EE200100075A - 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid - Google Patents

2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid

Info

Publication number: EE200100075A
Authority: EE; Estonia
Prior art keywords: piperidylbenzimidazole; orl; substituted; compounds; receptor agonists
Prior art date: 1998-08-06

Application number

EEP200100075A

Other languages

English (en)

Estonian (et)

Inventor

Ito Fumitaka

Noguchi Hirohide

Kondo Hiroshi

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

1999-07-05

Publication date

2002-06-17

1999-07-05 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2002-06-17 Publication of EE200100075A publication Critical patent/EE200100075A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EEP200100075A 1998-08-06 1999-07-05 2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid EE200100075A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IBPCT/IB98/01206		1998-08-06
PCT/IB1999/001239 WO2000008013A2 (fr)	1998-08-06	1999-07-05	Composés de 1-pipéridyl benzimidazole substitué en 2, agonistes du récepteur orl1

Publications (1)

Publication Number	Publication Date
EE200100075A true EE200100075A (et)	2002-06-17

Family

ID=11004738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100075A EE200100075A (et)	1998-08-06	1999-07-05	2-asendatud 1-piperidüülbensimidasoolühendid kui ORL-1 retseptori agonistid

Country Status (44)

Country	Link
US (1)	US6172067B1 (fr)
EP (1)	EP1102762B1 (fr)
JP (1)	JP3367945B2 (fr)
CN (1)	CN1317968A (fr)
AP (1)	AP2001002063A0 (fr)
AR (1)	AR018686A1 (fr)
AT (1)	ATE227716T1 (fr)
AU (1)	AU749166B2 (fr)
BG (1)	BG105301A (fr)
BR (1)	BR9912778A (fr)
CA (1)	CA2339621C (fr)
CZ (1)	CZ2001397A3 (fr)
DE (1)	DE69903953T2 (fr)
DK (1)	DK1102762T3 (fr)
EA (1)	EA200100104A1 (fr)
EE (1)	EE200100075A (fr)
ES (1)	ES2185357T3 (fr)
GE (1)	GEP20033000B (fr)
GT (1)	GT199900125A (fr)
HK (1)	HK1040188A1 (fr)
HN (1)	HN1999000105A (fr)
HR (1)	HRP20010089B1 (fr)
HU (1)	HUP0103567A3 (fr)
ID (1)	ID27212A (fr)
IL (1)	IL141029A0 (fr)
IS (1)	IS5812A (fr)
MA (1)	MA26659A1 (fr)
NO (1)	NO20010603L (fr)
NZ (1)	NZ509299A (fr)
OA (1)	OA11590A (fr)
PA (1)	PA8477701A1 (fr)
PE (1)	PE20000868A1 (fr)
PL (1)	PL346211A1 (fr)
PT (1)	PT1102762E (fr)
SI (1)	SI1102762T1 (fr)
SK (1)	SK1602001A3 (fr)
SV (1)	SV1999000099A (fr)
TN (1)	TNSN99142A1 (fr)
TR (1)	TR200100403T2 (fr)
TW (1)	TW513424B (fr)
UY (1)	UY25659A1 (fr)
WO (1)	WO2000008013A2 (fr)
YU (1)	YU8201A (fr)
ZA (1)	ZA200100900B (fr)

Families Citing this family (51)

