SK164796A3 - Novel cyclosporine preparation forms for oral administration of and process for producing them - Google Patents

Novel cyclosporine preparation forms for oral administration of and process for producing them Download PDF

Info

Publication number: SK164796A3
Authority: SK; Slovakia
Prior art keywords: cyclosporin; oral administration; amorphous; ethanol; cyclosporine
Prior art date: 1994-11-03

Application number

SK1647-96A

Other languages

English (en)

Slovak (sk)

Inventor

Matthias Olbrich

Heinrich Poetter

Original Assignee

Dresden Arzneimittel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-03

Filing date

1995-07-19

Publication date

1997-06-04

1995-07-19 Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel

1997-06-04 Publication of SK164796A3 publication Critical patent/SK164796A3/sk

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 44
108010036949 Cyclosporine Proteins 0.000 title claims abstract description 42
229960001265 ciclosporin Drugs 0.000 title claims abstract description 41
229930182912 cyclosporin Natural products 0.000 title claims abstract description 31
238000002360 preparation method Methods 0.000 title claims abstract description 6
238000000034 method Methods 0.000 title claims description 7
229930105110 Cyclosporin A Natural products 0.000 claims abstract description 37
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 27
239000000203 mixture Substances 0.000 claims abstract description 13
239000002775 capsule Substances 0.000 claims abstract description 11
230000035622 drinking Effects 0.000 claims abstract description 10
239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
239000000194 fatty acid Substances 0.000 claims abstract description 7
235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 6
229930195729 fatty acid Natural products 0.000 claims abstract description 6
ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 claims abstract description 3
ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 claims abstract description 3
108010019249 cyclosporin G Proteins 0.000 claims abstract description 3
238000003756 stirring Methods 0.000 claims description 12
239000008194 pharmaceutical composition Substances 0.000 claims description 10
239000004480 active ingredient Substances 0.000 claims description 6
239000006184 cosolvent Substances 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 4
-1 saturated hydroxy fatty acid Chemical class 0.000 claims description 4
238000011049 filling Methods 0.000 claims description 3
150000002148 esters Chemical class 0.000 abstract description 2
229920006395 saturated elastomer Polymers 0.000 abstract description 2
238000013019 agitation Methods 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 description 16
238000009472 formulation Methods 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
239000003921 oil Substances 0.000 description 4
235000019198 oils Nutrition 0.000 description 4
239000004094 surface-active agent Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
239000002904 solvent Substances 0.000 description 3
108010036941 Cyclosporins Proteins 0.000 description 2
239000013543 active substance Substances 0.000 description 2
239000002285 corn oil Substances 0.000 description 2
235000005687 corn oil Nutrition 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000003814 drug Substances 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
238000002156 mixing Methods 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
108010069514 Cyclic Peptides Proteins 0.000 description 1
102000001189 Cyclic Peptides Human genes 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
206010029164 Nephrotic syndrome Diseases 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
206010046851 Uveitis Diseases 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000002141 anti-parasite Effects 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
230000036765 blood level Effects 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000037029 cross reaction Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000004530 micro-emulsion Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000003346 palm kernel oil Substances 0.000 description 1
235000019865 palm kernel oil Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000012453 solvate Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)

SK1647-96A 1994-11-03 1995-07-19 Novel cyclosporine preparation forms for oral administration of and process for producing them SK164796A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4438861		1994-11-03
PCT/DE1995/000951 WO1996014079A1 (de)	1994-11-03	1995-07-19	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
SK164796A3 true SK164796A3 (en)	1997-06-04

Family

ID=6532126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1647-96A SK164796A3 (en)	1994-11-03	1995-07-19	Novel cyclosporine preparation forms for oral administration of and process for producing them

Country Status (27)

