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TNSN00007A1 - Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN00007A1
TNSN00007A1 TNTNSN00007A TNSN00007A TNSN00007A1 TN SN00007 A1 TNSN00007 A1 TN SN00007A1 TN TNSN00007 A TNTNSN00007 A TN TNSN00007A TN SN00007 A TNSN00007 A TN SN00007A TN SN00007 A1 TNSN00007 A1 TN SN00007A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel macrolides
macrolides
Prior art date
Application number
TNTNSN00007A
Other languages
English (en)
Inventor
Thomas Mc Millen William
Kaneko Takushi
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN00007A1 publication Critical patent/TNSN00007A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

L’INVENTION CONCERNE DES COMPOSES DE FORMULE 1 : DANS LAQUELLE X1, X2, R2, R8, R9, R10 ET R11 REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS, COMME AGENTS ANTIBACTERIENS ET ANTIPROTOZOAIRES, POUR LE TRAITEMENT DE DIVERSES INFECTIONS.
TNTNSN00007A 1999-01-27 2000-01-05 Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN00007A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11734299P 1999-01-27 1999-01-27

Publications (1)

Publication Number Publication Date
TNSN00007A1 true TNSN00007A1 (fr) 2005-11-10

Family

ID=22372371

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN00007A TNSN00007A1 (fr) 1999-01-27 2000-01-05 Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (39)

Country Link
US (1) US6833444B2 (fr)
EP (1) EP1147121B1 (fr)
JP (1) JP3947360B2 (fr)
KR (1) KR20020002380A (fr)
CN (1) CN1342163A (fr)
AP (1) AP2001002222A0 (fr)
AT (1) ATE256694T1 (fr)
AU (1) AU1675400A (fr)
BG (1) BG105730A (fr)
BR (1) BR9916969A (fr)
CA (1) CA2359708C (fr)
CO (1) CO5150229A1 (fr)
CZ (1) CZ20012675A3 (fr)
DE (1) DE69913738T2 (fr)
DK (1) DK1147121T3 (fr)
DZ (1) DZ3000A1 (fr)
EA (1) EA200100623A1 (fr)
EE (1) EE200100394A (fr)
ES (1) ES2212655T3 (fr)
HK (1) HK1042707A1 (fr)
HN (1) HN2000000003A (fr)
HR (1) HRP20010559A2 (fr)
HU (1) HUP0105190A3 (fr)
ID (1) ID30233A (fr)
IL (1) IL144178A0 (fr)
IS (1) IS5984A (fr)
MA (1) MA26717A1 (fr)
NO (1) NO20013680L (fr)
OA (1) OA11753A (fr)
PA (1) PA8489501A1 (fr)
PE (1) PE20001422A1 (fr)
PT (1) PT1147121E (fr)
SI (1) SI1147121T1 (fr)
SK (1) SK10172001A3 (fr)
TN (1) TNSN00007A1 (fr)
TR (1) TR200102128T2 (fr)
UY (1) UY25990A1 (fr)
WO (1) WO2000044761A2 (fr)
ZA (1) ZA200105580B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
ID30233A (id) 1999-01-27 2001-11-15 Pfizer Prod Inc Antibiotika ketolida
DE60030847T2 (de) * 1999-04-16 2007-04-19 Kosan Biosciences, Inc., Hayward Antiinfektiöse makrolidderivate
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
CN1351608A (zh) 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
PT1167376E (pt) 2000-06-30 2004-09-30 Pfizer Prod Inc Antibioticos macrolidos
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
CZ20031751A3 (cs) * 2000-12-21 2004-03-17 Glaxo Group Limited Makrolidy
UY27429A1 (es) * 2001-09-05 2003-10-31 Hokuriku Pharmaceutical Medicamento para el tratamiento terapéutico o preventivo de la tuberculosis que comprende un derivado de eritromicina
WO2004080391A2 (fr) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
US20080287376A1 (en) * 2004-07-28 2008-11-20 Mohammad Salman Ketolide Derivatives as Antibacterial Agents
HRP20100253T1 (hr) 2004-12-21 2010-06-30 Pfizer Products Inc. Makrolidi
EP2077271A4 (fr) * 2006-05-01 2010-09-15 Taisho Pharmaceutical Co Ltd Derive macrolide
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
CA2799937A1 (fr) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Procedes de preparation de macrolides et de ketolides et d'intermediaires de ceux-ci
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
HK1218864A1 (zh) 2013-03-15 2017-03-17 森普拉制药公司 用於制备大环内酯抗菌剂的收敛方法
JP6332266B2 (ja) 2013-03-28 2018-05-30 不二製油株式会社 緑豆蛋白ゲル状組成物及びチーズ様食品
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
EP3522896A4 (fr) * 2016-10-04 2020-06-17 Biopharmati SA Cétolides à activité antibactrienne

