WO2005056764A3 - Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 - Google Patents
Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 Download PDFInfo
- Publication number
- WO2005056764A3 WO2005056764A3 PCT/US2004/040885 US2004040885W WO2005056764A3 WO 2005056764 A3 WO2005056764 A3 WO 2005056764A3 US 2004040885 W US2004040885 W US 2004040885W WO 2005056764 A3 WO2005056764 A3 WO 2005056764A3
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- WO
- WIPO (PCT)
- Prior art keywords
- vascular endothelial
- endothelial growth
- growth factor
- inhibitors
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- C07K14/52—Cytokines; Lymphokines; Interferons
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- C—CHEMISTRY; METALLURGY
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- C07K2319/00—Fusion polypeptide
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- C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
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- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
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- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
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Abstract
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04813230A EP1711196A4 (fr) | 2003-12-05 | 2004-12-06 | Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 |
| CA002552435A CA2552435A1 (fr) | 2003-12-05 | 2004-12-06 | Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 |
| JP2006542876A JP5006651B2 (ja) | 2003-12-05 | 2004-12-06 | 2型血管内皮増殖因子受容体の阻害剤 |
| BRPI0417302-3A BRPI0417302A (pt) | 2003-12-05 | 2004-12-06 | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| MXPA06006406A MXPA06006406A (es) | 2003-12-05 | 2004-12-06 | Inhibidores de receptores de factor de crecimiento endotelial vascular tipo 2. |
| AU2004296376A AU2004296376B2 (en) | 2003-12-05 | 2004-12-06 | Inhibitors of type 2 vascular endothelial growth factor receptors |
| IL176135A IL176135A0 (en) | 2003-12-05 | 2006-06-05 | Inhibitors of type 2 vascular endothelial growth factor receptors |
| US11/448,171 US7858739B2 (en) | 2003-12-05 | 2006-06-05 | Inhibitors of type 2 vascular endothelial growth factor receptors |
| US11/482,641 US7847062B2 (en) | 2003-12-05 | 2006-07-07 | Pharmacokinetic modulation and compositions for modified FN3 polypeptides |
| US11/894,045 US20080220049A1 (en) | 2003-12-05 | 2007-08-17 | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins |
| US12/788,240 US8324362B2 (en) | 2003-12-05 | 2010-05-26 | Nucleic acid encoding 10FN3 polypeptide inhibitors of Type 2 vascular endothelial growth factor receptors |
| US13/552,398 US8609613B2 (en) | 2003-12-05 | 2012-07-18 | Methods of inhibiting type 2 vascular endothelial growth factor receptors using polypeptides |
| US14/071,069 US9328157B2 (en) | 2003-12-05 | 2013-11-04 | Inhibitors of type 2 vascular endothelial growth factor receptors |
| US15/070,572 US9862758B2 (en) | 2003-12-05 | 2016-03-15 | Inhibitors of type 2 vascular endothelial growth factor receptors |
| US15/826,196 US10995131B2 (en) | 2003-12-05 | 2017-11-29 | Libraries of modified fibronectin type III tenth domain-containing polypeptides |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52788603P | 2003-12-05 | 2003-12-05 | |
| US60/527,886 | 2003-12-05 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10195405A Continuation | 2003-12-05 | 2005-04-07 | |
| US11/448,171 Continuation US7858739B2 (en) | 2003-12-05 | 2006-06-05 | Inhibitors of type 2 vascular endothelial growth factor receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2005056764A2 WO2005056764A2 (fr) | 2005-06-23 |
| WO2005056764A3 true WO2005056764A3 (fr) | 2006-05-11 |
Family
ID=34676785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2004/040885 Ceased WO2005056764A2 (fr) | 2003-12-05 | 2004-12-06 | Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US7858739B2 (fr) |
| EP (1) | EP1711196A4 (fr) |
| JP (2) | JP5006651B2 (fr) |
| KR (1) | KR20060129246A (fr) |
| CN (1) | CN1946417A (fr) |
| AU (1) | AU2004296376B2 (fr) |
| BR (1) | BRPI0417302A (fr) |
| CA (1) | CA2552435A1 (fr) |
| IL (1) | IL176135A0 (fr) |
| MX (1) | MXPA06006406A (fr) |
| RU (1) | RU2402567C2 (fr) |
| SG (1) | SG149004A1 (fr) |
| TW (1) | TW200531979A (fr) |
| WO (1) | WO2005056764A2 (fr) |
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Families Citing this family (202)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0985039T3 (da) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Kunstige antistof-polypeptider |
| PT1137812E (pt) | 1998-12-02 | 2007-05-31 | Adnexus Therapeutics Inc | Fusões adn-proteína e suas utilizações |
| EP1158985B1 (fr) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38 |
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| CA2416219C (fr) | 2000-07-11 | 2016-10-11 | Research Corporation Technologies, Inc. | Polypeptides d'anticorps artificiels |
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| CA2475703C (fr) | 2002-02-11 | 2016-12-20 | Bayer Pharmaceuticals Corporation | Urees aryliques a activite inhibitrice d'angiogenese |
