[go: up one dir, main page]

WO2009028631A1 - 角膜内皮細胞接着促進剤 - Google Patents

角膜内皮細胞接着促進剤 Download PDF

Info

Publication number
WO2009028631A1
WO2009028631A1 PCT/JP2008/065459 JP2008065459W WO2009028631A1 WO 2009028631 A1 WO2009028631 A1 WO 2009028631A1 JP 2008065459 W JP2008065459 W JP 2008065459W WO 2009028631 A1 WO2009028631 A1 WO 2009028631A1
Authority
WO
WIPO (PCT)
Prior art keywords
corneal endothelial
agent
cell adhesion
endothelial cell
kinase inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065459
Other languages
English (en)
French (fr)
Inventor
Noriko Koizumi
Shigeru Kinoshita
Morio Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senju Pharmaceutical Co Ltd
Original Assignee
Senju Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1020227037529A priority Critical patent/KR20220151013A/ko
Priority to JP2009530186A priority patent/JP5657252B2/ja
Priority to RU2010111744/15A priority patent/RU2474434C2/ru
Priority to KR1020147033392A priority patent/KR20150004899A/ko
Priority to ES08828145.6T priority patent/ES2659980T3/es
Priority to EP08828145.6A priority patent/EP2193806B1/en
Priority to KR1020187007476A priority patent/KR20180031066A/ko
Priority to CN200880112897.XA priority patent/CN101835491B/zh
Priority to US12/675,475 priority patent/US9248125B2/en
Priority to MX2010002426A priority patent/MX2010002426A/es
Priority to KR1020157018932A priority patent/KR20150088907A/ko
Application filed by Senju Pharmaceutical Co Ltd filed Critical Senju Pharmaceutical Co Ltd
Priority to KR1020197022179A priority patent/KR20190091567A/ko
Priority to BRPI0816182 priority patent/BRPI0816182A2/pt
Priority to KR1020247009980A priority patent/KR20240045364A/ko
Priority to CA2697895A priority patent/CA2697895C/en
Priority to KR1020217017484A priority patent/KR20210070407A/ko
Publication of WO2009028631A1 publication Critical patent/WO2009028631A1/ja
Anticipated expiration legal-status Critical
Priority to US14/879,658 priority patent/US11633404B2/en
Priority to US14/879,857 priority patent/US11839618B2/en
Priority to US18/182,873 priority patent/US20230210864A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

　角膜内皮細胞を効率的に増殖可能な手段および角膜内皮製剤の安定的供給手段の提供。 　Ｒｈｏキナーゼ阻害剤を含有してなる角膜内皮細胞の接着促進剤、Ｒｈｏキナーゼ阻害剤を含有してなる角膜内皮細胞の培養液、Ｒｈｏキナーゼ阻害剤を含有してなる角膜保存液、前記培養液を用いて角膜内皮細胞を培養する工程を含む、角膜内皮製剤の製造方法。
PCT/JP2008/065459 2007-08-29 2008-08-28 角膜内皮細胞接着促進剤 Ceased WO2009028631A1 (ja)

Priority Applications (19)

