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MX2015014470A - Analogos de combretastatina. - Google Patents

Analogos de combretastatina.

Info

Publication number
MX2015014470A
MX2015014470A MX2015014470A MX2015014470A MX2015014470A MX 2015014470 A MX2015014470 A MX 2015014470A MX 2015014470 A MX2015014470 A MX 2015014470A MX 2015014470 A MX2015014470 A MX 2015014470A MX 2015014470 A MX2015014470 A MX 2015014470A
Authority
MX
Mexico
Prior art keywords
formula
combretastatin analogs
combretastatin
analogs
compounds
Prior art date
Application number
MX2015014470A
Other languages
English (en)
Inventor
Narsimha Reddy Penthala
Peter Crooks
Vijayakumar Sonar
Original Assignee
Univ Arkansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arkansas filed Critical Univ Arkansas
Publication of MX2015014470A publication Critical patent/MX2015014470A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a análogos heterocíclicos de combretastatina novedosos, sus síntesis y su uso como compuestos anticancerosos. En particular, se proporcionan los compuestos de fórmula (I), fórmula (II) y fórmula (V).
MX2015014470A 2013-04-19 2014-04-15 Analogos de combretastatina. MX2015014470A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361814028P 2013-04-19 2013-04-19
US201361866878P 2013-08-16 2013-08-16
US201361901710P 2013-11-08 2013-11-08
PCT/US2014/034185 WO2014172363A2 (en) 2013-04-19 2014-04-15 Combretastatin analogs

Publications (1)

Publication Number Publication Date
MX2015014470A true MX2015014470A (es) 2016-02-22

Family

ID=51731968

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015014470A MX2015014470A (es) 2013-04-19 2014-04-15 Analogos de combretastatina.

Country Status (9)

Country Link
US (2) US9884842B2 (es)
EP (1) EP2986596A4 (es)
JP (1) JP2016516814A (es)
AU (1) AU2014254078A1 (es)
BR (1) BR112015026048A2 (es)
CA (1) CA2907853A1 (es)
MX (1) MX2015014470A (es)
SG (1) SG11201508054UA (es)
WO (1) WO2014172363A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014105957A1 (en) 2012-12-28 2014-07-03 Board Of Trustees University Of Arkansas Indole compounds for use in treating inflammation and cancer
AU2014254078A1 (en) 2013-04-19 2015-10-15 Bioventures, Llc Combretastatin analogs
CA2940694A1 (en) 2014-03-31 2015-10-08 Board Of Trustees Of The University Of Arkansas Disubstituted triazole analogs
US10800766B2 (en) * 2015-11-28 2020-10-13 Russell Dahl Quinoline alkenes as cytoprotective agents

Family Cites Families (30)

* Cited by examiner, † Cited by third party
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CH489510A (de) 1967-02-07 1970-04-30 Geigy Ag J R Verfahren zur Herstellung von substituierten v-Triazolen
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DE3410700A1 (de) 1984-03-23 1985-09-26 Basf Ag, 6700 Ludwigshafen 2,4,5-triphenyl-v-triazole und deren verwendung
GB9019841D0 (en) 1990-09-11 1990-10-24 Smith Kline French Lab Compounds
CN1053658C (zh) 1994-04-06 2000-06-21 日本新药株式会社 氨基芪唑衍生物和药
US5484940A (en) 1994-11-28 1996-01-16 Grant; Francine S. Substituted 3-indolyl-5-pyrazolone compounds
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GB0013655D0 (en) 2000-06-05 2000-07-26 Prolifix Ltd Therapeutic compounds
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EP1921072A1 (en) 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,3-Triazole derivatives as cannabinoid-receptor modulators
US7781580B2 (en) 2007-04-23 2010-08-24 Virginia Commonwealth University Stilbene derivatives as new cancer therapeutic agents
WO2009023773A2 (en) 2007-08-15 2009-02-19 University Of Miami Galactokinase inhibitors
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
US8450334B2 (en) 2008-06-11 2013-05-28 Fred Hutchinson Cancer Research Center Hepsin inhibitors
US8304421B2 (en) 2008-09-30 2012-11-06 Vanderbilt University Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents
TW201021797A (en) 2008-12-04 2010-06-16 Nat Univ Tsing Hua 1,2,3-triazole derivatives as new cannabinoid-1 receptor antagonists
EP2266562A1 (en) 2009-06-23 2010-12-29 Centre National de la Recherche Scientifique Use of derivatives of indoles for the treatment of cancer
US20110077250A1 (en) * 2009-06-26 2011-03-31 Ryder Sean Compounds for modulating rna binding proteins and uses therefor
JP2013533846A (ja) 2010-04-06 2013-08-29 ブリガム・ヤング・ユニバーシティ 抗転移化合物
JP5786402B2 (ja) * 2011-03-29 2015-09-30 コニカミノルタ株式会社 光学フィルム、及びそれを用いた偏光板、液晶表示装置
WO2014105957A1 (en) 2012-12-28 2014-07-03 Board Of Trustees University Of Arkansas Indole compounds for use in treating inflammation and cancer
AU2014254078A1 (en) 2013-04-19 2015-10-15 Bioventures, Llc Combretastatin analogs
CA2910063A1 (en) 2013-04-23 2014-10-30 The Board Of Trustees Of The University Of Arkansas Polymerase, endonuclease, and helicase inhibitors and methods of using thereof
CN105283190A (zh) 2013-06-13 2016-01-27 飞鱼有限公司 包含白藜芦醇或其衍生物的用于治疗、延缓和/或预防阿尔茨海默氏病的海洋油制剂
CA2940694A1 (en) 2014-03-31 2015-10-08 Board Of Trustees Of The University Of Arkansas Disubstituted triazole analogs
US20200024249A1 (en) 2017-02-02 2020-01-23 Bioventures, Llc Methods of protecting against neurodegeneration

Also Published As

Publication number Publication date
CA2907853A1 (en) 2014-10-23
US20160068506A1 (en) 2016-03-10
US10100029B2 (en) 2018-10-16
JP2016516814A (ja) 2016-06-09
AU2014254078A1 (en) 2015-10-15
EP2986596A4 (en) 2017-02-08
US20180118710A1 (en) 2018-05-03
WO2014172363A3 (en) 2014-12-31
US9884842B2 (en) 2018-02-06
EP2986596A2 (en) 2016-02-24
BR112015026048A2 (pt) 2017-07-25
WO2014172363A2 (en) 2014-10-23
SG11201508054UA (en) 2015-11-27

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