MA40094B1 - Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation - Google Patents
Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisationInfo
- Publication number
- MA40094B1 MA40094B1 MA40094A MA40094A MA40094B1 MA 40094 B1 MA40094 B1 MA 40094B1 MA 40094 A MA40094 A MA 40094A MA 40094 A MA40094 A MA 40094A MA 40094 B1 MA40094 B1 MA 40094B1
- Authority
- MA
- Morocco
- Prior art keywords
- interleukin
- polypeptide
- methods
- fusion proteins
- fusion protein
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 title abstract 4
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 4
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000007351 Interleukin-2 Receptor alpha Subunit Human genes 0.000 abstract 1
- 108010032774 Interleukin-2 Receptor alpha Subunit Proteins 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
Abstract
L'invention concerne divers procédés et compositions qui peuvent être employés pour moduler le système immunitaire. Les compositions comprennent une protéine de fusion comprenant : a) un premier polypeptide comprenant l'interleukine-2 (il-2) ou un variant ou fragment fonctionnel de celle-ci; et b) un second polypeptide, fusionné dans le cadre au premier polypeptide, dans lequel le second polypeptide comprend un domaine extracellulaire du récepteur alpha de l'interleukine-2 (il-2 ra) ou un variant ou fragment fonctionnel de celui-ci, et où la protéine de fusion présente une activité d'il-2. Divers procédés sont proposés pour moduler la réponse immunitaire chez un sujet comprenant l'administration à un sujet qui en a besoin d'une quantité thérapeutiquement efficace de la protéine de fusion d'il-2/il-2ra selon l'invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033726P | 2014-08-06 | 2014-08-06 | |
| PCT/US2015/043792 WO2016022671A1 (fr) | 2014-08-06 | 2015-08-05 | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40094A1 MA40094A1 (fr) | 2021-09-30 |
| MA40094B1 true MA40094B1 (fr) | 2022-05-31 |
Family
ID=53836871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40094A MA40094B1 (fr) | 2014-08-06 | 2015-08-04 | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| MA40721A MA40721B1 (fr) | 2014-08-06 | 2015-08-05 | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40721A MA40721B1 (fr) | 2014-08-06 | 2015-08-05 | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US12084483B2 (fr) |
| EP (2) | EP4438621A3 (fr) |
| JP (3) | JP6723982B2 (fr) |
| KR (1) | KR102653758B1 (fr) |
| CN (2) | CN107074967B (fr) |
| AU (3) | AU2015301071C1 (fr) |
| BR (1) | BR112017001940A2 (fr) |
| CA (1) | CA2957273C (fr) |
| CL (1) | CL2017000284A1 (fr) |
| CO (1) | CO2017002166A2 (fr) |
| DK (1) | DK3177307T3 (fr) |
| EA (2) | EA202091342A3 (fr) |
| ES (1) | ES2986097T3 (fr) |
| FI (1) | FI3177307T3 (fr) |
| HR (1) | HRP20241258T1 (fr) |
| HU (1) | HUE068478T2 (fr) |
| IL (2) | IL250007B (fr) |
| LT (1) | LT3177307T (fr) |
| MA (2) | MA40094B1 (fr) |
| MX (1) | MX388977B (fr) |
| MY (1) | MY180831A (fr) |
| PE (1) | PE20170503A1 (fr) |
| PH (1) | PH12017500042A1 (fr) |
| PT (1) | PT3177307T (fr) |
| RS (1) | RS65930B1 (fr) |
| SA (1) | SA517380842B1 (fr) |
| SG (2) | SG11201700706WA (fr) |
| SI (1) | SI3177307T1 (fr) |
| SM (1) | SMT202400414T1 (fr) |
| TN (1) | TN2017000020A1 (fr) |
| WO (1) | WO2016022671A1 (fr) |
| ZA (1) | ZA201700245B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| US11098099B2 (en) | 2014-02-06 | 2021-08-24 | Hoffmann-La Roche Inc. | Interleukin-2 fusion proteins and uses thereof |
| MA40094B1 (fr) * | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
| EP3458485B1 (fr) * | 2016-05-19 | 2021-12-29 | The General Hospital Corporation | Interleukine-2 liée à son récepteur il-2rbêta, plate-forme pour améliorer l'activité des cellules tueuses naturelles et des lymphocytes t régulateurs |
| KR20190057113A (ko) | 2016-09-28 | 2019-05-27 | 조마 (유에스) 엘엘씨 | 인터루킨-2에 결합하는 항체 및 그 용도 |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| KR20200010354A (ko) | 2017-05-24 | 2020-01-30 | 팬디온 테라퓨틱스, 인코포레이티드 | 표적화된 면역관용 |
| US11780899B2 (en) | 2017-12-06 | 2023-10-10 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered proteins to enhance sensitivity of a cell to IL-2 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| EP3768700A1 (fr) | 2018-03-23 | 2021-01-27 | Kite Pharma, Inc. | Protéines transmembranaires chimériques et leurs utilisations |
| CN112154153B (zh) * | 2018-03-28 | 2025-05-23 | 百时美施贵宝公司 | 白介素-2/白介素-2受体α融合蛋白以及使用方法 |
| BR112021016962A2 (pt) * | 2019-03-18 | 2021-11-23 | Biontech Cell & Gene Therapies Gmbh | Variantes do receptor de interleucina-2 (il2r) e da interleucina-2 (il2) para ativação específica de células efetoras imunes |
| CN111944036B (zh) | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