Country	Link
US (1)	US6486124B2 (xx)
EP (1)	EP0789580B1 (xx)
JP (1)	JP3833248B2 (xx)
KR (1)	KR970704464A (xx)
CN (1)	CN1121238C (xx)
AT (1)	ATE218359T1 (xx)
AU (1)	AU715165B2 (xx)
BG (1)	BG62955B1 (xx)
BR (1)	BR9509550A (xx)
CA (1)	CA2231404C (xx)
CZ (1)	CZ287806B6 (xx)
DE (2)	DE59510233D1 (xx)
DK (1)	DK0789580T3 (xx)
EE (1)	EE03425B1 (xx)
ES (1)	ES2177652T3 (xx)
FI (1)	FI118722B (xx)
HU (1)	HUT77283A (xx)
LT (1)	LT4306B (xx)
LV (1)	LV11884B (xx)
NO (1)	NO970741D0 (xx)
PL (1)	PL183579B1 (xx)
PT (1)	PT789580E (xx)
RU (1)	RU2158601C2 (xx)
SK (1)	SK164796A3 (xx)
TR (1)	TR199501361A2 (xx)
TW (1)	TW492876B (xx)
WO (1)	WO1996014079A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0789580B1 (de)	1994-11-03	2002-06-05	Novartis AG	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
DE69632125T2 (de) *	1995-08-25	2004-09-16	Sangstat Medical Corp., Menlo Park	Orale cyclosporinformulierungen
DE19544507B4 (de) *	1995-11-29	2007-11-15	Novartis Ag	Cyclosporin enthaltende Präparate
KR20000069900A (ko) *	1997-01-30	2000-11-25	한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터	오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
AU762247B2 (en) *	1997-01-30	2003-06-19	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
DE19821951A1 (de) *	1998-05-15	1999-11-18	Basf Ag	Cyclosporin-Zubereitungen
AUPP627498A0 (en)	1998-10-02	1998-10-22	University Of Queensland, The	Novel peptides - i
NZ512599A (en)	1998-12-30	2003-10-31	Dexcel Ltd	Formulation for cyclosporin administration featuring a hydrophilic solvent and a surfactant with a HLB of less than 5
US6656504B1 (en)	1999-09-09	2003-12-02	Elan Pharma International Ltd.	Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
US6506742B2 (en)	1999-12-13	2003-01-14	Ortho-Mcneil Pharmaceutical, Inc.	Soluble contraceptive liquid formulation
US7851444B2 (en)	2002-12-02	2010-12-14	Xenome Ltd.	χ-conotoxin peptides (-1)
WO2004050688A1 (en)	2002-12-02	2004-06-17	Xenome Ltd	NOVEL χ-CONOTOXIN PEPTIDES (-II)
SE0301119D0 (sv) *	2003-04-14	2003-04-14	Astrazeneca Ab	New non-ionic surfactants for solubilizing poorly soluble molecules
CN102552917A (zh)	2003-08-13	2012-07-11	比奥孔有限公司	用于治疗剂的微-粒子脂肪酸盐固体剂量制剂
US20050059583A1 (en) *	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
RU2272643C2 (ru) *	2004-06-11	2006-03-27	Маргарита Васильевна Бибикова	Высокоактивный кристаллический препарат циклоспорина а и способ его получения
US7151085B2 (en)	2004-11-15	2006-12-19	Allergan, Inc.	Therapeutic methods using cyclosporine components
US7135455B2 (en) *	2004-11-15	2006-11-14	Allergan, Inc	Methods for the therapeutic use of cyclosporine components
JP2008535921A (ja)	2005-04-12	2008-09-04	エラン・ファルマ・インターナショナル・リミテッド	シクロスポリンを含むナノ粒子および放出調節された組成物
US7202209B2 (en)	2005-07-13	2007-04-10	Allergan, Inc.	Cyclosporin compositions
US7288520B2 (en)	2005-07-13	2007-10-30	Allergan, Inc.	Cyclosporin compositions
US20070015691A1 (en) *	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US20070015693A1 (en) *	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US7297679B2 (en)	2005-07-13	2007-11-20	Allergan, Inc.	Cyclosporin compositions
US7276476B2 (en) *	2005-07-13	2007-10-02	Allergan, Inc.	Cyclosporin compositions
US7501393B2 (en) *	2005-07-27	2009-03-10	Allergan, Inc.	Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
AU2012339693B2 (en) *	2011-11-15	2017-09-07	Allergan, Inc.	Cyclosporine A Form 2 and method of making same
ES2791751T3 (es) *	2011-11-15	2020-11-05	Allergan Inc	Suspensiones de forma 2 de ciclosporina A

