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MD20140001A2 - Modulatori alosterici pozitivi ai receptorului nicotinic al acetilcolinei - Google Patents

Modulatori alosterici pozitivi ai receptorului nicotinic al acetilcolinei Download PDF

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Publication number
MD20140001A2
MD20140001A2 MDA20140001A MD20140001A MD20140001A2 MD 20140001 A2 MD20140001 A2 MD 20140001A2 MD A20140001 A MDA20140001 A MD A20140001A MD 20140001 A MD20140001 A MD 20140001A MD 20140001 A2 MD20140001 A2 MD 20140001A2
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MD
Moldova
Prior art keywords
acetylcholine receptor
positive allosteric
allosteric modulators
nicotinic acetylcholine
compounds
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Application number
MDA20140001A
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English (en)
Russian (ru)
Other versions
MD4634B1 (ro
Inventor
Юрген ЭСКИЛСЕН
Анетт Гравен САМС
Аск ПЮСЛ
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H. Lundbeck A/S
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Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of MD20140001A2 publication Critical patent/MD20140001A2/ro
Publication of MD4634B1 publication Critical patent/MD4634B1/ro

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Prezenta invenţie se referă la compuşii cu formula (I), utili pentru tratament, la compoziţii, care conţin compuşii menţionaţi şi la metode de tratament al afecţiunilor, care includ administrarea acestora. Compuşii menţionaţi reprezintă modulatori alosterici pozitivi (PAM) ai receptorului α7 nicotinic al acetilcolinei.(I)
MDA20140001A 2011-07-08 2012-07-06 Modulatori alosterici pozitivi ai receptorului nicotinic al acetilcolinei MD4634B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201100520 2011-07-08
PCT/EP2012/063219 WO2013007621A1 (en) 2011-07-08 2012-07-06 Positive allosteric modulators of nicotinic acetylcholine receptor

Publications (2)

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MD20140001A2 true MD20140001A2 (ro) 2014-04-30
MD4634B1 MD4634B1 (ro) 2019-06-30

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MDA20140001A MD4634B1 (ro) 2011-07-08 2012-07-06 Modulatori alosterici pozitivi ai receptorului nicotinic al acetilcolinei
MDA20160066A MD4639C1 (ro) 2011-07-08 2012-07-06 Modulatori alosterici pozitivi ai receptorului nicotinic acetilcolinic

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MDA20160066A MD4639C1 (ro) 2011-07-08 2012-07-06 Modulatori alosterici pozitivi ai receptorului nicotinic acetilcolinic

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EP (2) EP2729447B1 (ro)
JP (1) JP5706043B2 (ro)
KR (1) KR101928123B1 (ro)
CN (3) CN107082760A (ro)
AP (2) AP2016009188A0 (ro)
AR (1) AR087089A1 (ro)
AU (2) AU2012283208B2 (ro)
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DK3788043T3 (da) 2018-05-01 2024-12-16 Merck Sharp & Dohme Llc Spiropiperidin som allosteriske modulatorer af nicotinacetylcholinreceptorer
WO2021091751A1 (en) 2019-11-05 2021-05-14 Merck Sharp & Dohme Corp. Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors
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WO2023049060A1 (en) * 2021-09-21 2023-03-30 Merck Sharp & Dohme Llc Allosteric modulators of nicotinic acetylcholine receptors

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