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TW218381B - - Google Patents

Info

Publication number
TW218381B
TW218381B TW081103954A TW81103954A TW218381B TW 218381 B TW218381 B TW 218381B TW 081103954 A TW081103954 A TW 081103954A TW 81103954 A TW81103954 A TW 81103954A TW 218381 B TW218381 B TW 218381B
Authority
TW
Taiwan
Prior art keywords
4alkyl
represents hydrogen
4alkyloxy
halo
substituted
Prior art date
Application number
TW081103954A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of TW218381B publication Critical patent/TW218381B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Detergent Compositions (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW081103954A 1991-06-13 1992-05-21 TW218381B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71448691A 1991-06-13 1991-06-13
US85363192A 1992-03-18 1992-03-18

Publications (1)

Publication Number Publication Date
TW218381B true TW218381B (zh) 1994-01-01

Family

ID=27109168

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081103954A TW218381B (zh) 1991-06-13 1992-05-21

Country Status (28)

Country Link
US (1) US5468743A (zh)
EP (2) EP0518435A1 (zh)
JP (1) JP2845407B2 (zh)
KR (1) KR0184017B1 (zh)
CN (2) CN1033586C (zh)
AT (1) ATE250061T1 (zh)
AU (1) AU652840B2 (zh)
CA (1) CA2103242C (zh)
DE (1) DE69233205T2 (zh)
DK (1) DK0588858T3 (zh)
DZ (1) DZ1582A1 (zh)
ES (1) ES2207632T3 (zh)
FI (1) FI104175B1 (zh)
HR (1) HRP920155A2 (zh)
HU (2) HU221016B1 (zh)
IE (1) IE921918A1 (zh)
IL (1) IL101850A (zh)
MA (1) MA22553A1 (zh)
MX (1) MX9202856A (zh)
NO (2) NO934492D0 (zh)
NZ (1) NZ242774A (zh)
PT (1) PT588858E (zh)
SG (1) SG47823A1 (zh)
SI (1) SI9200105B (zh)
TN (1) TNSN92048A1 (zh)
TW (1) TW218381B (zh)
WO (1) WO1992022551A1 (zh)
YU (1) YU61192A (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
GR1001393B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως.
PL176593B1 (pl) * 1992-12-04 1999-06-30 Janssen Pharmaceutica Nv Nowe związki, pochodne triazolobenzoazepiny o działaniu przeciwalergicznym, kompozycja farmaceutyczna i sposób wytwarzania pochodnych triazolobenzoazepiny
KR100346802B1 (ko) * 1993-07-13 2002-11-29 얀센 파마슈티카 엔.브이. 항앨러지성이미다조아제핀
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
JP3775780B2 (ja) * 1997-09-18 2006-05-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 薬剤の経口的バイオアベイラビリテイを向上させるための縮合イミダゾール誘導体
SI1144411T1 (en) * 1998-12-19 2005-10-31 Janssen Pharmaceutica N.V. Antihistaminic spiro compounds
AU2002319232B2 (en) 2001-06-12 2007-09-06 Janssen Pharmaceutica N.V. Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine
CN1160557C (zh) * 2001-09-03 2004-08-04 北京埃索特核电子机械有限公司 钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备
CN101137657B (zh) 2005-03-08 2011-02-02 詹森药业有限公司 作为神经激肽（nk1）拮抗剂的二氮杂-螺-[4.4]-壬烷衍生物
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions
EA016221B1 (ru) * 2006-03-31 2012-03-30 ВИСТЭКОН ФАРМАСЬЮТИКАЛС, ЭлЭлСи Офтальмические композиции и способ лечения аллергических заболеваний глаз
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
EP2131834A2 (en) * 2007-04-11 2009-12-16 Alcon Research, Ltd. Use of an inhibitor of tnfa plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
BR112012007091A2 (pt) * 2009-10-01 2016-04-19 Alcon Res Ltd composições de olopatadina e seus usos
AR079170A1 (es) * 2009-12-10 2011-12-28 Lilly Co Eli Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par
JP2014518278A (ja) * 2011-06-29 2014-07-28 アラーガン インコーポレイテッド 蕁麻疹の治療に用いるアルカフタジン
WO2014080259A1 (en) * 2012-11-21 2014-05-30 Enaltec Labs Pvt. Ltd. Novel polymorphic forms of alcaftadine
WO2014083571A1 (en) * 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine
WO2014087208A2 (en) * 2012-12-06 2014-06-12 Enaltec Labs Pvt. Ltd. A process of preparing alcaftadine
EP2978765B1 (en) * 2013-03-25 2018-05-02 Crystal Pharma S.A.U Methods for the preparation of alcaftadine
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法
US9708272B2 (en) 2014-08-29 2017-07-18 Tes Pharma S.R.L. Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase
CN104710427A (zh) * 2014-12-20 2015-06-17 威海法莫斯特医药技术开发有限公司 一种阿卡他定新晶型
CN104860920B (zh) * 2015-04-15 2017-08-25 武汉武药科技有限公司 一种阿卡他定中间体的制备方法
CN104987337B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种制备阿卡他定的氧化方法
CN105130993B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种合成阿卡他定的新氧化方法
MX2019001633A (es) 2016-08-12 2019-09-18 Silk Tech Ltd Proteina derivada de la seda para el tratamiento de la inflamacion.
CN108727384A (zh) * 2018-07-07 2018-11-02 张正光 一种阿卡他定中间体的制备方法
US20220411482A1 (en) 2019-11-15 2022-12-29 Silk Technologies, Ltd. Stable formulations of silk-derived protein
KR20230024928A (ko) 2020-06-15 2023-02-21 알켐 라보라토리즈 리미티드 알카프타딘과 코르티코스테로이드의 병용
BR112023019795A2 (pt) 2021-04-01 2023-11-07 Alkem Laboratories Ltd Composições nasais compreendendo alcaftadina

