SG47823A1 - Imidazo[2,1B] [3] benzazepine derivatives compositions and method of use - Google Patents
Imidazo[2,1B] [3] benzazepine derivatives compositions and method of useInfo
- Publication number
- SG47823A1 SG47823A1 SG1996004579A SG1996004579A SG47823A1 SG 47823 A1 SG47823 A1 SG 47823A1 SG 1996004579 A SG1996004579 A SG 1996004579A SG 1996004579 A SG1996004579 A SG 1996004579A SG 47823 A1 SG47823 A1 SG 47823A1
- Authority
- SG
- Singapore
- Prior art keywords
- 4alkyl
- represents hydrogen
- 4alkyloxy
- halo
- substituted
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- YGLDQFWPUCURIP-UHFFFAOYSA-N 3h-3-benzazepine Chemical class C1=CNC=CC2=CC=CC=C21 YGLDQFWPUCURIP-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- NWMRTUTXGPXHGP-UHFFFAOYSA-N 11-piperidin-4-ylidene-5,6-dihydroimidazo[2,1-b][3]benzazepine Chemical compound C1CNCCC1=C1C2=CC=CC=C2CCN2C=CN=C21 NWMRTUTXGPXHGP-UHFFFAOYSA-N 0.000 abstract 1
- WCQUXHMDSKHEPY-UHFFFAOYSA-N 3h-imidazo[2,1-b][3]benzazepine Chemical class C1=CN2CC=NC2=CC2=CC=CC=C21 WCQUXHMDSKHEPY-UHFFFAOYSA-N 0.000 abstract 1
- -1 C1-4alkyloxy Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Detergent Compositions (AREA)
- Paper (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71448691A | 1991-06-13 | 1991-06-13 | |
| US85363192A | 1992-03-18 | 1992-03-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG47823A1 true SG47823A1 (en) | 1998-04-17 |
Family
ID=27109168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996004579A SG47823A1 (en) | 1991-06-13 | 1992-06-09 | Imidazo[2,1B] [3] benzazepine derivatives compositions and method of use |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5468743A (zh) |
| EP (2) | EP0518435A1 (zh) |
| JP (1) | JP2845407B2 (zh) |
| KR (1) | KR0184017B1 (zh) |
| CN (2) | CN1033586C (zh) |
| AT (1) | ATE250061T1 (zh) |
| AU (1) | AU652840B2 (zh) |
| CA (1) | CA2103242C (zh) |
| DE (1) | DE69233205T2 (zh) |
| DK (1) | DK0588858T3 (zh) |
| DZ (1) | DZ1582A1 (zh) |
| ES (1) | ES2207632T3 (zh) |
| FI (1) | FI104175B1 (zh) |
| HR (1) | HRP920155A2 (zh) |
| HU (2) | HU221016B1 (zh) |
| IE (1) | IE921918A1 (zh) |
| IL (1) | IL101850A (zh) |
| MA (1) | MA22553A1 (zh) |
| MX (1) | MX9202856A (zh) |
| NO (2) | NO934492D0 (zh) |
| NZ (1) | NZ242774A (zh) |
| PT (1) | PT588858E (zh) |
| SG (1) | SG47823A1 (zh) |
| SI (1) | SI9200105B (zh) |
| TN (1) | TNSN92048A1 (zh) |
| TW (1) | TW218381B (zh) |
| WO (1) | WO1992022551A1 (zh) |
| YU (1) | YU61192A (zh) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor |
| GR1001393B (el) * | 1992-10-12 | 1993-10-29 | Janssen Pharmaceutica Nv | Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως. |
| US5932569A (en) * | 1992-12-04 | 1999-08-03 | Janssen Pharmaceutica, N.V. | Triazolobenzazepine derivatives |
| EP0708776B1 (en) * | 1993-07-13 | 2001-01-03 | Janssen Pharmaceutica N.V. | Antiallergic imidazoazepines |
| TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
| TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| JP3775780B2 (ja) | 1997-09-18 | 2006-05-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 薬剤の経口的バイオアベイラビリテイを向上させるための縮合イミダゾール誘導体 |
| EA004500B1 (ru) * | 1998-12-19 | 2004-04-29 | Янссен Фармацевтика Н.В. | Антигистаминные спиросоединения |
| JP4452496B2 (ja) | 2001-06-12 | 2010-04-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 新規な置換四環式イミダゾール誘導体、それらの製造法、それらを含む製薬学的組成物及び薬剤としてのそれらの使用 |
| CN1160557C (zh) * | 2001-09-03 | 2004-08-04 | 北京埃索特核电子机械有限公司 | 钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备 |
| ES2350647T3 (es) | 2005-03-08 | 2011-01-25 | Janssen Pharmaceutica Nv | Derivados de diaza-espiro-[4.4]-nonano como antagonistas de neuroquininas (nk1). |
| US20070077302A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for stabilizing ophthalmic compositions |
| US20070077303A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for providing oxidatively stable ophthalmic compositions |
| ES2594655T3 (es) | 2006-03-31 | 2016-12-21 | Vistakon Pharmaceuticals, Llc | Tratamiento de alergias oculares |
| US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
| JP2010523695A (ja) * | 2007-04-11 | 2010-07-15 | アルコン リサーチ， リミテッド | アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用 |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| US20110082145A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| AR079170A1 (es) * | 2009-12-10 | 2011-12-28 | Lilly Co Eli | Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par |
