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MX2012004148A - Compuestos de dioxido de iminotiadiazina como inhibidores de la enzima de disociacion de la proteina precursora amiloide en el sitio beta, composiciones, y su uso. - Google Patents

Compuestos de dioxido de iminotiadiazina como inhibidores de la enzima de disociacion de la proteina precursora amiloide en el sitio beta, composiciones, y su uso.

Info

Publication number
MX2012004148A
MX2012004148A MX2012004148A MX2012004148A MX2012004148A MX 2012004148 A MX2012004148 A MX 2012004148A MX 2012004148 A MX2012004148 A MX 2012004148A MX 2012004148 A MX2012004148 A MX 2012004148A MX 2012004148 A MX2012004148 A MX 2012004148A
Authority
MX
Mexico
Prior art keywords
sup
sub
compounds
iminothiadiazine dioxide
dioxide compounds
Prior art date
Application number
MX2012004148A
Other languages
English (en)
Inventor
Jack D Scott
Jared N Cumming
Guoqing Li
Ulrich Iserloh
Eric J Gilbert
Andrew W Stamford
Jeffrey A Misiaszek
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857101&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012004148(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2012004148A publication Critical patent/MX2012004148A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07C309/01—Sulfonic acids
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    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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Abstract

En sus muchas modalidades, la presente invención proporciona ciertos compuestos de dióxido de iminotiadiazina, incluyendo los compuestos de la Fórmula (I): (ver fórmula (I)) e incluyen sus estereoisómeros, y las sales farmacéuticamente aceptables de dichos compuestos, estereoisómeros, donde cada uno de R1, R2, R3, R4, R5, R9, el anillo A, el anillo B, m, n, p, -L1-,-L2-, y -L3- se selecciona independientemente y según lo definido en esta invención; se ha descubierto, sorprendentemente, que los compuestos de dióxido de iminotiadiazina novedosos de la invención exhiben propiedades las cuales se espera que los convierta en ventajosos como inhibidores de BACE y/o para el tratamiento y prevención de diversas patologías relacionadas con la producción de ß-amiloides ("Aß"); también se describen composiciones farmacéuticas que comprenden uno o más de dichos compuestos (solos y en combinación con uno o más otros agentes activos), y métodos para su preparación y uso en el tratamiento de patologías asociadas con la proteína amiloide beta (Aß), incluyendo la enfermedad de Alzheimer.
MX2012004148A 2009-10-08 2010-10-06 Compuestos de dioxido de iminotiadiazina como inhibidores de la enzima de disociacion de la proteina precursora amiloide en el sitio beta, composiciones, y su uso. MX2012004148A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24968509P 2009-10-08 2009-10-08
PCT/US2010/051553 WO2011044181A1 (en) 2009-10-08 2010-10-06 Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use

Publications (1)

Publication Number Publication Date
MX2012004148A true MX2012004148A (es) 2012-05-08

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MX2012004148A MX2012004148A (es) 2009-10-08 2010-10-06 Compuestos de dioxido de iminotiadiazina como inhibidores de la enzima de disociacion de la proteina precursora amiloide en el sitio beta, composiciones, y su uso.

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US (6) US8729071B2 (es)
EP (2) EP2485736B1 (es)
JP (4) JP5592494B2 (es)
KR (3) KR101759856B1 (es)
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