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1274354A (fr)	1956-03-10	1961-10-27		Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1171125A (en)	1966-06-08	1969-11-19	Glaxo Lab Ltd	Improvements in or relating to Injectable Preparations
US3813345A (en)	1971-08-05	1974-05-28	Vanguard Chem Co Inc	Method of producing microcolloidal aqueous emulsions of unsaturated organic compounds
US3954967A (en)	1971-08-05	1976-05-04	Vanguard Chemical Company, Inc.	Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds
DE2463138C2 (de)	1973-12-06	1984-07-05	Sandoz-Patent-GmbH, 7850 Lörrach	Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung
US4073943A (en)	1974-09-11	1978-02-14	Apoteksvarucentralen Vitrum Ab	Method of enhancing the administration of pharmalogically active agents
US4117118A (en)	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
US4146499A (en)	1976-09-18	1979-03-27	Rosano Henri L	Method for preparing microemulsions
JPS53107408A (en)	1977-02-28	1978-09-19	Yamanouchi Pharmaceut Co Ltd	Micellar preparation for rectal infusion
CH636013A5 (en)	1978-03-07	1983-05-13	Sandoz Ag	More readily absorbable pharmaceutical composition
FI65914C (fi)	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
CH641356A5 (en)	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
AU543727B2 (en)	1980-06-02	1985-05-02	Ayerst Mckenna & Harrison Inc.	Injectable composition of rapamycin
FR2502951B1 (fr)	1981-04-06	1985-12-06	Sandoz Sa	Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
AU558155B2 (en)	1982-02-01	1987-01-22	Sandoz Ltd.	Treating multiple sclerosis with dihydro-cyclosporin d
DE3225706C2 (de)	1982-07-09	1984-04-26	A. Nattermann & Cie GmbH, 5000 Köln	Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3235612A1 (de)	1982-09-25	1984-03-29	Bayer Ag, 5090 Leverkusen	Mikroemulsionen
DE3237814A1 (de)	1982-10-12	1984-04-12	Warner-Lambert Co., 07950 Morris Plains, N.J.	Wasserfreie emulsionen und verwendung derselben
DE3315805A1 (de)	1983-04-30	1984-11-08	Bayer Ag, 5090 Leverkusen	Wirkstoffzubereitungen
JPS6061535A (ja)	1983-08-24	1985-04-09	エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト	製薬学的組成物
FR2553661B1 (fr)	1983-10-19	1985-12-20	Rhone Poulenc Sante	Nouvelles microemulsions pharmaceutiquement acceptables
DE3406497A1 (de)	1984-02-23	1985-09-05	Mueller Bernhard Willi Werner	Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4794000A (en)	1987-01-08	1988-12-27	Synthetic Blood Corporation	Coacervate-based oral delivery system for medically useful compositions
US4963367A (en)	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
GB8903804D0 (en)	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
EP0170623B1 (en)	1984-08-02	1990-11-28	Sandoz Ag	Novel pharmaceutical use of (nva)2-cyclosporine
CH662944A5 (it)	1984-10-18	1987-11-13	Pier Luigi Prof Dr Luisi	Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
JPS61280435A (ja)	1985-04-04	1986-12-11	Kanji Takada	サイクロスポリン類のリンパ指向性製剤
JPS61249918A (ja)	1985-04-26	1986-11-07	Yutaka Mizushima	点眼剤
IL78929A0 (en)	1985-07-29	1986-09-30	Abbott Lab	Microemulsion compositions for parenteral administration
US5023271A (en)	1985-08-13	1991-06-11	California Biotechnology Inc.	Pharmaceutical microemulsions
US4797272A (en)	1985-11-15	1989-01-10	Eli Lilly And Company	Water-in-oil microemulsions for cosmetic uses
SE457693B (sv)	1986-07-01	1989-01-23	Drilletten Ab	Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
EP0256856A3 (en)	1986-08-14	1989-01-11	Synthetic Blood Corporation	A parenterally administrable composition
