SV1999000061A - Agonistas y antagonistas il-2 selectivos ref. 5038p1-sv - Google Patents
Agonistas y antagonistas il-2 selectivos ref. 5038p1-svInfo
- Publication number
- SV1999000061A SV1999000061A SV1999000061A SV1999000061A SV1999000061A SV 1999000061 A SV1999000061 A SV 1999000061A SV 1999000061 A SV1999000061 A SV 1999000061A SV 1999000061 A SV1999000061 A SV 1999000061A SV 1999000061 A SV1999000061 A SV 1999000061A
- Authority
- SV
- El Salvador
- Prior art keywords
- cells
- agonists
- ref
- antagonists
- selective
- Prior art date
Links
- 229940124753 IL-2 agonist Drugs 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 4
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102220622777 Sphingomyelin phosphodiesterase_N88G_mutation Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
LA PRESENTE INVENCIÓN ESTA ORIENTADA A UN POLIPÉPTIDO QUE COMPRENDE UNA MUTEÍNA DE IL-2 HUMANA NUMERADA DE ACUERDO CON LA IL-2 DE TIPO SALVAJE EN LA CUAL DICHA IL-2 HUMANA ESTA SUSTITUIDA EN POR LO MENOS UNA DE LAS POSICIONES 20, 88 Ó 126, CON LO CUAL DICHA MUTEÍNA ACTIVA CÉLULAS T CON MAYOR PREFERENCIA CON RESPECTO A LAS CÉLULAS NK. EL D2OH E I, N88G, I, Y R, EN PARTICULAR, TIENEN UNA ACTIVIDAD DIFERENCIAL PARA LAS CÉLULAS T, MUCHO MAYOR QUE LA IL-2 NATIVA, CON UNA TOXICIDAD IN VIVO ASOCIADA PREDICHA, REDUCIDA. LA INVENCIÓN TAMBIÉN PROVEE POLINUCLEÓTIDOS QUE CODIFICAN LAS MUTEÍNAS DE LA INVENCIÓN, VECTORES QUE CONTIENEN LOS POLINUCLEÓTIDOS, CÉLULAS HOSPEDANTES TRANSFORMADAS, COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LAS MUTEÍNAS, Y MÉTODOS TERAPÉUTICOS DE TRATAMIENTO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8008098A | 1998-05-15 | 1998-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV1999000061A true SV1999000061A (es) | 2000-03-14 |
Family
ID=22155135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV1999000061A SV1999000061A (es) | 1998-05-15 | 1999-05-14 | Agonistas y antagonistas il-2 selectivos ref. 5038p1-sv |
Country Status (39)
| Country | Link |
|---|---|
| EP (1) | EP1076704B1 (es) |
| JP (1) | JP4276783B2 (es) |
| KR (1) | KR100607609B1 (es) |
| CN (2) | CN101319247B (es) |
| AR (1) | AR020322A1 (es) |
| AT (1) | ATE351907T1 (es) |
| AU (1) | AU759697B2 (es) |
| BG (1) | BG65139B1 (es) |
| BR (1) | BRPI9910504B1 (es) |
| CA (1) | CA2327349C (es) |
| CO (1) | CO5070701A1 (es) |
| CU (2) | CU23273B7 (es) |
| CY (1) | CY1107533T1 (es) |
| CZ (1) | CZ302071B6 (es) |
| DE (1) | DE69934881T2 (es) |
| DK (1) | DK1076704T3 (es) |
| DZ (1) | DZ2788A1 (es) |
| ES (1) | ES2281175T3 (es) |
| HK (1) | HK1039963B (es) |
| HN (1) | HN1999000075A (es) |
| HU (1) | HU226142B1 (es) |
| IL (2) | IL139136A0 (es) |
| MY (1) | MY130274A (es) |
| NO (1) | NO329235B1 (es) |
| NZ (1) | NZ508098A (es) |
| PA (1) | PA8472601A1 (es) |
| PE (1) | PE20000475A1 (es) |
| PL (1) | PL201675B1 (es) |
| PT (1) | PT1076704E (es) |
| RO (1) | RO122150B1 (es) |
| RU (1) | RU2235729C2 (es) |
| SI (1) | SI20643B (es) |
| SK (1) | SK288100B6 (es) |
| SV (1) | SV1999000061A (es) |
| TN (1) | TNSN99090A1 (es) |
| TR (1) | TR200003354T2 (es) |
| TW (1) | TWI223663B (es) |
| UA (1) | UA73719C2 (es) |
| WO (1) | WO1999060128A1 (es) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999029732A2 (en) | 1997-12-08 | 1999-06-17 | Lexigen Pharmaceuticals Corporation | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| AU4057300A (en) | 1999-03-30 | 2000-10-16 | Board Of Regents, The University Of Texas System | Compositions and methods for modifying toxic effects of proteinacious compounds |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| WO2001010912A1 (en) | 1999-08-09 | 2001-02-15 | Lexigen Pharmaceuticals Corp. | Multiple cytokine-antibody complexes |
| JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
| WO2001058957A2 (en) | 2000-02-11 | 2001-08-16 | Lexigen Pharmaceuticals Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
| EP1935431A3 (en) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Cancer treatments by using a combination of an antibody against her2 and interleukin-2 |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| US7517526B2 (en) | 2000-06-29 | 2009-04-14 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
| US7723102B2 (en) * | 2000-09-28 | 2010-05-25 | Bayer Corporation | Enhanced transfection system |
| MY139948A (en) * | 2000-09-28 | 2009-11-30 | Bayer Corp | Enhanced transfection system |
| EP1366067B1 (en) | 2001-03-07 | 2012-09-26 | Merck Patent GmbH | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| DE60239454D1 (de) | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
| ATE542137T1 (de) * | 2001-12-04 | 2012-02-15 | Merck Patent Gmbh | Immunocytokine mit modulierter selektivität |
| BRPI0317376B8 (pt) | 2002-12-17 | 2021-05-25 | Merck Patent Gmbh | proteína de fusão de anticorpo-il2 designada como hu14.18-il2, usos da mesma, vetor e composição farmacêutica |
| US7569215B2 (en) | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
| EP1944318B1 (en) | 2003-07-21 | 2011-03-02 | Transgene S.A. | Multifunctional cytokines |
| EP2149585B1 (en) | 2003-11-04 | 2013-08-14 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonistic anti-CD40 monoclonal antibodies |
| ATE516305T1 (de) * | 2004-02-27 | 2011-07-15 | Inst Nat Sante Rech Med | Il-15-bindungsstelle für il-15-ralpha und spezifische il-15-mutanten mit wirkung als agonisten/antagonisten |
| CA2557677A1 (en) * | 2004-03-05 | 2005-10-06 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| US8906356B2 (en) | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| CN101244261B (zh) * | 2008-03-10 | 2010-09-15 | 山东大学 | 一种含未复性重组蛋白的生物制剂及其制备方法与应用 |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| US20110274650A1 (en) | 2009-01-21 | 2011-11-10 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| CN102101885B (zh) * | 2010-09-01 | 2013-06-05 | 南京发士达生物科技有限公司 | 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途 |
| MX388465B (es) | 2010-11-12 | 2025-03-20 | Nektar Therapeutics | Conjugados de un resto de interleucina-2 y un polímero. |
| CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| JP6093712B2 (ja) * | 2010-12-22 | 2017-03-08 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン２のスーパーアゴニストおよびアンタゴニスト |
| PL3489255T3 (pl) | 2011-02-10 | 2021-11-22 | Roche Glycart Ag | Zmutowane polipeptydy interleukiny-2 |
| WO2012119093A1 (en) * | 2011-03-03 | 2012-09-07 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| WO2015042707A1 (en) | 2013-09-24 | 2015-04-02 | Medicenna Therapeutics Pte Ltd | Interleukin-2 fusion proteins and uses thereof |
| NZ719654A (en) | 2014-02-06 | 2020-06-26 | Hoffmann La Roche | Interleukin-2 fusion proteins and uses thereof |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US10150802B2 (en) | 2014-04-24 | 2018-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| CN113234138A (zh) * | 2014-08-11 | 2021-08-10 | 德里尼亚公司 | 选择性地活化调节性t细胞用于治疗自身免疫病的修饰的il-2变体 |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR20240115933A (ko) * | 2016-05-04 | 2024-07-26 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| US12202856B2 (en) | 2016-05-19 | 2025-01-21 | The General Hospital Corporation | Tethered interleukin-2 to its receptor IL-2RBETA, a platform to enhance natural killer and regulatory T cell activity |