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US5141926A (en) 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
IL114589A (en) 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
FR2697524B1 (fr) 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
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AP1060A (en) 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
FR2777282B1 (fr) * 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
ATE298761T1 (de) 1998-09-22 2005-07-15 Pfizer Prod Inc Carbamat- und carbazatketolidantibiotika
US6100240A (en) 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
FR2785612A1 (fr) 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
OA11670A (en) 1998-11-03 2005-01-12 Pfizer Prod Inc Novel macrolide antibiotics.
FR2786188B1 (fr) 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
ID30233A (id) 1999-01-27 2001-11-15 Pfizer Prod Inc Antibiotika ketolida
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE60030847T2 (de) 1999-04-16 2007-04-19 Kosan Biosciences, Inc., Hayward Antiinfektiöse makrolidderivate
JP2002542197A (ja) 1999-04-16 2002-12-10 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ケトライド抗菌剤
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
CN1351608A (zh) 1999-05-24 2002-05-29 辉瑞产品公司 13－甲基红霉素衍生物
EP1114826A3 (fr) 1999-12-29 2001-10-31 Pfizer Products Inc. Macrolides antibactériennes et prokinétiques
EP1122261A3 (fr) 2000-01-31 2001-09-26 Pfizer Products Inc. Macrolides antibactériennes à 13 ou 14 chainons
US20020061856A1 (en) 2000-04-24 2002-05-23 Yong-Jin Wu Novel tricyclic erythromycin derivatives
PT1167376E (pt) 2000-06-30 2004-09-30 Pfizer Prod Inc Antibioticos macrolidos

Also Published As

Publication number Publication date
WO2000044761A2 (fr) 2000-08-03
US6833444B2 (en) 2004-12-21
TR200102128T2 (tr) 2001-12-21
ID30233A (id) 2001-11-15
US20020156027A1 (en) 2002-10-24
EP1147121B1 (fr) 2003-12-17
ZA200105580B (en) 2003-02-17
KR20020002380A (ko) 2002-01-09
AU1675400A (en) 2000-08-18
EE200100394A (et) 2002-10-15
PE20001422A1 (es) 2000-12-18
CO5150229A1 (es) 2002-04-29
HRP20010559A2 (en) 2002-08-31
DK1147121T3 (da) 2004-04-13
CA2359708C (fr) 2005-10-25
ATE256694T1 (de) 2004-01-15
ES2212655T3 (es) 2004-07-16
HUP0105190A2 (hu) 2002-04-29
IS5984A (is) 2001-06-28
WO2000044761A3 (fr) 2001-01-04
EA200100623A1 (ru) 2002-02-28
NO20013680L (no) 2001-09-19
DE69913738T2 (de) 2004-06-17
UY25990A1 (es) 2000-09-29
OA11753A (en) 2005-07-19
PA8489501A1 (es) 2000-09-29
DE69913738D1 (de) 2004-01-29
BG105730A (en) 2002-03-29
CZ20012675A3 (cs) 2002-04-17
HN2000000003A (es) 2001-02-02
SK10172001A3 (sk) 2002-06-04
EP1147121A2 (fr) 2001-10-24
NO20013680D0 (no) 2001-07-26
AP2001002222A0 (en) 2001-09-30
CA2359708A1 (fr) 2000-08-03
HUP0105190A3 (en) 2003-03-28
CN1342163A (zh) 2002-03-27
JP2002535414A (ja) 2002-10-22
HK1042707A1 (zh) 2002-08-23
SI1147121T1 (en) 2004-04-30
JP3947360B2 (ja) 2007-07-18
MA26717A1 (fr) 2004-12-20
DZ3000A1 (fr) 2004-03-27
IL144178A0 (en) 2002-05-23
PT1147121E (pt) 2004-04-30
BR9916969A (pt) 2001-11-06

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