SI9210081B - Pneumococcal polysaccharide conjugate vaccine - Google Patents
Pneumococcal polysaccharide conjugate vaccine Download PDFInfo
- Publication number
- SI9210081B SI9210081B SI9210081A SI9210081A SI9210081B SI 9210081 B SI9210081 B SI 9210081B SI 9210081 A SI9210081 A SI 9210081A SI 9210081 A SI9210081 A SI 9210081A SI 9210081 B SI9210081 B SI 9210081B
- Authority
- SI
- Slovenia
- Prior art keywords
- polysaccharide
- ompc
- conjugate
- viscosity
- pneumococcal
- Prior art date
Links
- 229920001282 polysaccharide Polymers 0.000 title claims abstract 32
- 239000005017 polysaccharide Substances 0.000 title claims abstract 32
- 150000004676 glycans Chemical class 0.000 title claims abstract 31
- 108010060123 Conjugate Vaccines Proteins 0.000 title abstract 2
- 229940031670 conjugate vaccine Drugs 0.000 title abstract 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims abstract 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract 5
- 102000004169 proteins and genes Human genes 0.000 claims abstract 5
- 230000002163 immunogen Effects 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 3
- 229960005486 vaccine Drugs 0.000 claims abstract 3
- 244000052769 pathogen Species 0.000 claims abstract 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 8
- 239000001488 sodium phosphate Substances 0.000 claims 8
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 8
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 7
- 230000007062 hydrolysis Effects 0.000 claims 4
- 238000006460 hydrolysis reaction Methods 0.000 claims 4
- 230000021615 conjugation Effects 0.000 claims 3
- 238000005194 fractionation Methods 0.000 claims 3
- 238000000527 sonication Methods 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 208000005252 hepatitis A Diseases 0.000 claims 2
- 239000012535 impurity Substances 0.000 claims 2
- 230000000269 nucleophilic effect Effects 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 201000005505 Measles Diseases 0.000 claims 1
- 208000005647 Mumps Diseases 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 101710116435 Outer membrane protein Proteins 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241001607520 Streptococcus pneumoniae 23F Species 0.000 claims 1
- 206010043376 Tetanus Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 230000003497 anti-pneumococcal effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 206010013023 diphtheria Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002270 exclusion chromatography Methods 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000007306 functionalization reaction Methods 0.000 claims 1
- 229910052733 gallium Inorganic materials 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000000951 immunodiffusion Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 208000010805 mumps infectious disease Diseases 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 201000005404 rubella Diseases 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000004513 sizing Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 230000036962 time dependent Effects 0.000 claims 1
- 238000000196 viscometry Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 abstract 3
- 230000001681 protective effect Effects 0.000 abstract 3
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 208000035109 Pneumococcal Infections Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64657091A | 1991-01-28 | 1991-01-28 | |
| US80794291A | 1991-12-19 | 1991-12-19 | |
| YU8192A YU49068B (sh) | 1991-01-28 | 1992-01-27 | Postupak za izradu pneumokoknog polisaharidnog imunogenog proteinskog konjugata |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9210081A SI9210081A (en) | 1996-02-29 |
