[go: up one dir, main page]

NO970741L - Nye preparatformer av cyklosporin for oral administrering med enkel sammensetning og höy biotilgjengelighet og fremgangsmåte for fremstilling av disse - Google Patents

Nye preparatformer av cyklosporin for oral administrering med enkel sammensetning og höy biotilgjengelighet og fremgangsmåte for fremstilling av disse

Info

Publication number
NO970741L
NO970741L NO970741A NO970741A NO970741L NO 970741 L NO970741 L NO 970741L NO 970741 A NO970741 A NO 970741A NO 970741 A NO970741 A NO 970741A NO 970741 L NO970741 L NO 970741L
Authority
NO
Norway
Prior art keywords
cyclosporin
oral administration
weight
parts
high bioavailability
Prior art date
Application number
NO970741A
Other languages
English (en)
Other versions
NO970741D0 (no
Inventor
Matthias Olbrich
Heinrich Poetter
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of NO970741L publication Critical patent/NO970741L/no
Publication of NO970741D0 publication Critical patent/NO970741D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Det er beskrevet nye preparaformer av cyklosporin med enkel sammensetning og høy biotilgjengelighet for oral administrering, som inneholder 0,5 til 2 vektdeler av en eller flere amorfe cyklosporiner, fortrinnsvis cyklosporin A og/eller cyklosporin G, samt 6 til 9 vektdeler av en eller flere polyetylenglykolestere av mettede CIO - C22 hydroksy-fettsyrer, spesielt "SOLUTOL HS15", samt 1-3 vektdeler av en eller flere en- eller flerverdige alkoholer, fortrinnsvis etanol og propylenglykol. Fremstillingen av medika-mentformen foregår ved at det amorfe cyklosporinet først oppløses i etanol og under omrøring tilsettes polyetylenglykol og "SOLUTOL" inntil en klar, viskøs oppløsning oppstår, som på i og for seg kjent måte fylles som drikkeoppløsning eller fylles i kapsler.
NO970741A 1994-11-03 1997-02-18 Nye preparatformer av cyklosporin for oral administrering med enkel sammensetning og höy biotilgjengelighet og fremgangsmåte for fremstilling av disse NO970741D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438861 1994-11-03
PCT/DE1995/000951 WO1996014079A1 (de) 1994-11-03 1995-07-19 Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
NO970741L true NO970741L (no) 1997-02-18
NO970741D0 NO970741D0 (no) 1997-02-18

Family

ID=6532126

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970741A NO970741D0 (no) 1994-11-03 1997-02-18 Nye preparatformer av cyklosporin for oral administrering med enkel sammensetning og höy biotilgjengelighet og fremgangsmåte for fremstilling av disse

Country Status (27)

