MA41197B1 - Traitement de le pemphigus - Google Patents
Traitement de le pemphigusInfo
- Publication number
- MA41197B1 MA41197B1 MA41197A MA41197A MA41197B1 MA 41197 B1 MA41197 B1 MA 41197B1 MA 41197 A MA41197 A MA 41197A MA 41197 A MA41197 A MA 41197A MA 41197 B1 MA41197 B1 MA 41197B1
- Authority
- MA
- Morocco
- Prior art keywords
- pemphigus
- corticosteroids
- therapy
- relates
- present
- Prior art date
Links
- 241000721454 Pemphigus Species 0.000 title abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 abstract 3
- 239000003246 corticosteroid Substances 0.000 abstract 3
- 229960001334 corticosteroids Drugs 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 201000011152 Pemphigus Diseases 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 238000009093 first-line therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000001976 pemphigus vulgaris Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000009256 replacement therapy Methods 0.000 abstract 1
- 238000009094 second-line therapy Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des procédés de traitement, avec un inhibiteur de btk, d'une maladie bulleuse, en particulier du pemphigus vulgaire ou du pemphigus foliacé chez un mammifère, l'utilisation d'un inhibiteur de btk en tant que thérapie de remplacement d'une thérapie par corticoïdes pour les maladies pouvant être traitées avec des corticoïdes, telles qu'une maladie auto-immune ou une maladie inflammatoire et en particulier lorsque des corticoïdes sont utilisés comme thérapie de première ou de seconde ligne. La présente invention concerne également des formulations pharmaceutiques comprenant ces inhibiteurs de btk.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093891P | 2014-12-18 | 2014-12-18 | |
| PCT/US2015/066868 WO2016100914A1 (fr) | 2014-12-18 | 2015-12-18 | Traitement du pemphigus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA41197B1 true MA41197B1 (fr) | 2021-01-29 |
Family
ID=55080225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA41197A MA41197B1 (fr) | 2014-12-18 | 2015-12-18 | Traitement de le pemphigus |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10485797B2 (fr) |
| EP (1) | EP3233103B1 (fr) |
| CN (1) | CN107257686B (fr) |
| AU (2) | AU2015364335B2 (fr) |
| CA (1) | CA2970723C (fr) |
| EA (1) | EA036269B1 (fr) |
| ES (1) | ES2843323T3 (fr) |
| IL (1) | IL252839B (fr) |
| MA (1) | MA41197B1 (fr) |
| MX (1) | MX381283B (fr) |
| PL (1) | PL3233103T3 (fr) |
| PT (1) | PT3233103T (fr) |
| SG (1) | SG11201704808VA (fr) |
| WO (1) | WO2016100914A1 (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104822681B (zh) | 2012-09-10 | 2018-01-30 | 普林斯匹亚生物制药公司 | 作为激酶抑制剂的吡唑并嘧啶化合物 |
| ES2619125T3 (es) | 2013-04-25 | 2017-06-23 | Beigene, Ltd. | Compuestos heterocíclicos fusionados como inhibidores de proteína cinasa |
| IL296026B2 (en) | 2013-09-13 | 2024-10-01 | Beigene Switzerland Gmbh | Anti-pd1 antibodies and their use as therapeutics and diagnostics |
| EP3107544B1 (fr) | 2014-02-21 | 2020-10-07 | Principia Biopharma Inc. | Sels et forme solide d'un inhibiteur de btk |
| JP6526189B2 (ja) | 2014-07-03 | 2019-06-05 | ベイジーン リミテッド | 抗pd−l1抗体並びにその治療及び診断のための使用 |
| CA2970723C (fr) | 2014-12-18 | 2023-09-05 | Principia Biopharma Inc. | Traitement du pemphigus |
| EP3313839A1 (fr) | 2015-06-24 | 2018-05-02 | Principia Biopharma Inc. | Inhibiteurs de la tyrosine kinase |
| IL293621B2 (en) | 2016-06-29 | 2023-09-01 | Principia Biopharma Inc | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[4,3-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4 -Methyl-4-[4-(oxane-3-yl)piperazine-1-yl)penta-2-ananitrile |