| SI9210081B true SI9210081B (en) | 2001-12-31 |
Family
ID=27094961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9210081A SI9210081B (en) | 1991-01-28 | 1992-01-27 | Pneumococcal polysaccharide conjugate vaccine |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5623057A (es) |
| EP (1) | EP0497525B2 (es) |
| JP (1) | JPH0794472B2 (es) |
| KR (1) | KR100243958B1 (es) |
| CN (1) | CN1080124C (es) |
| AT (1) | ATE169825T1 (es) |
| AU (1) | AU651656B2 (es) |
| CA (1) | CA2059692C (es) |
| CZ (1) | CZ283284B6 (es) |
| DE (1) | DE69226668T3 (es) |
| DK (1) | DK0497525T4 (es) |
| ES (1) | ES2121820T5 (es) |
| FI (1) | FI107370B (es) |
| HU (1) | HU216101B (es) |
| IE (1) | IE920244A1 (es) |
| IL (5) | IL100716A (es) |
| LV (1) | LV12309B (es) |
| MX (1) | MX9200328A (es) |
| NO (1) | NO304117B1 (es) |
| NZ (1) | NZ241367A (es) |
| SI (1) | SI9210081B (es) |
| SK (1) | SK280659B6 (es) |
| YU (1) | YU49068B (es) |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| US5445817A (en) * | 1992-08-21 | 1995-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines |
| US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| US5681570A (en) * | 1995-01-12 | 1997-10-28 | Connaught Laboratories Limited | Immunogenic conjugate molecules |
| US5747287A (en) * | 1995-04-28 | 1998-05-05 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US5695768A (en) * | 1995-06-07 | 1997-12-09 | Alberta Research Council | Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides |
| IL121585A0 (en) * | 1995-06-07 | 1998-02-08 | Alberta Res Council | Immunogenic and immunostimulatory oligosaccharide compositions and methods of preparing and using them |
| US5866132A (en) * | 1995-06-07 | 1999-02-02 | Alberta Research Council | Immunogenic oligosaccharide compositions |
| US6410025B1 (en) | 1996-02-14 | 2002-06-25 | Merck & Co., Inc. | Polysaccharide precipitation process |
| SE9601158D0 (sv) * | 1996-03-26 | 1996-03-26 | Stefan Svenson | Method of producing immunogenic products and vaccines |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| DK0939647T4 (da) * | 1996-08-27 | 2006-10-23 | Novartis Vaccines & Diagnostic | Neisseria Meningitidis-serogruppe B-glycokonjugat og fremgangsmåde til anvendelse deraf |
| FR2763244B1 (fr) | 1997-05-14 | 2003-08-01 | Pasteur Merieux Serums Vacc | Composition vaccinale multivalente a porteur mixte |
| US6764686B2 (en) | 1997-07-21 | 2004-07-20 | Baxter International Inc. | Modified immunogenic pneumolysin compositions as vaccines |
| US6224880B1 (en) | 1997-09-24 | 2001-05-01 | Merck & Co., Inc. | Immunization against Streptococcus pneumoniae using conjugated and unconjugated pneumoccocal polysaccharide vaccines |
| US6756361B1 (en) * | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| GB9727262D0 (en) * | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| KR100585408B1 (ko) * | 1998-02-12 | 2006-06-01 | 와이어쓰 홀딩스 코포레이션 | 인터루킨-12로 제형된 폐렴구균 및 수막구균 백신 |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| EP1073667A2 (en) * | 1998-04-28 | 2001-02-07 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
| GB9816337D0 (en) * | 1998-07-27 | 1998-09-23 | Cortecs Uk Ltd | Proteins |
| US6824997B1 (en) | 1998-09-18 | 2004-11-30 | Binax, Inc. | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies |
| US9134303B1 (en) | 1998-08-25 | 2015-09-15 | Alere Scarborough, Inc. | ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto |
| US20080096236A1 (en) * | 1998-08-25 | 2008-04-24 | Binax, Inc. | Method for Detecting the Presence of Target Bacteria or a Target Component Carbohydrate Antigen Thereof |
