[go: up one dir, main page]

MX2013000474A - Derivados de arilamida novedosos que tienen propiedades antiandrogenicas. - Google Patents

Derivados de arilamida novedosos que tienen propiedades antiandrogenicas.

Info

Publication number
MX2013000474A
MX2013000474A MX2013000474A MX2013000474A MX2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A MX 2013000474 A MX2013000474 A MX 2013000474A
Authority
MX
Mexico
Prior art keywords
arylamide derivatives
antiandrogenic properties
novel
formula
derivatives
Prior art date
Application number
MX2013000474A
Other languages
English (en)
Inventor
Jari Ratilainen
Milla Koistinaho
Anu Muona
Original Assignee
Medeia Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medeia Therapeutics Ltd filed Critical Medeia Therapeutics Ltd
Publication of MX2013000474A publication Critical patent/MX2013000474A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a derivados novedosos de arilamida que tiene la fórmula (I) (Ver Formula) y estereoisómeros y sus sales farmacéuticamente aceptables, donde R1 - R11, R', R", z y X son tal como se definieron en las reivindicaciones. Los derivados de arilamida de la fórmula (I) tienen propiedades antiandrogénicas. La invención también se refiere a compuestos de la fórmula (I) para utilizar como un medicamento y a composiciones farmacéuticas que los contienen y a su preparación.
MX2013000474A 2010-07-15 2011-07-14 Derivados de arilamida novedosos que tienen propiedades antiandrogenicas. MX2013000474A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20105806A FI20105806A0 (fi) 2010-07-15 2010-07-15 Uudet aryyliamidijohdannaiset, joilla on antiandrogeenisia ominaisuuksia
PCT/FI2011/050655 WO2012007644A1 (en) 2010-07-15 2011-07-14 Novel arylamide derivatives having antiandrogenic properties

Publications (1)

Publication Number Publication Date
MX2013000474A true MX2013000474A (es) 2013-05-17

Family

ID=42555499

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000474A MX2013000474A (es) 2010-07-15 2011-07-14 Derivados de arilamida novedosos que tienen propiedades antiandrogenicas.

Country Status (18)

Country Link
US (1) US8816119B2 (es)
EP (1) EP2593424B1 (es)
JP (1) JP5990833B2 (es)
KR (1) KR101928375B1 (es)
CN (1) CN102985403B (es)
AR (1) AR082218A1 (es)
AU (1) AU2011278201B2 (es)
BR (1) BR112013000783B1 (es)
CA (1) CA2804765C (es)
EA (1) EA022619B1 (es)
ES (1) ES2750309T3 (es)
FI (1) FI20105806A0 (es)
MX (1) MX2013000474A (es)
NZ (1) NZ605636A (es)
SG (1) SG187049A1 (es)
TW (1) TWI542343B (es)
WO (1) WO2012007644A1 (es)
ZA (1) ZA201300300B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201332953A (zh) * 2012-01-13 2013-08-16 Medeia Therapeutics Ltd 具抗雄激素性質新芳醯胺衍生物
WO2016079521A1 (en) * 2014-11-20 2016-05-26 University College Cardiff Consultants Limited Androgen receptor modulators and their use as anti-cancer agents
AU2016252753A1 (en) 2015-04-21 2017-11-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
MX2017013565A (es) 2015-04-21 2018-02-19 Gtx Inc Ligandos degradadores selectivos del receptor androgénico (sard) y sus métodos uso.
US10017471B2 (en) 2015-04-21 2018-07-10 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10093613B2 (en) 2015-04-21 2018-10-09 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10654809B2 (en) 2016-06-10 2020-05-19 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10806720B2 (en) 2015-04-21 2020-10-20 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US9834507B2 (en) 2015-04-21 2017-12-05 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10035763B2 (en) 2015-04-21 2018-07-31 Gtx, Inc. Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10865184B2 (en) 2015-04-21 2020-12-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US10441570B2 (en) 2015-04-21 2019-10-15 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) Ligands and methods of use thereof
US11230523B2 (en) 2016-06-10 2022-01-25 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof
US12202815B2 (en) 2018-09-05 2025-01-21 University Of Tennessee Research Foundation Selective androgen receptor degrader (SARD) ligands and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099165A1 (en) * 1982-03-23 1984-01-25 Imperial Chemical Industries Plc Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis
ZA831466B (en) * 1982-03-23 1984-10-31 Ici Plc Heterocyclic compounds
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
AU7604798A (en) * 1997-05-30 1998-12-30 University Of Tennessee Research Corporation, The Non-steroidal agonist compounds and their use in male hormone therapy
US7741371B2 (en) * 2002-06-17 2010-06-22 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
CA2642598C (en) * 2006-03-03 2014-05-27 Orion Corporation Selective androgen receptor modulators
TW200812962A (en) 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
MX2009000715A (es) 2006-07-19 2009-07-22 Osurf Ohio State University Re Moduladores de receptor de androgeno selectivos, analogos y derivados de los mismos.
CN101516835A (zh) * 2006-07-19 2009-08-26 俄亥俄州立大学研究基金会 选择性雄激素受体调节剂、它们的类似物和衍生物以及它们的用途
EP2083624A4 (en) * 2006-10-18 2010-06-16 Merck Sharp & Dohme 2-HYDROXY-2-PHENYL / THIOPHENYLPROPIONAMIDE AS ANDROGEN RECEPTOR MODULATORS
DE102006061913A1 (de) * 2006-12-21 2008-06-26 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
US8067448B2 (en) * 2008-02-22 2011-11-29 Radius Health, Inc. Selective androgen receptor modulators
EP2424853B1 (en) 2009-04-10 2018-09-19 Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori (I.R.S.T.) S.R.L. Non-steroidal compounds for androgen receptor modulation, processes for the preparation and uses thereof