| WO2018007885A1 (fr) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | Association d'un antagoniste de pd-1 et d'un inhibiteur du raf pour le traitement du cancer. |
| SG11201901141WA (en) | 2016-08-16 | 2019-03-28 | Beigene Ltd | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| PT3500299T (pt) * | 2016-08-19 | 2024-02-21 | Beigene Switzerland Gmbh | Combinação de zanubrutinib com um anticorpo anti-cd20 ou anti-pd-1 para utilização no tratamento do cancro |
| MX386843B (es) | 2016-12-15 | 2025-03-19 | Hoffmann La Roche | Proceso para preparar inhibidores de tirosina cinasa de bruton (btk) |
| CN108329274B (zh) * | 2017-01-13 | 2021-09-03 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| CN110461847B (zh) * | 2017-01-25 | 2022-06-07 | 百济神州有限公司 | (S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途 |
| CN108727404B (zh) * | 2017-04-14 | 2020-05-12 | 中国科学院上海药物研究所 | 噻吩并[3,2-d]嘧啶类化合物、其制备方法及用途 |
| TWI877099B (zh) | 2017-06-26 | 2025-03-21 | 英屬開曼群島商百濟神州有限公司 | 抗pd-1抗體或其抗原結合片段在製備治療用於患有肝細胞癌(hcc)之藥物的用途 |
| WO2019034009A1 (fr) | 2017-08-12 | 2019-02-21 | Beigene, Ltd. | Inhibiteur de btk ayant une double sélectivité améliorée |
| WO2019108795A1 (fr) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Traitement de lymphomes à cellules b indolentes ou agressives au moyen d'une combinaison comprenant des inhibiteurs de btk |
| US20210113568A1 (en) * | 2018-04-27 | 2021-04-22 | Ono Pharmaceutical Co., Ltd. | PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT |
| MX2021003064A (es) * | 2018-09-18 | 2021-05-27 | Beijing Innocare Pharma Tech Co Ltd | Formas cristalinas de 6-(1-acriloilpiperidin-4-il)-2-(4-fenoxifeni l)nicotinamida. |
| AU2019376368B2 (en) | 2018-11-06 | 2025-05-08 | Beijing Innocare Pharma Tech Co., Ltd. | Amorphous solid dispersion comprising 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide |
| CN109939223B (zh) * | 2019-04-04 | 2020-04-07 | 中南大学湘雅二医院 | 一种白介素2在制备用于治疗寻常型天疱疮口腔糜烂药物的应用 |
| TWI856111B (zh) | 2019-06-10 | 2024-09-21 | 瑞士商百濟神州瑞士有限責任公司 | 一種含有布魯頓氏酪胺酸激酶抑制劑的口服固體錠劑及其製備方法 |
| MX2022004283A (es) | 2019-10-09 | 2022-07-12 | Principia Biopharma Inc | Metodos para tratar penfigo mediante la administracion de (r)-2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)pirazolo[3,4-d]pirim idin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)pipera zin-1-il]pent-2-enonitrilo. |
| IL291994A (en) | 2019-10-14 | 2022-06-01 | Principia Biopharma Inc | Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine- 1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| KR20220124753A (ko) | 2020-01-08 | 2022-09-14 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)-1H-피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카보닐]-4,4-디메틸펜트-2-엔니트릴을 포함하는 국소 약제학적 조성물 |
| CN115461341A (zh) | 2020-01-22 | 2022-12-09 | 普林斯匹亚生物制药公司 | 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)-1h-吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的晶型 |
| WO2021207662A1 (fr) * | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Utilisation d'il-22-fc pour le traitement ou la prévention de la pneumonie, du syndrome de détresse respiratoire aiguë ou du syndrome de libération de cytokines |
| US20240207277A1 (en) * | 2021-04-16 | 2024-06-27 | Principia Biopharma Inc. | Methods For Treating Drug and Vaccine Induced Immune Thrombocytopenia by Administering Specific Compounds |
| US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
| TW202432135A (zh) | 2022-10-31 | 2024-08-16 | 美商普林斯匹亞生物製藥公司 | 藉由投予(r)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑並[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-氧雜環丁-3-基)哌𠯤-1-基]戊-2-烯腈治療免疫性血小板減少症的方法 |