| WO2003104418A2 (fr) | 2002-06-06 | 2003-12-18 | Research Corporation Technologies, Inc. | Polypeptides reconstitues |
| WO2004113274A2 (fr) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl-urees presentant une activite d'inhibition des kinases |
| CN100450998C (zh) | 2003-11-11 | 2009-01-14 | 卫材R&D管理有限公司 | 脲衍生物的制备方法 |
| CN1946417A (zh) | 2003-12-05 | 2007-04-11 | 阿德内克休斯治疗公司 | 2型血管内皮生长因子受体的抑制剂 |
| EP1943521A4 (fr) * | 2005-11-02 | 2009-12-30 | Bayer Healthcare Llc | Methodes pour la prevision et le pronostic du cancer, et pour la surveillance de therapie anticancereuse |
| WO2008066752A2 (fr) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R & D Company | Substances thérapeutiques à base de protéines modifiées ciblées sur des récepteurs de tyrosine kinases, dont l'igf-ir |
| EP2111228B1 (fr) | 2007-02-02 | 2011-07-20 | Bristol-Myers Squibb Company | Domaine 10Fn3 pour utilisation dans le traitement de maladies associées à une angiogenese inappropriée |
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| EP2696203A3 (fr) * | 2007-08-16 | 2014-05-28 | The Royal Institution for the Advancement of Learning/McGill University | Microvesicules issues d´une cellule tumorale |
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
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| US8633297B2 (en) | 2007-10-31 | 2014-01-21 | Medimmune, Llc | Protein scaffolds |
| WO2009073115A1 (fr) * | 2007-11-28 | 2009-06-11 | Bristol-Myers Squibb Company | Combinaison d'une thérapie par vegfr-2 avec des inhibiteurs de mtor |
| CN104650235A (zh) | 2007-11-30 | 2015-05-27 | 葛兰素集团有限公司 | 抗原结合构建体 |
| JP2011505873A (ja) * | 2007-12-18 | 2011-03-03 | シェーリング コーポレイション | 抗igf1r療法に対する感受性のバイオマーカー |
| US20100322930A1 (en) * | 2007-12-27 | 2010-12-23 | Frank Kolbinger | Fibronectin-based binding molecules and their use |
| JP2011517314A (ja) * | 2008-02-14 | 2011-06-02 | ブリストル−マイヤーズ スクイブ カンパニー | Egfrに結合する操作されたタンパク質に基づく標的化された治療薬 |
| MX2010011957A (es) * | 2008-05-02 | 2011-03-04 | Novartis Ag Star | Moleculas de union basadas en fibronectina mejoradas y usos de las mismas. |
| CL2009001077A1 (es) | 2008-05-06 | 2010-09-24 | Glaxo Group Ltd | Vehiculo particulado polimerico que comprende un agente biologico en fase acuosa en un lumen hueco; procedimiento para suministrar una proteina en el ojo; composicion farmaceutica que comprende dicho vehiculo; y su uso para profilaxis y tratar enfermedades o trastornos del ojo. |
| JP2011520961A (ja) * | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | 多価フィブロネクチンをベースとする足場ドメインタンパク質 |
| ES2434850T3 (es) * | 2008-09-30 | 2013-12-17 | Abbvie Inc. | Método mejorado de presentación de ARN |
| US8394924B2 (en) * | 2008-10-23 | 2013-03-12 | Massachusetts Institute Of Technology | Directed engagement of activating Fc receptors |
| EP2356269B1 (fr) | 2008-10-31 | 2016-06-29 | Janssen Biotech, Inc. | Compositions d'échafaudage à base de domaines de la fibronectine de type iii, procédés et utilisations |
| US8415291B2 (en) * | 2008-10-31 | 2013-04-09 | Centocor Ortho Biotech Inc. | Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses |
| NZ592591A (en) | 2008-11-03 | 2012-04-27 | Molecular Partners Ag | Binding proteins comprising ankyrin repeast domains that inhibit the vegf-a receptor interaction |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| UY32341A (es) | 2008-12-19 | 2010-07-30 | Glaxo Group Ltd | Proteínas de unión antígeno novedosas |
| EP2396000A1 (fr) * | 2009-02-11 | 2011-12-21 | Bristol-Myers Squibb Company | Thérapie vegfr2 de combinaison avec le témozolomide |
| WO2010097386A1 (fr) | 2009-02-24 | 2010-09-02 | Glaxo Group Limited | Constructions de liaison d'antigène |
| JP2012518400A (ja) | 2009-02-24 | 2012-08-16 | グラクソ グループ リミテッド | 多価および/または複数特異的rankl結合性構築物 |
| EP2401298A1 (fr) | 2009-02-24 | 2012-01-04 | Glaxo Group Limited | Constructions de liaison d'antigène |
| DK2405929T3 (en) | 2009-03-11 | 2018-08-27 | Promedior Inc | SAP polypeptide for use in the treatment of autoimmune disorders and graft-versus-host disease |
| EP2405928B1 (fr) | 2009-03-11 | 2016-11-02 | Promedior Inc. | Procédés de traitement et de diagnostic pour troubles d'hypersensibilité |
| US8067201B2 (en) * | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
| SG177763A1 (en) | 2009-07-28 | 2012-03-29 | Hoffmann La Roche | Non-invasive in vivo optical imaging method |
| EP2464663A4 (fr) * | 2009-08-13 | 2013-05-29 | Massachusetts Inst Technology | Protéines recombinées comprenant des domaines mutants de fibronectine |
| WO2011051327A2 (fr) | 2009-10-30 | 2011-05-05 | Novartis Ag | Petites protéines à chaîne unique de type anticorps |
| ES2691717T3 (es) | 2009-10-30 | 2018-11-28 | Novartis Ag | Bibliotecas universales del dominio de unión del lado inferior de tipo iii de la fibronectina de tipo III |
| WO2011051466A1 (fr) | 2009-11-02 | 2011-05-05 | Novartis Ag | Molécules de liaison anti-idiotypiques à base de fibronectine et leurs utilisations |
| WO2011094259A2 (fr) | 2010-01-28 | 2011-08-04 | Glaxo Group Limited | Protéines de liaison à cd127 |
| WO2011092233A1 (fr) | 2010-01-29 | 2011-08-04 | Novartis Ag | Conjugaison de levures pour produire des combinaisons de liants à base de fibronectine à haute affinité |
