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TNSN99142A1 - Derives de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procede pour leur preparation. - Google Patents

Derives de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procede pour leur preparation.

Info

Publication number
TNSN99142A1
TNSN99142A1 TNTNSN99142A TNSN99142A TNSN99142A1 TN SN99142 A1 TNSN99142 A1 TN SN99142A1 TN TNSN99142 A TNTNSN99142 A TN TNSN99142A TN SN99142 A TNSN99142 A TN SN99142A TN SN99142 A1 TNSN99142 A1 TN SN99142A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
benzimidazole derivatives
novel benzimidazole
Prior art date
Application number
TNTNSN99142A
Other languages
English (en)
Inventor
Ito Fumitaka
Noguchi Hirohide
Kondo Hiroshi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN99142A1 publication Critical patent/TNSN99142A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

=J137=J136-L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE A, R, Y, Z1, Z2, Z3 ET Z4 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS COMME ANALGESIQUES CHEZ DES MAMMIFERES.
TNTNSN99142A 1998-08-06 1999-07-05 Derives de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procede pour leur preparation. TNSN99142A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IBPCT/IB98/01206 1998-08-06

Publications (1)

Publication Number Publication Date
TNSN99142A1 true TNSN99142A1 (fr) 2005-11-10

Family

ID=11004738

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99142A TNSN99142A1 (fr) 1998-08-06 1999-07-05 Derives de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procede pour leur preparation.

Country Status (44)

Country Link
US (1) US6172067B1 (fr)
EP (1) EP1102762B1 (fr)
JP (1) JP3367945B2 (fr)
CN (1) CN1317968A (fr)
AP (1) AP2001002063A0 (fr)
AR (1) AR018686A1 (fr)
AT (1) ATE227716T1 (fr)
AU (1) AU749166B2 (fr)
BG (1) BG105301A (fr)
BR (1) BR9912778A (fr)
CA (1) CA2339621C (fr)
CZ (1) CZ2001397A3 (fr)
DE (1) DE69903953T2 (fr)
DK (1) DK1102762T3 (fr)
EA (1) EA200100104A1 (fr)
EE (1) EE200100075A (fr)
ES (1) ES2185357T3 (fr)
GE (1) GEP20033000B (fr)
GT (1) GT199900125A (fr)
HK (1) HK1040188A1 (fr)
HN (1) HN1999000105A (fr)
HR (1) HRP20010089B1 (fr)
HU (1) HUP0103567A3 (fr)
ID (1) ID27212A (fr)
IL (1) IL141029A0 (fr)
IS (1) IS5812A (fr)
MA (1) MA26659A1 (fr)
NO (1) NO20010603L (fr)
NZ (1) NZ509299A (fr)
OA (1) OA11590A (fr)
PA (1) PA8477701A1 (fr)
PE (1) PE20000868A1 (fr)
PL (1) PL346211A1 (fr)
PT (1) PT1102762E (fr)
SI (1) SI1102762T1 (fr)
SK (1) SK1602001A3 (fr)
SV (1) SV1999000099A (fr)
TN (1) TNSN99142A1 (fr)
TR (1) TR200100403T2 (fr)
TW (1) TW513424B (fr)
UY (1) UY25659A1 (fr)
WO (1) WO2000008013A2 (fr)
YU (1) YU8201A (fr)
ZA (1) ZA200100900B (fr)