Country Link
US (1) US6486124B2 (no)
EP (1) EP0789580B1 (no)
JP (1) JP3833248B2 (no)
KR (1) KR970704464A (no)
CN (1) CN1121238C (no)
AT (1) ATE218359T1 (no)
AU (1) AU715165B2 (no)
BG (1) BG62955B1 (no)
BR (1) BR9509550A (no)
CA (1) CA2231404C (no)
CZ (1) CZ287806B6 (no)
DE (2) DE59510233D1 (no)
DK (1) DK0789580T3 (no)
EE (1) EE03425B1 (no)
ES (1) ES2177652T3 (no)
FI (1) FI118722B (no)
HU (1) HUT77283A (no)
LT (1) LT4306B (no)
LV (1) LV11884B (no)
NO (1) NO970741D0 (no)
PL (1) PL183579B1 (no)
PT (1) PT789580E (no)
RU (1) RU2158601C2 (no)
SK (1) SK164796A3 (no)
TR (1) TR199501361A2 (no)
TW (1) TW492876B (no)
WO (1) WO1996014079A1 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0789580B1 (de) 1994-11-03 2002-06-05 Novartis AG Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE69632125T2 (de) * 1995-08-25 2004-09-16 Sangstat Medical Corp., Menlo Park Orale cyclosporinformulierungen
DE19544507B4 (de) * 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
KR20000069900A (ko) * 1997-01-30 2000-11-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 오일을 함유하지 않은 사이클로스포린 ａ 함유 제약 조성물
AU762247B2 (en) * 1997-01-30 2003-06-19 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
DE19821951A1 (de) * 1998-05-15 1999-11-18 Basf Ag Cyclosporin-Zubereitungen
AUPP627498A0 (en) 1998-10-02 1998-10-22 University Of Queensland, The Novel peptides - i
NZ512599A (en) 1998-12-30 2003-10-31 Dexcel Ltd Formulation for cyclosporin administration featuring a hydrophilic solvent and a surfactant with a HLB of less than 5
US6656504B1 (en) 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
US6506742B2 (en) 1999-12-13 2003-01-14 Ortho-Mcneil Pharmaceutical, Inc. Soluble contraceptive liquid formulation
US7851444B2 (en) 2002-12-02 2010-12-14 Xenome Ltd. χ-conotoxin peptides (-1)
WO2004050688A1 (en) 2002-12-02 2004-06-17 Xenome Ltd NOVEL χ-CONOTOXIN PEPTIDES (-II)
SE0301119D0 (sv) * 2003-04-14 2003-04-14 Astrazeneca Ab New non-ionic surfactants for solubilizing poorly soluble molecules
CN102552917A (zh) 2003-08-13 2012-07-11 比奥孔有限公司 用于治疗剂的微-粒子脂肪酸盐固体剂量制剂
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
RU2272643C2 (ru) * 2004-06-11 2006-03-27 Маргарита Васильевна Бибикова Высокоактивный кристаллический препарат циклоспорина а и способ его получения
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
JP2008535921A (ja) 2005-04-12 2008-09-04 エラン・ファルマ・インターナショナル・リミテッド シクロスポリンを含むナノ粒子および放出調節された組成物
US7202209B2 (en) 2005-07-13 2007-04-10 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
US20070015691A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US20070015693A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7297679B2 (en) 2005-07-13 2007-11-20 Allergan, Inc. Cyclosporin compositions
US7276476B2 (en) * 2005-07-13 2007-10-02 Allergan, Inc. Cyclosporin compositions
US7501393B2 (en) * 2005-07-27 2009-03-10 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
AU2012339693B2 (en) * 2011-11-15 2017-09-07 Allergan, Inc. Cyclosporine A Form 2 and method of making same
ES2791751T3 (es) * 2011-11-15 2020-11-05 Allergan Inc Suspensiones de forma 2 de ciclosporina A