DE3629386A1 (de)	1986-08-29	1988-03-03	Scherer Gmbh R P	Gelatinekapseln und verfahren zu ihrer herstellung
DE3707711A1 (de)	1987-03-11	1988-09-22	Hoechst Ag	Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung
CA1301642C (en)	1987-03-30	1992-05-26	Howard Bernard Dawson	Chemical formulations
US4798823A (en)	1987-06-03	1989-01-17	Merck & Co., Inc.	New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de)	1987-06-17	1993-10-15	Sandoz Ag	Cyclosporine und deren benutzung als arzneimittel.
GB2206119B (en)	1987-06-22	1990-10-31	Merck & Co Inc	A new cyclosporin derivative with modified "8-amino acid"
US4835002A (en)	1987-07-10	1989-05-30	Wolf Peter A	Microemulsions of oil in water and alcohol
HU205010B (en)	1987-09-15	1992-03-30	Sandoz Ag	Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
US5756450A (en)	1987-09-15	1998-05-26	Novartis Corporation	Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
IL88076A (en)	1987-10-28	1993-01-14	Nippon Shinyaku Co Ltd	Fat emulsions as drug carriers
US4914188A (en)	1987-11-16	1990-04-03	Merck & Co., Inc.	Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en)	1987-12-21	1991-08-28	Sandoz Ag	Process for producing new orthorombos cyclosporin without solvatation
ES2033086T3 (es)	1988-01-29	1993-03-01	Sankyo Company Limited	Un procedimiento para la preparacion de una composicion farmaceutica.
CH679119A5 (xx)	1988-05-13	1991-12-31	Sandoz Ag
HU201567B (en) *	1988-07-21	1990-11-28	Gyogyszerkutato Intezet	Process for production of intravenous medical compositions containing cyclosphorin
KR0148748B1 (ko)	1988-09-16	1998-08-17	장 크라메르, 한스 루돌프 하우스	사이클로스포린을 함유하는 약학조성물
US5342625A (en)	1988-09-16	1994-08-30	Sandoz Ltd.	Pharmaceutical compositions comprising cyclosporins
CA1337397C (en)	1988-09-29	1995-10-24	Hideo Nakajima	Emulsified composition
BE1003578A4 (fr)	1988-10-26	1992-04-28	Sandoz Sa	Nouvelles compositions ophtalmiques a base d'une cyclosporine.
AU5157590A (en)	1989-02-06	1990-08-24	Abbott Laboratories	Pharmaceutical compositions for oral administration
BE1003009A5 (fr)	1989-02-09	1991-10-22	Sandoz Sa	Nouvelles compositions pharmaceutiques a base de cyclosporines.
US4996193A (en)	1989-03-03	1991-02-26	The Regents Of The University Of California	Combined topical and systemic method of administration of cyclosporine
US5177110A (en)	1989-10-27	1993-01-05	Ciba-Geigy Corporation	Injectable parasiticidal composition
HU207222B (en)	1990-02-15	1993-03-29	Chinoin Gyogyszer Es Vegyeszet	Process for producing eyedrops containing primycin
US5260301A (en)	1990-03-01	1993-11-09	Fujisawa Pharmaceutical Co., Ltd.	Pharmaceutical solution containing FK-506
HU208491B (en)	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en)	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
US5206219A (en)	1991-11-25	1993-04-27	Applied Analytical Industries, Inc.	Oral compositions of proteinaceous medicaments
GB9208712D0 (en)	1992-04-22	1992-06-10	Sandoz Ltd	Pharmaceutical compositions containing cyclosporin derivates
ES2168271T3 (es)	1992-09-25	2002-06-16	Novartis Ag	Composiciones farmaceuticas que contienen ciclosporinas.
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
IL111003A0 (en)	1993-09-30	1994-11-28	American Home Prod	Multi-component oral rapamycin formulation
KR0146671B1 (ko) *	1994-02-25	1998-08-17	김충환	사이클로스포린-함유 분말 조성물
EP0705601B1 (de)	1994-10-04	2000-01-19	LOMAPHARM Rudolf Lohmann GmbH KG Pharmazeutische Fabrik	Lösungen von Anthrachinonen zur parenteralen Applikation
EP0789580B1 (de)	1994-11-03	2002-06-05	Novartis AG	Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