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US6340681B1 (en) *	1999-07-16	2002-01-22	Pfizer Inc	2-benzimidazolylamine compounds as ORL-1-receptor agonists
SE9902987D0 (sv)	1999-08-24	1999-08-24	Astra Pharma Prod	Novel compounds
SE9903544D0 (sv)	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
EP1122257B1 (fr) *	2000-01-05	2005-10-12	Pfizer Inc.	Composés de benzimidazole comme agonistes du récepteur ORL1
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359078A (en) *	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
AU2403802A (en)	2000-11-15	2002-05-27	Banyu Pharma Co Ltd	Benzimidazole derivatives
GB0104050D0 (en)	2001-02-19	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0107228D0 (en)	2001-03-22	2001-05-16	Astrazeneca Ab	Chemical compounds
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
SI1975164T1 (sl)	2001-04-18	2010-05-31	Euro Celtique Sa	Oktahidrobenzimidazolonske spojine kot analgetiki
US6828440B2 (en)	2001-04-18	2004-12-07	Euro-Celtique, S.A.	Spiroindene and spiroindane compounds
EP1379252A4 (fr) *	2001-04-18	2005-11-02	Euro Celtique Sa	Analogues de la nociceptine
CZ20032850A3 (cs)	2001-04-18	2004-02-18	Euro-Celtique, S. A.	Analogy nociceptinu
CN1516584A (zh)	2001-04-18	2004-07-28	ŷ��ǹɷ��޹�˾	螺吡唑化合物
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
WO2003004034A1 (fr) *	2001-07-02	2003-01-16	Omeros Corporation	Procede visant a induire une analgesie, qui comprend l'administration alternee d'un agoniste de recepteur d'opioides et d'un agoniste de recepteur 1 du type recepteur d'opioides, et pompe a perfusion implantable
SE0102716D0 (sv) *	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
SE0103818D0 (sv) *	2001-11-15	2001-11-15	Astrazeneca Ab	Chemical compounds
US7812035B2 (en) *	2001-12-11	2010-10-12	Sepracor Inc.	4-substituted piperidines, and methods of use thereof
DK1491212T3 (da)	2002-03-29	2012-10-29	Mitsubishi Tanabe Pharma Corp	Middel til behandling af søvnforstyrrelser
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221829D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
DE10252666A1 (de)	2002-11-11	2004-08-05	Grünenthal GmbH	N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de)	2002-11-11	2004-06-03	Grünenthal GmbH	4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
SE0301369D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	Chemical compounds
GB0315203D0 (en) *	2003-06-28	2003-08-06	Celltech R&D Ltd	Chemical compounds
SA04250305B1 (ar)	2003-09-25	2008-06-02	سولفاي فارماسوتيكالز بي . في	مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
GB0328243D0 (en) *	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
US20050228023A1 (en) *	2003-12-19	2005-10-13	Sri International	Agonist and antagonist ligands of the nociceptin receptor
US20080021069A1 (en) *	2004-10-08	2008-01-24	Takeda Pharmaceutical Company Limited	Receptor Function Regulating Agent
JP2008526815A (ja)	2005-01-11	2008-07-24	ノイロサーチアクティーゼルスカブ	低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用
AU2007271243A1 (en) *	2006-07-03	2008-01-10	Neurosearch A/S	Combinations of monoamine reuptake inhibitors and potassium channel activators
CN101595100B (zh)	2007-01-16	2014-06-11	普渡制药公司	作为orl-1配体的杂环取代的哌啶
EP3564240B1 (fr) *	2007-08-31	2022-04-06	Purdue Pharma L.P.	Derivés de pipéridine comme intermédiaires
US8119661B2 (en) *	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
WO2010010458A1 (fr)	2008-07-21	2010-01-28	Purdue Pharma L.P.	Composés pipéridine à liaison et substitués par une quinoxaline, et leurs utilisations
CA2807093A1 (fr)	2010-08-05	2012-02-09	Amgen Inc.	Composes benzimidazole et azabenzimidazole qui inhibent la kinase des lymphomes anaplasiques
PL2800737T3 (pl)	2012-01-06	2020-11-02	Novus International Inc.	Środki powierzchniowo czynne na bazie sulfotlenku
ES2702723T3 (es)	2012-02-09	2019-03-05	Novus Int Inc	Heteroátomos que contienen dímeros cíclicos
JO3300B1 (ar)	2012-06-06	2018-09-16	Novartis Ag	مركبات وتركيبات لتعديل نشاط egfr
MX2015000395A (es)	2012-07-12	2015-04-10	Novus Int Inc	Composiciones de matriz y capa para proteccion de bioactivos.
US9085561B2 (en) *	2012-07-30	2015-07-21	Purdue Pharma L.P.	Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9090618B2 (en)	2012-12-27	2015-07-28	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
EP2976077A4 (fr)	2013-03-22	2016-11-30	Scripps Research Inst	Benzimidazoles substitués en tant que modulateurs d'un récepteur de nociceptine
JP6577012B2 (ja)	2014-03-20	2019-09-18	カペラセラピューティクス，インコーポレーテッド	癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体
CN108291055B (zh)	2015-11-12	2021-07-06	诺华丝国际股份有限公司	作为溶剂的含硫化合物
US10584306B2 (en)	2017-08-11	2020-03-10	Board Of Regents Of The University Of Oklahoma	Surfactant microemulsions