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1274354A (fr) 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
GB1171125A (en) 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
US3813345A (en) 1971-08-05 1974-05-28 Vanguard Chem Co Inc Method of producing microcolloidal aqueous emulsions of unsaturated organic compounds
US3954967A (en) 1971-08-05 1976-05-04 Vanguard Chemical Company, Inc. Method of producing microcolloidal aqueous emulsions of unsaturated organic insecticidal compounds
DE2463138C2 (de) 1973-12-06 1984-07-05 Sandoz-Patent-GmbH, 7850 Lörrach Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung
US4073943A (en) 1974-09-11 1978-02-14 Apoteksvarucentralen Vitrum Ab Method of enhancing the administration of pharmalogically active agents
US4117118A (en) 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4146499A (en) 1976-09-18 1979-03-27 Rosano Henri L Method for preparing microemulsions
JPS53107408A (en) 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
CH636013A5 (en) 1978-03-07 1983-05-13 Sandoz Ag More readily absorbable pharmaceutical composition
FI65914C (fi) 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
CH641356A5 (en) 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU543727B2 (en) 1980-06-02 1985-05-02 Ayerst Mckenna & Harrison Inc. Injectable composition of rapamycin
FR2502951B1 (fr) 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
AU558155B2 (en) 1982-02-01 1987-01-22 Sandoz Ltd. Treating multiple sclerosis with dihydro-cyclosporin d
DE3225706C2 (de) 1982-07-09 1984-04-26 A. Nattermann & Cie GmbH, 5000 Köln Flüssige Wirkstofformulierungen in Form von Konzentraten für Mikroemulsionen
DE3235612A1 (de) 1982-09-25 1984-03-29 Bayer Ag, 5090 Leverkusen Mikroemulsionen
DE3237814A1 (de) 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3315805A1 (de) 1983-04-30 1984-11-08 Bayer Ag, 5090 Leverkusen Wirkstoffzubereitungen
JPS6061535A (ja) 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
FR2553661B1 (fr) 1983-10-19 1985-12-20 Rhone Poulenc Sante Nouvelles microemulsions pharmaceutiquement acceptables
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4794000A (en) 1987-01-08 1988-12-27 Synthetic Blood Corporation Coacervate-based oral delivery system for medically useful compositions
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
GB8903804D0 (en) 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
EP0170623B1 (en) 1984-08-02 1990-11-28 Sandoz Ag Novel pharmaceutical use of (nva)2-cyclosporine
CH662944A5 (it) 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
JPS61280435A (ja) 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤
JPS61249918A (ja) 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
IL78929A0 (en) 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration
US5023271A (en) 1985-08-13 1991-06-11 California Biotechnology Inc. Pharmaceutical microemulsions
US4797272A (en) 1985-11-15 1989-01-10 Eli Lilly And Company Water-in-oil microemulsions for cosmetic uses
SE457693B (sv) 1986-07-01 1989-01-23 Drilletten Ab Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
EP0256856A3 (en) 1986-08-14 1989-01-11 Synthetic Blood Corporation A parenterally administrable composition
DE3629386A1 (de) 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
DE3707711A1 (de) 1987-03-11 1988-09-22 Hoechst Ag Oel-in-wasser-emulsionen, verfahren zu deren herstellung und deren verwendung
CA1301642C (en) 1987-03-30 1992-05-26 Howard Bernard Dawson Chemical formulations
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ATE95193T1 (de) 1987-06-17 1993-10-15 Sandoz Ag Cyclosporine und deren benutzung als arzneimittel.
GB2206119B (en) 1987-06-22 1990-10-31 Merck & Co Inc A new cyclosporin derivative with modified "8-amino acid"
US4835002A (en) 1987-07-10 1989-05-30 Wolf Peter A Microemulsions of oil in water and alcohol
HU205010B (en) 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
US5756450A (en) 1987-09-15 1998-05-26 Novartis Corporation Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
IL88076A (en) 1987-10-28 1993-01-14 Nippon Shinyaku Co Ltd Fat emulsions as drug carriers
US4914188A (en) 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
HU203564B (en) 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
ES2033086T3 (es) 1988-01-29 1993-03-01 Sankyo Company Limited Un procedimiento para la preparacion de una composicion farmaceutica.
CH679119A5 (no) 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
KR0148748B1 (ko) 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
CA1337397C (en) 1988-09-29 1995-10-24 Hideo Nakajima Emulsified composition
BE1003578A4 (fr) 1988-10-26 1992-04-28 Sandoz Sa Nouvelles compositions ophtalmiques a base d'une cyclosporine.
AU5157590A (en) 1989-02-06 1990-08-24 Abbott Laboratories Pharmaceutical compositions for oral administration
BE1003009A5 (fr) 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
US4996193A (en) 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5177110A (en) 1989-10-27 1993-01-05 Ciba-Geigy Corporation Injectable parasiticidal composition
HU207222B (en) 1990-02-15 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Process for producing eyedrops containing primycin
US5260301A (en) 1990-03-01 1993-11-09 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical solution containing FK-506
HU208491B (en) 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en) 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US5206219A (en) 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
GB9208712D0 (en) 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
IL111003A0 (en) 1993-09-30 1994-11-28 American Home Prod Multi-component oral rapamycin formulation
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
EP0705601B1 (de) 1994-10-04 2000-01-19 LOMAPHARM Rudolf Lohmann GmbH KG Pharmazeutische Fabrik Lösungen von Anthrachinonen zur parenteralen Applikation
EP0789580B1 (de) 1994-11-03 2002-06-05 Novartis AG Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung

Also Published As

Publication number Publication date
LV11884B (lv) 1998-03-20
CA2231404C (en) 2009-02-17
CN1121238C (zh) 2003-09-17
EE9700112A (et) 1997-12-15
DE19539860A1 (de) 1996-05-09
LT4306B (lt) 1998-03-25
CN1162265A (zh) 1997-10-15
RU2158601C2 (ru) 2000-11-10
NO970741D0 (no) 1997-02-18
EP0789580A1 (de) 1997-08-20
EE03425B1 (et) 2001-06-15
CZ361696A3 (en) 1997-07-16
CA2231404A1 (en) 1996-05-17
LT97002A (en) 1997-11-25
AU715165B2 (en) 2000-01-20
FI970634L (fi) 1997-02-14
TW492876B (en) 2002-07-01
JP3833248B2 (ja) 2006-10-11
PT789580E (pt) 2002-09-30
ES2177652T3 (es) 2002-12-16
PL318560A1 (en) 1997-06-23
US20020025927A1 (en) 2002-02-28
KR970704464A (ko) 1997-09-06
TR199501361A2 (tr) 1996-06-21
BG62955B1 (bg) 2000-12-29
EP0789580B1 (de) 2002-06-05
HUT77283A (hu) 1998-03-30
SK164796A3 (en) 1997-06-04
BR9509550A (pt) 1997-09-16
PL183579B1 (pl) 2002-06-28
LV11884A (lv) 1997-12-20
BG101117A (en) 1997-08-29
FI970634A0 (fi) 1997-02-14
JPH10508306A (ja) 1998-08-18
AU2975195A (en) 1996-05-31
CZ287806B6 (en) 2001-02-14
US6486124B2 (en) 2002-11-26
WO1996014079A1 (de) 1996-05-17
DE59510233D1 (de) 2002-07-11
DK0789580T3 (da) 2002-09-09
ATE218359T1 (de) 2002-06-15
FI118722B (fi) 2008-02-29

Similar Documents

Publication Publication Date Title
NO970741L (no) Nye preparatformer av cyklosporin for oral administrering med enkel sammensetning og höy biotilgjengelighet og fremgangsmåte for fremstilling av disse
BR9406604A (pt) Formulações de doses altas
ZA921875B (en) New esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
IL139113A0 (en) Pharmaceutical compositions capable of being gelled
RU97108682A (ru) Новые лекарственные формы циклоспорина для орального применения с простым составом и с высокой биоготовностью и способ их получения
CA2318128A1 (en) Oral liquid compositions
PT86186A (en) Process for the preparation of benzimidazol derivatives and of pharmaceutical compositions containing the same
IL96636A0 (en) Piperidine derivatives and pharmaceutical compositions containing them
HUT67661A (en) New pyrazine derivatives, their preparation and pharmaceutical compositions containing them
AU4846690A (en) Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament
HUT49808A (en) Process for producing retarde pharmaceutical compositions containing aselastine
GR3003355T3 (en) Nicorandil-containing preparation for injection
GB1442159A (en) Pharmaceutical compositions containing paracetamol
ATE136783T1 (de) Arzneimittel mit antineoplastischer wirkung enthaltend als wirkstoff octadecyl-(2-(n- methylpiperidino)-ethyl>-phosphat und verfahren zu dessen herstellung
NZ220800A (en) Tetrahydrobenzothiazoles and pharmaceutical compositions
GB1424432A (en) Pharmaceutical compositions
ATE212840T1 (de) Oral anzuwendende feste arzneizubereitungen mit modulierter wirkstoffabgabe enthaltend nicorandil und verfahren zu deren herstellung
GB1446237A (en) Pharmaceutical preparations containing pyrazolones
HK40085856A (en) Composition for external use on skin
IE34397L (en) Therapeutic composition containing benzodiazepine derivative
JPS5517359A (en) Preparation of stable freeze-dried carboquone injection pharmaceutical
IT1247030B (it) Forma microcristallina dell'acido meclofenamico, metodo e formulazioni farmaceutiche
GB1183240A (en) New Scilliglaucosidol Derivative
KR870010056A (ko) 인돌 유도체의 제조방법

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application