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MX2015005312A - Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12. - Google Patents

Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12.

Info

Publication number
MX2015005312A
MX2015005312A MX2015005312A MX2015005312A MX2015005312A MX 2015005312 A MX2015005312 A MX 2015005312A MX 2015005312 A MX2015005312 A MX 2015005312A MX 2015005312 A MX2015005312 A MX 2015005312A MX 2015005312 A MX2015005312 A MX 2015005312A
Authority
MX
Mexico
Prior art keywords
antagonists
indole
carboxamide derivatives
carboxamide
derivatives
Prior art date
Application number
MX2015005312A
Other languages
English (en)
Inventor
Alain Badorc
Christophe Boldron
Valérie FOSSEY
Angelina Besse
Gernot Zech
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2015005312A publication Critical patent/MX2015005312A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)

Abstract

La invención se relaciona con los compuestos que corresponden a la fórmula (I); y al uso de los mismos como antagonistas del receptor P2Y12 para el tratamiento de las enfermedades cardiovasculares.
MX2015005312A 2012-10-26 2013-10-24 Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12. MX2015005312A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306334.9A EP2725025A1 (fr) 2012-10-26 2012-10-26 Dérives de 1H-indole-3-carboxamide et leurs utilisation comme antagonistes du P2Y12
PCT/EP2013/072322 WO2014064219A1 (fr) 2012-10-26 2013-10-24 Derives de 1 h-indole-3-carboxamide et leurs utilisation comme antagonistes du p2y12

Publications (1)

Publication Number Publication Date
MX2015005312A true MX2015005312A (es) 2015-11-16

Family

ID=47146304

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005312A MX2015005312A (es) 2012-10-26 2013-10-24 Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12.

Country Status (14)

Country Link
US (1) US20150274703A1 (es)
EP (2) EP2725025A1 (es)
JP (1) JP6235029B2 (es)
KR (1) KR20150074131A (es)
CN (1) CN104936950B (es)
AU (1) AU2013336628A1 (es)
BR (1) BR112015009136A2 (es)
CA (1) CA2889538A1 (es)
ES (1) ES2608787T3 (es)
IL (1) IL238461A0 (es)
MX (1) MX2015005312A (es)
RU (1) RU2015119642A (es)
SG (1) SG11201503221PA (es)
WO (1) WO2014064219A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS60878B1 (sr) 2014-04-04 2020-11-30 Iomet Pharma Ltd Derivati indola za upotrebu u medicini
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
BR112020005174A2 (pt) 2017-09-14 2020-11-10 Daiichi Sankyo Company,Limited composto que possui estrutura cíclica

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
US7700620B2 (en) * 2005-06-27 2010-04-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
CN101663293B (zh) * 2007-04-23 2013-07-31 塞诺菲-安万特股份有限公司 作为p2y12拮抗剂的喹啉-甲酰胺衍生物
EP2238127B1 (en) * 2007-12-26 2012-08-15 Sanofi Pyrazole-carboxamide derivatives as p2y12 antagonists
FR2974576B1 (fr) * 2011-04-29 2013-07-19 Sanofi Aventis Derives de n-[(1h-pyrazol-1-yl)aryl]-1h-indole ou 1h- indazole-3-carboxamide, leur preparation et leurs applications en therapeutique

Also Published As

Publication number Publication date
KR20150074131A (ko) 2015-07-01
EP2725025A1 (fr) 2014-04-30
US20150274703A1 (en) 2015-10-01
CA2889538A1 (en) 2014-05-01
BR112015009136A2 (pt) 2017-07-04
EP2917204B1 (fr) 2016-09-28
JP6235029B2 (ja) 2017-11-22
ES2608787T3 (es) 2017-04-17
SG11201503221PA (en) 2015-06-29
JP2015535230A (ja) 2015-12-10
EP2917204A1 (fr) 2015-09-16
RU2015119642A (ru) 2016-12-20
CN104936950A (zh) 2015-09-23
WO2014064219A1 (fr) 2014-05-01
CN104936950B (zh) 2017-08-08
AU2013336628A1 (en) 2015-05-21
IL238461A0 (en) 2015-06-30

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