MX2016014504A - Animales c5 y c3 humanizados. - Google Patents
Animales c5 y c3 humanizados.Info
- Publication number
- MX2016014504A MX2016014504A MX2016014504A MX2016014504A MX2016014504A MX 2016014504 A MX2016014504 A MX 2016014504A MX 2016014504 A MX2016014504 A MX 2016014504A MX 2016014504 A MX2016014504 A MX 2016014504A MX 2016014504 A MX2016014504 A MX 2016014504A
- Authority
- MX
- Mexico
- Prior art keywords
- human
- humanized
- animals
- gene
- human animals
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 6
- 101150071258 C3 gene Proteins 0.000 abstract 3
- 101150069146 C5 gene Proteins 0.000 abstract 3
- 101000901154 Homo sapiens Complement C3 Proteins 0.000 abstract 3
- 102000057770 human C3 Human genes 0.000 abstract 3
- 101100440311 Homo sapiens C5 gene Proteins 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 241000699670 Mus sp. Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 241000283984 Rodentia Species 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
Abstract
Se proporcionan animales no humanos que comprenden una secuencia de ácidos nucleicos C3 y/o C5 humanos o humanizados, así como también métodos para usar los mismos para identificar compuestos capaces de modular el sistema del complemento. Se describen animales no humanos que comprenden una sustitución del gen C5 endógeno y/o gen C3 con un gen C5 humano o humanizado, así como métodos para elaborar y usar los animales no humanos. También se proporcionan animales no humanos que comprenden un gen C5 humano o humanizado bajo control de elementos regulatorios C5 no humanos, incluyendo animales no humanos que tienen una sustitución de secuencia de codificación de proteína C5 no humana con secuencia de codificación de proteína C5 humana o humanizada en el locus C5 endógeno no humano. También se proporcionan animales no humanos que comprenden un gen C3 humano o humanizado bajo control de elementos regulatorios C3 no humanos, incluyendo animales no humanos que tienen una sustitución de secuencia de codificación de proteína C3 no humana con secuencia de codificación de proteína C3 humana o humanizada en el locus C3 endógeno no humano. Los animales no humanos que comprenden secuencias C3 y/o C5 humanas o humanizadas, en donde los animales no humanos son roedores, por ejemplo, se proporcionan ratones o ratas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461988581P | 2014-05-05 | 2014-05-05 | |
| US201462067836P | 2014-10-23 | 2014-10-23 | |
| PCT/US2015/029111 WO2015171523A1 (en) | 2014-05-05 | 2015-05-04 | Humanized c5 and c3 animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016014504A true MX2016014504A (es) | 2017-05-23 |
Family
ID=53177902
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014504A MX2016014504A (es) | 2014-05-05 | 2015-05-04 | Animales c5 y c3 humanizados. |
| MX2019013850A MX386644B (es) | 2014-05-05 | 2015-05-04 | Animales c5 y c3 humanizados. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019013850A MX386644B (es) | 2014-05-05 | 2015-05-04 | Animales c5 y c3 humanizados. |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9795121B2 (es) |
| EP (3) | EP3142483B1 (es) |
| JP (1) | JP6598798B2 (es) |
| KR (1) | KR102461511B1 (es) |
| CN (1) | CN106659146B (es) |
| AU (1) | AU2015256299C1 (es) |
| BR (1) | BR112016025751A2 (es) |
| CA (2) | CA3225091A1 (es) |
| ES (2) | ES2779070T3 (es) |
| IL (1) | IL248481B (es) |
| MA (1) | MA51519A (es) |
| MX (2) | MX2016014504A (es) |
| RU (2) | RU2020103811A (es) |
| SG (2) | SG10202003996YA (es) |
| WO (1) | WO2015171523A1 (es) |
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| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| SG10202003996YA (en) * | 2014-05-05 | 2020-06-29 | Regeneron Pharma | Humanized c5 and c3 animals |
| NO2785538T3 (es) | 2014-05-07 | 2018-08-04 | ||
| TWI797060B (zh) | 2015-08-04 | 2023-04-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| EP3407915A4 (en) * | 2016-01-25 | 2019-11-20 | President and Fellows of Harvard College | METHOD AND COMPOSITIONS FOR DETECTING AND TREATING SCHIZOPHRENIA |
| SG10202012243VA (en) | 2016-06-14 | 2021-01-28 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| EP3504328A1 (en) | 2016-08-24 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| JP7169979B2 (ja) * | 2017-02-27 | 2022-11-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 補体関連腎症および肝線維症の候補治療剤の治療有効性を評価する方法 |
| JP7265494B2 (ja) | 2017-07-06 | 2023-04-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 糖タンパク質を作製するための細胞培養方法 |
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| CN107736281A (zh) * | 2017-09-29 | 2018-02-27 | 中国水产科学研究院珠江水产研究所 | 一种利用益生菌发酵酱油渣防治池塘养殖鳜鱼寄生虫的方法 |
| DK3687287T5 (da) * | 2017-09-29 | 2024-08-26 | Regeneron Pharma | Gnavere, udtrykkende humaniseret c1q-kompleks |
| CN120571008A (zh) | 2017-12-13 | 2025-09-02 | 瑞泽恩制药公司 | 抗c5抗体组合及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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- 2015-05-04 MA MA051519A patent/MA51519A/fr unknown
- 2015-05-04 US US14/703,818 patent/US9795121B2/en not_active Expired - Fee Related
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- 2015-05-04 BR BR112016025751A patent/BR112016025751A2/pt not_active Application Discontinuation
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- 2015-05-04 EP EP23202404.2A patent/EP4317445A3/en not_active Withdrawn
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- 2015-05-04 CN CN201580034127.8A patent/CN106659146B/zh active Active
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- 2015-05-04 KR KR1020167032659A patent/KR102461511B1/ko active Active
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