ZA200303847B - Guanidine and amidine derivatives as factor XA inhibitors. - Google Patents

Guanidine and amidine derivatives as factor XA inhibitors. Download PDF

Info

Publication number: ZA200303847B
Authority: ZA; South Africa
Prior art keywords: alkyl; another; unsubstituted; mono; trisubstituted independently
Prior art date: 2000-12-06

Application number

ZA200303847A

Other languages

English (en)

Inventor

Anuschirwan Peyman

David William Will

Uwe Gerlach

Marc Nazare

Gerhard Zoller

Hans-Peter Nestler

Hans Matter

Fahad L-Obeidi

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-06

Filing date

2003-05-19

Publication date

2004-04-15

2003-05-19 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2004-04-15 Publication of ZA200303847B publication Critical patent/ZA200303847B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA200303847A 2000-12-06 2003-05-19 Guanidine and amidine derivatives as factor XA inhibitors. ZA200303847B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00126750		2000-12-06

Publications (1)

Publication Number	Publication Date
ZA200303847B true ZA200303847B (en)	2004-04-15

Family

ID=8170585

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200303847A ZA200303847B (en)	2000-12-06	2003-05-19	Guanidine and amidine derivatives as factor XA inhibitors.

Country Status (26)

Country	Link
US (2)	US20020173656A1 (ru)
EP (1)	EP1345900B1 (ru)
JP (1)	JP4274522B2 (ru)
KR (1)	KR20040015036A (ru)
CN (1)	CN1479722A (ru)
AR (1)	AR033684A1 (ru)
AU (2)	AU3320602A (ru)
BR (1)	BR0115938A (ru)
CA (1)	CA2430518C (ru)
CZ (1)	CZ20031554A3 (ru)
DE (1)	DE60126143T2 (ru)
DK (1)	DK1345900T3 (ru)
EE (1)	EE200300192A (ru)
ES (1)	ES2278798T3 (ru)
HR (1)	HRP20030447A2 (ru)
HU (1)	HUP0302604A3 (ru)
IL (2)	IL156214A0 (ru)
MX (1)	MXPA03004848A (ru)
NO (1)	NO20032489L (ru)
NZ (1)	NZ526269A (ru)
PL (1)	PL362320A1 (ru)
PT (1)	PT1345900E (ru)
RU (1)	RU2003120070A (ru)
SK (1)	SK6862003A3 (ru)
WO (1)	WO2002046159A1 (ru)
ZA (1)	ZA200303847B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL374971A1 (en) *	2002-08-09	2005-11-14	Transtech Pharma, Inc.	Aryl and heteroaryl compounds and methods to modulate coagulation
US7405210B2 (en)	2003-05-21	2008-07-29	Osi Pharmaceuticals, Inc.	Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
US7208601B2 (en) *	2003-08-08	2007-04-24	Mjalli Adnan M M	Aryl and heteroaryl compounds, compositions, and methods of use
US7501538B2 (en)	2003-08-08	2009-03-10	Transtech Pharma, Inc.	Aryl and heteroaryl compounds, compositions and methods of use
AU2004263508A1 (en) *	2003-08-08	2005-02-17	Transtech Pharma, Inc.	Aryl and heteroaryl compounds, compositions, and methods of use
JP4794303B2 (ja) *	2003-10-10	2011-10-19	中外製薬株式会社	固形腫瘍治療剤
ATE483708T1 (de)	2004-03-08	2010-10-15	Prosidion Ltd	Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase
ES2324173T3 (es)	2004-12-02	2009-07-31	Prosidion Limited	Amidas del acido pirrolopiridin-2-carboxilico.
DE102006048300A1 (de) *	2006-01-26	2007-08-02	Hellstern, Peter, Prof. Dr.med.	Inhibitoren des Blutgerinnungsfaktors Xa zur Verwendung als Antikoagulans
US20100222381A1 (en)	2009-02-27	2010-09-02	Hariprasad Vankayalapati	Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
US8507640B2 (en)	2010-08-19	2013-08-13	International Business Machines Corporation	Methods of ring opening polymerization and catalysts therefor
JO3407B1 (ar)	2012-05-31	2019-10-20	Eisai R&D Man Co Ltd	مركبات رباعي هيدرو بيرازولو بيريميدين
TW201920081A (zh)	2017-07-11	2019-06-01	美商維泰克斯製藥公司	作為鈉通道調節劑的羧醯胺
CN111148743B (zh)	2017-10-06	2023-12-15	福马治疗有限公司	抑制泛素特异性肽酶30
IL278291B2 (en)	2018-05-17	2023-10-01	Forma Therapeutics Inc	Fused bicyclic compounds useful as ubiquitin-specific peptidase 30 inhibitors
SG11202102815SA (en)	2018-10-05	2021-04-29	Forma Therapeutics Inc	Fused pyrrolines which act as ubiquitin-specific protease 30 (usp30) inhibitors
WO2020146612A1 (en)	2019-01-10	2020-07-16	Vertex Pharmaceuticals Incorporated	Esters and carbamates as modulators of sodium channels
US12441703B2 (en)	2019-01-10	2025-10-14	Vertex Pharmaceuticals Incorporated	Carboxamides as modulators of sodium channels
US20250389737A1 (en) *	2024-06-20	2025-12-25	Instrumentation Laboratory Company	FACTOR Xa REAGENT
EP4667582A1 (en) *	2024-06-20	2025-12-24	Instrumentation Laboratory Company	Factor xa reagent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW201303B (ru) *	1990-07-05	1993-03-01	Hoffmann La Roche
US5506134A (en)	1990-10-22	1996-04-09	Corvas International, Inc.	Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5833982A (en)	1991-02-28	1998-11-10	Zymogenetics, Inc.	Modified factor VII
US5788965A (en)	1991-02-28	1998-08-04	Novo Nordisk A/S	Modified factor VII
ES2103181B1 (es) *	1994-08-01	1998-04-01	Menarini Lab	Amidas naftalenicas con accion antagonista de los leucotrienos.
SI9520044B (sl) *	1994-04-26	2004-08-31	Aventis Pharmaceuticals Inc.	Inhibitorji Xa faktorja
US5792769A (en) *	1995-09-29	1998-08-11	3-Dimensional Pharmaceuticals, Inc.	Guanidino protease inhibitors
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
TW542822B (en) *	1997-01-17	2003-07-21	Ajinomoto Kk	Benzamidine derivatives
IL133625A0 (en) *	1997-06-26	2001-04-30	Lilly Co Eli	Antithrombotic agents
BR9909086A (pt)	1998-03-23	2001-09-04	Aventis Pharm Prod Inc	Derivados de piperidinila e n-amidinopiperidinila
US20020016339A1 (en) *	1998-03-23	2002-02-07	Klein Scott I.	Piperididinyl and N-amidinopiperidinyl derivatives
EP0987274A1 (en)	1998-09-15	2000-03-22	Hoechst Marion Roussel Deutschland GmbH	Factor VIIa Inhibitors
BR0014076A (pt) *	1999-09-17	2002-10-15	Millennium Pharm Inc	Benzamidas e inibidores correlatos do fator xa

