO2016089692A1 (en) 2014-12-05 2016-06-09 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
CA2968675C (en) * 2014-12-09 2023-10-17 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 274 gene
HK1245010A1 (zh) 2014-12-10 2018-08-24 明尼苏达大学董事会 用於治疗疾病的遗传修饰的细胞、组织和器官
PT3280257T (pt) 2015-04-06 2023-09-12 Regeneron Pharma Respostas imunes mediadas por células t humanizadas em animais não humanos
CN115943929B (zh) * 2015-04-13 2025-01-10 再生元制药公司 人源化SIRPα-IL15敲入小鼠及其使用方法
US10306874B2 (en) 2015-11-20 2019-06-04 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized lymphocyte-activation gene 3
EP3422845B1 (en) 2016-02-29 2021-06-02 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
RS66700B1 (sr) 2016-06-03 2025-05-30 Regeneron Pharma Glodari koji eksprimiraju egzogenu terminalnu dezoksinukleotidil transferazu
CN109456942A (zh) * 2017-09-06 2019-03-12 亘喜生物科技（上海）有限公司 通用型嵌合抗原受体t细胞制备技术
CN111386039B (zh) * 2017-09-29 2023-02-28 瑞泽恩制药公司 经基因修饰的啮齿动物基因组
ES2962277T3 (es) 2017-09-29 2024-03-18 Regeneron Pharma Roedores que comprenden un locus Ttr humanizado y métodos de uso
CN116064611A (zh) 2017-11-30 2023-05-05 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
SMT202500038T1 (it) 2018-03-24 2025-03-12 Regeneron Pharma Topi o ratti geneticamente modificati per la generazione di anticorpi terapeutici contro complessi peptide-mhc, metodi di produzione e loro utilizzo
WO2019190990A1 (en) 2018-03-26 2019-10-03 Regeneron Pharmaceuticals, Inc. Humanized rodents for testing therapeutic agents
AU2019308205B2 (en) 2018-07-16 2025-11-06 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
CA3133638A1 (en) * 2019-03-25 2020-10-01 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same
CN117178959A (zh) 2019-04-04 2023-12-08 瑞泽恩制药公司 包括人源化凝血因子12基因座的非人动物
EP3801011A1 (en) 2019-06-04 2021-04-14 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
US11622547B2 (en) 2019-06-07 2023-04-11 Regeneran Pharmaceuticals, Inc. Genetically modified mouse that expresses human albumin
IL294356A (en) * 2020-01-10 2022-08-01 Biocytogen Pharmaceuticals Beijing Co Ltd Genetically modified non-human animal with human or chimeric mhc protein complex
CN116848254A (zh) 2020-12-16 2023-10-03 瑞泽恩制药公司 表达人源化Fcα受体的小鼠
WO2022133155A1 (en) * 2020-12-16 2022-06-23 Xenotherapeutics, Inc. Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs
CN118511853A (zh) 2021-03-31 2024-08-20 瑞泽恩制药公司 包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠
CA3258639A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Multispecific molecules to modulate T lymphocyte activity, and their uses
WO2023240124A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
CA3265746A1 (en) 2022-09-22 2024-03-28 Regeneron Pharmaceuticals, Inc. GENETICALLY MODIFIED MICE EXPRESSING COMPONENTS OF A HUMAN CELLULAR IMMUNE SYSTEM
WO2024159071A1 (en) 2023-01-27 2024-08-02 Regeneron Pharmaceuticals, Inc. Modified rhabdovirus glycoproteins and uses thereof
TW202520975A (zh) * 2023-08-09 2025-06-01 英商劍橋企業有限公司 基因改造之囓齒動物及囓齒動物細胞以及其等用途
WO2025064470A1 (en) 2023-09-19 2025-03-27 Regeneron Pharmaceuticals, Inc. Viral peptides and uses thereof
WO2025064738A1 (en) 2023-09-22 2025-03-27 Regeneron Pharmaceuticals, Inc. Dntt 250-258 off-target peptides and uses thereof
WO2025064761A1 (en) 2023-09-22 2025-03-27 Regeneron Pharmaceuticals, Inc. Kras10-18 g12d off-target peptides and uses thereof
WO2025136809A2 (en) 2023-12-19 2025-06-26 Regeneron Pharmaceuticals, Inc. Foxp3 peptides and uses thereof
WO2025178991A1 (en) 2024-02-21 2025-08-28 Regeneron Pharmaceuticals, Inc. Splicing factor gene mutation-associated neoantigenic peptides and uses thereof