| AU2011218243A1 (en) | 2010-02-18 | 2012-10-04 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind IL-23 |
| EP3153521B1 (fr) | 2010-03-26 | 2019-09-04 | Trustees of Dartmouth College | Protéine médiatrice de lymphocytes t régulateurs de vue, agents de liaison de vue et leur utilisation |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| CA2796010C (fr) | 2010-04-13 | 2020-05-12 | Medimmune, Llc | Echafaudages multimeres specifiques de trail r2 |
| EA036055B1 (ru) | 2010-04-13 | 2020-09-21 | Бристол-Майерс Сквибб Компани | Применение полипептида, связывающего pcsk9, для лечения атеросклероза или гиперхолистеринемии |
| EP3103478B1 (fr) | 2010-04-30 | 2019-04-17 | Janssen Biotech, Inc. | Compositions de domaine de fibronectine stabilisées, procédés et utilisations |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| CA2797741A1 (fr) | 2010-05-07 | 2011-11-10 | F. Hoffmann-La Roche Ag | Procede de diagnostic pour la detection de cellules ex vivo |
| EP2576615B1 (fr) | 2010-05-26 | 2016-03-30 | Bristol-Myers Squibb Company | Protéines d'échafaudage à base de fibronectine ayant une stabilité améliorée |
| UY33421A (es) | 2010-06-03 | 2011-12-30 | Glaxo Wellcome House | Proteinas de union al antígeno humanizados |
| UA111954C2 (uk) | 2010-11-23 | 2016-07-11 | Ґлаксо Ґруп Лімітед | Білки зв'язування антигену |
| SG190362A1 (en) | 2010-11-24 | 2013-06-28 | Glaxo Group Ltd | Multispecific antigen binding proteins targeting hgf |
| HUE033008T2 (hu) | 2011-04-13 | 2017-11-28 | Bristol Myers Squibb Co | FC fúziós proteinek, amelyek tartalmaznak új linkereket |
| EP2697256A1 (fr) | 2011-04-15 | 2014-02-19 | Compugen Ltd. | Polypeptides et polynucléotides et leurs utilisations pour un traitement de troubles liés au système immunitaire et du cancer |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| MX351069B (es) | 2011-05-27 | 2017-09-29 | Glaxo Group Ltd | Proteinas de union abcma (cd269/tnfrsf17). |
| EP2714937B1 (fr) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de la thyroïde et du rein vis-à-vis de composés lenvatinib |
| WO2012171057A1 (fr) | 2011-06-13 | 2012-12-20 | Csl Limited | Anticorps contre g-csfr et leurs utilisations |
| WO2013049275A1 (fr) | 2011-09-27 | 2013-04-04 | Janssen Biotech, Inc. | Echafaudages protéiques à base de répétition de fibronectine type iii avec de nouvelles surfaces de liaison |
| LT2771022T (lt) | 2011-10-11 | 2020-12-10 | Viela Bio, Inc. | Cd40l-specifiniai iš tn3 kilę karkasai ir jų naudojimo būdai |
| WO2013059886A1 (fr) | 2011-10-28 | 2013-05-02 | Patrys Limited | Epitopes pat-lm1 et leurs procédés d'utilisation |
| EP2773659A2 (fr) | 2011-10-31 | 2014-09-10 | Bristol-Myers Squibb Company | Domaines de liaison à la fibronectine à immunogénicité réduite |
| HRP20200964T1 (hr) | 2012-02-13 | 2020-10-30 | Agency For Science, Technology And Research | IL-ß NEUTRALIZIRAJUĆA LJUDSKA MONOKLONSKA PROTUTIJELA |
| US9603897B2 (en) | 2012-03-12 | 2017-03-28 | Massachusetts Institute Of Technology | Methods for treating tissue damage associated with ischemia with apolipoprotein D |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| WO2013169614A1 (fr) | 2012-05-07 | 2013-11-14 | Allergan, Inc. | Procédé de traitement d'amd chez des patients souffrant d'un état réfractaire à la thérapie anti-vegf |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| TWI705073B (zh) | 2012-06-22 | 2020-09-21 | 達特茅斯學院基金會 | 新穎之vista-ig構築體及vista-ig用於治療自體免疫、過敏及發炎病症之用途 |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| CN109793893B (zh) | 2012-09-07 | 2023-05-26 | 达特茅斯大学理事会 | 用于诊断和治疗癌症的vista调节剂 |
| MX390017B (es) | 2012-09-13 | 2025-03-11 | Bristol Myers Squibb Co | Proteinas del dominio de soporte basadas en fibronectina que se fijan a miostatina. |
| KR20150064205A (ko) | 2012-11-08 | 2015-06-10 | 에프. 호프만-라 로슈 아게 | Her3의 베타-헤어핀에 결합하는 her3 항원 결합 단백질 |
| WO2014120891A2 (fr) | 2013-02-01 | 2014-08-07 | Bristol-Myers Squibb Company | Protéines d'échafaudage à base de fibronectine |
| EP2953968B1 (fr) | 2013-02-06 | 2018-07-25 | Bristol-Myers Squibb Company | Les proteines de domaine de type iii de fibronectine avec meilleure solubilite |
| EP3617220B1 (fr) | 2013-02-12 | 2021-03-24 | Bristol-Myers Squibb Company | Procédés de repliement de protéine à ph élevé |
| EP3744728A1 (fr) | 2013-02-12 | 2020-12-02 | Bristol-Myers Squibb Company | Procédés de repliement de protéine utilisant la filtration tangentielle |
| JP2016512489A (ja) * | 2013-02-26 | 2016-04-28 | ロシュ グリクアート アーゲー | 抗mcsp抗体 |
| WO2014165093A2 (fr) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci |
| KR102049990B1 (ko) | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| EP2997377B1 (fr) | 2013-05-14 | 2018-07-18 | Eisai R&D Management Co., Ltd. | Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de l' endometre vis-à-vis de composés lenvatinib |
| EP3038641B1 (fr) | 2013-10-06 | 2019-04-17 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Exotoxine a de pseudomonas modifiée |
| CA2926418A1 (fr) | 2013-10-08 | 2015-04-16 | Promedior, Inc. | Methodes de traitement de cancers fibreux |
| JP6612246B2 (ja) | 2013-11-28 | 2019-11-27 | シーエスエル、リミテッド | 腎症を処置する方法 |