1995
- 1995-07-19 EP EP95925707A patent/EP0789580B1/de not_active Expired - Lifetime
- 1995-07-19 DE DE59510233T patent/DE59510233D1/de not_active Expired - Fee Related
- 1995-07-19 KR KR1019970700361A patent/KR970704464A/ko not_active Ceased
- 1995-07-19 HU HU9702144A patent/HUT77283A/hu unknown
- 1995-07-19 EE EE9700112A patent/EE03425B1/xx not_active IP Right Cessation
- 1995-07-19 CA CA002231404A patent/CA2231404C/en not_active Expired - Fee Related
- 1995-07-19 WO PCT/DE1995/000951 patent/WO1996014079A1/de not_active Ceased
- 1995-07-19 BR BR9509550A patent/BR9509550A/pt not_active Application Discontinuation
- 1995-07-19 SK SK1647-96A patent/SK164796A3/sk unknown
- 1995-07-19 ES ES95925707T patent/ES2177652T3/es not_active Expired - Lifetime
- 1995-07-19 DK DK95925707T patent/DK0789580T3/da active
- 1995-07-19 PT PT95925707T patent/PT789580E/pt unknown
- 1995-07-19 AU AU29751/95A patent/AU715165B2/en not_active Ceased
- 1995-07-19 RU RU97108682/14A patent/RU2158601C2/ru active
- 1995-07-19 AT AT95925707T patent/ATE218359T1/de not_active IP Right Cessation
- 1995-07-19 JP JP51493496A patent/JP3833248B2/ja not_active Expired - Fee Related
- 1995-07-19 CN CN95196010A patent/CN1121238C/zh not_active Expired - Fee Related
- 1995-07-19 CZ CZ19963616A patent/CZ287806B6/cs not_active IP Right Cessation
- 1995-08-08 TW TW084108225A patent/TW492876B/zh active
- 1995-10-26 DE DE19539860A patent/DE19539860A1/de not_active Withdrawn
- 1995-11-02 TR TR95/01361A patent/TR199501361A2/xx unknown
1997
- 1997-01-06 BG BG101117A patent/BG62955B1/bg unknown
- 1997-01-09 LT LT97-002A patent/LT4306B/lt not_active IP Right Cessation
- 1997-02-14 FI FI970634A patent/FI118722B/fi active IP Right Grant
- 1997-02-18 NO NO970741A patent/NO970741D0/no not_active Application Discontinuation
- 1997-05-14 LV LVP-97-94A patent/LV11884B/lv unknown
1998
- 1998-03-09 PL PL95318560A patent/PL183579B1/pl unknown
2001
- 2001-10-17 US US09/981,929 patent/US6486124B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
LV11884B (lv)	1998-03-20
CA2231404C (en)	2009-02-17
CN1121238C (zh)	2003-09-17
EE9700112A (et)	1997-12-15
DE19539860A1 (de)	1996-05-09
NO970741L (no)	1997-02-18
LT4306B (lt)	1998-03-25
CN1162265A (zh)	1997-10-15
RU2158601C2 (ru)	2000-11-10
NO970741D0 (no)	1997-02-18
EP0789580A1 (de)	1997-08-20
EE03425B1 (et)	2001-06-15
CZ361696A3 (en)	1997-07-16
CA2231404A1 (en)	1996-05-17
LT97002A (en)	1997-11-25
AU715165B2 (en)	2000-01-20
FI970634L (fi)	1997-02-14
TW492876B (en)	2002-07-01
JP3833248B2 (ja)	2006-10-11
PT789580E (pt)	2002-09-30
ES2177652T3 (es)	2002-12-16
PL318560A1 (en)	1997-06-23
US20020025927A1 (en)	2002-02-28
KR970704464A (ko)	1997-09-06
TR199501361A2 (tr)	1996-06-21
BG62955B1 (bg)	2000-12-29
EP0789580B1 (de)	2002-06-05
HUT77283A (hu)	1998-03-30
BR9509550A (pt)	1997-09-16
PL183579B1 (pl)	2002-06-28
LV11884A (lv)	1997-12-20
BG101117A (en)	1997-08-29
FI970634A0 (fi)	1997-02-14
JPH10508306A (ja)	1998-08-18
AU2975195A (en)	1996-05-31
CZ287806B6 (en)	2001-02-14
US6486124B2 (en)	2002-11-26
WO1996014079A1 (de)	1996-05-17
DE59510233D1 (de)	2002-07-11
DK0789580T3 (da)	2002-09-09
ATE218359T1 (de)	2002-06-15
FI118722B (fi)	2008-02-29

