AR020322A1 - "un polipeptido que comprende una muteina de interleuquina-2-- humana, una composicion farmaceutica que lo comprende, un polinucleotido, una celula procariota, una celula eucariota aislada, y un vector" - Google Patents
"un polipeptido que comprende una muteina de interleuquina-2-- humana, una composicion farmaceutica que lo comprende, un polinucleotido, una celula procariota, una celula eucariota aislada, y un vector"Info
- Publication number
- AR020322A1 AR020322A1 ARP990102269A ARP990102269A AR020322A1 AR 020322 A1 AR020322 A1 AR 020322A1 AR P990102269 A ARP990102269 A AR P990102269A AR P990102269 A ARP990102269 A AR P990102269A AR 020322 A1 AR020322 A1 AR 020322A1
- Authority
- AR
- Argentina
- Prior art keywords
- cell
- polypeptide
- procariot
- interleuquina
- eucariot
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 abstract 1
- 102220622777 Sphingomyelin phosphodiesterase_N88G_mutation Human genes 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102220273516 rs768267292 Human genes 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Un polipéptido que comprende una muteína de IL-2-humana numerada de acuerdo con la IL-2 de tipo salvaje en la cual dicha IL-2 humana está sustituida en porlo menos una de las posiciones 20, 88 o 126, con lo cual dicha muteína activa células T conmay or preferencia con respecto a las células NK. El D20H e I,N88G, I y R, en particular, tienen una actividad diferencial para las células T, mucho mayor que la IL-2 nativa, con una toxicidad in vivo asociada predicha,reducida. También proveepolinucle otidos que codifican las muteínas de la invencion, vectores que contienen los polinucleotidos, células hospedantestransformadas, composiciones farmacéuticas que contienen las muteínas y el uso del mismo para la manufactura de unmedicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8008098A | 1998-05-15 | 1998-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020322A1 true AR020322A1 (es) | 2002-05-08 |
Family
ID=22155135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102269A AR020322A1 (es) | 1998-05-15 | 1999-05-13 | "un polipeptido que comprende una muteina de interleuquina-2-- humana, una composicion farmaceutica que lo comprende, un polinucleotido, una celula procariota, una celula eucariota aislada, y un vector" |
Country Status (39)
| Country | Link |
|---|---|
| EP (1) | EP1076704B1 (es) |
| JP (1) | JP4276783B2 (es) |
| KR (1) | KR100607609B1 (es) |
| CN (2) | CN101319247B (es) |
| AR (1) | AR020322A1 (es) |
| AT (1) | ATE351907T1 (es) |
| AU (1) | AU759697B2 (es) |
| BG (1) | BG65139B1 (es) |
| BR (1) | BRPI9910504B1 (es) |
| CA (1) | CA2327349C (es) |
| CO (1) | CO5070701A1 (es) |
| CU (2) | CU23273B7 (es) |
| CY (1) | CY1107533T1 (es) |
| CZ (1) | CZ302071B6 (es) |
| DE (1) | DE69934881T2 (es) |
| DK (1) | DK1076704T3 (es) |
| DZ (1) | DZ2788A1 (es) |
| ES (1) | ES2281175T3 (es) |
| HK (1) | HK1039963B (es) |
| HN (1) | HN1999000075A (es) |
| HU (1) | HU226142B1 (es) |
| IL (2) | IL139136A0 (es) |
| MY (1) | MY130274A (es) |
| NO (1) | NO329235B1 (es) |
| NZ (1) | NZ508098A (es) |
| PA (1) | PA8472601A1 (es) |
| PE (1) | PE20000475A1 (es) |
| PL (1) | PL201675B1 (es) |
| PT (1) | PT1076704E (es) |
| RO (1) | RO122150B1 (es) |
| RU (1) | RU2235729C2 (es) |
| SI (1) | SI20643B (es) |
| SK (1) | SK288100B6 (es) |
| SV (1) | SV1999000061A (es) |
| TN (1) | TNSN99090A1 (es) |
| TR (1) | TR200003354T2 (es) |
| TW (1) | TWI223663B (es) |
| UA (1) | UA73719C2 (es) |
| WO (1) | WO1999060128A1 (es) |
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| AU4057300A (en) * | 1999-03-30 | 2000-10-16 | Board Of Regents, The University Of Texas System | Compositions and methods for modifying toxic effects of proteinacious compounds |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
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| JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
| DE60122286T2 (de) | 2000-02-11 | 2007-08-02 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| EP1935431A3 (en) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Cancer treatments by using a combination of an antibody against her2 and interleukin-2 |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
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| KR20240113459A (ko) | 2021-10-06 | 2024-07-22 | 일투 파마 | 염증 조직에 대한 표적화 특이성을 갖는 인터루킨 2 키메라 구성체 |
| CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
| CN119731204A (zh) | 2022-06-16 | 2025-03-28 | 赛福伦有限责任公司 | 抗pd-1抗体-衰减的il-2免疫偶联物及其用途 |
| IL319435A (en) | 2022-09-12 | 2025-05-01 | Inserm Institut National De La Sant? Et De La Rech M?Dicale | Interleukin-2 for use in the treatment of autism spectrum disorder |
| FR3140287B1 (fr) | 2022-10-03 | 2025-11-21 | Arkema France | Procede de granulation de composes azoiques et granules obtenus |
| AU2023382265A1 (en) | 2022-11-18 | 2025-10-09 | Nanjing Novoacine Biotechnology Co., Ltd. | Site-specific coupled pegylated interleukin-2 mutant with receptor affinity preference and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2003334C1 (ru) * | 1988-07-26 | 1993-11-30 | Хем Рисерч, Инк, (US) | Способ лечени больных с опухол ми |
| FR2684878B1 (fr) * | 1991-12-12 | 1994-02-11 | Roussel Uclaf | Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation. |
| US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
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