| KR20250114128A (ko) | 2022-12-09 | 2025-07-28 | 프린시피아 바이오파마, 인코퍼레이티드 | 인지 장애가 있는 대상체의 면역성 혈소판감소증을 릴자브루티닙 투여로 치료하는 방법 |
| CN116849178A (zh) * | 2023-06-26 | 2023-10-10 | 武汉大学中南医院 | 胎源性成年骨关节炎易感模型的构建方法、共性干预靶标及其应用 |
| WO2025006680A1 (fr) | 2023-06-30 | 2025-01-02 | Principia Biopharma Inc. | Méthodes de traitement de la thrombocytopénie immunitaire persistante ou chronique chez les enfants, les adolescents et les adultes par administration de (r)-2-[3-[4-amino-3-(2-fluoro-4-phénoxyphényl)pyrazolo[3,4-d]pyrimidin-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétan-3-yl)pipérazin-1-yl]pent-2-ènenitrile |
| CN121368486A (zh) | 2023-07-17 | 2026-01-20 | 卡德门企业有限公司 | 包含btk抑制剂和贝舒地尔的组合疗法 |
| TW202535404A (zh) | 2023-10-25 | 2025-09-16 | 美商普林斯匹亞生物製藥公司 | 使用btk抑制劑2-[(3r)-3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧雜環丁烷-3-基)哌𠯤-1-基]戊-2-烯腈治療與異位性皮炎和/或結節性癢疹相關的搔癢 |
| WO2025122747A1 (fr) | 2023-12-06 | 2025-06-12 | Principia Biopharma Inc. | Traitement de l'asthme modéré à sévère par administration de rilzabrutinib |
| WO2026024765A1 (fr) | 2024-07-23 | 2026-01-29 | Principia Biopharma Inc. | Traitement de la thrombose veineuse avec du rilzabrutinib et ses dérivés |
| WO2026024885A1 (fr) | 2024-07-24 | 2026-01-29 | Principia Biopharma Inc. | Rizalbrutinib pour le traitement de l'anémie hémolytique auto-immune à anticorps chaud |
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-
2015
- 2015-12-18 CA CA2970723A patent/CA2970723C/fr active Active
- 2015-12-18 CN CN201580076193.1A patent/CN107257686B/zh active Active
- 2015-12-18 PL PL15823107T patent/PL3233103T3/pl unknown
- 2015-12-18 EP EP15823107.6A patent/EP3233103B1/fr active Active
- 2015-12-18 EA EA201791243A patent/EA036269B1/ru not_active IP Right Cessation
- 2015-12-18 AU AU2015364335A patent/AU2015364335B2/en active Active
- 2015-12-18 PT PT158231076T patent/PT3233103T/pt unknown
- 2015-12-18 MX MX2017007973A patent/MX381283B/es unknown
- 2015-12-18 SG SG11201704808VA patent/SG11201704808VA/en unknown
- 2015-12-18 WO PCT/US2015/066868 patent/WO2016100914A1/fr not_active Ceased
- 2015-12-18 MA MA41197A patent/MA41197B1/fr unknown
- 2015-12-18 US US15/537,294 patent/US10485797B2/en active Active
- 2015-12-18 ES ES15823107T patent/ES2843323T3/es active Active
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2017
- 2017-06-12 IL IL252839A patent/IL252839B/en active IP Right Grant
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2019
- 2019-10-04 US US16/593,352 patent/US10946008B2/en active Active
-
2020
- 2020-11-05 AU AU2020264338A patent/AU2020264338A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020264338A1 (en) | 2020-12-03 |
| US20180050027A1 (en) | 2018-02-22 |
| CN107257686A (zh) | 2017-10-17 |
| US20200101059A1 (en) | 2020-04-02 |
| CA2970723C (fr) | 2023-09-05 |
| PT3233103T (pt) | 2021-01-18 |
| US10485797B2 (en) | 2019-11-26 |
| AU2015364335A1 (en) | 2017-07-20 |
| BR112017013022A2 (pt) | 2018-02-27 |
| IL252839B (en) | 2021-03-25 |
| EP3233103B1 (fr) | 2020-10-14 |
| ES2843323T3 (es) | 2021-07-16 |
| CA2970723A1 (fr) | 2016-06-23 |
| IL252839A0 (en) | 2017-08-31 |
| CN107257686B (zh) | 2021-01-29 |
| US10946008B2 (en) | 2021-03-16 |
| MX381283B (es) | 2025-03-12 |
| MX2017007973A (es) | 2018-02-09 |
| EP3233103A1 (fr) | 2017-10-25 |
| AU2015364335B2 (en) | 2020-11-26 |
| PL3233103T3 (pl) | 2021-04-19 |
| EA201791243A1 (ru) | 2017-12-29 |
| SG11201704808VA (en) | 2017-07-28 |
| WO2016100914A1 (fr) | 2016-06-23 |
| EA036269B1 (ru) | 2020-10-21 |
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