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MX2014015558A - Analogos de glucagon que exhiben actividad del receptor gip. - Google Patents

Analogos de glucagon que exhiben actividad del receptor gip.

Info

Publication number
MX2014015558A
MX2014015558A MX2014015558A MX2014015558A MX2014015558A MX 2014015558 A MX2014015558 A MX 2014015558A MX 2014015558 A MX2014015558 A MX 2014015558A MX 2014015558 A MX2014015558 A MX 2014015558A MX 2014015558 A MX2014015558 A MX 2014015558A
Authority
MX
Mexico
Prior art keywords
gip receptor
receptor activity
glucagon analogs
analogs exhibiting
exhibiting gip
Prior art date
Application number
MX2014015558A
Other languages
English (en)
Inventor
Richard D Dimarchi
Original Assignee
Univ Indiana Res & Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Indiana Res & Tech Corp filed Critical Univ Indiana Res & Tech Corp
Publication of MX2014015558A publication Critical patent/MX2014015558A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan en la presente, análogos de glucagón que exhiben potente actividad en el receptor GIP, 'y, como tales se contemplan para el uso en el tratamiento de la diabetes y obesidad. En modalidades ejemplares, el análogo de glucagón de las presentes descripciones exhibe una EC50 en el receptor GIP que está dentro del intervalo nanomolar o picomolar.
MX2014015558A 2012-06-21 2013-06-18 Analogos de glucagon que exhiben actividad del receptor gip. MX2014015558A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662868P 2012-06-21 2012-06-21
US201261716878P 2012-10-22 2012-10-22
PCT/US2013/046228 WO2013192129A1 (en) 2012-06-21 2013-06-18 Glucagon analogs exhibiting gip receptor activity

Publications (1)

Publication Number Publication Date
MX2014015558A true MX2014015558A (es) 2015-03-05

Family

ID=48699335

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014015558A MX2014015558A (es) 2012-06-21 2013-06-18 Analogos de glucagon que exhiben actividad del receptor gip.

Country Status (13)

Country Link
US (1) US9340600B2 (es)
EP (1) EP2864351B1 (es)
JP (1) JP6311708B2 (es)
KR (1) KR20150023013A (es)
CN (1) CN104583232B (es)
AR (1) AR091477A1 (es)
CA (1) CA2877358A1 (es)
ES (1) ES2602486T3 (es)
HK (1) HK1209764A1 (es)
MX (1) MX2014015558A (es)
RU (1) RU2015101697A (es)
TW (1) TWI599575B (es)
WO (1) WO2013192129A1 (es)

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