| PL3082860T3 (pl) | 2013-12-18 | 2021-06-14 | Csl Limited | Sposób leczenia ran |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| JP6590810B2 (ja) | 2013-12-24 | 2019-10-16 | ヤンセン ファーマシューティカ エヌブイ | 抗vista抗体および断片 |
| WO2015143199A1 (fr) | 2014-03-20 | 2015-09-24 | Bristol-Myers Squibb Company | Domaines de fibronectine de type iii se liant à l'albumine sérique |
| MX371403B (es) | 2014-03-20 | 2020-01-29 | Bristol Myers Squibb Co | Moleculas de andamiaje a base de fibronectina estabilizada. |
| US11123426B2 (en) | 2014-06-11 | 2021-09-21 | The Trustees Of Dartmouth College | Use of vista agonists and antagonists to suppress or enhance humoral immunity |
| WO2016025647A1 (fr) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Traitement tumoral synergique avec l'il-2, un anticorps thérapeutique, et un vaccin contre le cancer |
| EP3180018B1 (fr) | 2014-08-12 | 2019-07-24 | Massachusetts Institute Of Technology | Traitement tumoral synergique avec il-2 une protéine de fusion de fc liant l'intégrine |
| MX394386B (es) | 2014-08-28 | 2025-03-24 | Eisai R&D Man Co Ltd | Derivado de quinolina muy puro y metodo para su produccion. |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| WO2016054315A1 (fr) | 2014-10-01 | 2016-04-07 | Medimmune, Llc | Méthode de conjugaison d'un polypeptide |
| WO2016059602A2 (fr) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Méthodes de traitement du cancer et compositions associées |
| HRP20200679T1 (hr) | 2014-11-14 | 2020-07-24 | F. Hoffmann - La Roche Ag | Molekule koje vežu antigen i sadrže trimer tnf ligand obitelji |
| EP3702367B1 (fr) * | 2014-11-25 | 2024-05-15 | Bristol-Myers Squibb Company | Nouveaux polypeptides de liaison pd-l1 pour imagerie |
| JP6701217B2 (ja) | 2014-11-25 | 2020-05-27 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 生物学的製剤の18f−放射性標識方法および組成物 |
| MX2017007136A (es) | 2014-12-05 | 2017-12-04 | Immunext Inc | Identificacion de vsig8 como el receptor vista putativo y su uso para producir moduladores vista/vsig8. |
| KR20160075107A (ko) * | 2014-12-19 | 2016-06-29 | 주식회사 이노테라피 | 페길화된 vegf 트랩 및 이의 제조방법 |
| PL3263106T3 (pl) | 2015-02-25 | 2024-04-02 | Eisai R&D Management Co., Ltd. | Sposób tłumienia goryczy pochodnej chinoliny |
| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| JP6836512B2 (ja) | 2015-03-31 | 2021-03-03 | イルドン ファーム カンパニー リミテッド | 組織透過性ペプチドと抗血管内皮細胞成長因子製剤が融合された融合タンパク質を有効成分として含む眼疾患の予防及び治療用薬学的組成物 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| RU2729936C2 (ru) | 2015-06-16 | 2020-08-13 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противораковое средство |
| MX388164B (es) | 2015-06-24 | 2025-03-19 | Janssen Pharmaceutica Nv | Anticuerpos y fragmentos anti-vista |
| ES2887426T3 (es) | 2015-08-20 | 2021-12-22 | Eisai R&D Man Co Ltd | Lenvatinib combinado con etopósido e ifosfamida para su uso en el tratamiento de un tumor |
| RU2727238C2 (ru) | 2015-09-01 | 2020-07-21 | Илдонг Фармасьютикал Ко., Лтд. | Фармацевтическая композиция, содержащая в качестве активного ингредиента слитый белок, в котором слиты проникающий в опухоль пептид и антиангиогенное средство, для предупреждения и лечения рака или связанных с ангиогенезом заболеваний |
| WO2017053617A1 (fr) | 2015-09-23 | 2017-03-30 | Bristol-Myers Squibb Company | Domaines de la fibronectine de type iii se liant à l'albumine sérique à vitesse de dissociation élevée |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| KR102431342B1 (ko) | 2015-10-02 | 2022-08-10 | 에프. 호프만-라 로슈 아게 | Pd1 및 tim3에 특이적인 이중특이성 항체 |
| CN115594765A (zh) | 2015-10-02 | 2023-01-13 | 豪夫迈·罗氏有限公司(Ch) | 对共刺激性tnf受体特异性的双特异性抗体 |
| MA45640A (fr) | 2015-10-07 | 2019-05-22 | Hoffmann La Roche | Anticorps bispécifiques tétravalents pour un récepteur de co-stimulation du tnf |
| KR102802396B1 (ko) | 2015-11-27 | 2025-05-07 | 씨에스엘 리미티드 | Cd131 결합 단백질 및 이의 용도 |
| JP2019509993A (ja) | 2016-02-12 | 2019-04-11 | ヤンセン ファーマシューティカ エヌブイ | 抗vista(b7h5)抗体 |
| EP3231813A1 (fr) | 2016-03-29 | 2017-10-18 | F. Hoffmann-La Roche AG | Molécules de liaison d'antigène costimulantes trimères contenant un ligand de la famille du tnf |
| PH12018502203B1 (en) | 2016-04-15 | 2024-05-15 | Immunext Inc | Anti-human vista antibodies and use thereof |
| WO2017194442A1 (fr) | 2016-05-11 | 2017-11-16 | F. Hoffmann-La Roche Ag | Molécules de liaison à un antigène comprenant un ligand trimérique de la famille du tnf et un fragment de liaison à la ténascine |
| EP3243832A1 (fr) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf et un fragment de liaison pd1 |
| WO2017210335A1 (fr) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Méthodes d'imagerie faisant intervenir des substances biologiques radiomarquées au 18f |
| US11344639B2 (en) | 2016-06-01 | 2022-05-31 | Bristol-Myers Squibb Company | PET imaging with PD-L1 binding polypeptides |
| JP7051826B2 (ja) | 2016-09-23 | 2022-04-11 | シーエスエル、リミテッド | 凝固因子結合タンパク質及びその使用 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
| CN110225770B (zh) | 2016-12-14 | 2022-04-26 | 杨森生物科技公司 | 结合cd8a的纤连蛋白iii型结构域 |
| WO2018111976A1 (fr) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Domaines de fibronectine de type iii se liant à pd-l1 |