Application Number Priority Date Filing Date Title
KR1020157018932A KR20150088907A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
RU2010111744/15A RU2474434C2 (ru) 2007-08-29 2008-08-28 Средство для содействия адгезии роговичных эндотелиальных клеток
KR1020147033392A KR20150004899A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
ES08828145.6T ES2659980T3 (es) 2007-08-29 2008-08-28 Agente para promover la adherencia de células endoteliales de la córnea
EP08828145.6A EP2193806B1 (en) 2007-08-29 2008-08-28 Agent for promoting corneal endothelial cell adhesion
KR1020187007476A KR20180031066A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
KR1020197022179A KR20190091567A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
JP2009530186A JP5657252B2 (ja) 2007-08-29 2008-08-28 角膜内皮細胞接着促進剤
MX2010002426A MX2010002426A (es) 2007-08-29 2008-08-28 Agente para promover la adhesion de las celulas del endotelio corneal.
KR1020227037529A KR20220151013A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
US12/675,475 US9248125B2 (en) 2007-08-29 2008-08-28 Agent for promoting corneal endothelial cell adhesion
CN200880112897.XA CN101835491B (zh) 2007-08-29 2008-08-28 促进角膜内皮细胞粘附的药剂
BRPI0816182 BRPI0816182A2 (pt) 2007-08-29 2008-08-28 Agente para promoção de adesão celular endotelial corneana
KR1020247009980A KR20240045364A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
CA2697895A CA2697895C (en) 2007-08-29 2008-08-28 Agent for promoting corneal endothelial cell adhesion
KR1020217017484A KR20210070407A (ko) 2007-08-29 2008-08-28 각막 내피 세포 접착 촉진제
US14/879,658 US11633404B2 (en) 2007-08-29 2015-10-09 Agent for promoting corneal endothelial cell adhesion
US14/879,857 US11839618B2 (en) 2007-08-29 2015-10-09 Agent for promoting corneal endothelial cell adhesion
US18/182,873 US20230210864A1 (en) 2007-08-29 2023-03-13 Agent for promoting corneal endothelial cell adhesion

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-223141 2007-08-29
JP2007223141 2007-08-29
JP2008-016088 2008-01-28
JP2008016088 2008-01-28

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US12/675,475 A-371-Of-International US9248125B2 (en) 2007-08-29 2008-08-28 Agent for promoting corneal endothelial cell adhesion
US14/879,857 Continuation US11839618B2 (en) 2007-08-29 2015-10-09 Agent for promoting corneal endothelial cell adhesion
US14/879,658 Continuation US11633404B2 (en) 2007-08-29 2015-10-09 Agent for promoting corneal endothelial cell adhesion

Publications (1)

Publication Number Publication Date
WO2009028631A1 true WO2009028631A1 (ja) 2009-03-05

Family

ID=40387345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065459 Ceased WO2009028631A1 (ja) 2007-08-29 2008-08-28 角膜内皮細胞接着促進剤

Country Status (11)

Country Link
US (4) US9248125B2 (ja)
EP (1) EP2193806B1 (ja)
JP (10) JP5657252B2 (ja)
KR (8) KR20220151013A (ja)
CN (3) CN103931608B (ja)
BR (1) BRPI0816182A2 (ja)
CA (1) CA2697895C (ja)
ES (1) ES2659980T3 (ja)
MX (1) MX2010002426A (ja)
RU (1) RU2474434C2 (ja)
WO (1) WO2009028631A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011081221A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
JP2012521200A (ja) * 2009-03-23 2012-09-13 中国海洋大学 組織工学によって作製されたヒト角膜内皮の再生方法
WO2013100208A1 (ja) 2011-12-28 2013-07-04 京都府公立大学法人 角膜内皮細胞の培養正常化
WO2014007402A1 (ja) * 2012-07-06 2014-01-09 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
WO2014038639A1 (ja) 2012-09-07 2014-03-13 日本ケミカルリサーチ株式会社 間葉系幹細胞の馴化培地を含有する角膜内皮細胞培養用培地
WO2015097920A1 (ja) * 2013-12-27 2015-07-02 京都府公立大学法人 角膜内皮細胞の細胞治療併用剤
WO2016047647A1 (ja) * 2014-09-24 2016-03-31 興和株式会社 角膜厚調節剤
WO2020071438A1 (ja) * 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
JP2020054330A (ja) * 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
JPWO2022085680A1 (ja) * 2020-10-22 2022-04-28

