TNSN94046A1 - PROCESS FOR THE PREPARATION OF DRY PREPARED PARTICLES, DRY PREPARED PARTICLES THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PARTICLES - Google Patents
PROCESS FOR THE PREPARATION OF DRY PREPARED PARTICLES, DRY PREPARED PARTICLES THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PARTICLESInfo
- Publication number
- TNSN94046A1 TNSN94046A1 TNTNSN94046A TNSN94046A TNSN94046A1 TN SN94046 A1 TNSN94046 A1 TN SN94046A1 TN TNSN94046 A TNTNSN94046 A TN TNSN94046A TN SN94046 A TNSN94046 A TN SN94046A TN SN94046 A1 TNSN94046 A1 TN SN94046A1
- Authority
- TN
- Tunisia
- Prior art keywords
- particles
- dry prepared
- active ingredient
- prepared particles
- preparation
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 4
- 229920000249 biocompatible polymer Polymers 0.000 abstract 3
- 238000013019 agitation Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000011806 microball Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'INVENTION CONCERNE UN PROCEDE POUR LA PREPARATION DE PARTICULES PREPAREES A SEC, DE FORME SUBTANTIELLEMENT SPHEROIDALE ET CONSISTANT EN UN PRINCIPE ACTIF INCORPORE DANS UN POLYMERE BIOCOMPATIBLE DE HAUT POINT DE FUSION, LEDIT PROCEDE COMPRENANT LE MELANGE, SOUS AGITATION, DUDIT POLYMERE BIOCOMPATIBLE ET DUDIT PRINCIPE ACTIF, DANS UNE PHASE SUPPORT VISQUEUSE HOMOGENE NON-MISCIBLE, LEDIT PRINCIPE ACTIF ET LEDIT POLYMERE BIOCOMPATIBLE ETANT INSOLUBLES DANS LADITE PHASE SUPPORT VISQUEUSE HOMOGENE ; PUIS LE MAINTIEN DE L'AGITATION, JUSQU'A LA FORMATION DE MICROBILLES DE POLYMERE BIOCOMPATIBLE ET LA COMPLETE INCORPORATION DU PRINCIPE ACTIF A L'INTERIEUR, LA TEMPERATURE DE MISE EN OEUVRE DU PROCEDE ETANT AU-DESSUS DE LA TEMPERATURE DE TRANSITION VITREUSE DU POLYMERE BIOCOMPATIBLE ; ENFIN, LA RECUPERATION DES BILLES AINSI OBTENUES. L'INVENTION CONCERNE AUSSI LES PARTICULES PREPAREES A SEC AINSI OBTENUES ET DES COMPOSITIONS PHARMACEUTIQUES CONTENANT DE TELLES PARTICULESTHE INVENTION RELATES TO A PROCESS FOR THE PREPARATION OF DRY PREPARED PARTICLES, SUBTANTIALLY SPHEROIDAL IN FORM AND CONSISTING OF AN ACTIVE INGREDIENT INCORPORATED IN A BIOCOMPATIBLE POLYMER OF HIGH MELTING, SUCH A PROCESS AS MIXTURE AND SOITUTIA. ACTIVE INGREDIENT, IN A HOMOGENEOUS NON-MISCIBLE VISCOUS SUPPORT PHASE, SAID ACTIVE INGREDIENT AND THE SAME BIOCOMPATIBLE POLYMER BEING INSOLUBLE IN SAID HOMOGENEOUS VISCOUS SUPPORT PHASE; THEN MAINTAINING THE AGITATION, UNTIL THE FORMATION OF MICROBALLS OF BIOCOMPATIBLE POLYMER AND THE COMPLETE INCORPORATION OF THE ACTIVE INGREDIENT INSIDE, THE TEMPERATURE OF IMPLEMENTING THE PROCESS BEING ABOVE THE POLY TRANSITION TEMPERATURE BIOCOMPATIBLE; FINALLY, THE RECOVERY OF THE BALLS SO OBTAINED. THE INVENTION ALSO CONCERNS THE DRY PREPARED PARTICLES THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PARTICLES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939310030A GB9310030D0 (en) | 1993-05-15 | 1993-05-15 | Dry processed particles and process for the preparation of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN94046A1 true TNSN94046A1 (en) | 1995-04-25 |
Family
ID=10735537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN94046A TNSN94046A1 (en) | 1993-05-15 | 1994-05-13 | PROCESS FOR THE PREPARATION OF DRY PREPARED PARTICLES, DRY PREPARED PARTICLES THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PARTICLES |
Country Status (34)
| Country | Link |
|---|---|
| JP (1) | JP3139913B2 (en) |
| KR (1) | KR100341261B1 (en) |
| CN (1) | CN1050534C (en) |
| AT (1) | AT406017B (en) |
| AU (1) | AU685094B2 (en) |
| BE (1) | BE1008323A3 (en) |
| BR (1) | BR9401968A (en) |