| BR112013034055A2 (pt) * | 2011-06-29 | 2017-02-07 | Allergan Inc | alcaftadina para uso no tratamento de urticária |
| US9409913B2 (en) | 2012-11-21 | 2016-08-09 | Enaltec Labs Private Limited | Polymorphic forms of alcaftadine |
| WO2014083571A1 (en) | 2012-11-29 | 2014-06-05 | Neuland Laboratories Limited | A process for the preparation of alcaftadine |
| WO2014087208A2 (en) * | 2012-12-06 | 2014-06-12 | Enaltec Labs Pvt. Ltd. | A process of preparing alcaftadine |
| WO2014154620A1 (en) | 2013-03-25 | 2014-10-02 | Crystal Pharma S.A.U. | Methods for the preparation of alcaftadine |
| CN103408549B (zh) * | 2013-06-14 | 2016-01-20 | 苏州汇和药业有限公司 | 一种阿卡他定中间体的制备方法 |
| CN113121450A (zh) | 2014-08-29 | 2021-07-16 | Tes制药有限责任公司 | α-氨基-β-羧基粘康酸半醛脱羧酶抑制剂 |
| CN104710427A (zh) * | 2014-12-20 | 2015-06-17 | 威海法莫斯特医药技术开发有限公司 | 一种阿卡他定新晶型 |
| CN104860920B (zh) * | 2015-04-15 | 2017-08-25 | 武汉武药科技有限公司 | 一种阿卡他定中间体的制备方法 |
| CN105130993B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种合成阿卡他定的新氧化方法 |
| CN104987337B (zh) * | 2015-07-28 | 2018-01-12 | 武汉武药科技有限公司 | 一种制备阿卡他定的氧化方法 |
| US11242367B2 (en) | 2016-08-12 | 2022-02-08 | Silk Technologies, Ltd. | Silk-derived protein for treating inflammation |
| CN108727384A (zh) * | 2018-07-07 | 2018-11-02 | 张正光 | 一种阿卡他定中间体的制备方法 |
| CN115701988A (zh) * | 2020-06-15 | 2023-02-14 | 阿尔克姆实验室有限公司 | 阿卡他定和皮质类固醇的组合 |
| MX2023011546A (es) | 2021-04-01 | 2023-10-06 | Alkem Laboratories Ltd | Composiciones nasales que comprenden alcaftadina. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4148903A (en) * | 1977-07-28 | 1979-04-10 | Merck & Co., Inc. | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines |
| GB8900380D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| JPH089616B2 (ja) * | 1990-10-10 | 1996-01-31 | シェリング・コーポレーション | 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類 |
| IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor |
-
1992
- 1992-05-13 IL IL10185092A patent/IL101850A/en not_active IP Right Cessation
- 1992-05-15 NZ NZ242774A patent/NZ242774A/en not_active IP Right Cessation
- 1992-05-16 CN CN92105040A patent/CN1033586C/zh not_active Expired - Lifetime
- 1992-05-18 DZ DZ920051A patent/DZ1582A1/fr active
- 1992-05-21 TW TW081103954A patent/TW218381B/zh not_active IP Right Cessation
- 1992-06-09 AU AU19001/92A patent/AU652840B2/en not_active Expired
- 1992-06-09 ES ES92911635T patent/ES2207632T3/es not_active Expired - Lifetime
- 1992-06-09 DE DE69233205T patent/DE69233205T2/de not_active Expired - Lifetime
- 1992-06-09 US US08/142,474 patent/US5468743A/en not_active Expired - Lifetime
- 1992-06-09 HU HU9303553A patent/HU221016B1/hu unknown
- 1992-06-09 PT PT92911635T patent/PT588858E/pt unknown
- 1992-06-09 JP JP4510733A patent/JP2845407B2/ja not_active Expired - Lifetime
- 1992-06-09 DK DK92911635T patent/DK0588858T3/da active
- 1992-06-09 WO PCT/EP1992/001330 patent/WO1992022551A1/en not_active Ceased
- 1992-06-09 CA CA002103242A patent/CA2103242C/en not_active Expired - Lifetime
- 1992-06-09 EP EP92201666A patent/EP0518435A1/en active Pending
- 1992-06-09 KR KR1019930703788A patent/KR0184017B1/ko not_active Expired - Lifetime
- 1992-06-09 AT AT92911635T patent/ATE250061T1/de active
- 1992-06-09 EP EP92911635A patent/EP0588858B1/en not_active Expired - Lifetime
- 1992-06-09 SG SG1996004579A patent/SG47823A1/en unknown
- 1992-06-10 HR HR920155A patent/HRP920155A2/hr not_active Application Discontinuation
- 1992-06-11 MA MA22843A patent/MA22553A1/fr unknown
- 1992-06-12 MX MX9202856A patent/MX9202856A/es unknown
- 1992-06-12 YU YU61192A patent/YU61192A/sh unknown
- 1992-06-12 SI SI9200105A patent/SI9200105B/sl unknown
- 1992-06-15 TN TNTNSN92048A patent/TNSN92048A1/fr unknown
- 1992-07-01 IE IE191892A patent/IE921918A1/en not_active Application Discontinuation
-
1993
- 1993-12-09 NO NO934492D patent/NO934492D0/no unknown
- 1993-12-09 NO NO934492A patent/NO300636B1/no not_active IP Right Cessation
- 1993-12-10 FI FI935556A patent/FI104175B1/fi not_active IP Right Cessation
-
1995
- 1995-06-06 HU HU95P/P00164P patent/HU211289A9/hu unknown
-
1996
- 1996-04-24 CN CN96106116A patent/CN1070368C/zh not_active Expired - Lifetime
Also Published As
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