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JPS5297978A (en) *	1976-06-02	1977-08-17	Yoshitomi Pharmaceut Ind Ltd	Preparation of alicyclic derivatives
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CA2229202C (fr)	1995-08-15	2008-05-20	Universite Libre De Bruxells	Methodes pour l'identification d'antagonistes ou d'agonistes du recepteur orl-1 humain
US5866346A (en)	1995-09-27	1999-02-02	Indiana Unversity Foundation	Methods of using dynorphins as ligands for XOR1 receptor
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EP0813065A3 (fr)	1996-06-13	1998-07-22	F. Hoffmann-La Roche Ag	Modulation de la fonction d'un récepteur LC-132(analogue à opioide)
EP0829481A1 (fr) *	1996-09-16	1998-03-18	Pfizer Inc.	Dérivés de l'acide morphinane hydroxamique
US5718912A (en) *	1996-10-28	1998-02-17	Merck & Co., Inc.	Muscarine agonists
JP4366532B2 (ja)	1997-05-30	2009-11-18	萬有製薬株式会社	２−オキソイミダゾール誘導体
AU8334298A (en)	1997-07-15	1999-02-10	Novo Nordisk A/S	Nociceptin analogues
US5929035A (en)	1998-04-14	1999-07-27	Regents Of The University Of Michigan	Methods of treating intestinal disorders
ID29137A (id)	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

1999
- 1999-06-25 MA MA25646A patent/MA26659A1/fr unknown
- 1999-06-28 TW TW088110899A patent/TW513424B/zh not_active IP Right Cessation
- 1999-07-05 IL IL14102999A patent/IL141029A0/xx unknown
- 1999-07-05 DK DK99926688T patent/DK1102762T3/da active
- 1999-07-05 JP JP2000563646A patent/JP3367945B2/ja not_active Expired - Fee Related
- 1999-07-05 AT AT99926688T patent/ATE227716T1/de not_active IP Right Cessation
- 1999-07-05 DE DE69903953T patent/DE69903953T2/de not_active Expired - Fee Related
- 1999-07-05 CA CA002339621A patent/CA2339621C/fr not_active Expired - Fee Related
- 1999-07-05 SK SK160-2001A patent/SK1602001A3/sk unknown
- 1999-07-05 SI SI9930151T patent/SI1102762T1/xx unknown
- 1999-07-05 OA OA1200100031A patent/OA11590A/en unknown
- 1999-07-05 HK HK02101444.8A patent/HK1040188A1/zh unknown
- 1999-07-05 PT PT99926688T patent/PT1102762E/pt unknown
- 1999-07-05 TR TR2001/00403T patent/TR200100403T2/xx unknown
- 1999-07-05 ID IDW20010284D patent/ID27212A/id unknown
- 1999-07-05 CZ CZ2001397A patent/CZ2001397A3/cs unknown
- 1999-07-05 ES ES99926688T patent/ES2185357T3/es not_active Expired - Lifetime
- 1999-07-05 EP EP99926688A patent/EP1102762B1/fr not_active Expired - Lifetime
- 1999-07-05 AU AU43859/99A patent/AU749166B2/en not_active Ceased
- 1999-07-05 BR BR9912778-4A patent/BR9912778A/pt not_active Application Discontinuation
- 1999-07-05 TN TNTNSN99142A patent/TNSN99142A1/fr unknown
- 1999-07-05 EE EEP200100075A patent/EE200100075A/xx unknown
- 1999-07-05 HN HN1999000105A patent/HN1999000105A/es unknown
- 1999-07-05 AP APAP/P/2001/002063A patent/AP2001002063A0/en unknown
- 1999-07-05 HU HU0103567A patent/HUP0103567A3/hu unknown
- 1999-07-05 PL PL99346211A patent/PL346211A1/xx not_active Application Discontinuation
- 1999-07-05 CN CN99810857A patent/CN1317968A/zh active Pending
- 1999-07-05 NZ NZ509299A patent/NZ509299A/en not_active Application Discontinuation
- 1999-07-05 YU YU8201A patent/YU8201A/sh unknown
- 1999-07-05 WO PCT/IB1999/001239 patent/WO2000008013A2/fr not_active Ceased
- 1999-07-05 HR HR970081A patent/HRP20010089B1/xx not_active IP Right Cessation
- 1999-07-05 EA EA200100104A patent/EA200100104A1/ru unknown
- 1999-07-05 GE GEAP19995740A patent/GEP20033000B/en unknown
- 1999-07-06 AR ARP990103264A patent/AR018686A1/es active IP Right Grant
- 1999-07-15 PE PE1999000717A patent/PE20000868A1/es not_active Application Discontinuation
- 1999-07-16 SV SV1999000099A patent/SV1999000099A/es not_active Application Discontinuation
- 1999-07-16 PA PA19998477701A patent/PA8477701A1/es unknown
- 1999-08-05 US US09/369,208 patent/US6172067B1/en not_active Expired - Fee Related
- 1999-08-06 GT GT199900125A patent/GT199900125A/es unknown
- 1999-08-13 UY UY25659A patent/UY25659A1/es not_active Application Discontinuation
2001
- 2001-01-16 IS IS5812A patent/IS5812A/is unknown
- 2001-02-01 ZA ZA200100900A patent/ZA200100900B/xx unknown
- 2001-02-05 NO NO20010603A patent/NO20010603L/no not_active Application Discontinuation
- 2001-03-01 BG BG105301A patent/BG105301A/xx unknown