| EP3471754A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 antibodies |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| JP7206190B2 (ja) * | 2016-06-22 | 2023-01-17 | ダヴィド・クラッツマン | 遺伝的に修飾されたｔリンパ球 |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| MX2019005400A (es) | 2016-11-08 | 2019-08-05 | Delinia Inc | Variantes de il-2 para el tratamiento de enfermedades autoinmunes. |
| CA3044416A1 (en) * | 2016-12-13 | 2018-06-21 | Delinia, Inc. | Multivalent regulatory t cell modulators |
| US10961310B2 (en) | 2017-03-15 | 2021-03-30 | Pandion Operations, Inc. | Targeted immunotolerance |
| CN111107868A (zh) * | 2017-05-24 | 2020-05-05 | 诺华股份有限公司 | 抗体细胞因子移植蛋白及使用方法 |
| EA201992765A1 (ru) | 2017-05-24 | 2020-03-25 | Новартис Аг | Белки на основе антител с привитым цитокином и способы их применения в лечении рака |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| SG11201909949XA (en) | 2017-05-24 | 2019-11-28 | Pandion Therapeutics Inc | Targeted immunotolerance |
| US11542312B2 (en) | 2017-06-19 | 2023-01-03 | Medicenna Therapeutics, Inc. | IL-2 superagonists in combination with anti-PD-1 antibodies |
| KR20250130723A (ko) * | 2017-08-03 | 2025-09-02 | 신톡스, 인크. | 증식성 질환 및 감염성 질환의 치료를 위한 사이토카인 접합체 |
| MX2020005041A (es) * | 2017-11-21 | 2020-10-12 | Univ Leland Stanford Junior | Agonistas parciales de interleucina-2. |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US11319355B2 (en) | 2017-12-19 | 2022-05-03 | Xencor, Inc. | Engineered IL-2 Fc fusion proteins |
| US11534479B2 (en) | 2018-02-16 | 2022-12-27 | Iltoo Pharma | Use of interleukin 2 for treating Sjögren's syndrome |
| MX2020009975A (es) | 2018-03-28 | 2020-10-12 | Bristol Myers Squibb Co | Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso. |
| EP3773680A1 (en) | 2018-03-28 | 2021-02-17 | Ascendis Pharma Oncology Division A/S | Il-2 conjugates |
| WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| WO2020020783A1 (en) * | 2018-07-24 | 2020-01-30 | Biontech Rna Pharmaceuticals Gmbh | Il2 agonists |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| CN111971295B (zh) | 2018-09-17 | 2024-08-02 | Gi医诺微新 | 包含il-2蛋白和cd80蛋白的融合蛋白及其用途 |
| AU2019343251B2 (en) | 2018-09-21 | 2022-06-09 | Innovent Biologics (Suzhou) Co., Ltd. | Novel interleukin 2 and use thereof |
| CN113383013B (zh) | 2018-12-21 | 2022-11-04 | 江苏恒瑞医药股份有限公司 | 一种人白细胞介素2变体或其衍生物 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| TW202115105A (zh) * | 2019-06-24 | 2021-04-16 | 德商拜恩迪克Ｒｎａ製藥有限公司 | Ｉｌ２激動劑 |
| US12084484B2 (en) | 2019-07-26 | 2024-09-10 | Visterra, Inc. | Interleukin-2 agents and uses thereof |
| MX2022001866A (es) * | 2019-08-13 | 2022-03-11 | Amgen Inc | Muteinas de interleucina-2 para la expansion de celulas t reguladoras. |
| EP4073094A1 (en) | 2019-12-12 | 2022-10-19 | Iltoo Pharma | Interleukin 2 chimeric constructs |
| WO2021127262A1 (en) | 2019-12-17 | 2021-06-24 | Amgen Inc. | Dual interleukin-2 /tnf receptor agonist for use in therapy |
| US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| EP4090354A4 (en) * | 2020-01-14 | 2024-05-22 | Synthekine, Inc. | IL2 MUTEINS |
| MX2022008771A (es) | 2020-01-14 | 2022-10-07 | Synthekine Inc | Metodos y composiciones de muteinas de il2 sesgadas. |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| JP2023518434A (ja) | 2020-03-19 | 2023-05-01 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | インターロイキン２変異体およびその使用 |
| CN115427437B (zh) | 2020-03-31 | 2024-04-19 | 韩美药品株式会社 | 新型免疫刺激il-2类似物 |