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010002426A (es) 2007-08-29 2010-04-27 Senju Pharma Co Agente para promover la adhesion de las celulas del endotelio corneal.
CA2858173C (en) 2011-12-06 2023-09-26 Advanced Cell Technology, Inc. Method of directed differentiation producing corneal endothelial cells, compositions thereof, and uses thereof
CN103053511A (zh) * 2012-12-10 2013-04-24 山东省眼科研究所 一种角膜中期保存液及其制备和使用方法
JP6730701B2 (ja) * 2013-11-14 2020-07-29 学校法人同志社 細胞増殖促進または細胞障害抑制による角膜内皮治療薬
EP3074508B1 (en) 2013-11-27 2019-11-06 Kyoto Prefectural Public University Corporation Application of laminin to corneal endothelial cell culture
CN113559246A (zh) * 2014-10-31 2021-10-29 京都府公立大学法人 使用层粘连蛋白的新的角膜的治疗
JP6770435B2 (ja) 2014-10-31 2020-10-14 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
CA3008113C (en) 2015-12-24 2024-10-29 The Doshisha A MEDICINE FOR THE TREATMENT OR PREVENTION OF A DISORDER CAUSED BY TGF-β SIGNALS AND ITS APPLICATION
ES2947826T3 (es) * 2016-02-15 2023-08-21 Kyoto Prefectural Public Univ Corp Célula endotelial corneal funcional humana y aplicación de la misma
CN113056556A (zh) * 2018-08-31 2021-06-29 学校法人同志社 用于对眼细胞进行保存或培养的组合物以及方法
CA3216719A1 (en) 2021-05-03 2022-11-10 Astellas Institute For Regenerative Medicine Methods of generating mature corneal endothelial cells
CN115006593B (zh) * 2022-06-26 2023-07-25 中国海洋大学 机械增强型组织工程角膜内皮的体外构建方法
CN117243954A (zh) * 2023-10-26 2023-12-19 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) 一种含烟酰胺的眼内手术灌注液及其制备方法和应用

Citations (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3421217A (en) 1967-06-29 1969-01-14 Schick Electric Inc Hair receptacle for electric shaver
US4678783A (en) 1983-11-04 1987-07-07 Asahi Kasei Kogyo Kabushiki Kaisha Substituted isoquinolinesulfonyl compounds
JPH10113187A (ja) * 1995-11-20 1998-05-06 Kirin Brewery Co Ltd Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
WO1999020620A1 (en) 1997-10-22 1999-04-29 Nippon Shinyaku Co Ltd Isoquinoline derivative and drug
WO1999061403A1 (en) 1998-05-25 1999-12-02 Santen Pharmaceutical Co., Ltd. Novel vinylbenzene derivatives
WO2001074393A1 (fr) * 2000-04-04 2001-10-11 Wakamoto Pharmaceutical Co., Ltd. Agents de protection des tissus vitaux
WO2002076977A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002076976A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002083175A1 (en) 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Visual function improving agents
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
WO2003059913A1 (en) 2002-01-10 2003-07-24 Bayer Healthcare Ag Roh-kinase inhibitors
WO2003062227A1 (en) 2002-01-23 2003-07-31 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
WO2004009555A1 (ja) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation ５−置換イソキノリン誘導体
WO2004022541A1 (en) 2002-09-03 2004-03-18 Universite De Montreal 1,4-substituted cyclohexane derivatives
WO2004108724A1 (ja) 2003-06-06 2004-12-16 Asahi Kasei Pharma Corporation ３環系化合物
WO2005003101A2 (en) 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
WO2005035501A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規オレフィン誘導体
WO2005035503A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規イソキノリン誘導体
WO2005035506A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規インダゾール誘導体
WO2005034866A2 (en) 2003-10-06 2005-04-21 Glaxo Group Limited Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors
WO2005037198A2 (en) 2003-10-06 2005-04-28 Glaxo Group Limited Preparation of 1,7-disubstituted azabenzimidazoles as kinase inhibitors
WO2005037197A2 (en) 2003-10-06 2005-04-28 Glaxo Group Limited Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
WO2005039564A1 (en) 2003-10-02 2005-05-06 Vertex Pharmaceuticals Incorporated Phthalimide compounds useful as protein kinase inhibitors
WO2005078071A1 (ja) * 2004-02-18 2005-08-25 Satoru Yamagami ヒト角膜内皮細胞の培養物層積層体及びその作製方法
WO2005080394A1 (en) 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
WO2005103050A2 (en) 2004-04-02 2005-11-03 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of rock and other protein kinases
WO2005118582A1 (ja) 2004-06-03 2005-12-15 Senju Pharmaceutical Co., Ltd. アミド化合物を含有する角膜知覚回復剤
WO2006057270A1 (ja) 2004-11-26 2006-06-01 Asahi Kasei Pharma Corporation 含窒素３環化合物
WO2007018226A1 (ja) * 2005-08-10 2007-02-15 Mitsubishi Tanabe Pharma Corporation 角膜障害の予防及び／又は治療剤
WO2007026664A1 (ja) 2005-08-30 2007-03-08 Asahi Kasei Pharma Corporation スルホンアミド化合物
WO2007083685A1 (ja) * 2006-01-19 2007-07-26 Senju Pharmaceutical Co., Ltd. 生体内で細胞増殖可能な角膜内皮製剤