2001
- 2001-11-28 JP JP2002547898A patent/JP4274522B2/ja not_active Expired - Fee Related
- 2001-11-28 PL PL01362320A patent/PL362320A1/xx unknown
- 2001-11-28 CZ CZ20031554A patent/CZ20031554A3/cs unknown
- 2001-11-28 KR KR10-2003-7007612A patent/KR20040015036A/ko not_active Withdrawn
- 2001-11-28 ES ES01984775T patent/ES2278798T3/es not_active Expired - Lifetime
- 2001-11-28 HR HR20030447A patent/HRP20030447A2/hr not_active Application Discontinuation
- 2001-11-28 SK SK686-2003A patent/SK6862003A3/sk unknown
- 2001-11-28 DK DK01984775T patent/DK1345900T3/da active
- 2001-11-28 DE DE60126143T patent/DE60126143T2/de not_active Expired - Lifetime
- 2001-11-28 HU HU0302604A patent/HUP0302604A3/hu unknown
- 2001-11-28 CA CA2430518A patent/CA2430518C/en not_active Expired - Fee Related
- 2001-11-28 IL IL15621401A patent/IL156214A0/xx unknown
- 2001-11-28 CN CNA018201121A patent/CN1479722A/zh active Pending
- 2001-11-28 EE EEP200300192A patent/EE200300192A/xx unknown
- 2001-11-28 PT PT01984775T patent/PT1345900E/pt unknown
- 2001-11-28 EP EP01984775A patent/EP1345900B1/en not_active Expired - Lifetime
- 2001-11-28 WO PCT/EP2001/013874 patent/WO2002046159A1/en not_active Ceased
- 2001-11-28 MX MXPA03004848A patent/MXPA03004848A/es active IP Right Grant
- 2001-11-28 RU RU2003120070/04A patent/RU2003120070A/ru not_active Application Discontinuation
- 2001-11-28 AU AU3320602A patent/AU3320602A/xx active Pending
- 2001-11-28 AU AU2002233206A patent/AU2002233206B2/en not_active Ceased
- 2001-11-28 NZ NZ526269A patent/NZ526269A/en unknown
- 2001-11-28 BR BR0115938-0A patent/BR0115938A/pt not_active Application Discontinuation
- 2001-12-04 AR ARP010105642A patent/AR033684A1/es unknown
- 2001-12-06 US US10/004,422 patent/US20020173656A1/en not_active Abandoned
2003
- 2003-05-19 ZA ZA200303847A patent/ZA200303847B/en unknown
- 2003-05-29 IL IL156214A patent/IL156214A/en not_active IP Right Cessation
- 2003-06-02 NO NO20032489A patent/NO20032489L/no not_active Application Discontinuation
2004
- 2004-07-07 US US10/886,312 patent/US7435747B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HRP20030447A2 (en)	2005-04-30
KR20040015036A (ko)	2004-02-18
AU3320602A (en)	2002-06-18
PT1345900E (pt)	2007-03-30
DE60126143T2 (de)	2007-11-15
CA2430518A1 (en)	2002-06-13
ES2278798T3 (es)	2007-08-16
DK1345900T3 (da)	2007-05-21
JP4274522B2 (ja)	2009-06-10
IL156214A (en)	2010-05-31
BR0115938A (pt)	2003-12-23
HUP0302604A2 (hu)	2003-11-28
US20020173656A1 (en)	2002-11-21
DE60126143D1 (de)	2007-03-08
RU2003120070A (ru)	2004-12-27
CZ20031554A3 (cs)	2003-08-13
NO20032489L (no)	2003-07-25
NZ526269A (en)	2004-11-26
EP1345900B1 (en)	2007-01-17
CN1479722A (zh)	2004-03-03
SK6862003A3 (en)	2004-02-03
PL362320A1 (en)	2004-10-18
AR033684A1 (es)	2004-01-07
IL156214A0 (en)	2003-12-23
CA2430518C (en)	2010-06-15
NO20032489D0 (no)	2003-06-02
AU2002233206B2 (en)	2006-06-22
US7435747B2 (en)	2008-10-14
HUP0302604A3 (en)	2005-09-28
EE200300192A (et)	2003-08-15
JP2004515492A (ja)	2004-05-27
MXPA03004848A (es)	2003-08-19
WO2002046159A1 (en)	2002-06-13
EP1345900A1 (en)	2003-09-24
US20050143419A1 (en)	2005-06-30

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