MX2010002426A - Agente para promover la adhesion de las celulas del endotelio corneal. - Google Patents
Agente para promover la adhesion de las celulas del endotelio corneal.Info
- Publication number
- MX2010002426A MX2010002426A MX2010002426A MX2010002426A MX2010002426A MX 2010002426 A MX2010002426 A MX 2010002426A MX 2010002426 A MX2010002426 A MX 2010002426A MX 2010002426 A MX2010002426 A MX 2010002426A MX 2010002426 A MX2010002426 A MX 2010002426A
- Authority
- MX
- Mexico
- Prior art keywords
- corneal endothelial
- agent
- corneal
- cells
- adhesion
- Prior art date
Links
- 210000000399 corneal endothelial cell Anatomy 0.000 abstract 4
- 239000003590 rho kinase inhibitor Substances 0.000 abstract 3
- 230000003511 endothelial effect Effects 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 238000009630 liquid culture Methods 0.000 abstract 2
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Se proveen medios capaces de desarrollar eficientemente c?lulas de endotelio corneal y medios para suministrar establemente una preparaci?n de endotelio corneal; se provee un agente para promover la adhesi?n de c?lulas de endotelio corneal que contiene un inhibidor de Rho cinasa; un medio de cultivo de c?lulas de endotelio corneal que contiene un inhibidor de Rho cinasa; una soluci?n para la conservaci?n de c?rnea que contiene un inhibidor de Rho cinasa; y un m?todo de producci?n de una preparaci?n de endotelio corneal que incluye el paso de cultivar las c?lulas de endotelio corneal usando el medio de cultivo anteriormente mencionado.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007223141 | 2007-08-29 | ||
| JP2008016088 | 2008-01-28 | ||
| PCT/JP2008/065459 WO2009028631A1 (ja) | 2007-08-29 | 2008-08-28 | 角膜内皮細胞接着促進剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002426A true MX2010002426A (es) | 2010-04-27 |
Family
ID=40387345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002426A MX2010002426A (es) | 2007-08-29 | 2008-08-28 | Agente para promover la adhesion de las celulas del endotelio corneal. |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9248125B2 (es) |
| EP (1) | EP2193806B1 (es) |
| JP (10) | JP5657252B2 (es) |
| KR (8) | KR20150088907A (es) |
| CN (3) | CN103931608B (es) |
| BR (1) | BRPI0816182A2 (es) |
| CA (1) | CA2697895C (es) |
| ES (1) | ES2659980T3 (es) |
| MX (1) | MX2010002426A (es) |
| RU (1) | RU2474434C2 (es) |
| WO (1) | WO2009028631A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5657252B2 (ja) | 2007-08-29 | 2015-01-21 | 千寿製薬株式会社 | 角膜内皮細胞接着促進剤 |
| CN101508971B (zh) * | 2009-03-23 | 2011-04-06 | 中国海洋大学 | 一种组织工程人角膜内皮的重建方法 |
| WO2011080984A1 (en) | 2009-12-29 | 2011-07-07 | Senju Pharmaceutical Co., Ltd. | Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction |
| PT2788472T (pt) | 2011-12-06 | 2019-04-01 | Astellas Inst For Regenerative Medicine | Método de diferenciação dirigida para a produção de células endoteliais corneanas |
| EP3553169B1 (en) | 2011-12-28 | 2021-11-03 | Kyoto Prefectural Public University Corporation | Normalization of culture of corneal endothelial cells |
| JP6519851B2 (ja) * | 2012-07-06 | 2019-05-29 | 京都府公立大学法人 | 眼細胞の分化マーカーおよび分化制御 |
| CN104662148A (zh) | 2012-09-07 | 2015-05-27 | 日本化学研究株式会社 | 含有间充质干细胞的条件培养基的角膜内皮细胞培养用培养基 |
| CN103053511A (zh) * | 2012-12-10 | 2013-04-24 | 山东省眼科研究所 | 一种角膜中期保存液及其制备和使用方法 |
| JP6730701B2 (ja) * | 2013-11-14 | 2020-07-29 | 学校法人同志社 | 細胞増殖促進または細胞障害抑制による角膜内皮治療薬 |