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5906819A (en) * 1995-11-20 1999-05-25 Kirin Beer Kabushiki Kaisha Rho target protein Rho-kinase
IL128456A0 (en) * 1996-08-12 2000-01-31 Yoshitomi Pharmaceutical Compositions containing a Rho kinase inhibitor
PL336990A1 (en) * 1997-05-22 2000-07-31 Searle & Co 3(5)-heteroaryl group substituted pyrazoles as inhibitors of kinase p 38
EP1034793B1 (en) * 1998-08-17 2005-10-26 Senju Pharmaceutical Co., Ltd. Preventives/remedies for glaucoma
CA2369552A1 (en) 1999-04-22 2000-11-02 Hisashi Kai Agent for prophylaxis and treatment of angiostenosis
CA2325842C (en) * 2000-11-02 2007-08-07 Lisa Mckerracher Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
CA2483659A1 (en) * 2002-04-30 2003-11-13 Amniotec Inc. Corneal endothelium-like sheet and method of constructing the same
US20040213782A1 (en) * 2003-02-03 2004-10-28 Pharmacia Corporation Compositions of an aquaporin modulating agent and an aqueous humor modulating agent for the treatment of elevated intraocular pressure
KR101076638B1 (ko) 2003-04-18 2011-10-27 센주 세이야꾸 가부시키가이샤 각막 지각 회복제
WO2007043255A1 (ja) 2005-09-13 2007-04-19 Arblast Co., Ltd. 培養角膜内皮シート及びその作製方法
US7867999B1 (en) * 2005-12-22 2011-01-11 Alcon Research, Ltd. Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions
MX2010002426A (es) 2007-08-29 2010-04-27 Senju Pharma Co Agente para promover la adhesion de las celulas del endotelio corneal.
US8550908B2 (en) * 2010-03-16 2013-10-08 Harmonix Music Systems, Inc. Simulating musical instruments
KR20150111645A (ko) 2014-03-26 2015-10-06 주식회사 인프라웨어 단일 통신인터페이스 전송방법 및 장치

