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MX2007008555A - Amino-imidazolonas para la inhibicion de (-secretasa. - Google Patents

Amino-imidazolonas para la inhibicion de (-secretasa.

Info

Publication number
MX2007008555A
MX2007008555A MX2007008555A MX2007008555A MX2007008555A MX 2007008555 A MX2007008555 A MX 2007008555A MX 2007008555 A MX2007008555 A MX 2007008555A MX 2007008555 A MX2007008555 A MX 2007008555A MX 2007008555 A MX2007008555 A MX 2007008555A
Authority
MX
Mexico
Prior art keywords
secretase
amino
imidazolones
inhibition
formula
Prior art date
Application number
MX2007008555A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Boyd Lynn Harrison
James Joseph Erdei
Iwan Suwandi Gunawan
Pawel Nowak
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2007008555A publication Critical patent/MX2007008555A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion suministra un compuesto de amino-imidazolona de formula (ver formula (I)) Tambien se suministran composiciones y metodos para el uso de estos para inhibir (-secretasa (BACE) y tratar depositos (-amiloides y ovillos neurofibrilares.
MX2007008555A 2005-01-14 2006-01-09 Amino-imidazolonas para la inhibicion de (-secretasa. MX2007008555A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64380505P 2005-01-14 2005-01-14
PCT/US2006/000656 WO2006076284A2 (en) 2005-01-14 2006-01-09 AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE

Publications (1)

Publication Number Publication Date
MX2007008555A true MX2007008555A (es) 2007-11-21

Family

ID=36581776

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007008555A MX2007008555A (es) 2005-01-14 2006-01-09 Amino-imidazolonas para la inhibicion de (-secretasa.

Country Status (20)

Country Link
US (2) US7563796B2 (es)
EP (2) EP1836208A2 (es)
JP (1) JP2008526966A (es)
KR (1) KR20070095948A (es)
CN (1) CN101103034A (es)
AR (1) AR052458A1 (es)
AU (1) AU2006205127A1 (es)
BR (1) BRPI0606690A2 (es)
CA (1) CA2593515A1 (es)
CR (1) CR9244A (es)
GT (1) GT200600009A (es)
IL (1) IL183938A0 (es)
MX (1) MX2007008555A (es)
NO (1) NO20073099L (es)
PA (1) PA8660001A1 (es)
PE (1) PE20060842A1 (es)
RU (1) RU2007126570A (es)
TW (1) TW200637866A (es)
WO (1) WO2006076284A2 (es)
ZA (1) ZA200705783B (es)

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Also Published As

Publication number Publication date
IL183938A0 (en) 2007-10-31
KR20070095948A (ko) 2007-10-01
PE20060842A1 (es) 2006-10-12
US20090253716A1 (en) 2009-10-08
JP2008526966A (ja) 2008-07-24
TW200637866A (en) 2006-11-01
RU2007126570A (ru) 2009-02-20
US7563796B2 (en) 2009-07-21
EP2264036A1 (en) 2010-12-22
AR052458A1 (es) 2007-03-21
ZA200705783B (en) 2008-09-25
CA2593515A1 (en) 2006-07-20
NO20073099L (no) 2007-07-31
CR9244A (es) 2007-09-07
BRPI0606690A2 (pt) 2009-07-14
EP1836208A2 (en) 2007-09-26
CN101103034A (zh) 2008-01-09
WO2006076284A2 (en) 2006-07-20
AU2006205127A1 (en) 2006-07-20
PA8660001A1 (es) 2006-09-08
WO2006076284A3 (en) 2007-04-19
US20060160828A1 (en) 2006-07-20
GT200600009A (es) 2006-08-17

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