WO2025212991A1 (en) 2024-04-05 2025-10-09 Regeneron Pharmaceuticals, Inc. Rodent models of disease
WO2026006734A1 (en) 2024-06-28 2026-01-02 Regeneron Pharmaceuticals, Inc. Off-target peptide-mhc complex conformation modeling systems and methods for antigen-recognition molecule development
WO2026006724A1 (en) 2024-06-28 2026-01-02 Regeneron Pharmaceuticals, Inc. Prame off-target peptides and uses thereof
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991001140A1 (en) 1989-07-25 1991-02-07 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
GB9100481D0 (en) 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
AU2661692A (en) 1991-09-19 1993-04-27 President And Fellows Of Harvard College Transgenic mhc class i and class ii antigen-deficient mammals
WO1994006908A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Transgenic non-human animals having targeted lymphocyte transduction genes
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
GB9315303D0 (en) 1993-07-23 1993-09-08 Zeneca Ltd Polypeptide
US5965787A (en) 1995-08-31 1999-10-12 Mayo Foundation For Medical Education And Research HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis
US6002066A (en) 1996-01-16 1999-12-14 Ortho Pharmaceutical Corp. H2-M modified transgenic mice
WO1997032603A1 (en) 1996-03-05 1997-09-12 The Scripps Research Institute Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
JP4215172B2 (ja) 1996-12-03 2009-01-28 アムジェン フレモント インク． 複数のＶ▲下Ｈ▼およびＶ▲下κ▼領域を含むヒトＩｇ遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体
JP4485679B2 (ja) 1997-09-16 2010-06-23 オレゴン ヘルス アンド サイエンス ユニバーシティー 抗原特異的ｔ細胞の操作において有用な組換えｍｈｃ分子
ATE267516T1 (de) * 1998-02-17 2004-06-15 Ortho Mcneil Pharm Inc H2-o modifizierte transgene tiere
US6372955B1 (en) 1998-02-17 2002-04-16 Ortho Mcneil Pharmaceutical, Inc. Methods for Producing B cells and antibodies from H2-O modified transgenic mice
WO2001027291A1 (en) * 1999-10-12 2001-04-19 Institut Pasteur Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AU2002222610A1 (en) 2000-12-13 2002-06-24 Sumitomo Pharmaceuticals Company, Limited Transgenic animal expressing hla-a24 and utilization thereof
WO2002059263A2 (en) 2000-12-19 2002-08-01 Sunol Molecular Corporation Transgenic animals comprising a humanized immune system
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US8895020B2 (en) 2002-04-19 2014-11-25 Washington University Single chain trimers and uses therefor
US7179645B2 (en) * 2002-09-24 2007-02-20 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
US7663017B2 (en) * 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
WO2005085438A1 (ja) 2004-03-09 2005-09-15 Nagoya Industrial Science Research Institute ヒト関節リウマチの病態を再現するトランスジェニック非ヒト哺乳動物
PT1802193E (pt) 2004-10-19 2014-06-23 Regeneron Pharma Método para gerar um murganho homozigótico para uma modificação genética
JP4830139B2 (ja) * 2006-03-10 2011-12-07 学校法人明治大学 クローン胚の作製方法
NZ547859A (en) * 2006-06-09 2009-05-31 Dec Int Nz Ltd Treatment method and composition for mastitis
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
EP1878798A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Method of producing a multichimeric mouse and applications to study the immunopathogenesis of human tissue-specific pathologies
EP2152750A1 (en) * 2007-04-23 2010-02-17 Schering Corporation Anti-mdl-1 antibodies
WO2009114400A1 (en) 2008-03-07 2009-09-17 Regeneron Pharmaceuticals, Inc. Es cell-derived mice from diploid host embryo injection
US20090328240A1 (en) 2008-06-24 2009-12-31 Sing George L Genetically modified mice as predictors of immune response
EP2153845A1 (en) * 2008-08-13 2010-02-17 Julius-Maximilians-Universität Würzburg Endoglin peptides, vaccines and methods for preparing the same