| TW202210502A (zh) | 2020-06-03 | 2022-03-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 新穎il-2序列及其用途 |
| CN114507643A (zh) * | 2020-10-29 | 2022-05-17 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-2的多能干细胞衍生物及应用 |
| KR20230097094A (ko) | 2020-10-29 | 2023-06-30 | 브리스톨-마이어스 스큅 컴퍼니 | 질환의 치료를 위한 융합 단백질 |
| EP4255466A1 (en) | 2020-12-04 | 2023-10-11 | Visterra, Inc. | Methods of using interleukin-2 agents |
| CN113308477A (zh) * | 2021-04-08 | 2021-08-27 | 华南农业大学 | 一种鸭il-2基因真核表达重组质粒及其制备方法 |
| US20240391973A1 (en) | 2021-09-22 | 2024-11-28 | Fortvita Biologics (Singapore) Pte. Ltd. | Interleukin-2 mutant and fusion protein thereof |
| CN118414160A (zh) | 2021-10-06 | 2024-07-30 | 艾尔图制药公司 | 对发炎组织具有靶向特异性的白介素2嵌合构建体 |
| CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
| CN119731204A (zh) * | 2022-06-16 | 2025-03-28 | 赛福伦有限责任公司 | 抗pd-1抗体-衰减的il-2免疫偶联物及其用途 |
| CA3265946A1 (en) | 2022-09-12 | 2024-03-21 | Sorbonne Universite | INTERLEUKIN-2 FOR THE TREATMENT OF AUTISM SPECTRUM DISORDERS |
| FR3140287B1 (fr) | 2022-10-03 | 2025-11-21 | Arkema France | Procede de granulation de composes azoiques et granules obtenus |
| AU2023382265A1 (en) | 2022-11-18 | 2025-10-09 | Nanjing Novoacine Biotechnology Co., Ltd. | Site-specific coupled pegylated interleukin-2 mutant with receptor affinity preference and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2003334C1 (ru) * | 1988-07-26 | 1993-11-30 | Хем Рисерч, Инк, (US) | Способ лечени больных с опухол ми |
| FR2684878B1 (fr) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
| US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
-
1999
- 1999-05-12 DZ DZ990088A patent/DZ2788A1/xx active
- 1999-05-13 HK HK02101283.2A patent/HK1039963B/zh not_active IP Right Cessation
- 1999-05-13 TR TR2000/03354T patent/TR200003354T2/xx unknown
- 1999-05-13 SK SK1724-2000A patent/SK288100B6/sk not_active IP Right Cessation
- 1999-05-13 BR BRPI9910504A patent/BRPI9910504B1/pt not_active IP Right Cessation
- 1999-05-13 JP JP2000549735A patent/JP4276783B2/ja not_active Expired - Lifetime
- 1999-05-13 ES ES99924232T patent/ES2281175T3/es not_active Expired - Lifetime
- 1999-05-13 DE DE69934881T patent/DE69934881T2/de not_active Expired - Lifetime
- 1999-05-13 IL IL13913699A patent/IL139136A0/xx unknown
- 1999-05-13 WO PCT/US1999/010643 patent/WO1999060128A1/en not_active Ceased
- 1999-05-13 UA UA2000127206A patent/UA73719C2/uk unknown
- 1999-05-13 CN CN2007101609093A patent/CN101319247B/zh not_active Expired - Lifetime
- 1999-05-13 CN CNB998086509A patent/CN100366742C/zh not_active Expired - Lifetime
- 1999-05-13 AT AT99924232T patent/ATE351907T1/de active
- 1999-05-13 PE PE1999000399A patent/PE20000475A1/es not_active Application Discontinuation
- 1999-05-13 PA PA19998472601A patent/PA8472601A1/es unknown
- 1999-05-13 HU HU0101948A patent/HU226142B1/hu unknown
- 1999-05-13 PT PT99924232T patent/PT1076704E/pt unknown
- 1999-05-13 KR KR1020007012747A patent/KR100607609B1/ko not_active Expired - Lifetime
- 1999-05-13 AU AU40784/99A patent/AU759697B2/en not_active Expired
- 1999-05-13 EP EP99924232A patent/EP1076704B1/en not_active Expired - Lifetime
- 1999-05-13 RO ROA200001123A patent/RO122150B1/ro unknown
- 1999-05-13 CA CA2327349A patent/CA2327349C/en not_active Expired - Lifetime
- 1999-05-13 DK DK99924232T patent/DK1076704T3/da active
- 1999-05-13 NZ NZ508098A patent/NZ508098A/en not_active IP Right Cessation
- 1999-05-13 PL PL344407A patent/PL201675B1/pl unknown
- 1999-05-13 RU RU2000131593/04A patent/RU2235729C2/ru active
- 1999-05-13 SI SI9920034A patent/SI20643B/sl active Search and Examination