Also Published As

Publication number	Publication date
ATE227716T1 (de)	2002-11-15
AP2001002063A0 (en)	2001-03-31
IL141029A0 (en)	2002-02-10
WO2000008013A3 (fr)	2000-03-23
AR018686A1 (es)	2001-11-28
NO20010603L (no)	2001-04-05
AU4385999A (en)	2000-02-28
OA11590A (en)	2004-08-18
CA2339621C (fr)	2005-04-05
HRP20010089B1 (en)	2003-04-30
CN1317968A (zh)	2001-10-17
CZ2001397A3 (cs)	2002-05-15
GT199900125A (es)	2001-01-27
ZA200100900B (en)	2002-08-28
BR9912778A (pt)	2001-09-25
EP1102762B1 (fr)	2002-11-13
PA8477701A1 (es)	2000-09-29
WO2000008013A2 (fr)	2000-02-17
US6172067B1 (en)	2001-01-09
PT1102762E (pt)	2003-02-28
SK1602001A3 (en)	2002-09-10
NZ509299A (en)	2003-05-30
HUP0103567A3 (en)	2003-01-28
HN1999000105A (es)	2000-11-11
GEP20033000B (en)	2003-06-25
BG105301A (en)	2001-12-29
SV1999000099A (es)	2000-09-05
HK1040188A1 (zh)	2002-05-31
ES2185357T3 (es)	2003-04-16
NO20010603D0 (no)	2001-02-05
IS5812A (is)	2001-01-16
SI1102762T1 (en)	2003-04-30
UY25659A1 (es)	2000-02-23
JP2002522431A (ja)	2002-07-23
DE69903953T2 (de)	2003-03-27
EA200100104A1 (ru)	2001-08-27
DK1102762T3 (da)	2002-12-16
DE69903953D1 (de)	2002-12-19
PE20000868A1 (es)	2000-08-31
HUP0103567A2 (hu)	2002-02-28
TW513424B (en)	2002-12-11
EP1102762A2 (fr)	2001-05-30
JP3367945B2 (ja)	2003-01-20
HRP20010089A2 (en)	2002-02-28
PL346211A1 (en)	2002-01-28
MA26659A1 (fr)	2004-12-20
CA2339621A1 (fr)	2000-02-17
AU749166B2 (en)	2002-06-20
TR200100403T2 (tr)	2001-07-23
ID27212A (id)	2001-03-08
TNSN99142A1 (fr)	2005-11-10
YU8201A (sh)	2003-07-07

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NO20010467L (no)	2001-03-26	Ligander med høy affinitet for nociceptinreseptor ORL-1
PT1049689E (pt)	2002-09-30	Compostos de 4-(2-ceto-1-benzimidazolinil)piperidina como agonistas do receptor orl1
PT1192169E (pt)	2003-09-30	C-pirazoles agonistas do receptor a2a
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DE69921351D1 (de)	2004-11-25	4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
EE200200588A (et)	2004-04-15	Bensoamiidpiperidiinühendid kui substants P antagonistid
DK2332915T3 (da)	2013-05-27	beta2-Adrenoceptoragonister
DK1192170T3 (da)	2003-08-11	Propargylphenylether A2A-receptoragonister
DK1068202T3 (da)	2009-03-16	1-(-heteroarylpropyl- eller -prop-2-enyl)-4benzylpipderidiner som NMDA-receptor-antagonister
ID26223A (id)	2000-12-07	Antagonis reseptor vitronektin
ID28811A (id)	2001-07-05	Antagonis reseptor vitronektin
EE200000733A (et)	2002-06-17	Tetrahüdrokinoliini derivaadid kui glütsiini antagonistid
IS5897A (is)	2001-03-16	Úreídópíperidín afleiður sem valvís NK3 viðtakamótlyf fyrir manneskjur
NO20010353L (no)	2001-01-22	IL-8 reseptor-antagonist