PL346211A1 - 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists - Google Patents

2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Info

Publication number: PL346211A1
Authority: PL; Poland
Prior art keywords: orl1; piperidyl; substituted; receptor agonists; benzimidazole compounds
Prior art date: 1998-08-06

Application number

PL99346211A

Other languages

English (en)

Inventor

Fumitaka Ito

Hirohide Noguchi

Hiroshi Kondo

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

1999-07-05

Publication date

2002-01-28

1999-07-05 Application filed by Pfizer filed Critical Pfizer

2002-01-28 Publication of PL346211A1 publication Critical patent/PL346211A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL99346211A 1998-08-06 1999-07-05 2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists PL346211A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IBPCT/IB98/01206		1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en)	1998-08-06	1999-07-05	2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (1)

Publication Number	Publication Date
PL346211A1 true PL346211A1 (en)	2002-01-28

Family

ID=11004738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL99346211A PL346211A1 (en)	1998-08-06	1999-07-05	2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Country Status (44)

Country	Link
US (1)	US6172067B1 (xx)
EP (1)	EP1102762B1 (xx)
JP (1)	JP3367945B2 (xx)
CN (1)	CN1317968A (xx)
AP (1)	AP2001002063A0 (xx)
AR (1)	AR018686A1 (xx)
AT (1)	ATE227716T1 (xx)
AU (1)	AU749166B2 (xx)
BG (1)	BG105301A (xx)
BR (1)	BR9912778A (xx)
CA (1)	CA2339621C (xx)
CZ (1)	CZ2001397A3 (xx)
DE (1)	DE69903953T2 (xx)
DK (1)	DK1102762T3 (xx)
EA (1)	EA200100104A1 (xx)
EE (1)	EE200100075A (xx)
ES (1)	ES2185357T3 (xx)
GE (1)	GEP20033000B (xx)
GT (1)	GT199900125A (xx)
HK (1)	HK1040188A1 (xx)
HN (1)	HN1999000105A (xx)
HR (1)	HRP20010089B1 (xx)
HU (1)	HUP0103567A3 (xx)
ID (1)	ID27212A (xx)
IL (1)	IL141029A0 (xx)
IS (1)	IS5812A (xx)
MA (1)	MA26659A1 (xx)
NO (1)	NO20010603L (xx)
NZ (1)	NZ509299A (xx)
OA (1)	OA11590A (xx)
PA (1)	PA8477701A1 (xx)
PE (1)	PE20000868A1 (xx)
PL (1)	PL346211A1 (xx)
PT (1)	PT1102762E (xx)
SI (1)	SI1102762T1 (xx)
SK (1)	SK1602001A3 (xx)
SV (1)	SV1999000099A (xx)
TN (1)	TNSN99142A1 (xx)
TR (1)	TR200100403T2 (xx)
TW (1)	TW513424B (xx)
UY (1)	UY25659A1 (xx)
WO (1)	WO2000008013A2 (xx)
YU (1)	YU8201A (xx)
ZA (1)	ZA200100900B (xx)