| MX2019007795A (es) | 2017-01-03 | 2019-08-16 | Hoffmann La Roche | Moleculas de union a antigeno biespecificas que comprenden el clon 20h4.9 anti-4-1bb. |
| US10350266B2 (en) | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
| US10603358B2 (en) | 2017-01-10 | 2020-03-31 | Nodus Therapeutics | Combination tumor treatment with an integrin-binding-Fc fusion protein and immune stimulator |
| CA3044658A1 (fr) | 2017-02-08 | 2018-08-16 | Eisai R&D Management Co., Ltd. | Composition pharmaceutique pour oncotherapie |
| WO2018178074A1 (fr) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Molécules trimériques de liaison à l'antigène spécifiques pour récepteur de co-stimulation du tnf |
| CN110573528B (zh) | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| WO2018178076A1 (fr) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf |
| CA3053358A1 (fr) | 2017-04-04 | 2018-10-11 | F. Hoffmann-La Roche Ag | Nouvelles molecules bispecifiques de liaison a l'antigene capables de se lier specifiquement a cd40 et a fap |
| SG11201909154SA (en) | 2017-04-05 | 2019-10-30 | Hoffmann La Roche | Bispecific antibodies specifically binding to pd1 and lag3 |
| US11078254B2 (en) * | 2017-04-11 | 2021-08-03 | National Institute Of Advanced Industrial Science And Technology | Method for immobilizing lectin |
| RU2019134940A (ru) | 2017-05-16 | 2021-06-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Лечение гепатоцеллюлярной карциномы |
| AR111963A1 (es) | 2017-05-26 | 2019-09-04 | Univ California | Método y moléculas |
| US11485781B2 (en) | 2017-08-17 | 2022-11-01 | Massachusetts Institute Of Technology | Multiple specificity binders of CXC chemokines |
| SI3681911T1 (sl) | 2017-09-11 | 2025-01-31 | Monash University | Proteini za vezavo na humani trombinski receptor, par4 |
| CA3072634A1 (fr) | 2017-10-18 | 2019-04-25 | Sabine Rauth | Variants d'albumine seriques humains et leurs utilisations |
| CN111182944B (zh) | 2017-11-01 | 2022-11-22 | 豪夫迈·罗氏有限公司 | 双特异性2+1 Contorsbody |
| EP3703746A1 (fr) | 2017-11-01 | 2020-09-09 | F. Hoffmann-La Roche AG | Nouvelles molécules de liaison à l'antigène contenant un trimère de ligands de la famille du tnf |
| ES2939461T3 (es) | 2017-11-29 | 2023-04-24 | Csl Ltd | Método para tratar o prevenir la lesión por isquemia-reperfusión |
| EP3502140A1 (fr) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t |
| WO2019178645A1 (fr) | 2018-03-23 | 2019-09-26 | Csl Limited | Procédé de traitement de l'asthme |
| CN111741979B (zh) | 2018-04-13 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 包含4-1BBL的Her2靶向性抗原结合分子 |
| EP3818082A1 (fr) | 2018-07-04 | 2021-05-12 | F. Hoffmann-La Roche AG | Nouvelles molécules de liaison à l'antigène 4-1bb bispécifiques |
| KR102716634B1 (ko) | 2018-10-01 | 2024-10-16 | 에프. 호프만-라 로슈 아게 | 항-fap 클론 212를 포함하는 이중특이적 항원 결합 분자 |
| CN112654641A (zh) | 2018-10-01 | 2021-04-13 | 豪夫迈·罗氏有限公司 | 具有与cd40的三价结合的双特异性抗原结合分子 |
| WO2020127628A1 (fr) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Molécules de liaison à l'antigène cd28 superagonistes ciblant des tumeurs |
| KR20210108981A (ko) | 2018-12-21 | 2021-09-03 | 에프. 호프만-라 로슈 아게 | 종양-표적화된 효현성 cd28 항원 결합 분자 |
| WO2020154032A1 (fr) | 2019-01-23 | 2020-07-30 | Massachusetts Institute Of Technology | Schéma posologique de dosage d'immunothérapie combinée pour un blocage de points de contrôle immunitaires |
| GB201903767D0 (en) | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
| EP3952996A1 (fr) | 2019-04-12 | 2022-02-16 | F. Hoffmann-La Roche AG | Molécules bispécifiques de liaison à un antigène comprenant des mutéines de lipocalines |
| AU2020304813A1 (en) | 2019-06-26 | 2022-01-06 | F. Hoffmann-La Roche Ag | Fusion of an antibody binding CEA and 4-1BBL |
| EP3990492A1 (fr) | 2019-06-27 | 2022-05-04 | F. Hoffmann-La Roche AG | Nouveaux anticorps anti-icos et molécules de liaison à un antigène ciblant les tumeurs les comprenant |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| JP2022551204A (ja) | 2019-10-14 | 2022-12-07 | アロ・バイオセラピューティクス・カンパニー | Cd71結合フィブロネクチンiii型ドメイン |
| JP2023508023A (ja) | 2019-12-20 | 2023-02-28 | ハドソン インスティチュート オブ メディカル リサーチ | Cxcl10結合タンパク質及びその使用 |
| CN116568341A (zh) | 2020-02-28 | 2023-08-08 | 百时美施贵宝公司 | 基于纤连蛋白的放射性标记的支架和抗体及其治疗诊断用途 |
| WO2021190980A1 (fr) | 2020-03-22 | 2021-09-30 | Quadrucept Bio Limited | Multimères pour l'évolution d'une souche virale |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| AU2021295549A1 (en) | 2020-06-23 | 2022-11-24 | F. Hoffmann-La Roche Ag | Agonistic CD28 antigen binding molecules targeting Her2 |
| EP4172203A1 (fr) | 2020-06-25 | 2023-05-03 | F. Hoffmann-La Roche AG | Molécules bispécifiques de liaison à l'antigène anti-cd3/anti-cd28 |
| JP2023549316A (ja) | 2020-11-16 | 2023-11-24 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Fapを標的としたcd40アゴニストとの併用療法 |
| IL304067A (en) | 2021-01-06 | 2023-08-01 | Hoffmann La Roche | Combined treatment using PD1-LAG3 bispecific antibody and CD20 T cell bispecific antibody |
| CN113151126B (zh) * | 2021-02-10 | 2023-08-08 | 大连大学 | 一种高表达n-糖基化抗vegfr2单体拟抗体的重组渗漏菌株、其构建方法及应用 |
| WO2022184659A1 (fr) | 2021-03-01 | 2022-09-09 | Quadrucept Bio Limited | Domaines d'anticorps et multimères |