Publication	Publication Date	Title
SK164796A3 (en)	1997-06-04	Novel cyclosporine preparation forms for oral administration of and process for producing them
FI89065C (fi)	1993-09-30	Foerfarande foer framstaellning av en ny siklosporin kristallform
JP4073503B2 (ja)	2008-04-09	サイクロスポリンを含有する液体製剤とその調製方法
AT400517B (de)	1996-01-25	Topisches terbinafinpräparat und verfahren zu seiner herstellung
AT403435B (de)	1998-02-25	Cyclosporin enthaltende pharmazeutische zusammensetzung
EP0710103B1 (de)	2001-06-13	Pharmazeutische präparate für schwerlösliche wirkstoffe
HUT73664A (en)	1996-09-30	Pharmaceutically acceptable improved compositions containing an alcohol and a hydrophobic drug
DE4005190A1 (de)	1990-08-23	Neue cyclosporinhaltige galenische formen
JP2006001947A (ja)	2006-01-05	新規シクロスポリン製剤
NL195094C (nl)	2003-12-17	Farmaceutische preparaat dat opgelost cyclosporine bevat en werkwijze voor de bereiding daarvan.
LV11885B (en)	1998-03-20	Medical preparations containing n-methylated cyclic undecapeptides
US20030180350A1 (en)	2003-09-25	Combination compositions
EP1002546B1 (de)	2005-08-24	Verwendung von Estern der 12-Hydroxystearinsäure als Solubilisatoren
AP197A (en)	1992-06-30	Pharmaceutical formulations for treatment of virus infections of the skin containing penciclovir.
JP3584064B2 (ja)	2004-11-04	静脈注射用ラパマイシン製剤
MXPA97000019A (en)	1999-05-31	New formulations to prepare the cyclosporine for oral administration with a simple composition and high biodisponibility, and procedure for its manufacture
JPH0157091B2 (xx)	1989-12-04
SK8702001A3 (en)	2002-01-07	Cyclosporin solution
WO2017015690A1 (de)	2017-02-02	Konzentrat enthaltend alprostadil