Also Published As

Publication number Publication date
US8816119B2 (en) 2014-08-26
AU2011278201B2 (en) 2014-08-21
JP2013532178A (ja) 2013-08-15
TW201208669A (en) 2012-03-01
ZA201300300B (en) 2013-09-25
JP5990833B2 (ja) 2016-09-14
ES2750309T3 (es) 2020-03-25
CA2804765C (en) 2018-08-07
EP2593424A1 (en) 2013-05-22
CN102985403B (zh) 2016-03-23
KR101928375B1 (ko) 2018-12-12
EP2593424B1 (en) 2019-08-28
AR082218A1 (es) 2012-11-21
FI20105806A0 (fi) 2010-07-15
SG187049A1 (en) 2013-02-28
BR112013000783A2 (pt) 2020-11-03
EA022619B1 (ru) 2016-02-29
CN102985403A (zh) 2013-03-20
AU2011278201A1 (en) 2013-01-31
WO2012007644A1 (en) 2012-01-19
EA201390008A1 (ru) 2013-05-30
US20130109750A1 (en) 2013-05-02
KR20130079479A (ko) 2013-07-10
NZ605636A (en) 2014-05-30
TWI542343B (zh) 2016-07-21
BR112013000783B1 (pt) 2022-01-25
CA2804765A1 (en) 2012-01-19

Similar Documents

Publication Publication Date Title
MX2013000474A (es) Derivados de arilamida novedosos que tienen propiedades antiandrogenicas.
MX2022013596A (es) Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico.
MX2011012122A (es) Derivados de tiofeno.
MY149731A (en) Compounds
MX2011011661A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750.
TN2015000121A1 (en) Gdf-8 inhibitors
EP4245369A3 (en) Neuroactive steroids, compositions, and uses thereof
NZ608116A (en) Triazine-oxadiazoles
MX2009011802A (es) Imidazoquinolinas con propiedades inmunomoduladoras.
MX2013001929A (es) Nuevos compuestos
TN2013000253A1 (en) Bicyclo[3.2.1]octyl amide derivatives and uses of same
IN2012DN03182A (es)
WO2012051988A3 (de) Derivate von steroidbenzylaminen mit antiparasitärer, antibakterieller, antimykotischer und/oder antiviraler wirkung
MX2011013648A (es) Nuevos compuestos, composiciones farmaceuticas y metodos relacionados con ellos.
MX2009013501A (es) Compuestos piperidinicos y sus usos.
WO2009125434A3 (en) Oxime derivatives, process for their preparation, pharmaceutical composition containing the same and medicinal use thereof
IN2012DN01292A (es)
WO2012135615A3 (en) Enopeptins, uses thereof, and methods of synthesis thereto
MX2009006010A (es) Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2.
MY161749A (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
TN2012000105A1 (en) Spirolactam derivatives and uses of same
TN2011000531A1 (en) 5- alkynyl - pyridines
PH12013500671A1 (en) Novel gpr 119 agonists
WO2011087712A3 (en) Tricyclic derivatives and their pharmaceutical use and compositions
GEP20156269B (en) New secondary 8-hydroxyquinoline-7- carboxamide derivatives

Legal Events

Date Code Title Description
FG Grant or registration