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MX2013012798A - Compuestos heterociclicos fusionados como moduladores del canal de sodio. - Google Patents

Compuestos heterociclicos fusionados como moduladores del canal de sodio.

Info

Publication number
MX2013012798A
MX2013012798A MX2013012798A MX2013012798A MX2013012798A MX 2013012798 A MX2013012798 A MX 2013012798A MX 2013012798 A MX2013012798 A MX 2013012798A MX 2013012798 A MX2013012798 A MX 2013012798A MX 2013012798 A MX2013012798 A MX 2013012798A
Authority
MX
Mexico
Prior art keywords
sodium channel
heterocyclic compounds
fused heterocyclic
channel modulators
compounds
Prior art date
Application number
MX2013012798A
Other languages
English (en)
Other versions
MX361350B (es
Inventor
Britton Kenneth Corkey
Elfatih Elzein
Robert H Jiang
Rao V Kalla
Tetsuya Kobayashi
Dmitry Koltun
Xiaofen Li
Ruben Martinez
Gregory Notte
Eric Q Parkhill
Thao Perry
Jeff Zablocki
Chandrasekar Venkataramani
Michael Graupe
Juan Guerrero
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2013012798A publication Critical patent/MX2013012798A/es
Publication of MX361350B publication Critical patent/MX361350B/es

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    • C07D253/04—1,2,3-Triazines
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  • Neurology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La invención actual se refiere a compuestos que son inhibidores del canal de sodio y su uso en el tratamiento de varios estados de enfermedad, incluyendo enfermedades cardiovasculares y diabetes. En modalidades particulares, la estructura de los compuestos se da por la Fórmula (I), (ver Fórmula) en donde Q, R1, X1, X2, Y, y R2 son como se describe en la presente, a métodos para la preparación y uso de los compuestos y a composiciones farmacéuticas que contienen los mismos.
MX2013012798A 2011-05-10 2012-05-08 Compuestos heterocíclicos fusionados como moduladores del canal de sodio. MX361350B (es)

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