[go: up one dir, main page]

TNSN94046A1 - Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules - Google Patents

Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules

Info

Publication number
TNSN94046A1
TNSN94046A1 TNTNSN94046A TNSN94046A TNSN94046A1 TN SN94046 A1 TNSN94046 A1 TN SN94046A1 TN TNSN94046 A TNTNSN94046 A TN TNSN94046A TN SN94046 A TNSN94046 A TN SN94046A TN SN94046 A1 TNSN94046 A1 TN SN94046A1
Authority
TN
Tunisia
Prior art keywords
particles
dry prepared
active ingredient
prepared particles
preparation
Prior art date
Application number
TNTNSN94046A
Other languages
English (en)
Inventor
Ruiz Jean-Marc
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of TNSN94046A1 publication Critical patent/TNSN94046A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'INVENTION CONCERNE UN PROCEDE POUR LA PREPARATION DE PARTICULES PREPAREES A SEC, DE FORME SUBTANTIELLEMENT SPHEROIDALE ET CONSISTANT EN UN PRINCIPE ACTIF INCORPORE DANS UN POLYMERE BIOCOMPATIBLE DE HAUT POINT DE FUSION, LEDIT PROCEDE COMPRENANT LE MELANGE, SOUS AGITATION, DUDIT POLYMERE BIOCOMPATIBLE ET DUDIT PRINCIPE ACTIF, DANS UNE PHASE SUPPORT VISQUEUSE HOMOGENE NON-MISCIBLE, LEDIT PRINCIPE ACTIF ET LEDIT POLYMERE BIOCOMPATIBLE ETANT INSOLUBLES DANS LADITE PHASE SUPPORT VISQUEUSE HOMOGENE ; PUIS LE MAINTIEN DE L'AGITATION, JUSQU'A LA FORMATION DE MICROBILLES DE POLYMERE BIOCOMPATIBLE ET LA COMPLETE INCORPORATION DU PRINCIPE ACTIF A L'INTERIEUR, LA TEMPERATURE DE MISE EN OEUVRE DU PROCEDE ETANT AU-DESSUS DE LA TEMPERATURE DE TRANSITION VITREUSE DU POLYMERE BIOCOMPATIBLE ; ENFIN, LA RECUPERATION DES BILLES AINSI OBTENUES. L'INVENTION CONCERNE AUSSI LES PARTICULES PREPAREES A SEC AINSI OBTENUES ET DES COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELLES PARTICULES
TNTNSN94046A 1993-05-15 1994-05-13 Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules TNSN94046A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939310030A GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same

Publications (1)

Publication Number Publication Date
TNSN94046A1 true TNSN94046A1 (fr) 1995-04-25

Family

ID=10735537

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN94046A TNSN94046A1 (fr) 1993-05-15 1994-05-13 Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules

Country Status (34)