| CA3211463A1 (fr) * | 2021-03-01 | 2022-09-09 | Nantbio, Inc. | Anticorps monoclonaux anti-cd30 et recepteurs antigeniques chimeriques |
| KR20240031947A (ko) | 2021-04-14 | 2024-03-08 | 에이알오 바이오테라퓨틱스 컴패니 | Fn3 도메인-시르나 접합체 및 이의 용도 |
| WO2022221505A2 (fr) | 2021-04-14 | 2022-10-20 | Aro Biotherapeutics Company | Domaines fibronectine de type iii de liaison à cd71 |
| WO2022243261A1 (fr) | 2021-05-19 | 2022-11-24 | F. Hoffmann-La Roche Ag | Molécules de liaison à l'antigène cd40 agonistes ciblant cea |
| AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
| EP4363449A2 (fr) | 2021-07-02 | 2024-05-08 | Genentech, Inc. | Méthodes et compositions pour le traitement du cancer |
| CA3224180A1 (fr) | 2021-07-28 | 2023-02-02 | F. Hoffmann-La Roche Ag | Methodes et compositions pour le traitement du cancer |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| EP4499229A1 (fr) | 2022-03-28 | 2025-02-05 | F. Hoffmann-La Roche AG | Variants d'interféron gamma et molécules de liaison à l'antigène les comprenant |
| WO2024056861A1 (fr) | 2022-09-15 | 2024-03-21 | Avidicure Ip B.V. | Protéines de liaison à un antigène multispécifiques pour stimuler des cellules nk et utilisation associée |
| CN120225552A (zh) * | 2022-11-04 | 2025-06-27 | 庄伟哲 | 纤维黏蛋白第iii型结构域衍生的蛋白质及其应用 |
| GB202216503D0 (en) | 2022-11-05 | 2022-12-21 | Quadrucept Bio Ltd | Non-human vertebrates & cells |
| WO2024163009A1 (fr) | 2023-01-31 | 2024-08-08 | Genentech, Inc. | Méthodes et compositions pour le traitement du cancer de la vessie urothéliale |
| WO2024163494A1 (fr) | 2023-01-31 | 2024-08-08 | F. Hoffmann-La Roche Ag | Procédés et compositions pour le traitement du cancer du poumon non à petites cellules et du cancer du sein triple négatif |
| WO2024188965A1 (fr) | 2023-03-13 | 2024-09-19 | F. Hoffmann-La Roche Ag | Polythérapie utilisant un anticorps bispécifique pd1-lag3 et un anticorps bispécifique de lymphocytes t hla-g |
| TW202502811A (zh) | 2023-06-01 | 2025-01-16 | 瑞士商赫孚孟拉羅股份公司 | 與bcma特異性結合之免疫刺激性抗原結合分子 |
| TW202504918A (zh) | 2023-06-01 | 2025-02-01 | 瑞士商赫孚孟拉羅股份公司 | 靶向bcma及cd28的雙特異性抗體 |
| WO2025006676A2 (fr) | 2023-06-27 | 2025-01-02 | Firecyte Therapeutics, Inc. | Compositions à base de protéines de liaison des facteurs de croissance de type insuline de type 1 (igfbpl1) et leurs procédés d'utilisation |
| WO2025007195A1 (fr) | 2023-07-05 | 2025-01-09 | CSL Innovation Pty Ltd | Méthodes de traitement ou de prévention d'une complication de la drépanocytose |
| WO2025149633A1 (fr) | 2024-01-12 | 2025-07-17 | Laigo Bio B.V. | Protéines bispécifiques de liaison à l'antigène |
| WO2025191137A1 (fr) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Conjugués de protéines de liaison à l'antigène spécifiques de trop2 et de cytokines |
| WO2025191136A1 (fr) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Mutéines de domaine extracellulaire de ligand 4-1 bb, protéines de fusion les comprenant et leurs utilisations |
| WO2025191133A1 (fr) | 2024-03-15 | 2025-09-18 | Avidicure Ip B.V. | Mutéines d'il-21, protéines de fusion les comprenant et leurs utilisations |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998012226A1 (fr) * | 1996-09-20 | 1998-03-26 | The Burnham Institute | Procede permettant de freiner l'evolution des cancers et d'inhiber l'angiogenese a l'aide de fibronectine |
Family Cites Families (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5770697A (en) | 1986-11-04 | 1998-06-23 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5514581A (en) | 1986-11-04 | 1996-05-07 | Protein Polymer Technologies, Inc. | Functional recombinantly prepared synthetic protein polymer |
| US6018030A (en) | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5641648A (en) | 1986-11-04 | 1997-06-24 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
| US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| US4997652A (en) | 1987-12-22 | 1991-03-05 | Visionex | Biodegradable ocular implants |
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| JP3051145B2 (ja) * | 1990-08-28 | 2000-06-12 | 住友製薬株式会社 | 新規なポリエチレングリコール誘導体修飾ペプチド |
| US6255458B1 (en) * | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| US5235041A (en) | 1990-12-28 | 1993-08-10 | Protein Polymer Technologies, Inc. | Purification of structurally ordered recombinant protein polymers |
| US5792742A (en) | 1991-06-14 | 1998-08-11 | New York University | Fibrin-binding peptide fragments of fibronectin |
| WO1994017097A1 (fr) | 1993-01-19 | 1994-08-04 | Regents Of The University Of Minnesota | Fragments de fibronectine synthetique utilises comme inhibiteurs d'infections retrovirales |
| ATE195065T1 (de) | 1993-02-26 | 2000-08-15 | Santen Pharmaceutical Co Ltd | Biologisch abbaubarer sklerastopfen |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| US5516522A (en) | 1994-03-14 | 1996-05-14 | Board Of Supervisors Of Louisiana State University | Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6369116B1 (en) | 1995-06-02 | 2002-04-09 | Oculex Pharmaceuticals, Inc. | Composition and method for treating glaucoma |
| GB9618960D0 (en) | 1996-09-11 | 1996-10-23 | Medical Science Sys Inc | Proteases |