| US6146902A (en) * | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| GB9906437D0 (en) * | 1999-03-19 | 1999-05-12 | Smithkline Beecham Biolog | Vaccine |
| HU229968B1 (hu) * | 1999-03-19 | 2015-03-30 | Smithkline Beecham Biologicals S.A | Sztreptokokkusz oltóanyag |
| US20040191834A1 (en) * | 1999-10-28 | 2004-09-30 | Laferriere Craig Antony Joseph | Novel method |
| EP2279748A1 (en) * | 2000-06-29 | 2011-02-02 | SmithKline Beecham Biologicals S.A. | Multivalent vaccine composition |
| GB0108364D0 (en) | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| WO2004050711A2 (en) * | 2002-12-03 | 2004-06-17 | Sloan-Kettering Institute For Cancer Research | Gp120 specific antigens, conjugates thereof, methods for their preparation and uses thereof |
| US7369578B2 (en) * | 2003-07-01 | 2008-05-06 | Nortel Networks Limited | Digital processing of SONET pointers |
| MY144231A (en) * | 2003-12-17 | 2011-08-15 | Wyeth Corp | Aß IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME |
| CN1984676A (zh) * | 2003-12-17 | 2007-06-20 | 惠氏公司 | 免疫原性肽载体结合物及其生产方法 |
| JP2008513406A (ja) | 2004-09-22 | 2008-05-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| EP2425853A1 (en) * | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent Pneumococcal Polysaccharide-Protein Conjugate Composition |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| KR101408113B1 (ko) | 2005-06-27 | 2014-06-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| EA014107B1 (ru) | 2005-12-22 | 2010-10-29 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae |
| GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| CN101024079B (zh) * | 2006-02-17 | 2012-02-01 | 福州昌晖生物工程有限公司 | 肺炎链球菌多糖-外膜蛋白结合疫苗及制备方法 |
| BRPI0710210A2 (pt) | 2006-03-30 | 2011-05-24 | Glaxomithkline Biolog S A | composição imunogênica, vacina, métodos para preparar a vacina, e para prevenir ou tratar infecção estafilocócica, uso da composição imunogênica, e, processo para conjugar oligassacarìdeo ou polissacarìdeo capsular |
| AU2013200552B9 (en) * | 2006-04-07 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Conjugate vaccines |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| CN101553246B (zh) * | 2006-08-07 | 2019-05-21 | 哈佛大学校长及研究员协会 | 蛋白质基质疫苗及这种疫苗的制备和给药方法 |
| HRP20120557T1 (hr) | 2006-09-07 | 2012-07-31 | GlaxoSmithKline@Biologicals@s@a | Kombinirano cjepivo sa smanjenim količinama antigena poliovirusa |
| ATE473289T1 (de) * | 2006-10-10 | 2010-07-15 | Wyeth Llc | Verbesserte verfahren zur trennung von streptococcus pneumoniae-3-polysacchariden |
| CN1963500B (zh) * | 2006-12-06 | 2010-05-12 | 云南沃森生物技术股份有限公司 | 一种肺炎链球菌荚膜多糖结合物中游离多糖含量的测定方法 |
| GB0700136D0 (en) | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| HUE039169T2 (hu) | 2007-03-23 | 2018-12-28 | Wyeth Llc | Rövidített tisztítási eljárás Streptococcus pneumoniae tok-poliszacharidok elõállítására |
| US8398985B2 (en) | 2007-04-23 | 2013-03-19 | Serum Institute Of India Ltd. | Antigenic polysaccharides and process for their preparation |
| MX2009011837A (es) | 2007-05-02 | 2010-04-22 | Glaxosmithkline Biolog Sa | Vacuna. |
| US20100183662A1 (en) | 2007-06-26 | 2010-07-22 | Ralph Leon Biemans | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
| WO2010042481A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
| MX2011006432A (es) * | 2008-12-18 | 2011-09-29 | Wyeth Llc | Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a. |
| KR101307703B1 (ko) * | 2008-12-18 | 2013-09-11 | 와이어쓰 엘엘씨 | 탄소를 사용하여 스트렙토코커스 뉴모니에 폴리사카라이드 분자량을 조절하는 방법 |
| EP2387417B1 (en) | 2009-01-16 | 2016-05-11 | University of Maryland, Baltimore | Broad spectrum vaccine against non-typhoidal salmonella |