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GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
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AU2403802A (en)	2000-11-15	2002-05-27	Banyu Pharma Co Ltd	Benzimidazole derivatives
GB0104050D0 (en)	2001-02-19	2001-04-04	Astrazeneca Ab	Chemical compounds
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SI1975164T1 (sl)	2001-04-18	2010-05-31	Euro Celtique Sa	Oktahidrobenzimidazolonske spojine kot analgetiki
US6828440B2 (en)	2001-04-18	2004-12-07	Euro-Celtique, S.A.	Spiroindene and spiroindane compounds
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CZ20032850A3 (cs)	2001-04-18	2004-02-18	Euro-Celtique, S. A.	Analogy nociceptinu
CN1516584A (zh)	2001-04-18	2004-07-28	ŷ��ǹɷ��޹�˾	螺吡唑化合物
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
WO2003004034A1 (en) *	2001-07-02	2003-01-16	Omeros Corporation	Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
SE0102716D0 (sv) *	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
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DK1491212T3 (da)	2002-03-29	2012-10-29	Mitsubishi Tanabe Pharma Corp	Middel til behandling af søvnforstyrrelser
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221829D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
DE10252666A1 (de)	2002-11-11	2004-08-05	Grünenthal GmbH	N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de)	2002-11-11	2004-06-03	Grünenthal GmbH	4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
SE0301369D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	Chemical compounds
GB0315203D0 (en) *	2003-06-28	2003-08-06	Celltech R&D Ltd	Chemical compounds
SA04250305B1 (ar)	2003-09-25	2008-06-02	سولفاي فارماسوتيكالز بي . في	مشتقات بنزيميدازولون cenzimidazolone وكينازولينون quinazolinone كمساعادات على مستقبلات ORL1 البشرية
GB0328243D0 (en) *	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
US20050228023A1 (en) *	2003-12-19	2005-10-13	Sri International	Agonist and antagonist ligands of the nociceptin receptor
US20080021069A1 (en) *	2004-10-08	2008-01-24	Takeda Pharmaceutical Company Limited	Receptor Function Regulating Agent
JP2008526815A (ja)	2005-01-11	2008-07-24	ノイロサーチアクティーゼルスカブ	低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用
AU2007271243A1 (en) *	2006-07-03	2008-01-10	Neurosearch A/S	Combinations of monoamine reuptake inhibitors and potassium channel activators
CN101595100B (zh)	2007-01-16	2014-06-11	普渡制药公司	作为orl-1配体的杂环取代的哌啶
EP3564240B1 (en) *	2007-08-31	2022-04-06	Purdue Pharma L.P.	Piperidine intermediates
US8119661B2 (en) *	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
WO2010010458A1 (en)	2008-07-21	2010-01-28	Purdue Pharma L.P.	Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
CA2807093A1 (en)	2010-08-05	2012-02-09	Amgen Inc.	Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase
PL2800737T3 (pl)	2012-01-06	2020-11-02	Novus International Inc.	Środki powierzchniowo czynne na bazie sulfotlenku
ES2702723T3 (es)	2012-02-09	2019-03-05	Novus Int Inc	Heteroátomos que contienen dímeros cíclicos
JO3300B1 (ar)	2012-06-06	2018-09-16	Novartis Ag	مركبات وتركيبات لتعديل نشاط egfr
MX2015000395A (es)	2012-07-12	2015-04-10	Novus Int Inc	Composiciones de matriz y capa para proteccion de bioactivos.
US9085561B2 (en) *	2012-07-30	2015-07-21	Purdue Pharma L.P.	Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9090618B2 (en)	2012-12-27	2015-07-28	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