| WO1998031794A1 (fr) * | 1997-01-17 | 1998-07-23 | Toa Gosei Co., Ltd. | Polypeptide liant le facteur vegf |
| JP3692542B2 (ja) | 1997-01-21 | 2005-09-07 | ザ ジェネラル ホスピタル コーポレーション | Rna−蛋白質の融合体を用いた蛋白質の選抜 |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| WO1998048837A1 (fr) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Polypeptides a chaine unique modifies par oxyde de polyalkylene |
| DK0985039T3 (da) | 1997-06-12 | 2008-06-09 | Novartis Int Pharm Ltd | Kunstige antistof-polypeptider |
| US6159722A (en) | 1997-12-03 | 2000-12-12 | Boehringer Mannheim Gmbh | Chimeric serine proteases |
| IL138668A0 (en) | 1998-04-03 | 2001-10-31 | Phylos Inc | Addressable protein arrays |
| JP4108827B2 (ja) | 1998-05-28 | 2008-06-25 | 大日本印刷株式会社 | 無機質系化粧板 |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| DK1137941T4 (da) | 1998-12-10 | 2014-01-06 | Brystol Myers Squibb Company | Protein-scaffolds til antistof-mimetika og andre bindingsproteiner |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6524583B1 (en) | 1999-04-28 | 2003-02-25 | Board Of Regents, The University Of Texas System | Antibody methods for selectively inhibiting VEGF |
| DK1196637T3 (da) | 1999-07-27 | 2007-07-30 | Adnexus Therapeutics Inc | Peptidacceptor-ligeringsmetoder |
| EP1268544A2 (fr) | 2000-03-31 | 2003-01-02 | Institut Pasteur | Peptides inhibant l'angiogenese induite par le vegf (facteur de croissance endotheliale), polynucleotides codant pour ces peptides et leurs procedes d'utilisation |
| EP1364009A2 (fr) | 2000-06-15 | 2003-11-26 | Board of Regents, The University of Texas System | Acides nucleiques pouvant etre regules et actifs du point de vue catalytique |
| CA2416219C (fr) | 2000-07-11 | 2016-10-11 | Research Corporation Technologies, Inc. | Polypeptides d'anticorps artificiels |
| CA2418835A1 (fr) | 2000-10-16 | 2002-04-25 | Phylos, Inc. | Echafaudages proteiniques internes pour analogues d'anticorps et autres proteines de liaison |
| US7598352B2 (en) * | 2000-11-17 | 2009-10-06 | University Of Rochester | Method of identifying polypeptide monobodies which bind to target proteins and use thereof |
| AU2002236495B2 (en) | 2000-11-29 | 2006-05-11 | Allergan, Inc. | Intraocular implants for preventing transplant rejection in the eye |
| US7556925B2 (en) | 2001-04-04 | 2009-07-07 | University Of Rochester | ανβ3 integrin-binding polypeptide monobodies and their use |
| WO2003022858A2 (fr) | 2001-09-11 | 2003-03-20 | Nascacell Gmbh | Procede de criblage d'inhibiteurs de l'interaction proteine-proteine, et ribozymes utilises a cet effet |
| DK1487856T3 (da) | 2002-03-04 | 2010-10-18 | Imclone Llc | KDR-specifikke humane antistoffer og deres anvendelse |
| WO2003104418A2 (fr) | 2002-06-06 | 2003-12-18 | Research Corporation Technologies, Inc. | Polypeptides reconstitues |
| US7053701B2 (en) | 2003-11-04 | 2006-05-30 | Vice Michael W | Power amplifier output stage with multiple power states and improved efficiency |
| CN1946417A (zh) | 2003-12-05 | 2007-04-11 | 阿德内克休斯治疗公司 | 2型血管内皮生长因子受体的抑制剂 |
| US20080220049A1 (en) | 2003-12-05 | 2008-09-11 | Adnexus, A Bristol-Myers Squibb R&D Company | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins |
| US20070059336A1 (en) | 2004-04-30 | 2007-03-15 | Allergan, Inc. | Anti-angiogenic sustained release intraocular implants and related methods |
| US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| WO2005110374A1 (fr) | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Systemes de distribution de medicaments intraoculaires contenant un agent therapeutique, une cyclodextrine et un composant polymere |
| US20060182783A1 (en) | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| EP1804751A2 (fr) | 2004-10-04 | 2007-07-11 | QLT USA, Inc. | Apport oculaire de preparations d'apport polymere |
| US20070072933A1 (en) | 2005-09-26 | 2007-03-29 | Peyman Gholam A | Delivery of an ocular agent |
| MX339797B (es) | 2005-10-18 | 2016-06-10 | Allergan Inc | Terapia ocular que usa derivados glucocorticoides que penetran selectivamente los tejidos del segmento posterior. |
| US20070099879A1 (en) | 2005-10-31 | 2007-05-03 | Wisconsin Alumni Research Foundation (Warf) | Method of using calcitriol for treating intraocular diseases associated with angiogenesis |
| BRPI0707446A2 (pt) | 2006-02-02 | 2011-05-03 | Allergan Inc | composições e métodos para o tratamento de doença oftálmica |
| WO2008031098A1 (fr) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Bibliothèques d'acides aminés binaires pour monocorps polypeptidiques de fibronectines de type iii |
| WO2008066752A2 (fr) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R & D Company | Substances thérapeutiques à base de protéines modifiées ciblées sur des récepteurs de tyrosine kinases, dont l'igf-ir |
| EP2111228B1 (fr) | 2007-02-02 | 2011-07-20 | Bristol-Myers Squibb Company | Domaine 10Fn3 pour utilisation dans le traitement de maladies associées à une angiogenese inappropriée |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| US8680019B2 (en) | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| AU2008287426B2 (en) | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| CN101883578A (zh) | 2007-08-20 | 2010-11-10 | 百时美施贵宝公司 | Vefr-2抑制剂用于治疗转移癌的用途 |