Patent Citations (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3421217A (en) 1967-06-29 1969-01-14 Schick Electric Inc Hair receptacle for electric shaver
US4678783A (en) 1983-11-04 1987-07-07 Asahi Kasei Kogyo Kabushiki Kaisha Substituted isoquinolinesulfonyl compounds
US4678783B1 (en) 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
JPH10113187A (ja) * 1995-11-20 1998-05-06 Kirin Brewery Co Ltd Ｒｈｏ標的タンパク質Ｒｈｏキナーゼ
WO1999020620A1 (en) 1997-10-22 1999-04-29 Nippon Shinyaku Co Ltd Isoquinoline derivative and drug
WO1999061403A1 (en) 1998-05-25 1999-12-02 Santen Pharmaceutical Co., Ltd. Novel vinylbenzene derivatives
WO2001074393A1 (fr) * 2000-04-04 2001-10-11 Wakamoto Pharmaceutical Co., Ltd. Agents de protection des tissus vitaux
WO2002076977A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002076976A2 (en) 2001-03-23 2002-10-03 Bayer Corporation Rho-kinase inhibitors
WO2002083175A1 (en) 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Visual function improving agents
WO2002100833A1 (en) 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
WO2003059913A1 (en) 2002-01-10 2003-07-24 Bayer Healthcare Ag Roh-kinase inhibitors
WO2003062227A1 (en) 2002-01-23 2003-07-31 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
WO2004009555A1 (ja) 2002-07-22 2004-01-29 Asahi Kasei Pharma Corporation ５−置換イソキノリン誘導体
WO2004022541A1 (en) 2002-09-03 2004-03-18 Universite De Montreal 1,4-substituted cyclohexane derivatives
WO2004108724A1 (ja) 2003-06-06 2004-12-16 Asahi Kasei Pharma Corporation ３環系化合物
WO2005003101A2 (en) 2003-07-02 2005-01-13 Biofocus Discovery Limited Pyrazine and pyridine derivatives as rho kinase inhibitors
WO2005039564A1 (en) 2003-10-02 2005-05-06 Vertex Pharmaceuticals Incorporated Phthalimide compounds useful as protein kinase inhibitors
WO2005034866A2 (en) 2003-10-06 2005-04-21 Glaxo Group Limited Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors
WO2005037198A2 (en) 2003-10-06 2005-04-28 Glaxo Group Limited Preparation of 1,7-disubstituted azabenzimidazoles as kinase inhibitors
WO2005037197A2 (en) 2003-10-06 2005-04-28 Glaxo Group Limited Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
WO2005035501A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規オレフィン誘導体
WO2005035503A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規イソキノリン誘導体
WO2005035506A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規インダゾール誘導体
WO2005078071A1 (ja) * 2004-02-18 2005-08-25 Satoru Yamagami ヒト角膜内皮細胞の培養物層積層体及びその作製方法
JP2005229869A (ja) 2004-02-18 2005-09-02 Satoshi Yamagami ヒト角膜内皮細胞の培養物層積層体及びその作製方法
WO2005080394A1 (en) 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
WO2005103050A2 (en) 2004-04-02 2005-11-03 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of rock and other protein kinases
WO2005118582A1 (ja) 2004-06-03 2005-12-15 Senju Pharmaceutical Co., Ltd. アミド化合物を含有する角膜知覚回復剤
WO2006057270A1 (ja) 2004-11-26 2006-06-01 Asahi Kasei Pharma Corporation 含窒素３環化合物
WO2007018226A1 (ja) * 2005-08-10 2007-02-15 Mitsubishi Tanabe Pharma Corporation 角膜障害の予防及び／又は治療剤
WO2007026664A1 (ja) 2005-08-30 2007-03-08 Asahi Kasei Pharma Corporation スルホンアミド化合物
WO2007083685A1 (ja) * 2006-01-19 2007-07-26 Senju Pharmaceutical Co., Ltd. 生体内で細胞増殖可能な角膜内皮製剤

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDERSON,SC ET AL.: "Rho and Rho-kinase (ROCK) signaling in adherens and gap junction assembly in corneal epithelium", INVST.OPTHAL.VIS.SCI., vol. 43, no. 4, April 2002 (2002-04-01), pages 978 - 986, XP008131969 *
ISHIZAKI, T. ET AL., THE EMBO J., vol. 15, no. 8, 1996, pages 1885 - 1893
LEE JG ET AL.: "FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway", INV.OPTHALMOL.VIS.SCI., vol. 47, no. 4, 2006, pages 1376 - 1386, XP008131970 *
LEUNG, T ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 29051 - 29054
NAT BIOTECHNOL., vol. 25, 2007, pages 681
SATPATHY M. ET AL.: "Thrombin-induced phosphorylation of the regulatory light chain of myosin II in cultured bovine corneal endothelial cells", EXPERIMENT.EYE.RES., vol. 79, no. 4, October 2004 (2004-10-01), pages 477 - 486, XP004566449 *

