LT3281521T - Humanizuotus il-4 ir il-4r alfa apimantis gyvūnai - Google Patents

Humanizuotus il-4 ir il-4r alfa apimantis gyvūnai

Info

Publication number: LT3281521T
Authority: LT; Lithuania
Prior art keywords: humanized; animals; alpha; alpha animals
Prior art date: 2014-05-07

Application number

LTEP17193855.8T

Other languages

English (en)

Inventor

Li-Hsien Wang

Yingzi Xue

Andrew J. Murphy

Sean Stevens

Original Assignee

Regeneron Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-07

Filing date

2015-05-07

Publication date

2021-09-27

2015-05-07 Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.

2021-09-27 Publication of LT3281521T publication Critical patent/LT3281521T/lt

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Biophysics (AREA)
Environmental Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Veterinary Medicine (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

LTEP17193855.8T 2014-05-07 2015-05-07 Humanizuotus il-4 ir il-4r alfa apimantis gyvūnai LT3281521T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201461989757P	2014-05-07	2014-05-07

Publications (1)

Publication Number	Publication Date
LT3281521T true LT3281521T (lt)	2021-09-27

Family

ID=53284509

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEP15727106.5T LT3027015T (lt)	2014-05-07	2015-05-07	Humanizuoti il-4 ir il-4r alfa gyvūnai
LTEP17193855.8T LT3281521T (lt)	2014-05-07	2015-05-07	Humanizuotus il-4 ir il-4r alfa apimantis gyvūnai

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LTEP15727106.5T LT3027015T (lt)	2014-05-07	2015-05-07	Humanizuoti il-4 ir il-4r alfa gyvūnai

Country Status (26)

Country	Link
US (7)	US9565841B2 (lt)
EP (3)	EP3906781A1 (lt)
JP (5)	JP6640740B2 (lt)
KR (2)	KR102517112B1 (lt)
CN (2)	CN106470545B (lt)
AU (3)	AU2015255977B2 (lt)
BR (1)	BR112016025745A2 (lt)
CA (2)	CA2947307C (lt)
CY (2)	CY1119773T1 (lt)
DK (2)	DK3027015T3 (lt)
ES (2)	ES2887852T3 (lt)
HR (2)	HRP20180242T1 (lt)
HU (2)	HUE055860T2 (lt)
IL (3)	IL248358B2 (lt)
LT (2)	LT3027015T (lt)
MX (1)	MX370672B (lt)
NO (1)	NO2785538T3 (lt)
PH (1)	PH12016502058A1 (lt)
PL (2)	PL3281521T3 (lt)
PT (2)	PT3281521T (lt)
RS (2)	RS62345B1 (lt)
RU (1)	RU2703139C2 (lt)
SG (2)	SG11201608570YA (lt)
SI (2)	SI3281521T1 (lt)
SM (2)	SMT202100560T1 (lt)
WO (1)	WO2015171861A1 (lt)

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2012
- 2012-11-22 NO NO12794266A patent/NO2785538T3/no unknown
2015
- 2015-05-07 RS RS20211141A patent/RS62345B1/sr unknown
- 2015-05-07 WO PCT/US2015/029638 patent/WO2015171861A1/en not_active Ceased
- 2015-05-07 SG SG11201608570YA patent/SG11201608570YA/en unknown
- 2015-05-07 SG SG10201912354PA patent/SG10201912354PA/en unknown
- 2015-05-07 ES ES17193855T patent/ES2887852T3/es active Active
- 2015-05-07 DK DK15727106.5T patent/DK3027015T3/en active
- 2015-05-07 IL IL248358A patent/IL248358B2/en unknown
- 2015-05-07 IL IL297105A patent/IL297105B2/en unknown
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Also Published As

