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HN2012000612A - Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su uso - Google Patents

Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su uso

Info

Publication number
HN2012000612A
HN2012000612A HN2012000612A HN2012000612A HN2012000612A HN 2012000612 A HN2012000612 A HN 2012000612A HN 2012000612 A HN2012000612 A HN 2012000612A HN 2012000612 A HN2012000612 A HN 2012000612A HN 2012000612 A HN2012000612 A HN 2012000612A
Authority
HN
Honduras
Prior art keywords
compounds
iminotiadiazine
dioxide
dioxide compounds
compositions
Prior art date
Application number
HN2012000612A
Other languages
English (en)
Inventor
Jack D Scott
Andrew W Stamford
Eric J Gilbert
Jared N Cumming
Ulrich Iserloh
Jeffrey A Misiaszek
Guoqing Li
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43857101&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HN2012000612(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HN2012000612A publication Critical patent/HN2012000612A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

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Abstract

EN SUS MUCHAS RELACIONES, LA PRESENTE INVENCION PROPORCIONA CIERTOS COMPUESTOS DE DIOXIDO DE IMINOTIADIAZINA, INCLUYENDO LOS COMPUESTOS DE LA FORMULA (1) E INCLUYEN SUS ESTEREOSOMEROS, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS, ESTEREOISOMEROS, DONDE CADA UNO DE R1, R2, R3, R4, R5, R9, EL ANILLO A, EL ANILLO B, M. N, P, L1,-L2, Y L3,- SE SELECCIONA INDEPENDIENTEMENTE Y SEGUN LO DEFINIDO EN ESTA INVENCION. SE HA DESCUBIERTO , SORPRENDENTEMENTE, QUE LOS COMPUESTOS DE DIOXIDO DE IMINOTIADIAZINA NOVEDOSOS DE LA INVENCION EXHIBEN PROPIEDADES LAS CUALES SE ESPERA QUE LOS CONVIERTA EN VENTAJOSOS COMO INHIBIDORES DE BACE Y/O PARA ELTRATAMIENTO Y PREVENCION DE DIVERSAS PATOLOGIAS RELACIONADAS CON LA PRODUCCION DE B-AMILOIDES (AB,) TAMBIENSE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN UNO O MAS DE DICHOS COMPUESTOS ( SOLOS Y EN COMBINACION CON UNO O MAS OTROS AGENTES ACTIVOS), Y METODOS PARA SU PREPARACION Y USO EN EL TRATAMIENTO DE PATOLOGIAS ASOCIADAS CON LA PROTEINA AMILOIDE BETA ( AB),INCLUYENDO LA ENFERMEDAD DE ALZHEIMER.
HN2012000612A 2009-10-08 2012-03-29 Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su uso HN2012000612A (es)

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US24968509P 2009-10-08 2009-10-08

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HN2012000612A true HN2012000612A (es) 2015-02-02

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HN2012000612A HN2012000612A (es) 2009-10-08 2012-03-29 Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su uso

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US (6) US8729071B2 (es)
EP (2) EP2485736B1 (es)
JP (4) JP5592494B2 (es)
KR (3) KR101759856B1 (es)
CN (2) CN104744403A (es)
AR (1) AR078534A1 (es)
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