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SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
ATE306488T1 (de) * 2000-01-05 2005-10-15 Pfizer Benzimidazol-verbindungen zur verwendung als orl1-rezeptor-antagonisten
GB2359081A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active thiazolopyrimidines
GB2359078A (en) 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en) 2000-03-10 2000-05-03 Astrazeneca Uk Ltd Chemical compounds
SE0003828D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
AU2002224038B2 (en) * 2000-11-15 2006-03-09 Banyu Pharmaceutical Co., Ltd. Benzimidazole derivatives
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0101322D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
EP2172468A1 (fr) 2001-04-18 2010-04-07 Euro-Celtique S.A. Composés de benzimidazolone
PT1385515E (pt) 2001-04-18 2008-09-15 Euro Celtique Sa Compostos de espiropirazole
BR0209128A (pt) * 2001-04-18 2005-11-01 Euro Celtique Sa Compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
ES2322158T3 (es) * 2001-04-18 2009-06-17 Euro-Celtique S.A. Derivados 1-(4-piperidinil)-1,3-dihidro-2h-indol-2-ona y compuestos afines como analogos de la nociceptina y ligandos del orl-1 para el tratamiento del dolor.
US6828440B2 (en) 2001-04-18 2004-12-07 Euro-Celtique, S.A. Spiroindene and spiroindane compounds
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
EP1406629A1 (fr) * 2001-07-02 2004-04-14 Omeros Corporation Procede visant a induire une analgesie, qui comprend l'administration alternee d'un agoniste de recepteur d'opioides et d'un agoniste de recepteur 1 du type recepteur d'opioides, et pompe a perfusion implantable
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
SE0103818D0 (sv) * 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
WO2003049736A1 (fr) * 2001-12-11 2003-06-19 Sepracor, Inc. Piperidines 4-substitues, et methodes d'utilisation
WO2003082333A1 (fr) 2002-03-29 2003-10-09 Mitsubishi Pharma Corporation Remede contre les troubles du sommeil
GB0221828D0 (en) 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
WO2005060947A2 (fr) * 2003-12-19 2005-07-07 Sri International Ligands agonistes et antagonistes du recepteur de la nociceptine
WO2006038738A1 (fr) * 2004-10-08 2006-04-13 Takeda Pharmaceutical Company Limited Agent de régulation du fonctionnement d'un récepteur
ATE488235T1 (de) 2005-01-11 2010-12-15 Neurosearch As Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
CA2654666A1 (fr) * 2006-07-03 2008-01-10 Neurosearch A/S Compositions pharmaceutiques
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KR20130108543A (ko) 2010-08-05 2013-10-04 암젠 인코포레이션 역형성 림프종 키나제를 억제하는 벤즈이미다졸 및 아자벤즈이미다졸 화합물
WO2013103598A2 (fr) 2012-01-06 2013-07-11 Novus International Inc. Agents tensio-actifs à base de sulfoxyde
EP2812372B1 (fr) 2012-02-09 2018-09-26 Novus International Inc. Hétéroatomes contenant des dimères cycliques
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
US9452143B2 (en) 2012-07-12 2016-09-27 Novus International, Inc. Matrix and layer compositions for protection of bioactives
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WO2014102594A2 (fr) * 2012-12-27 2014-07-03 Purdue Pharma L.P. Composés de pipéridine de type benzimidazole substitué et leurs utilisations
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US5929035A (en) 1998-04-14 1999-07-27 Regents Of The University Of Michigan Methods of treating intestinal disorders
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

Also Published As

Publication number Publication date
EP1102762A2 (fr) 2001-05-30
CN1317968A (zh) 2001-10-17
EA200100104A1 (ru) 2001-08-27
JP3367945B2 (ja) 2003-01-20
HUP0103567A3 (en) 2003-01-28
AU4385999A (en) 2000-02-28
JP2002522431A (ja) 2002-07-23
OA11590A (en) 2004-08-18
HRP20010089A2 (en) 2002-02-28
SV1999000099A (es) 2000-09-05
AU749166B2 (en) 2002-06-20
BR9912778A (pt) 2001-09-25
AR018686A1 (es) 2001-11-28
HRP20010089B1 (en) 2003-04-30
UY25659A1 (es) 2000-02-23
MA26659A1 (fr) 2004-12-20
NO20010603D0 (no) 2001-02-05
TW513424B (en) 2002-12-11
AP2001002063A0 (en) 2001-03-31
US6172067B1 (en) 2001-01-09
DE69903953D1 (de) 2002-12-19
CA2339621A1 (fr) 2000-02-17
PT1102762E (pt) 2003-02-28
PL346211A1 (en) 2002-01-28
EE200100075A (et) 2002-06-17
ATE227716T1 (de) 2002-11-15
NZ509299A (en) 2003-05-30
GT199900125A (es) 2001-01-27
ZA200100900B (en) 2002-08-28
PE20000868A1 (es) 2000-08-31
ID27212A (id) 2001-03-08
WO2000008013A2 (fr) 2000-02-17
NO20010603L (no) 2001-04-05
CA2339621C (fr) 2005-04-05
IL141029A0 (en) 2002-02-10
PA8477701A1 (es) 2000-09-29
WO2000008013A3 (fr) 2000-03-23
DE69903953T2 (de) 2003-03-27
ES2185357T3 (es) 2003-04-16
YU8201A (sh) 2003-07-07
GEP20033000B (en) 2003-06-25
SI1102762T1 (en) 2003-04-30
HN1999000105A (es) 2000-11-11
CZ2001397A3 (cs) 2002-05-15
SK1602001A3 (en) 2002-09-10
TR200100403T2 (tr) 2001-07-23
BG105301A (en) 2001-12-29
HUP0103567A2 (hu) 2002-02-28
DK1102762T3 (da) 2002-12-16
EP1102762B1 (fr) 2002-11-13
IS5812A (is) 2001-01-16
HK1040188A1 (zh) 2002-05-31

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