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JP6640740B2 (ja)	2020-02-05
US12310340B2 (en)	2025-05-27
RU2016143376A (ru)	2018-06-09
JP2024159985A (ja)	2024-11-08
IL297105B2 (en)	2024-01-01
NZ725615A (en)	2024-05-31
AU2021218060C1 (en)	2024-11-07
AU2015255977B2 (en)	2021-09-02
AU2021218060A1 (en)	2021-09-09
DK3027015T3 (en)	2018-01-22
HUE055860T2 (hu)	2021-12-28
PT3027015T (pt)	2018-02-09
KR102517112B1 (ko)	2023-04-03
IL304841B2 (en)	2026-01-01
JP6838131B2 (ja)	2021-03-03
NO2785538T3 (lt)	2018-08-04
US20150320021A1 (en)	2015-11-12
US10477842B2 (en)	2019-11-19
US11109578B2 (en)	2021-09-07
AU2015255977A1 (en)	2016-11-17
MX370672B (es)	2019-12-19
KR102473565B1 (ko)	2022-12-02
US20150320022A1 (en)	2015-11-12
RU2703139C2 (ru)	2019-10-15
CA2947307C (en)	2023-09-26
US11963521B2 (en)	2024-04-23
IL304841A (en)	2023-09-01
CN110269047A (zh)	2019-09-24
US20170311580A1 (en)	2017-11-02
EP3281521A1 (en)	2018-02-14
EP3027015A1 (en)	2016-06-08
CA3207834A1 (en)	2015-11-12
US9565841B2 (en)	2017-02-14
US20180000056A1 (en)	2018-01-04
CY1124605T1 (el)	2022-07-22
IL248358B2 (en)	2023-03-01
HRP20211455T1 (hr)	2022-01-07
IL297105A (en)	2022-12-01
US20200022344A1 (en)	2020-01-23
LT3027015T (lt)	2018-01-25
PH12016502058A1 (en)	2017-01-09
AU2024204694A1 (en)	2024-09-05
RU2019131253A (ru)	2019-12-06
SI3281521T1 (sl)	2021-11-30
CN106470545A (zh)	2017-03-01
PT3281521T (pt)	2021-09-16
PL3281521T3 (pl)	2022-01-03
CN106470545B (zh)	2019-08-20
EP3906781A1 (en)	2021-11-10
JP2020058379A (ja)	2020-04-16
SI3027015T1 (en)	2018-02-28
US9743647B2 (en)	2017-08-29
SMT201800018T1 (it)	2018-03-08
IL248358A0 (en)	2016-11-30
IL297105B1 (en)	2023-09-01
CN110269047B (zh)	2021-11-02
CA2947307A1 (en)	2015-11-12
JP2022171841A (ja)	2022-11-11
EP3027015B1 (en)	2017-11-08
US10588298B2 (en)	2020-03-17
WO2015171861A1 (en)	2015-11-12
SMT202100560T1 (it)	2021-11-12
HUE038028T2 (hu)	2018-09-28
SG11201608570YA (en)	2016-11-29
EP3281521B1 (en)	2021-06-30
JP2017514501A (ja)	2017-06-08
CY1119773T1 (el)	2018-06-27
KR20220165814A (ko)	2022-12-15
HRP20180242T1 (hr)	2018-03-09
ES2656529T3 (es)	2018-02-27
US20210368753A1 (en)	2021-12-02
ES2887852T3 (es)	2021-12-28
DK3281521T3 (da)	2021-09-20
BR112016025745A2 (pt)	2018-01-16
AU2021218060B2 (en)	2024-04-11
MX2016014563A (es)	2017-02-23
NZ763861A (en)	2024-05-31
SG10201912354PA (en)	2020-02-27
IL248358B (en)	2022-11-01
JP7755699B2 (ja)	2025-10-16
RS62345B1 (sr)	2021-10-29
RU2016143376A3 (lt)	2018-11-22
JP7145250B2 (ja)	2022-09-30
KR20160150637A (ko)	2016-12-30
IL304841B1 (en)	2025-09-01
US20230027494A1 (en)	2023-01-26
JP2021087434A (ja)	2021-06-10
CA3207834C (en)	2025-10-14
PL3027015T3 (pl)	2018-04-30
RS57073B1 (sr)	2018-06-29

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IL276946A (en)	2020-10-29	Antiproliferative compounds and methods of use
IL248481B (en)	2021-04-29	Animals containing c5 and c3 of human origin
IL252216B (en)	2021-12-01	Difluoromethyl-aminopyridines and difluoromethyl-aminopyrimidines
IL252929B (en)	2021-07-29	Anti-acth antibodies from humans and their use
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IL247315A0 (en)	2016-09-29	Anti-acth antibodies and their uses
SI3233105T1 (sl)	2021-01-29	Nove kombinacije in uporaba
IL251335A0 (en)	2017-05-29	Piperidinylpyrazolopyrimidinones and their use
GB201420805D0 (en)	2015-01-07	Ligatures and use thereof
PL3229772T3 (pl)	2020-11-02	6-arylo-9-glikozylopuryny i ich zastosowanie