Country Link
JP (1) JP3139913B2 (fr)
KR (1) KR100341261B1 (fr)
CN (1) CN1050534C (fr)
AT (1) AT406017B (fr)
AU (1) AU685094B2 (fr)
BE (1) BE1008323A3 (fr)
BR (1) BR9401968A (fr)
CA (1) CA2123481C (fr)
CH (1) CH688572A5 (fr)
DE (1) DE4416812C2 (fr)
DK (1) DK171454B1 (fr)
DZ (1) DZ1779A1 (fr)
ES (1) ES2097083B1 (fr)
FI (1) FI112915B (fr)
FR (1) FR2705232B1 (fr)
GB (2) GB9310030D0 (fr)
GR (1) GR1002034B (fr)
HU (1) HU220617B1 (fr)
IE (1) IE940392A1 (fr)
IN (1) IN182330B (fr)
IT (1) IT1269508B (fr)
LU (1) LU88482A1 (fr)
MA (1) MA23194A1 (fr)
NL (1) NL9400795A (fr)
NO (1) NO307403B1 (fr)
NZ (1) NZ260520A (fr)
OA (1) OA09939A (fr)
PL (1) PL175780B1 (fr)
PT (1) PT101518B (fr)
RU (1) RU2125869C1 (fr)
SE (1) SE519004C2 (fr)
SG (1) SG46631A1 (fr)
TN (1) TNSN94046A1 (fr)
ZA (1) ZA943316B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1203591B1 (fr) * 1993-01-06 2007-12-19 Ipsen Manufacturing Ireland Limited polyesters biodégradables pour fabriquer conjugués moléculaires ioniques avec polypeptides bioactifs
RU2185393C2 (ru) * 1993-01-06 2002-07-20 Кинертон Лимитед Сложный полиэфир и конъюгат на его основе
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6867181B1 (en) 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
DK1183014T3 (da) * 1999-06-14 2004-02-09 Cosmo Spa Smagsmaskerede orale farmaceutiske sammensætninger med kontrolleret frigivelse
CA2427938C (fr) 1999-11-15 2010-02-16 Bio Syntech Canada Inc. Nouvelles solution aqueuse et composition de biopolymeres autogelifiantes thermostatees et dependant du ph, et leur preparation
GB2374072B (en) * 2000-06-16 2004-09-22 Nippon Catalytic Chem Ind Crosslinked polymer method for manufacturing it and use thereof
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH468192A (de) * 1964-06-19 1969-02-15 Ciba Geigy Verfahren zur Herstellung von Arzneimitteln in Perlenform
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH672887A5 (fr) * 1987-10-14 1990-01-15 Debiopharm Sa
WO1989003678A1 (fr) * 1987-10-30 1989-05-05 Stolle Research & Development Corporation Microspheres a faible solvant residuaire et procede de microencapsulage
DE3916020C2 (de) * 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
DK0452145T3 (da) * 1990-04-12 1996-12-02 Shionogi & Co Overtrukket præparat og fremstilling deraf
JP3116311B2 (ja) * 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions
GB2246514B (en) * 1990-08-01 1993-12-15 Scras Sustained release pharmaceutical compositions and the preparation of particles for use therein
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
CA2055522A1 (fr) * 1990-12-12 1992-06-13 Masako Andoh Microspheres a usage ophtalmique
SE9101603L (sv) * 1991-05-27 1992-09-21 Bengt Hjalmar Aagerup Med Firm Metod foer att framstaella reproducerbara partiklar av definierad storlek
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
ATE154240T1 (de) * 1992-03-12 1997-06-15 Alkermes Inc Acth enthaltende mikrokugeln mit gesteuerter abgabe
SE9200858L (sv) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
CA2136434C (fr) * 1992-06-11 2008-12-02 Howard Bernstein Systemes pour la liberation d'un medicament a base d'erythropoietine
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Also Published As