NZ597481A (en) 2009-07-08 2013-10-25 Kymab Ltd Animal models and therapeutic molecules
US9557323B2 (en) 2010-09-24 2017-01-31 The United States Of America As Represented By The Secretary Of The Navy Humanized transgenic mouse model
JP6444895B2 (ja) 2013-02-20 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化ｔ細胞補助受容体を発現するマウス
DK2958937T3 (en) 2013-02-22 2018-11-26 Regeneron Pharma Mice expressing humanized major histocompatibility complex
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
SG11201509743WA (en) * 2013-06-03 2015-12-30 Theravectys Lentiviral vectors containing an mhc class i, mhc class ii, or beta-2 microglobulin upstream promoter sequence
JP6236461B2 (ja) * 2013-10-18 2017-11-22 大鵬薬品工業株式会社 Ｈｌａクラスｉ発現非ヒト動物
PT3280257T (pt) 2015-04-06 2023-09-12 Regeneron Pharma Respostas imunes mediadas por células t humanizadas em animais não humanos

Also Published As

Publication number Publication date
JP2017143840A (ja) 2017-08-24
EP4311833A2 (en) 2024-01-31
EP3563680A1 (en) 2019-11-06
SG11201400933VA (en) 2014-04-28
WO2013063346A1 (en) 2013-05-02
JP2014532412A (ja) 2014-12-08
MY164836A (en) 2018-01-30
RS59082B1 (sr) 2019-09-30
EP3262932B1 (en) 2019-05-15
CA3074400C (en) 2025-03-25
MX2020010763A (es) 2022-04-01
NZ734532A (en) 2022-12-23
EP2770821B1 (en) 2017-09-13
AU2012324016C1 (en) 2018-02-15
AU2016202688A1 (en) 2016-05-19
AU2017279797B2 (en) 2020-10-22
KR102074145B1 (ko) 2020-02-07
IL252022A0 (en) 2017-06-29
CA2850387A1 (en) 2013-05-02
CN113564188B (zh) 2025-03-04
SMT201700576T1 (it) 2018-01-11
US10869466B2 (en) 2020-12-22
CN104039132B9 (zh) 2017-09-05
ES2651517T3 (es) 2018-01-26
DK3262932T3 (da) 2019-08-05
ES2962287T3 (es) 2024-03-18
HUE035652T2 (en) 2018-05-28
AU2012324016A8 (en) 2016-03-03
US20170164590A1 (en) 2017-06-15
LT2770821T (lt) 2017-12-11
EP2770821A1 (en) 2014-09-03
RS56656B1 (sr) 2018-03-30
HRP20171761T1 (hr) 2017-12-29
HRP20191420T1 (hr) 2019-11-15
EP3563680B1 (en) 2023-08-30
PT2770821T (pt) 2017-12-18
US20130111617A1 (en) 2013-05-02
IL261239B (en) 2019-11-28
EP4311833A3 (en) 2024-05-01
CN107254480A (zh) 2017-10-17
PL2770821T3 (pl) 2018-02-28
AU2012324016A1 (en) 2013-05-16
US20200375160A1 (en) 2020-12-03
LT3262932T (lt) 2019-08-26
SG10201603188SA (en) 2016-05-30
CN104039132B (zh) 2017-06-16
JP2020146041A (ja) 2020-09-17
CN113564188A (zh) 2021-10-29
KR101921126B1 (ko) 2018-11-23
CA3074400A1 (en) 2013-05-02
HUE045879T2 (hu) 2020-01-28
IL261239A (en) 2018-10-31
MX391222B (es) 2025-03-21
MX2014004895A (es) 2014-09-12
KR20140089560A (ko) 2014-07-15
AU2017279797A1 (en) 2018-01-25
MX355725B (es) 2018-04-27
AU2016202688B2 (en) 2017-09-28
JP6866409B2 (ja) 2021-04-28
EP3563680C0 (en) 2023-08-30
KR20180128494A (ko) 2018-12-03
MY178723A (en) 2020-10-20
JP6154391B2 (ja) 2017-06-28
IL232097A0 (en) 2014-05-28
PT3262932T (pt) 2019-08-26
CN104039132A (zh) 2014-09-10
AU2017279797C1 (en) 2021-07-15
NZ719373A (en) 2018-06-29
JP6574457B2 (ja) 2019-09-11
DK2770821T3 (da) 2017-11-27
ZA201403085B (en) 2025-07-30
ES2741649T3 (es) 2020-02-11
KR20200013810A (ko) 2020-02-07
SMT201900478T1 (it) 2019-09-09
NZ623456A (en) 2016-05-27
SI2770821T1 (en) 2018-01-31
JP2019068857A (ja) 2019-05-09
BR112014009259A2 (pt) 2020-10-27
EP3262932A1 (en) 2018-01-03
IL232097A (en) 2017-06-29
SI3262932T1 (sl) 2019-09-30
HK1200272A1 (en) 2015-08-07
US9615550B2 (en) 2017-04-11
CY1121869T1 (el) 2020-10-14
KR102295746B1 (ko) 2021-09-01
CY1119657T1 (el) 2018-04-04
CN107254480B (zh) 2021-08-10
PL3262932T3 (pl) 2019-10-31
AU2012324016B2 (en) 2016-01-28
HK1249712B (en) 2020-06-26

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