| ES2908934T3 (es) * | 2007-10-04 | 2022-05-04 | Zymogenetics Inc | ZB7H6 miembro de la familia B7 y composiciones y métodos relacionados |
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-
2004
- 2004-12-06 CN CNA200480041450XA patent/CN1946417A/zh active Pending
- 2004-12-06 TW TW093137723A patent/TW200531979A/zh unknown
- 2004-12-06 AU AU2004296376A patent/AU2004296376B2/en not_active Ceased
- 2004-12-06 JP JP2006542876A patent/JP5006651B2/ja not_active Expired - Fee Related
- 2004-12-06 SG SG200809039-1A patent/SG149004A1/en unknown
- 2004-12-06 KR KR1020067013519A patent/KR20060129246A/ko not_active Ceased
- 2004-12-06 BR BRPI0417302-3A patent/BRPI0417302A/pt not_active IP Right Cessation
- 2004-12-06 CA CA002552435A patent/CA2552435A1/fr not_active Abandoned
- 2004-12-06 RU RU2006123945/10A patent/RU2402567C2/ru not_active IP Right Cessation
- 2004-12-06 WO PCT/US2004/040885 patent/WO2005056764A2/fr not_active Ceased
- 2004-12-06 MX MXPA06006406A patent/MXPA06006406A/es active IP Right Grant
- 2004-12-06 EP EP04813230A patent/EP1711196A4/fr not_active Withdrawn
-
2006
- 2006-06-05 IL IL176135A patent/IL176135A0/en unknown
- 2006-06-05 US US11/448,171 patent/US7858739B2/en not_active Expired - Lifetime
- 2006-07-07 US US11/482,641 patent/US7847062B2/en not_active Expired - Lifetime
-
2010
- 2010-05-26 US US12/788,240 patent/US8324362B2/en not_active Expired - Lifetime
-
2011
- 2011-11-18 JP JP2011252176A patent/JP2012100658A/ja active Pending
-
2012
- 2012-07-18 US US13/552,398 patent/US8609613B2/en not_active Expired - Lifetime
-
2013
- 2013-11-04 US US14/071,069 patent/US9328157B2/en not_active Expired - Lifetime
-
2016
- 2016-03-15 US US15/070,572 patent/US9862758B2/en not_active Expired - Lifetime
-
2017
- 2017-11-29 US US15/826,196 patent/US10995131B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998012226A1 (fr) * | 1996-09-20 | 1998-03-26 | The Burnham Institute | Procede permettant de freiner l'evolution des cancers et d'inhiber l'angiogenese a l'aide de fibronectine |
Non-Patent Citations (2)
| Title |
|---|
| BATORI V. ET AL: "Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain", PROTEIN ENGINEERING, vol. 15, no. 12, 2002, pages 1015 - 1020, XP002996047 * |
| KOIDE A. ET AL: "Stabilization of a Fibronectin Type III Domain by the Removal of Unfavorable Electrostatic Interactions on the Protein Surface", BIOCHEMISTRY, vol. 40, 28 August 2001 (2001-08-28), pages 10326 - 10333, XP002987268 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7994159B2 (en) | 2003-03-10 | 2011-08-09 | Eisai R&D Management Co., Ltd. | c-Kit kinase inhibitor |
| US9504746B2 (en) | 2004-09-17 | 2016-11-29 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide |
| US8969344B2 (en) | 2005-08-02 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Method for assay on the effect of vascularization inhibitor |
| US9006240B2 (en) | 2005-08-02 | 2015-04-14 | Eisai R&D Management Co., Ltd. | Method for assay on the effect of vascularization inhibitor |
| US9006256B2 (en) | 2006-05-18 | 2015-04-14 | Eisai R&D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| US8865737B2 (en) | 2006-08-28 | 2014-10-21 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
| US8962655B2 (en) | 2007-01-29 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Composition for treatment of undifferentiated gastric cancer |
| US8952035B2 (en) | 2007-11-09 | 2015-02-10 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
| US9012458B2 (en) | 2010-06-25 | 2015-04-21 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
| US8962650B2 (en) | 2011-04-18 | 2015-02-24 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| US9334239B2 (en) | 2012-12-21 | 2016-05-10 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
| US11453726B2 (en) | 2016-09-15 | 2022-09-27 | Quadrucept Bio Limited | Multimers, tetramers and octamers |
Also Published As
| Publication number | Publication date |
|---|---|
| US10995131B2 (en) | 2021-05-04 |
| US9328157B2 (en) | 2016-05-03 |
| BRPI0417302A (pt) | 2007-03-06 |
| TW200531979A (en) | 2005-10-01 |
| JP2012100658A (ja) | 2012-05-31 |
| EP1711196A2 (fr) | 2006-10-18 |
| US20070148126A1 (en) | 2007-06-28 |
| SG149004A1 (en) | 2009-01-29 |
| EP1711196A4 (fr) | 2011-09-14 |
| MXPA06006406A (es) | 2007-03-21 |
| IL176135A0 (en) | 2006-10-05 |
| JP5006651B2 (ja) | 2012-08-22 |
| KR20060129246A (ko) | 2006-12-15 |
| US9862758B2 (en) | 2018-01-09 |
| US8324362B2 (en) | 2012-12-04 |
| US8609613B2 (en) | 2013-12-17 |
| US20140179896A1 (en) | 2014-06-26 |
| US20160297869A1 (en) | 2016-10-13 |
| US20100310549A1 (en) | 2010-12-09 |
| US20120283184A1 (en) | 2012-11-08 |
| CN1946417A (zh) | 2007-04-11 |
| US7858739B2 (en) | 2010-12-28 |
| WO2005056764A2 (fr) | 2005-06-23 |
| RU2402567C2 (ru) | 2010-10-27 |
| RU2006123945A (ru) | 2008-01-10 |
| US7847062B2 (en) | 2010-12-07 |
| US20180162926A1 (en) | 2018-06-14 |
| AU2004296376B2 (en) | 2010-03-04 |
| AU2004296376A1 (en) | 2005-06-23 |
| US20070160533A1 (en) | 2007-07-12 |
| JP2007516707A (ja) | 2007-06-28 |
| CA2552435A1 (fr) | 2005-06-23 |
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