| EP2414387B1 (en) | 2009-04-03 | 2015-12-16 | University Of Chicago | Compositions and methods related to protein a (spa) variants |
| US20120135037A1 (en) | 2009-06-01 | 2012-05-31 | Mizel Steven B | Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same |
| KR101748453B1 (ko) * | 2009-06-29 | 2017-06-16 | 제노시아 바이오사이언스, 인크. | 폐렴구균(Streptococcus Pneumoniae)에 대항하는 백신과 조성물 |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| JP2013523818A (ja) | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法 |
| WO2011148382A1 (en) | 2010-05-28 | 2011-12-01 | Biological E Limited | An improved process for the purification of capsular polysaccharides of haemophilus influenza - b, neisseria meningitis such as serotypes a, c, y and w-135, and other similar related capsular polysaccharides produced from both gram negative and gram positive microorganisms using aluminium phosphate with alcohol. |
| ES2655701T3 (es) | 2010-07-02 | 2018-02-21 | The University Of Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SpA) |
| US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
| MY163871A (en) | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
| GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
| EP2688573B1 (en) | 2011-03-22 | 2016-11-30 | Serum Institute of India Private Limited | A novel process for preparation of polysaccharides |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| DK3106176T3 (en) | 2011-12-06 | 2018-01-08 | Valneva Austria Gmbh | ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES |
| WO2013109995A2 (en) | 2012-01-20 | 2013-07-25 | Genocea Biosciences, Inc. | Fused antigen vaccines and compositions against streptococcus pneumoniae |
| EP3805395A1 (en) | 2012-04-26 | 2021-04-14 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
| ITMI20121597A1 (it) * | 2012-09-25 | 2014-03-26 | Beta Pharma S A | Coniugato tra frammento di parete cellulare batterica ed un veicolo mucopolisaccaridico e suoi usi in ambito medico |
| AU2014214844B2 (en) | 2013-02-07 | 2017-12-14 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| HK1224300A1 (zh) * | 2013-07-07 | 2017-08-18 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | 合成针对1型肺炎链球菌的疫苗 |
| US11708411B2 (en) | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| PT3096785T (pt) * | 2014-01-21 | 2020-10-13 | Pfizer | Composições imunogénicas que compreendem antigénios de sacáridos capsulares conjugados e utilizações das mesmas |
| RU2743793C1 (ru) * | 2014-01-21 | 2021-02-26 | Пфайзер Инк. | Капсульные полисахариды Streptococcus pneumoniae и их конъюгаты |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| JP2017505792A (ja) * | 2014-02-14 | 2017-02-23 | ファイザー・インク | 免疫原性糖タンパク質コンジュゲート |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| AU2016276269B2 (en) * | 2015-06-08 | 2021-01-28 | Serum Institute Of India Private Ltd. | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof |
| WO2017117539A1 (en) | 2015-12-30 | 2017-07-06 | Northwestern University | Cell-free glycoprotein synthesis (cfgps) in prokaryotic cell lysates enriched with components for glycosylation |
| EP4488286A3 (en) | 2016-03-31 | 2025-04-02 | Pogona, Llc | Saccharide-polypeptide conjugate compositions and methods of use thereof |
| US11191822B2 (en) | 2016-06-22 | 2021-12-07 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Pneumococcal polysaccharide-protein conjugate composition |
| EP3269385A1 (en) | 2016-07-12 | 2018-01-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Pneumococcal polysaccharide-protein conjugate composition |
| US10829795B2 (en) | 2016-07-14 | 2020-11-10 | Northwestern University | Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates |
| MA47223A (fr) | 2016-12-30 | 2019-11-06 | Sutrovax Inc | Conjugués polypeptide-antigène avec des acides aminés non naturels |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20240169144A (ko) | 2017-01-31 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 다당류-단백질 접합체 제조 방법 |
| EP3576759B1 (en) | 2017-01-31 | 2025-09-24 | Merck Sharp & Dohme LLC | Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f |
| WO2018144799A1 (en) | 2017-02-03 | 2018-08-09 | SCHADECK, Eva, Barbara | Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof |
| PT3585803T (pt) | 2017-02-24 | 2025-12-22 | Merck Sharp & Dohme | Formulações de vacina pneumocócica conjugada |
| US11400162B2 (en) | 2017-02-24 | 2022-08-02 | Merck Sharp & Dohme Llc | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
| WO2018156467A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Methods for improving filterability of polysaccharide-protein conjugate reactions |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| WO2018227177A1 (en) | 2017-06-10 | 2018-12-13 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| MX394767B (es) | 2017-09-07 | 2025-03-24 | Merck Sharp & Dohme Llc | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| BR112020004410A8 (pt) | 2017-09-07 | 2023-01-31 | Merck Sharp & Dohme | Processos para a formulação de polissacarídeos pneumocócicos para conjugação a uma proteína carreadora |
| FI3678654T3 (fi) | 2017-09-07 | 2024-09-02 | Merck Sharp & Dohme Llc | Pneumokokkipolysakkaridit ja niiden käyttö immunogeenisissä polysakkaridi-kantajaproteiini-konjugaateissa |
| CN116898959A (zh) | 2017-09-07 | 2023-10-20 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| US11524076B2 (en) | 2017-09-07 | 2022-12-13 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| KR20250046326A (ko) | 2017-09-07 | 2025-04-02 | 머크 샤프 앤드 돔 엘엘씨 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
| WO2019070994A1 (en) | 2017-10-04 | 2019-04-11 | Liffey Biotech Limited | SACCHARIDE-POLYPEPTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE |
| AU2018400751B2 (en) | 2017-12-06 | 2022-07-21 | Merck Sharp & Dohme Llc | Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| CN108079286B (zh) * | 2018-01-19 | 2020-07-31 | 云南沃森生物技术股份有限公司 | 一种13价肺炎球菌多糖-蛋白结合物组合物及其制备方法和应用 |
| US11530432B2 (en) | 2018-03-19 | 2022-12-20 | Northwestern University | Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates |
| GEAP202415690A (en) | 2018-12-19 | 2024-01-10 | Merck Sharp & Dohme Llc | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| EP3908669A4 (en) | 2019-01-11 | 2023-05-03 | Northwestern University | SYNTHESIS OF BIOCONJUGATED VACCINES IN PROKARYOT CELL LYSATE |
| CA3139257A1 (en) | 2019-05-10 | 2020-11-19 | Glaxosmithkline Biologicals Sa | Conjugate production |
| US12226410B2 (en) | 2019-10-18 | 2025-02-18 | Northwestern University | Methods for enhancing cellular clearance of pathological molecules via activation of the cellular protein ykt6 |
| US12503715B2 (en) | 2019-10-25 | 2025-12-23 | Northwestern University | Cell-free extract preparation protocol for enrichment of membrane vesicles and increased glycoprotein yields |
| CA3161857A1 (en) | 2019-11-22 | 2021-05-27 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
| WO2021173632A1 (en) * | 2020-02-25 | 2021-09-02 | Merck Sharp & Dohme Corp. | Methods for monitoring the progress of polysaccharide size-reduction |
| EP3900739A1 (en) | 2020-04-21 | 2021-10-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic streptococcus pneumoniae saccharide conjugates to conserved membrane protein |