| CA (1) | CA2123481C (en) |
| CH (1) | CH688572A5 (en) |
| DE (1) | DE4416812C2 (en) |
| DK (1) | DK171454B1 (en) |
| DZ (1) | DZ1779A1 (en) |
| ES (1) | ES2097083B1 (en) |
| FI (1) | FI112915B (en) |
| FR (1) | FR2705232B1 (en) |
| GB (2) | GB9310030D0 (en) |
| GR (1) | GR1002034B (en) |
| HU (1) | HU220617B1 (en) |
| IE (1) | IE940392A1 (en) |
| IN (1) | IN182330B (en) |
| IT (1) | IT1269508B (en) |
| LU (1) | LU88482A1 (en) |
| MA (1) | MA23194A1 (en) |
| NL (1) | NL9400795A (en) |
| NO (1) | NO307403B1 (en) |
| NZ (1) | NZ260520A (en) |
| OA (1) | OA09939A (en) |
| PL (1) | PL175780B1 (en) |
| PT (1) | PT101518B (en) |
| RU (1) | RU2125869C1 (en) |
| SE (1) | SE519004C2 (en) |
| SG (1) | SG46631A1 (en) |
| TN (1) | TNSN94046A1 (en) |
| ZA (1) | ZA943316B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1203591B1 (en) * | 1993-01-06 | 2007-12-19 | Ipsen Manufacturing Ireland Limited | biodegradable polyesters for forming ionic molecular conjugates with bioactive polypeptides |
| RU2185393C2 (en) * | 1993-01-06 | 2002-07-20 | Кинертон Лимитед | Polyester and polyester-base conjugate |
| DE19604744A1 (en) | 1996-02-09 | 1997-08-14 | Henkel Kgaa | Technical di- / triglyceride mixtures |
| IE960308A1 (en) | 1996-04-23 | 1997-11-05 | Kinerton Ltd | Sustained release ionic conjugate |
| DE19617137C1 (en) * | 1996-04-29 | 1997-02-27 | Henkel Kgaa | Use of branched alcohol ester(s) of olefin-di:carboxylic acid copolymers |
| US5858531A (en) * | 1996-10-24 | 1999-01-12 | Bio Syntech | Method for preparation of polymer microparticles free of organic solvent traces |
| US6867181B1 (en) | 1997-06-02 | 2005-03-15 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides |
| DK1183014T3 (en) * | 1999-06-14 | 2004-02-09 | Cosmo Spa | Flavored controlled release oral pharmaceutical compositions |
| CA2427938C (en) | 1999-11-15 | 2010-02-16 | Bio Syntech Canada Inc. | Novel temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution, composition and preparation thereof |
| GB2374072B (en) * | 2000-06-16 | 2004-09-22 | Nippon Catalytic Chem Ind | Crosslinked polymer method for manufacturing it and use thereof |
| GB0705159D0 (en) * | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH468192A (en) * | 1964-06-19 | 1969-02-15 | Ciba Geigy | Process for the manufacture of medicaments in pearl form |
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CH672887A5 (en) * | 1987-10-14 | 1990-01-15 | Debiopharm Sa | |
| WO1989003678A1 (en) * | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
| DE3916020C2 (en) * | 1989-05-17 | 1994-06-01 | Burkhard Dr Wichert | Retarding microparticles made from biodegradable polyesters; Process for their preparation without the use of toxic solvents and pharmaceutical preparations containing these microparticles |
| DK0452145T3 (en) * | 1990-04-12 | 1996-12-02 | Shionogi & Co | Coated preparation and preparation thereof |
| JP3116311B2 (en) * | 1990-06-13 | 2000-12-11 | エーザイ株式会社 | Manufacturing method of microsphere |
| GB9016885D0 (en) * | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
| GB2246514B (en) * | 1990-08-01 | 1993-12-15 | Scras | Sustained release pharmaceutical compositions and the preparation of particles for use therein |
| SE9003296L (en) * | 1990-10-16 | 1992-04-17 | Kabi Pharmacia Ab | PROCEDURE SHOULD FORMULATE MEDICINAL PRODUCTS |
| CA2055522A1 (en) * | 1990-12-12 | 1992-06-13 | Masako Andoh | Microspheres for ophthalmic use |
| SE9101603L (en) * | 1991-05-27 | 1992-09-21 | Bengt Hjalmar Aagerup Med Firm | METHOD FOR MAKING REPRODUCABLE PARTICLES OF DEFINED SIZE |