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012521200A (ja) * 2009-03-23 2012-09-13 中国海洋大学 組織工学によって作製されたヒト角膜内皮の再生方法
WO2011080984A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
CN102770136A (zh) * 2009-12-29 2012-11-07 千寿制药株式会社 用于角膜内皮功能障碍的治疗剂(y-39983)
JP2013515676A (ja) * 2009-12-29 2013-05-09 千寿製薬株式会社 角膜内皮障害治療剤（ｙ−３９９８３）
WO2011081221A1 (en) 2009-12-29 2011-07-07 Senju Pharmaceutical Co., Ltd. Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
JPWO2013100208A1 (ja) * 2011-12-28 2015-05-11 京都府公立大学法人 角膜内皮細胞の培養正常化
WO2013100208A1 (ja) 2011-12-28 2013-07-04 京都府公立大学法人 角膜内皮細胞の培養正常化
EP3553169A1 (en) 2011-12-28 2019-10-16 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
WO2014007402A1 (ja) * 2012-07-06 2014-01-09 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
JPWO2014007402A1 (ja) * 2012-07-06 2016-06-02 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
US9616101B2 (en) 2012-07-06 2017-04-11 Kyoto Prefectural Public University Corporation Differentiation marker and differentiation control of eye cell
WO2014038639A1 (ja) 2012-09-07 2014-03-13 日本ケミカルリサーチ株式会社 間葉系幹細胞の馴化培地を含有する角膜内皮細胞培養用培地
US10174284B2 (en) 2012-09-07 2019-01-08 Jcr Pharmaceuticals Co., Ltd. Medium, for culturing corneal endothelial cells, containing conditioned medium from mesenchymal stem cells
WO2015097920A1 (ja) * 2013-12-27 2015-07-02 京都府公立大学法人 角膜内皮細胞の細胞治療併用剤
US10959997B2 (en) 2013-12-27 2021-03-30 Kyoto Prefectural Public University Corporation Combined agent for cell therapy of corneal endothelial cell
JPWO2016047647A1 (ja) * 2014-09-24 2017-07-06 興和株式会社 角膜厚調節剤
KR102432692B1 (ko) 2014-09-24 2022-08-12 교와 가부시키가이샤 각막 두께 조절제
KR20170058385A (ko) 2014-09-24 2017-05-26 교와 가부시키가이샤 각막 두께 조절제
WO2016047647A1 (ja) * 2014-09-24 2016-03-31 興和株式会社 角膜厚調節剤
US10034885B2 (en) 2014-09-24 2018-07-31 Kowa Company, Ltd. Corneal thickness modulating agent
WO2020071438A1 (ja) * 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
JP2020054330A (ja) * 2018-10-02 2020-04-09 学校法人同志社 角膜内皮細胞を保存するための方法および容器
US11445723B2 (en) 2018-10-02 2022-09-20 The Doshisha Method and container for preserving corneal endothelial cells
WO2022085680A1 (ja) 2020-10-22 2022-04-28 京都府公立大学法人 ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法
JPWO2022085680A1 (ja) * 2020-10-22 2022-04-28
JP2023139164A (ja) * 2020-10-22 2023-10-03 京都府公立大学法人 ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法
JP7361431B2 (ja) 2020-10-22 2023-10-16 京都府公立大学法人 ヒト角膜内皮細胞及び／又はヒト角膜内皮前駆細胞の保存方法
EP4234682A4 (en) * 2020-10-22 2024-11-27 Kyoto Prefectural Public University Corporation METHOD FOR PRESERVING HUMAN CORNEAL ENDOTHELIAL CELLS AND/OR HUMAN CORNEAL ENDOTHELIAL PROGENITOR CELLS
AU2021366805B2 (en) * 2020-10-22 2025-04-24 Kyoto Prefectural Public University Corporation A storage method of human corneal endothelial cells and/or human corneal endothelial precursor cells