| EP3919076A1 (en) | 2020-06-02 | 2021-12-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic oligosaccharide vaccines against streptococcus pneumoniae with microparticle adjuvant formulations |
| US20230250142A1 (en) | 2020-06-12 | 2023-08-10 | Glaxosmithkline Biologicals Sa | Dock tag system |
| US12053515B2 (en) | 2020-08-10 | 2024-08-06 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F |
| TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
| WO2022180648A1 (en) | 2021-02-26 | 2022-09-01 | Biological E Limited | Activated-quenched polysaccharide and improved methods for quantification of polysaccharide in a vaccine composition |
| EP4169513A1 (en) | 2021-10-19 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Adjuvant composition comprising sting agonists |
| AU2023346659A1 (en) | 2022-09-19 | 2025-03-27 | Biological E Limited | Method for the purification of capsular polysaccharides |
| TW202500153A (zh) | 2023-05-18 | 2025-01-01 | 美商默沙東有限責任公司 | 用於肺炎鏈球菌疫苗之化合物及佐劑調配物 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4324887A (en) * | 1978-08-16 | 1982-04-13 | President And Fellows Of Harvard College | Type II group B Streptococci polysaccharide |
| US4221906A (en) * | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| US4271147A (en) * | 1980-01-10 | 1981-06-02 | Behringwerke Aktiengesellschaft | Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same |
| IE51174B1 (en) * | 1980-04-14 | 1986-10-29 | Merck & Co Inc | Group b streptococcal capsular polysaccharides |
| FR2495939B1 (fr) * | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| NL8202527A (nl) * | 1982-06-22 | 1984-01-16 | Univ Utrecht | Vaccins tegen door bacterien met kapsel-polysacchariden verwekte ziekten en werkwijze voor het bereiden daarvan. |
| US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
| US4619828A (en) * | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
| US4644059A (en) * | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| US4459286A (en) * | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4882317A (en) * | 1984-05-10 | 1989-11-21 | Merck & Co., Inc. | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency |
| NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| IT1187753B (it) * | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| US4707543A (en) * | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| ES2000034A6 (es) * | 1985-11-26 | 1987-10-01 | Schweiz Serum & Impfinst | Procedimiento para la preparacion de una vacuna viva contra paperas |
| US4755381A (en) * | 1986-03-27 | 1988-07-05 | Swiss Serum And Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
| JP2754000B2 (ja) * | 1986-04-16 | 1998-05-20 | ザ ブリガム アンド ウィメンズ ホスピタル,インコーポレイテッド | 細菌抗原、抗体、ワクチン及びその製造方法 |
| NZ223009A (en) * | 1986-12-31 | 1990-06-26 | Nl Rivm Of Thoven | Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens |
| ATE105189T1 (de) * | 1988-04-19 | 1994-05-15 | American Cyanamid Co | Haemophilus influenzae typ b polysaccharidaussermembranprotein-konjugat als impfstoff. |
| US5091300A (en) * | 1989-08-03 | 1992-02-25 | Merck & Co., Inc. | Radio-immuno assay for hepatitis b virus pres2 antibodies |
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| JP2636128B2 (ja) * | 1993-02-03 | 1997-07-30 | 株式会社アマダメトレックス | パンチング金型 |
-
1992
- 1992-01-20 CA CA002059692A patent/CA2059692C/en not_active Expired - Lifetime
- 1992-01-21 IL IL10071692A patent/IL100716A/en not_active IP Right Cessation
- 1992-01-21 IL IL11996192A patent/IL119961A/xx not_active IP Right Cessation
- 1992-01-21 IL IL11996292A patent/IL119962A/xx not_active IP Right Cessation
- 1992-01-22 NZ NZ241367A patent/NZ241367A/en not_active IP Right Cessation