EP2976077A4 (en)	2013-03-22	2016-11-30	Scripps Research Inst	SUBSTITUTED BENZIMIDAZOLE AS NOCICEPTIN RECEPTOR MODULATORS
JP6577012B2 (ja)	2014-03-20	2019-09-18	カペラセラピューティクス，インコーポレーテッド	癌の治療のためのｅｒｂｂチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体
CN108291055B (zh)	2015-11-12	2021-07-06	诺华丝国际股份有限公司	作为溶剂的含硫化合物
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1999
- 1999-06-25 MA MA25646A patent/MA26659A1/fr unknown
- 1999-06-28 TW TW088110899A patent/TW513424B/zh not_active IP Right Cessation
- 1999-07-05 IL IL14102999A patent/IL141029A0/xx unknown
- 1999-07-05 DK DK99926688T patent/DK1102762T3/da active
- 1999-07-05 JP JP2000563646A patent/JP3367945B2/ja not_active Expired - Fee Related
- 1999-07-05 AT AT99926688T patent/ATE227716T1/de not_active IP Right Cessation
- 1999-07-05 DE DE69903953T patent/DE69903953T2/de not_active Expired - Fee Related
- 1999-07-05 CA CA002339621A patent/CA2339621C/en not_active Expired - Fee Related
- 1999-07-05 SK SK160-2001A patent/SK1602001A3/sk unknown
- 1999-07-05 SI SI9930151T patent/SI1102762T1/xx unknown
- 1999-07-05 OA OA1200100031A patent/OA11590A/en unknown
- 1999-07-05 HK HK02101444.8A patent/HK1040188A1/zh unknown
- 1999-07-05 PT PT99926688T patent/PT1102762E/pt unknown
- 1999-07-05 TR TR2001/00403T patent/TR200100403T2/xx unknown
- 1999-07-05 ID IDW20010284D patent/ID27212A/id unknown
- 1999-07-05 CZ CZ2001397A patent/CZ2001397A3/cs unknown
- 1999-07-05 ES ES99926688T patent/ES2185357T3/es not_active Expired - Lifetime
- 1999-07-05 EP EP99926688A patent/EP1102762B1/en not_active Expired - Lifetime
- 1999-07-05 AU AU43859/99A patent/AU749166B2/en not_active Ceased
- 1999-07-05 BR BR9912778-4A patent/BR9912778A/pt not_active Application Discontinuation
- 1999-07-05 TN TNTNSN99142A patent/TNSN99142A1/fr unknown
- 1999-07-05 EE EEP200100075A patent/EE200100075A/xx unknown
- 1999-07-05 HN HN1999000105A patent/HN1999000105A/es unknown
- 1999-07-05 AP APAP/P/2001/002063A patent/AP2001002063A0/en unknown
- 1999-07-05 HU HU0103567A patent/HUP0103567A3/hu unknown
- 1999-07-05 PL PL99346211A patent/PL346211A1/xx not_active Application Discontinuation
- 1999-07-05 CN CN99810857A patent/CN1317968A/zh active Pending
- 1999-07-05 NZ NZ509299A patent/NZ509299A/en not_active Application Discontinuation
- 1999-07-05 YU YU8201A patent/YU8201A/sh unknown
- 1999-07-05 WO PCT/IB1999/001239 patent/WO2000008013A2/en not_active Ceased
- 1999-07-05 HR HR970081A patent/HRP20010089B1/xx not_active IP Right Cessation
- 1999-07-05 EA EA200100104A patent/EA200100104A1/ru unknown
- 1999-07-05 GE GEAP19995740A patent/GEP20033000B/en unknown
- 1999-07-06 AR ARP990103264A patent/AR018686A1/es active IP Right Grant
- 1999-07-15 PE PE1999000717A patent/PE20000868A1/es not_active Application Discontinuation
- 1999-07-16 SV SV1999000099A patent/SV1999000099A/es not_active Application Discontinuation
- 1999-07-16 PA PA19998477701A patent/PA8477701A1/es unknown
- 1999-08-05 US US09/369,208 patent/US6172067B1/en not_active Expired - Fee Related
- 1999-08-06 GT GT199900125A patent/GT199900125A/es unknown
- 1999-08-13 UY UY25659A patent/UY25659A1/es not_active Application Discontinuation
2001
- 2001-01-16 IS IS5812A patent/IS5812A/is unknown
- 2001-02-01 ZA ZA200100900A patent/ZA200100900B/xx unknown
- 2001-02-05 NO NO20010603A patent/NO20010603L/no not_active Application Discontinuation
- 2001-03-01 BG BG105301A patent/BG105301A/xx unknown

