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PE20000475A1 - Agonistas y antagonistas il-2 selectivos - Google Patents

Agonistas y antagonistas il-2 selectivos

Info

Publication number
PE20000475A1
PE20000475A1 PE1999000399A PE00039999A PE20000475A1 PE 20000475 A1 PE20000475 A1 PE 20000475A1 PE 1999000399 A PE1999000399 A PE 1999000399A PE 00039999 A PE00039999 A PE 00039999A PE 20000475 A1 PE20000475 A1 PE 20000475A1
Authority
PE
Peru
Prior art keywords
refers
mutein
replaced
cells
agonists
Prior art date
Application number
PE1999000399A
Other languages
English (en)
Inventor
B Shanafelt Armen
Jesmok Gary
J Lembach Kenneth
M Greve Jeffrey
D Wetzel Gayle
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of PE20000475A1 publication Critical patent/PE20000475A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE REFIERE A UN POLIPEPTIDO QUE COMPRENDE UNA MUTEINA DE IL-2 HUMANA LA QUE SE CARACTERIZA POR ESTAR SUSTITUIDA EN LA POSICION 20 POR ISOLEUCINA O HISTIDINA; EN LA POSICION 88 SUSTITUIDA POR ARGININA, ISOLEUCINA O GLICINA; EN LA POSICION 126 SUSTITUIDA POR ASPARTATO, GLUTAMATO O LEUCINA. TAMBIEN SE REFIERE A UN POLINUCLEOTIDO QUE COMPRENDE UNA SECUENCIA DNA QUE CODIFICA MUTEINA IL-2 Y SUS VARIANTES DEGENERADAS; A UNA CELULA HOSPEDADORA PROCARIONTE Y A UN PLASMIDO. TAMBIEN SE REFIERE A UN METODO PARA SELECCIONAR MUTEINAS IL-2 UTILIZANDO IL-2ROßÔ. LA INTERLEUCINA-2 ES UN POTENTE ESTIMULANTE INMUNOLOGICO QUE ACTIVA LAS CELULAS T EN MAYOR GRADO QUE LAS CELULAS ASESINAS NATURALES; POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE HIV, CANCER, CARCINOMA RENAL, MELANOMA MALIGNO, ENFERMEDAD INMUNOLOGICA, ENFERMEDAD INFECCIOSA, INMUNODEFICIENCIA
PE1999000399A 1998-05-15 1999-05-13 Agonistas y antagonistas il-2 selectivos PE20000475A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8008098A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
PE20000475A1 true PE20000475A1 (es) 2000-07-07

Family

ID=22155135

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000399A PE20000475A1 (es) 1998-05-15 1999-05-13 Agonistas y antagonistas il-2 selectivos

Country Status (39)

Country Link
EP (1) EP1076704B1 (es)
JP (1) JP4276783B2 (es)
KR (1) KR100607609B1 (es)
CN (2) CN101319247B (es)
AR (1) AR020322A1 (es)
AT (1) ATE351907T1 (es)
AU (1) AU759697B2 (es)
BG (1) BG65139B1 (es)
BR (1) BRPI9910504B1 (es)
CA (1) CA2327349C (es)
CO (1) CO5070701A1 (es)
CU (2) CU23273B7 (es)
CY (1) CY1107533T1 (es)
CZ (1) CZ302071B6 (es)
DE (1) DE69934881T2 (es)
DK (1) DK1076704T3 (es)
DZ (1) DZ2788A1 (es)
ES (1) ES2281175T3 (es)
HK (1) HK1039963B (es)
HN (1) HN1999000075A (es)
HU (1) HU226142B1 (es)
IL (2) IL139136A0 (es)
MY (1) MY130274A (es)
NO (1) NO329235B1 (es)
NZ (1) NZ508098A (es)
PA (1) PA8472601A1 (es)
PE (1) PE20000475A1 (es)
PL (1) PL201675B1 (es)
PT (1) PT1076704E (es)
RO (1) RO122150B1 (es)
RU (1) RU2235729C2 (es)
SI (1) SI20643B (es)
SK (1) SK288100B6 (es)
SV (1) SV1999000061A (es)
TN (1) TNSN99090A1 (es)
TR (1) TR200003354T2 (es)
TW (1) TWI223663B (es)
UA (1) UA73719C2 (es)
WO (1) WO1999060128A1 (es)

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Also Published As

Publication number Publication date
CA2327349C (en) 2010-10-26
EP1076704B1 (en) 2007-01-17
TWI223663B (en) 2004-11-11
CA2327349A1 (en) 1999-11-25
KR20010043602A (ko) 2001-05-25
SI20643B (sl) 2008-02-29
RU2235729C2 (ru) 2004-09-10
AU759697B2 (en) 2003-04-17
CU23273B7 (es) 2008-04-09
BG104929A (en) 2001-09-28
CZ20004213A3 (en) 2001-05-16
ES2281175T3 (es) 2007-09-16
SI20643A (sl) 2002-02-28
JP4276783B2 (ja) 2009-06-10
NO329235B1 (no) 2010-09-20
HUP0101948A3 (en) 2003-08-28
RO122150B1 (ro) 2009-01-30
SV1999000061A (es) 2000-03-14
AR020322A1 (es) 2002-05-08
HU226142B1 (en) 2008-05-28
CY1107533T1 (el) 2013-03-13
TNSN99090A1 (fr) 2005-11-10
DZ2788A1 (fr) 2003-12-01
NO20005762D0 (no) 2000-11-14
KR100607609B1 (ko) 2006-08-02
CN101319247A (zh) 2008-12-10
EP1076704A1 (en) 2001-02-21
NO20005762L (no) 2001-01-11
JP2002515247A (ja) 2002-05-28
HK1039963A1 (zh) 2002-05-17
HN1999000075A (es) 1999-09-29
CN101319247B (zh) 2012-12-12
CO5070701A1 (es) 2001-08-28
CZ302071B6 (cs) 2010-09-29
IL139136A0 (en) 2001-11-25
CN1309705A (zh) 2001-08-22
CU23272A1 (es) 2008-04-09
PT1076704E (pt) 2007-02-28
DE69934881D1 (de) 2007-03-08
BR9910504A (pt) 2001-01-09
PL344407A1 (en) 2001-11-05
PA8472601A1 (es) 2000-09-29
HK1039963B (zh) 2008-09-05
ATE351907T1 (de) 2007-02-15
HUP0101948A2 (hu) 2001-09-28
SK17242000A3 (sk) 2001-07-10
IL139136A (en) 2009-05-04
SK288100B6 (sk) 2013-07-02
UA73719C2 (en) 2005-09-15
MY130274A (en) 2007-06-29
BRPI9910504B1 (pt) 2016-08-09
CN100366742C (zh) 2008-02-06
BG65139B1 (bg) 2007-03-30
TR200003354T2 (tr) 2001-03-21
DE69934881T2 (de) 2007-11-08
WO1999060128A1 (en) 1999-11-25
DK1076704T3 (da) 2007-03-12
NZ508098A (en) 2003-09-26
AU4078499A (en) 1999-12-06
PL201675B1 (pl) 2009-04-30

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