- 1999-05-13 AR ARP990102269A patent/AR020322A1/es active IP Right Grant
- 1999-05-13 TN TNTNSN99090A patent/TNSN99090A1/fr unknown
- 1999-05-13 CZ CZ20004213A patent/CZ302071B6/cs not_active IP Right Cessation
- 1999-05-14 CO CO99030158A patent/CO5070701A1/es unknown
- 1999-05-14 SV SV1999000061A patent/SV1999000061A/es active IP Right Grant
- 1999-05-14 MY MYPI99001912A patent/MY130274A/en unknown
- 1999-05-14 HN HN1999000075A patent/HN1999000075A/es unknown
- 1999-05-14 TW TW088107812A patent/TWI223663B/zh not_active IP Right Cessation
-
2000
- 2000-10-18 IL IL139136A patent/IL139136A/en not_active IP Right Cessation
- 2000-11-08 BG BG104929A patent/BG65139B1/bg unknown
- 2000-11-14 NO NO20005762A patent/NO329235B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000257A patent/CU23273B7/es not_active IP Right Cessation
-
2002
- 2002-06-19 CU CU20020125A patent/CU23272A1/es not_active IP Right Cessation
-
2007
- 2007-03-09 CY CY20071100330T patent/CY1107533T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SV1999000061A (es) | Agonistas y antagonistas il-2 selectivos ref. 5038p1-sv | |
| ES2171768T3 (es) | Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina. | |
| ES2146552B1 (es) | Peptidos inhibidores de tgf/31 | |
| Monte et al. | A study on significant sources of the" bournout syndrome" in workers at occupational centres for the mentally disabled | |
| BR9907189A (pt) | Produtos da fração lipìdica do carotenóide de pepino do mar e métodos de uso | |
| DK481383D0 (da) | Syntetisk mutein af et biologisk aktivt protein, gen kodende for samme, vektor omfattende dette gen, vaertcelle transformeret med denne vektor samt fremgangsmader til fremstilling af muteinet og genet kodende herfor | |
| GT199900070A (es) | Derivados de isotiazol, utiles como agentes anticancerosos. | |
| ES2053763T3 (es) | Composiciones estabilizadas de isotiazolonas. | |
| SI1161548T1 (en) | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein | |
| BRPI0410884A (pt) | composição de ração para uso em um animal de estimação, e, método para o controle de peso em um animal de estimação | |
| AR003641A1 (es) | Composiciones y metodos para controlar los hongos perjudiciales. | |
| ES2166551T3 (es) | Conjugados de hidroxietilalmidon de hemoglobina como transportadores de oxigeno. | |
| ES2193145T3 (es) | Proteinas procoagulants quimericas. | |
| ES2104914T3 (es) | Formas truncadas del factor de crecimiento de hepatocitos (hgf). | |
| BR9710080A (pt) | Composição de matéria de alta densidade. | |
| MX9303554A (es) | Peptido similar al glucagon y derivados de insulinotropina. | |
| ES2130575T3 (es) | Composiciones inmunogenicas mejoradas contra la gastrina 17 humana. | |
| ES2165360T3 (es) | Cicloalquenos y cicloalcanos 1,3-sustituidos como agentes del sistema nervioso central. | |
| AR041061A1 (es) | Uso de la eritropoyetina en pacientes con diabetes | |
| MX170185B (es) | , "mejoras en fibras cortas y composiciones elastomericas reforzada que contiene fibras cortas | |
| GT199700104AA (es) | Procedimientos e intermedios para preparar derivados de cromanol sustituidos | |
| ES2053464T3 (es) | Agentes reticulantes de s-triazina uretano-funcionales y composiciones curables que los contienen. | |
| Groves | Only the paranoid survive | |
| ES2039314T1 (es) | Complejos de sulfato de condoitrina con actividad antiflamatoria, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. | |
| ECSP992953A (es) | Agonistas y antagonistas il-2 selectivos (caso 5038p1-ec) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment | ||
| FG | Grant |