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
WO1992006981A1 (en) * 1990-10-10 1992-04-30 Schering Corporation Substituted imidazobenzazepines and imidazopyridoazepines
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor

Also Published As

Publication number Publication date
IL101850A (en) 1996-01-31
HRP920155A2 (en) 1994-08-31
US5468743A (en) 1995-11-21
DE69233205T2 (de) 2004-06-24
HU221016B1 (hu) 2002-07-29
FI104175B (fi) 1999-11-30
EP0518435A1 (en) 1992-12-16
CA2103242A1 (en) 1992-12-14
HU211289A9 (en) 1995-11-28
EP0588858A1 (en) 1994-03-30
IL101850A0 (en) 1992-12-30
PT588858E (pt) 2004-02-27
CN1068118A (zh) 1993-01-20
ATE250061T1 (de) 2003-10-15
CN1033586C (zh) 1996-12-18
JPH06507889A (ja) 1994-09-08
DK0588858T3 (da) 2004-01-26
SG47823A1 (en) 1998-04-17
FI104175B1 (fi) 1999-11-30
AU1900192A (en) 1993-01-12
HUT70529A (en) 1995-10-30
CA2103242C (en) 2002-11-12
HU9303553D0 (en) 1994-04-28
TNSN92048A1 (fr) 1993-06-08
NO934492L (no) 1994-01-04
NO300636B1 (no) 1997-06-30
CN1142360A (zh) 1997-02-12
CN1070368C (zh) 2001-09-05
JP2845407B2 (ja) 1999-01-13
ES2207632T3 (es) 2004-06-01
SI9200105B (en) 2001-10-31
FI935556A0 (fi) 1993-12-10
WO1992022551A1 (en) 1992-12-23
DE69233205D1 (de) 2003-10-23
MX9202856A (es) 1992-12-01
NO934492D0 (no) 1993-12-09
KR0184017B1 (ko) 1999-05-01
MA22553A1 (fr) 1992-12-31
DZ1582A1 (fr) 2002-02-17
YU61192A (sh) 1994-09-09
AU652840B2 (en) 1994-09-08
EP0588858B1 (en) 2003-09-17
IE921918A1 (en) 1992-12-16
SI9200105A (en) 1992-12-31
NZ242774A (en) 1995-02-24
FI935556A7 (fi) 1993-12-10

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