| MX2021014178A (es) | 2019-05-20 | 2022-01-04 | Pandion Operations Inc | Inmunotolerancia dirigida a la molecula de adhesion celular de adresina vascular de mucosas (madcam). |
| CA3136992A1 (fr) * | 2019-05-24 | 2020-12-03 | Proviva Therapeutics (Hong Kong) Limited | Compositions d'il-2 et leurs methodes d'utilisation |
| US11246906B2 (en) * | 2019-06-11 | 2022-02-15 | Alkermes Pharma Ireland Limited | Compositions and methods for subcutaneous administration of cancer immunotherapy |
| KR20220032569A (ko) * | 2019-07-12 | 2022-03-15 | 프로비바 테라퓨틱스 (홍콩) 리미티드 | Il-2 조성물 및 이의 사용 방법 |
| US20220281936A1 (en) * | 2019-07-25 | 2022-09-08 | The University Of Chicago | Compositions and methods comprising protease-activated therapeutic agents |
| US20220378933A1 (en) * | 2019-09-19 | 2022-12-01 | Proviva Therapeutics (Hong Kong) Limited | Il-2 compositions and methods of use thereof |
| JP2022553234A (ja) * | 2019-10-18 | 2022-12-22 | アルカームス ファーマ アイルランド リミテッド | 免疫チェックポイント阻害剤と組み合わせた免疫調節ｉｌ－２剤 |
| WO2021127495A1 (fr) | 2019-12-20 | 2021-06-24 | Regeneron Pharmaceuticals, Inc. | Nouveaux agonistes d'il2 et leurs procédés d'utilisation |
| WO2021168079A1 (fr) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Immunotolérance ciblée sur un tissu avec un effecteur cd39 |
| WO2021222762A2 (fr) | 2020-04-30 | 2021-11-04 | Aetio Biotherapy, Inc. | Composition d'il2 activable et procédés d'utilisation |
| CN116194480A (zh) * | 2020-08-13 | 2023-05-30 | 百时美施贵宝公司 | 将il-2重定向到目的靶细胞的方法 |
| TW202317623A (zh) * | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| KR20240149421A (ko) * | 2022-02-11 | 2024-10-14 | 뮤럴 온콜로지, 인코포레이티드 | 암 면역요법을 위한 조성물 및 방법 |
| EP4479090A4 (fr) * | 2022-02-16 | 2025-08-27 | Univ Miami | Protéines de fusion il-2 et tl1a et leurs procédés d'utilisation |
| CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
| EP4669671A1 (fr) * | 2023-02-22 | 2025-12-31 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anticorps anti-il2ra et leurs utilisations |
| WO2025207491A1 (fr) * | 2024-03-25 | 2025-10-02 | Mural Oncology, Inc. | Compositions et méthodes pour immunothérapie anticancéreuse |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| FR2619719B1 (fr) | 1987-09-01 | 1991-05-10 | Sanofi Sa | Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices |
| US5250296A (en) * | 1990-11-29 | 1993-10-05 | Takeda Chemical Industries, Ltd. | Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| EP1298144A3 (fr) | 1994-12-28 | 2006-05-31 | University of Kentucky Research Foundation | Anticorps monoclonal anti-idiotype murin 3H1 |
| US6967092B1 (en) * | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
| DE19701141C1 (de) * | 1997-01-16 | 1998-04-09 | Hoechst Ag | Genkonstrukte für durch Proteasen aktivierbare Wirksubstanzen |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US20040265272A1 (en) | 2001-09-28 | 2004-12-30 | Aikichi Iwamoto | Mammalian cell-infecting virus vector encoding epitope-bound beta2m and utilization thereof |
| KR20070003934A (ko) | 2004-03-05 | 2007-01-05 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 치료제의 환자 내약성을 예측하기 위한 시험관 내 테스트시스템 |
| EP3263581B2 (fr) * | 2005-05-17 | 2025-07-09 | University of Connecticut | Compositions et procédés d'immunomodulation dans un organisme |
| CN101255197B (zh) * | 2008-03-28 | 2012-01-25 | 浙江海正药业股份有限公司 | 血清白蛋白与白介素1受体拮抗剂的融合蛋白及应用 |
| GB0815216D0 (en) | 2008-08-21 | 2008-09-24 | Asterion Ltd | Interleukin |
| US8734774B2 (en) * | 2010-04-02 | 2014-05-27 | University Of Rochester | Protease activated cytokines |
| WO2012088383A2 (fr) | 2010-12-23 | 2012-06-28 | Genentech, Inc. | Interactions pilr alpha et procédés visant à les modifier |
| HUE037849T2 (hu) | 2012-06-08 | 2018-09-28 | Alkermes Pharma Ireland Ltd | Cirkuláris permutációval módosított ligandumok agonistaként és antagonistaként |
| US20140044675A1 (en) * | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| WO2014100913A1 (fr) | 2012-12-24 | 2014-07-03 | Beijing Anxinhuaide Biotech. Co., Ltd | Amélioration de la demi-vie d'un polypeptide thérapeutique par fusion avec une protéine d'échafaudage trimère via un espaceur |
| MA40094B1 (fr) | 2014-08-06 | 2022-05-31 | Univ Miami | Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation |
-
2015
- 2015-08-04 MA MA40094A patent/MA40094B1/fr unknown
- 2015-08-05 EA EA202091342A patent/EA202091342A3/ru unknown
- 2015-08-05 LT LTEPPCT/US2015/043792T patent/LT3177307T/lt unknown
- 2015-08-05 EP EP24181690.9A patent/EP4438621A3/fr active Pending
- 2015-08-05 FI FIEP15750560.3T patent/FI3177307T3/fi active
- 2015-08-05 ES ES15750560T patent/ES2986097T3/es active Active
- 2015-08-05 CA CA2957273A patent/CA2957273C/fr active Active
- 2015-08-05 WO PCT/US2015/043792 patent/WO2016022671A1/fr not_active Ceased
- 2015-08-05 KR KR1020177005686A patent/KR102653758B1/ko active Active
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