Also Published As

Publication number	Publication date
ATE227716T1 (de)	2002-11-15
AP2001002063A0 (en)	2001-03-31
IL141029A0 (en)	2002-02-10
WO2000008013A3 (en)	2000-03-23
AR018686A1 (es)	2001-11-28
NO20010603L (no)	2001-04-05
AU4385999A (en)	2000-02-28
OA11590A (en)	2004-08-18
CA2339621C (en)	2005-04-05
HRP20010089B1 (en)	2003-04-30
CN1317968A (zh)	2001-10-17
CZ2001397A3 (cs)	2002-05-15
GT199900125A (es)	2001-01-27
ZA200100900B (en)	2002-08-28
BR9912778A (pt)	2001-09-25
EP1102762B1 (en)	2002-11-13
PA8477701A1 (es)	2000-09-29
WO2000008013A2 (en)	2000-02-17
US6172067B1 (en)	2001-01-09
PT1102762E (pt)	2003-02-28
SK1602001A3 (en)	2002-09-10
NZ509299A (en)	2003-05-30
HUP0103567A3 (en)	2003-01-28
HN1999000105A (es)	2000-11-11
GEP20033000B (en)	2003-06-25
BG105301A (en)	2001-12-29
SV1999000099A (es)	2000-09-05
HK1040188A1 (zh)	2002-05-31
ES2185357T3 (es)	2003-04-16
NO20010603D0 (no)	2001-02-05
IS5812A (is)	2001-01-16
SI1102762T1 (en)	2003-04-30
UY25659A1 (es)	2000-02-23
JP2002522431A (ja)	2002-07-23
DE69903953T2 (de)	2003-03-27
EA200100104A1 (ru)	2001-08-27
DK1102762T3 (da)	2002-12-16
DE69903953D1 (de)	2002-12-19
PE20000868A1 (es)	2000-08-31
HUP0103567A2 (hu)	2002-02-28
EE200100075A (et)	2002-06-17
TW513424B (en)	2002-12-11
EP1102762A2 (en)	2001-05-30
JP3367945B2 (ja)	2003-01-20
HRP20010089A2 (en)	2002-02-28
MA26659A1 (fr)	2004-12-20
CA2339621A1 (en)	2000-02-17
AU749166B2 (en)	2002-06-20
TR200100403T2 (tr)	2001-07-23
ID27212A (id)	2001-03-08
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YU8201A (sh)	2003-07-07

Publication	Publication Date	Title
HRP20010089B1 (en)	2003-04-30	2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists
EP1082320A4 (en)	2001-11-21	NEW SUBSTITUTED IMIDAZOLE COMPOUNDS
HUP0203375A3 (en)	2005-03-29	Substituted oxoazaheterocyclyl compounds
GB9800575D0 (en)	1998-03-11	Heterocyclic compounds
EP1016400A4 (en)	2001-01-17	COMPOSITION FOR EXTERNAL USE
GB9804734D0 (en)	1998-04-29	Compounds
GB9804175D0 (en)	1998-04-22	Compounds
GB9805348D0 (en)	1998-05-06	Compound
AU5338699A (en)	2000-02-28	Imidazoles and related compounds as alpha1a agonists
GB9808268D0 (en)	1998-06-17	Compound
GB0015517D0 (en)	2000-08-16	Somatostatin agonists
PL352763A1 (en)	2003-09-08	Somatostatin agonists
IL144355A0 (en)	2002-05-23	5-ht1f agonists
GB9918341D0 (en)	1999-10-06	Hydrometer for house-plants
GB9809823D0 (en)	1998-07-08	Compounds
ZA9710576B (en)	1998-09-16	2-imidazolinylaminoindazole compounds useful as alpha-2-adrenoceptor agonists
GB9810876D0 (en)	1998-07-22	Compounds
GB9809217D0 (en)	1998-07-01	Compounds
GB9823175D0 (en)	1998-12-16	Compound
GB9806697D0 (en)	1998-05-27	Somatostatin agonists
SI1077935T1 (en)	2004-04-30	Phenylsulfonamide-phenylethylamines useful as dopamine receptors
SI1109560T1 (en)	2004-02-29	Compounds useful as aicarft inhibitors
GB9611245D0 (en)	1996-07-31	Benzimidazole compounds
GB9800571D0 (en)	1998-03-11	Heterocyclic compounds
GB9800567D0 (en)	1998-03-11	Heterocyclic compounds

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