| JP6470286B2 (ja) | 2013-11-27 | 2019-02-13 | 京都府公立大学法人 | ラミニンの角膜内皮細胞培養への応用 |
| US10959997B2 (en) | 2013-12-27 | 2021-03-30 | Kyoto Prefectural Public University Corporation | Combined agent for cell therapy of corneal endothelial cell |
| US10034885B2 (en) | 2014-09-24 | 2018-07-31 | Kowa Company, Ltd. | Corneal thickness modulating agent |
| WO2016067628A1 (ja) * | 2014-10-31 | 2016-05-06 | 京都府公立大学法人 | ラミニンによる角膜の新規治療 |
| JP6770435B2 (ja) | 2014-10-31 | 2020-10-14 | 京都府公立大学法人 | ラミニンによる網膜および神経の新規治療 |
| WO2017110093A1 (ja) | 2015-12-24 | 2017-06-29 | 学校法人同志社 | ＴＧＦ－βシグナルに起因する障害を治療または予防するための医薬およびその応用 |
| PL3416658T3 (pl) * | 2016-02-15 | 2023-09-04 | Kyoto Prefectural Public University Corporation | Funkcjonalna ludzka komórka śródbłonka rogówki i jej zastosowanie |
| CN113056556A (zh) * | 2018-08-31 | 2021-06-29 | 学校法人同志社 | 用于对眼细胞进行保存或培养的组合物以及方法 |
| JP6664755B1 (ja) * | 2018-10-02 | 2020-03-13 | 学校法人同志社 | 角膜内皮細胞を保存するための方法および容器 |
| CA3109705A1 (en) * | 2018-10-02 | 2020-04-09 | The Doshisha | Method and vessel for preserving corneal endothelial cells |
| IL302168A (en) * | 2020-10-22 | 2023-06-01 | Kyoto Prefectural Public Univ Corp | Storage method of human corneal endothelial cells and/or human corneal endothelial progenitor cells |
| BR112023021993A2 (pt) | 2021-05-03 | 2024-02-20 | Astellas Inst For Regenerative Medicine | Métodos de geração de células endoteliais da córnea madura |
| CN115006593B (zh) * | 2022-06-26 | 2023-07-25 | 中国海洋大学 | 机械增强型组织工程角膜内皮的体外构建方法 |
| CN117243954A (zh) * | 2023-10-26 | 2023-12-19 | 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) | 一种含烟酰胺的眼内手术灌注液及其制备方法和应用 |
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| EP1541559A4 (en) | 2002-07-22 | 2007-08-22 | Asahi Kasei Pharma Corp | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE |
| CA2400996A1 (en) | 2002-09-03 | 2004-03-03 | Lisa Mckerracher | 1,4-substituted cyclohexane derivatives |
| US20040213782A1 (en) * | 2003-02-03 | 2004-10-28 | Pharmacia Corporation | Compositions of an aquaporin modulating agent and an aqueous humor modulating agent for the treatment of elevated intraocular pressure |
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2008
- 2008-08-28 JP JP2009530186A patent/JP5657252B2/ja active Active
- 2008-08-28 KR KR1020157018932A patent/KR20150088907A/ko not_active Ceased
- 2008-08-28 RU RU2010111744/15A patent/RU2474434C2/ru active
- 2008-08-28 CN CN201410200380.3A patent/CN103931608B/zh active Active
- 2008-08-28 KR KR1020107006685A patent/KR20100080514A/ko not_active Ceased
- 2008-08-28 ES ES08828145.6T patent/ES2659980T3/es active Active
- 2008-08-28 BR BRPI0816182 patent/BRPI0816182A2/pt not_active Application Discontinuation
- 2008-08-28 KR KR1020187007476A patent/KR20180031066A/ko not_active Ceased
- 2008-08-28 MX MX2010002426A patent/MX2010002426A/es active IP Right Grant
- 2008-08-28 KR KR1020247009980A patent/KR20240045364A/ko active Pending
- 2008-08-28 CN CN200880112897.XA patent/CN101835491B/zh active Active
- 2008-08-28 US US12/675,475 patent/US9248125B2/en active Active
- 2008-08-28 EP EP08828145.6A patent/EP2193806B1/en active Active
- 2008-08-28 CN CN201410200362.5A patent/CN103937738B/zh active Active
- 2008-08-28 WO PCT/JP2008/065459 patent/WO2009028631A1/ja not_active Ceased
- 2008-08-28 KR KR1020147033392A patent/KR20150004899A/ko not_active Ceased
- 2008-08-28 KR KR1020227037529A patent/KR20220151013A/ko not_active Ceased
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