Publication number Publication date
CH688572A5 (fr) 1997-11-28
NL9400795A (nl) 1994-12-01
ATA98794A (de) 1999-06-15
FI942222L (fi) 1994-11-16
HU9401412D0 (en) 1994-08-29
PT101518B (pt) 2000-12-29
AU685094B2 (en) 1998-01-15
CA2123481C (fr) 2005-01-11
AT406017B (de) 2000-01-25
NZ260520A (en) 1994-12-22
BE1008323A3 (fr) 1996-04-02
MA23194A1 (fr) 1994-12-31
SE9401557L (sv) 1994-11-16
DE4416812A1 (de) 1994-11-17
FR2705232A1 (fr) 1994-11-25
IT1269508B (it) 1997-04-01
IN182330B (fr) 1999-03-20
ES2097083A1 (es) 1997-03-16
CA2123481A1 (fr) 1994-11-16
JP3139913B2 (ja) 2001-03-05
GB2277915B (en) 1997-10-29
NO941810D0 (no) 1994-05-13
SE9401557D0 (sv) 1994-05-05
PL175780B1 (pl) 1999-02-26
AU6308494A (en) 1994-11-17
GR1002034B (en) 1995-10-31
IE940392A1 (en) 1994-11-16
ITMI940931A0 (it) 1994-05-11
NO307403B1 (no) 2000-04-03
BR9401968A (pt) 1994-12-13
ITMI940931A1 (it) 1995-11-11
FI942222A0 (fi) 1994-05-13
RU2125869C1 (ru) 1999-02-10
FR2705232B1 (fr) 1995-08-25
GB9409565D0 (en) 1994-07-06
HK1002831A1 (en) 1998-09-18
CN1104557A (zh) 1995-07-05
GB9310030D0 (en) 1993-06-30
HUT67599A (en) 1995-04-28
DK171454B1 (da) 1996-11-04
HU220617B1 (hu) 2002-03-28
DZ1779A1 (fr) 2002-02-17
DK54994A (da) 1994-11-16
CN1050534C (zh) 2000-03-22
LU88482A1 (fr) 1994-12-01
DE4416812C2 (de) 2003-02-06
JPH072652A (ja) 1995-01-06
SG46631A1 (en) 1998-02-20
OA09939A (fr) 1994-11-15
ES2097083B1 (es) 1997-12-01
PT101518A (pt) 1995-03-01
SE519004C2 (sv) 2002-12-17
KR100341261B1 (ko) 2002-09-27
GB2277915A (en) 1994-11-16
ZA943316B (en) 1995-01-16
NO941810L (no) 1994-11-16
FI112915B (fi) 2004-02-13

Similar Documents

Publication Publication Date Title
TNSN94046A1 (fr) Procede pour la preparation de particules preparees a sec, particules preparees a sec ainsi obtenues et compositions pharmaceutiques contenant de telles particules
Arias et al. Influence of the preparation method of solid dispersions on their dissolution rate: study of triamterene-D-mannitol system
TNSN91067A1 (fr) Procede de preparation de compositions a liberation prolongee et compositions ainsi obtenues.
DK174917B1 (da) Polyamidpulver og fremgangsmåde til fremstilling af dette
AU608427B2 (en) Gelled emulsion particles and compositions in which they are present
DE69509671D1 (de) Pharmazeutische zusammensetzung mit einem schmelzbaren traegermaterial und verfahren zu seiner herstellung
DE69840495D1 (de) Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben
AU567271B2 (en) Lyophilization of oil in water emulsion to give galenic form for oral administration
CA2223417A1 (fr) Procede de fabrication de capsules d'un volume minimal contenant une substance biologique
KR910015288A (ko) 서방성 마이크로캡슐
JP2001524123A (ja) 局所的に施される活性剤用の化粧品粒状ゲル担体
HUP9901215A2 (hu) Mikroemulziók hatóanyagok beadására szolgáló hordozóként való alkalmazásra
CA2265766A1 (fr) Pastilles se desintegrant rapidement
NO964939D0 (no) Fremgangsmåte for fremstilling av virkestoffpreparater i form av en fast lösning av virkestoffet i en polymermatriks, samt virkestoffpreparater fremstilt ved hjelp av denne fremgangsmåte
BG102875A (en) Dispersion macromolecular compositions and methods for their preparation and application
HUP9800857A2 (hu) Peszticid készítmények, eljárás előállításukra és alkalmazásukra
HUT75247A (en) Solid pharmaceutical composition comprising an excipient capable of binding water and process for its production
AU626924B2 (en) Dispersable formulation of diclofenac in free acid form
JPH03133922A (ja) 活性化合物の徐放性を示す圧縮成形物品
KR960021061A (ko) 경구 투여용 약제학적 조성물
US3518344A (en) Tableting lubricant
GB2133983A (en) Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses
WO1990014073A1 (fr) Preparation pharmaceutique
US20040076676A1 (en) Drug-releasing system of biodegradable polymer type
Roy et al. Indomethacin-loaded microspheres: design and preparation by a multiple-emulsification technique and their in vitro evaluation