Also Published As

Publication number Publication date
KR20100080514A (ko) 2010-07-08
ES2659980T3 (es) 2018-03-20
JP2016193933A (ja) 2016-11-17
JP5657252B2 (ja) 2015-01-21
JP2016026199A (ja) 2016-02-12
JP2020050652A (ja) 2020-04-02
JP2015013905A (ja) 2015-01-22
JPWO2009028631A1 (ja) 2010-12-02
EP2193806B1 (en) 2017-12-06
JP5969679B2 (ja) 2016-08-17
US20230210864A1 (en) 2023-07-06
CA2697895C (en) 2017-10-31
JP2025062082A (ja) 2025-04-11
JP2022171847A (ja) 2022-11-11
EP2193806A4 (en) 2011-03-23
US11633404B2 (en) 2023-04-25
US9248125B2 (en) 2016-02-02
CN103937738A (zh) 2014-07-23
MX2010002426A (es) 2010-04-27
KR20150004899A (ko) 2015-01-13
KR20210070407A (ko) 2021-06-14
US20160030410A1 (en) 2016-02-04
CA2697895A1 (en) 2009-03-05
JP7631270B2 (ja) 2025-02-18
US11839618B2 (en) 2023-12-12
EP2193806A1 (en) 2010-06-09
BRPI0816182A2 (pt) 2015-04-14
CN103931608B (zh) 2016-02-03
JP2021073322A (ja) 2021-05-13
JP2018131445A (ja) 2018-08-23
JP2013151576A (ja) 2013-08-08
RU2010111744A (ru) 2011-10-10
KR20180031066A (ko) 2018-03-27
US20100209402A1 (en) 2010-08-19
KR20240045364A (ko) 2024-04-05
KR20150088907A (ko) 2015-08-03
JP5843373B2 (ja) 2016-01-13
KR20190091567A (ko) 2019-08-06
US20160101113A1 (en) 2016-04-14
CN101835491A (zh) 2010-09-15
KR20220151013A (ko) 2022-11-11
CN103931608A (zh) 2014-07-23
CN101835491B (zh) 2014-11-26
RU2474434C2 (ru) 2013-02-10
CN103937738B (zh) 2017-04-12

Similar Documents

Publication Publication Date Title
WO2009028631A1 (ja) 角膜内皮細胞接着促進剤
IL212387A0 (en) Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products
WO2007091255A3 (en) Method and apparatus for maintenance and expansion of hematopoietic stem cells from mononuclear cells
BRPI0922572A2 (pt) método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero.
MX356756B (es) Células madre pluripotentes en microportadores.
WO2011005773A3 (en) Method of culturing eukaryotic cells
IL252607A0 (en) Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
WO2009023525A3 (en) Methods of modulating mesenchymal stem cell differentiation
WO2008005520A3 (en) Temperature-responsive microcarrier
WO2011133902A3 (en) Cell culture medium comprising small peptides
WO2010089151A8 (en) Bioreactor for the cultivation of mammalian cells
CA2856867C (en) Methods for producing retinal tissue and retina-related cell
WO2008036447A3 (en) Pluripotent stem cell culture
WO2008060541A3 (en) In vitro expansion of postpartum-derived cells using microcarriers
EP4368701A3 (en) Feeder-free culture system
WO2010096588A3 (en) Cell culture media containing combinations of proteins
WO2010020876A3 (en) Cell culture method to form aggregates
ES2572214T3 (es) Métodos para expansión celular y usos de células y medios acondicionados producidos de este modo para terapia
WO2012118799A3 (en) Cell culture system
SE0850111L (sv) Förfarande för differentiering av stamceller till celler av den endodermala och pankreatiska utvecklingslinjen
WO2008154014A3 (en) A method for culturing mammalian cells to improve recombinant protein production
EP2594636A4 (en) CULTURE MEDIUM COMPOSITION FOR CULTURING MESENCHYMAL STEM CELLS FROM AMNIOTIC MEMBRANE, AND METHOD FOR CULTURING THE SAME USING THE SAME
WO2011008986A3 (en) A method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves
WO2008090826A1 (ja) 間葉系細胞の製造方法、歯の製造方法及び歯形成用間葉系細胞
WO2008153180A1 (ja) 脂肪組織由来細胞から肝小葉様細胞塊を得る方法

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880112897.X

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08828145

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009530186

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2697895

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: MX/A/2010/002426

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008828145

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1686/CHENP/2010

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 20107006685

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2010111744

Country of ref document: RU

WWE Wipo information: entry into national phase

Ref document number: 12675475

Country of ref document: US

ENP Entry into the national phase

Ref document number: PI0816182

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20100301

WWW Wipo information: withdrawn in national office

Ref document number: 1020227037529

Country of ref document: KR