- 1992-01-23 SK SK199-92A patent/SK280659B6/sk not_active IP Right Cessation
- 1992-01-23 CZ CS92199A patent/CZ283284B6/cs not_active IP Right Cessation
- 1992-01-24 AU AU10467/92A patent/AU651656B2/en not_active Expired
- 1992-01-27 DK DK92300655.5T patent/DK0497525T4/da active
- 1992-01-27 SI SI9210081A patent/SI9210081B/sl unknown
- 1992-01-27 IE IE024492A patent/IE920244A1/en unknown
- 1992-01-27 EP EP92300655A patent/EP0497525B2/en not_active Expired - Lifetime
- 1992-01-27 ES ES92300655T patent/ES2121820T5/es not_active Expired - Lifetime
- 1992-01-27 AT AT92300655T patent/ATE169825T1/de not_active IP Right Cessation
- 1992-01-27 YU YU8192A patent/YU49068B/sh unknown
- 1992-01-27 KR KR1019920001108A patent/KR100243958B1/ko not_active Expired - Lifetime
- 1992-01-27 CN CN92100700A patent/CN1080124C/zh not_active Expired - Lifetime
- 1992-01-27 DE DE69226668T patent/DE69226668T3/de not_active Expired - Lifetime
- 1992-01-27 NO NO920350A patent/NO304117B1/no not_active IP Right Cessation
- 1992-01-27 HU HUP9200252A patent/HU216101B/hu unknown
- 1992-01-27 MX MX9200328A patent/MX9200328A/es unknown
- 1992-01-27 FI FI920353A patent/FI107370B/fi active
- 1992-01-28 JP JP4012941A patent/JPH0794472B2/ja not_active Expired - Lifetime
-
1994
- 1994-05-20 US US08/246,394 patent/US5623057A/en not_active Expired - Lifetime
-
1997
- 1997-01-03 IL IL11996297A patent/IL119962A0/xx unknown
- 1997-01-03 IL IL11996197A patent/IL119961A0/xx unknown
-
1999
- 1999-04-26 LV LVP-99-69A patent/LV12309B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI9210081B (en) | Pneumococcal polysaccharide conjugate vaccine | |
| JP7796163B2 (ja) | 肺炎連鎖球菌多糖-タンパク質コンジュゲートの免疫原性の増強 | |
| AU601742B2 (en) | Immunogenic conjugates | |
| JP3027452B2 (ja) | 改良されたオリゴ糖結合体ワクチン | |
| DK171420B1 (da) | Kovalent-modificeret bakterielt polysaccharid/protein-konjugat, fremgangsmåde til fremstilling deraf og præparat omfattende et polysaccharid/protein-konjugat | |
| CA2692069C (en) | Modified polysaccharides for conjugate vaccines | |
| AU2007353769B2 (en) | Multivalent pneumococcal polysaccharide-protein conjugate composition | |
| HK1003326B (en) | Immunogenic conjugates | |
| HUE028421T2 (en) | Multivalent pneumococcal polysaccharide-protein conjugate preparation | |
| WO1996021465A2 (en) | Immunogenic conjugate molecules | |
| KR20090094163A (ko) | 다가 폐렴구균 다당류-단백질 접합체 조성물 | |
| JP2018518512A (ja) | 多価肺炎球菌コンジュゲートワクチン | |
| KR20220017996A (ko) | 면역원성 혈청형 35b 폐렴구균 폴리사카라이드-단백질 접합체 및 그를 제조하기 위한 접합 방법 | |
| KR102428253B1 (ko) | 신규한 다당류-단백질 접합체 및 이의 제조방법 | |
| AU2005302269B2 (en) | Modified streptococcal polysaccharides and uses thereof | |
| Joshi et al. | Meningococcal polysaccharide vaccines: A review | |
| AU733845B2 (en) | Immunogenic complex, use, method of preparation thereof and vaccine containing same | |
| US20250134980A1 (en) | Immunogenic compositions against enteric diseases and methods for its preparation thereof | |
| WO2020095324A1 (en) | Multivalent glycoconjugates immunogenic compositions | |
| WO2010015701A1 (en) | Improved bacterial polysaccharide-polypeptide conjugate compositions | |
| OA20613A (en) | Immunogenic compositions against enteric diseases and methods for its preparation thereof. | |
| KR20220018939A (ko) | 폐렴구균 다당류-세포벽 유래 물질 접합체를 포함하는 면역원성 조성물 | |
| BG60630B2 (bg) | Ковалентно модифицирани полианионни бактериални полизахариди,техни стабилни ковалентни конюгати с имуногенни протеини свързани с хибридни молекули, |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| SP73 | Change of data on owner |
Owner name: MERCK SHARP & DOHME CORP.; US Effective date: 20100330 |