| GB9203689D0 (en) * | 1992-02-20 | 1992-04-08 | Euro Celtique Sa | Pharmaceutical composition |
| ATE154240T1 (en) * | 1992-03-12 | 1997-06-15 | Alkermes Inc | ACTH CONTAINING MICRO SPHERES WITH CONTROLLED RELEASE |
| SE9200858L (en) * | 1992-03-20 | 1993-09-21 | Kabi Pharmacia Ab | Method for producing delayed release pellets |
| CA2136434C (en) * | 1992-06-11 | 2008-12-02 | Howard Bernstein | Erythropoietin drug delivery system |
| US5350584A (en) * | 1992-06-26 | 1994-09-27 | Merck & Co., Inc. | Spheronization process using charged resins |
| JP2651320B2 (en) * | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | Method for producing sustained-release microsphere preparation |
| FR2693905B1 (en) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Process for the preparation of microspheres for the sustained release of the hormone LHRH and its analogs, microspheres and formulations obtained. |
| GB2273874A (en) * | 1992-12-31 | 1994-07-06 | Pertti Olavi Toermaelae | Preparation of pharmaceuticals in a polymer matrix |
-
1993
- 1993-05-15 GB GB939310030A patent/GB9310030D0/en active Pending
-
1994
- 1994-04-28 GR GR940100215A patent/GR1002034B/en not_active IP Right Cessation
- 1994-05-05 SE SE9401557A patent/SE519004C2/en not_active IP Right Cessation
- 1994-05-06 HU HU9401412A patent/HU220617B1/en not_active IP Right Cessation
- 1994-05-09 BE BE9400480A patent/BE1008323A3/en not_active IP Right Cessation
- 1994-05-09 CH CH01436/94A patent/CH688572A5/en not_active IP Right Cessation
- 1994-05-11 FR FR9405782A patent/FR2705232B1/en not_active Expired - Fee Related
- 1994-05-11 ES ES09400996A patent/ES2097083B1/en not_active Expired - Fee Related
- 1994-05-11 OA OA60510A patent/OA09939A/en unknown
- 1994-05-11 LU LU88482A patent/LU88482A1/en unknown
- 1994-05-11 AT AT0098794A patent/AT406017B/en not_active IP Right Cessation
- 1994-05-11 IT ITMI940931A patent/IT1269508B/en active IP Right Grant
- 1994-05-12 IE IE039294A patent/IE940392A1/en not_active IP Right Cessation
- 1994-05-12 CA CA002123481A patent/CA2123481C/en not_active Expired - Fee Related
- 1994-05-13 GB GB9409565A patent/GB2277915B/en not_active Expired - Fee Related
- 1994-05-13 ZA ZA943316A patent/ZA943316B/en unknown
- 1994-05-13 NO NO941810A patent/NO307403B1/en not_active IP Right Cessation
- 1994-05-13 SG SG1996006870A patent/SG46631A1/en unknown
- 1994-05-13 AU AU63084/94A patent/AU685094B2/en not_active Ceased
- 1994-05-13 NZ NZ260520A patent/NZ260520A/en not_active IP Right Cessation
- 1994-05-13 TN TNTNSN94046A patent/TNSN94046A1/en unknown
- 1994-05-13 JP JP06099745A patent/JP3139913B2/en not_active Expired - Fee Related
- 1994-05-13 BR BR9401968A patent/BR9401968A/en not_active Application Discontinuation
- 1994-05-13 MA MA23503A patent/MA23194A1/en unknown
- 1994-05-13 DE DE4416812A patent/DE4416812C2/en not_active Expired - Fee Related
- 1994-05-13 DK DK054994A patent/DK171454B1/en not_active IP Right Cessation
- 1994-05-13 RU RU94016386A patent/RU2125869C1/en active
- 1994-05-13 PT PT101518A patent/PT101518B/en not_active IP Right Cessation
- 1994-05-13 PL PL94303441A patent/PL175780B1/en not_active IP Right Cessation
- 1994-05-13 IN IN595DE1994 patent/IN182330B/en unknown
- 1994-05-13 CN CN94105512A patent/CN1050534C/en not_active Expired - Fee Related
- 1994-05-13 FI FI942222A patent/FI112915B/en active
- 1994-05-14 KR KR1019940010570A patent/KR100341261B1/en not_active Expired - Fee Related
- 1994-05-15 DZ DZ940045A patent/DZ1779A1/en active
- 1994-05-16 NL NL9400795A patent/NL9400795A/en active Search and Examination
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