MX2011006432A - Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a. - Google Patents
Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a.Info
- Publication number
- MX2011006432A MX2011006432A MX2011006432A MX2011006432A MX2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A MX 2011006432 A MX2011006432 A MX 2011006432A
- Authority
- MX
- Mexico
- Prior art keywords
- fermentation culture
- streptococcus pneumoniae
- molecular weight
- capsular polysaccharides
- pneumoniae serotype
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 229920001282 polysaccharide Polymers 0.000 title abstract 4
- 239000005017 polysaccharide Substances 0.000 title abstract 4
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 abstract 7
- 230000004151 fermentation Effects 0.000 abstract 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La presente invención proporciona métodos mejorados para producir una solución que contiene polisacáridos capsulares Streptococcus pneumoniae 19A aislados de elevado peso molecular. En ciertos métodos, un cultivo de fermentación de células bacteriales Streptococcus pneumoniae que producen polisacáridos capsulares serotipo 19A es fermentado por menos de 6 horas antes de que las células bacteriales sean usadas y se recolecten los polisacáridos capsulares. En otros métodos, el CO2 es suministrado al cultivo de fermentación. El suministro de CO2 al cultivo de fermentación incluye agregar iones bicarbonato al cultivo de fermentación, agregar iones carbonato al cultivo de fermentación, agregar mezclas de iones bicarbonato y carbonato al cultivo de fermentación, y sobreponer el cultivo de fermentación con CO2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13856308P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/068429 WO2010080486A2 (en) | 2008-12-18 | 2009-12-17 | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011006432A true MX2011006432A (es) | 2011-09-29 |
Family
ID=42266457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006432A MX2011006432A (es) | 2008-12-18 | 2009-12-17 | Metodo para controlar el peso molecular del polisacarido streptococcus pneumoniae serotipo 19a. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8795689B2 (es) |
| EP (1) | EP2379734B1 (es) |
| JP (1) | JP5843612B2 (es) |
| KR (2) | KR101593770B1 (es) |
| CN (1) | CN102257155B (es) |
| AU (1) | AU2009335826B2 (es) |
| BR (1) | BRPI0922981A8 (es) |
| CA (1) | CA2743710C (es) |
| DK (1) | DK2379734T3 (es) |
| ES (1) | ES2666698T3 (es) |
| HU (1) | HUE037465T2 (es) |
| IL (1) | IL213169A (es) |
| MX (1) | MX2011006432A (es) |
| PL (1) | PL2379734T3 (es) |
| PT (1) | PT2379734T (es) |
| RU (1) | RU2511404C2 (es) |
| SI (1) | SI2379734T1 (es) |
| WO (1) | WO2010080486A2 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2749952T3 (es) * | 2008-12-18 | 2020-03-24 | Wyeth Llc | Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono |
| ES2552153T3 (es) | 2009-04-30 | 2015-11-26 | Coley Pharmaceutical Group, Inc. | Vacuna neumocócica y usos de la misma |
| US9249439B2 (en) | 2011-12-15 | 2016-02-02 | Serum Institute Of India Ltd. | Process of cultivating bacteria for yield improvement of capsular polyoses |
| WO2014038879A1 (ko) | 2012-09-07 | 2014-03-13 | 에스케이케미칼주식회사 | 폐렴 구균 혈청형을 갖는 협막 다당류의 제조방법 |
| CN110366428B (zh) | 2016-12-30 | 2024-05-17 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| AU2018225099B2 (en) | 2017-02-24 | 2024-08-22 | Merck Sharp & Dohme Llc | Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| CN118356485A (zh) | 2017-06-10 | 2024-07-19 | 创赏公司 | 提供改善的免疫原性和亲合力的具有二价或多价缀合物多糖的多价缀合物疫苗 |
| US11395849B2 (en) | 2017-09-07 | 2022-07-26 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| CA3074711A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| SG11202005255PA (en) | 2017-12-06 | 2020-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| KR20190121713A (ko) * | 2018-04-18 | 2019-10-28 | 에스케이바이오사이언스(주) | 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체 |
| US20210252125A1 (en) | 2018-04-30 | 2021-08-19 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| US11896656B2 (en) | 2018-04-30 | 2024-02-13 | Merck Sharp & Dohme Llc | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| JOP20210148A1 (ar) | 2018-12-19 | 2023-01-30 | Merck Sharp & Dohme | تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها |
| CA3191005A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US4686102A (en) | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5314822A (en) * | 1992-10-15 | 1994-05-24 | Merck & Co., Inc. | Method of clonal growth of Streptococcus pneumoniae |
| US5714354A (en) | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| IL151772A0 (en) * | 2000-03-16 | 2003-04-10 | Philadelphia Children Hospital | Methods for producing pneumococcal capsular polysaccharide |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| ITTS20010013A1 (it) | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| DK1664319T3 (da) | 2003-09-11 | 2010-05-10 | Staat Der Nederlanden Vert Doo | Fremgangsmåde til fremstilling af et kapsel-polysaccharid til anvendelse i konjugatvacciner |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| DK1866342T3 (en) | 2005-04-08 | 2019-01-28 | Wyeth Llc | SEPARATION OF POLLUTANTS CONTAMINATING FROM STREPTOCOCCUS PNEUMONIAE POLYSACCHARID BY PH-MANIPULATION |
| DK1868645T3 (da) | 2005-04-08 | 2012-04-10 | Wyeth Llc | Multivalent pneumokok-sakkarid-protein-konjugat-sammensætning |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| JP5260531B2 (ja) | 2006-10-10 | 2013-08-14 | ワイス・エルエルシー | 肺炎連鎖球菌３型多糖体の精製 |
| US7860500B2 (en) * | 2006-10-27 | 2010-12-28 | Motorola, Inc. | Method and apparatus for determining appropriate channels for communication |
| KR101500771B1 (ko) * | 2007-03-23 | 2015-03-18 | 와이어쓰 엘엘씨 | 스트렙토코커스 뉴모니아 협막 다당류를 제조하기 위한 단축 정제 방법 |
| ES2749952T3 (es) | 2008-12-18 | 2020-03-24 | Wyeth Llc | Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono |
-
2009
- 2009-12-17 KR KR1020137031507A patent/KR101593770B1/ko active Active
- 2009-12-17 SI SI200931830T patent/SI2379734T1/en unknown
- 2009-12-17 HU HUE09795862A patent/HUE037465T2/hu unknown
- 2009-12-17 JP JP2011542425A patent/JP5843612B2/ja active Active
- 2009-12-17 MX MX2011006432A patent/MX2011006432A/es active IP Right Grant
- 2009-12-17 KR KR1020117013836A patent/KR20110091546A/ko not_active Ceased
- 2009-12-17 WO PCT/US2009/068429 patent/WO2010080486A2/en not_active Ceased
- 2009-12-17 AU AU2009335826A patent/AU2009335826B2/en active Active
- 2009-12-17 ES ES09795862.3T patent/ES2666698T3/es active Active
- 2009-12-17 DK DK09795862.3T patent/DK2379734T3/en active
- 2009-12-17 EP EP09795862.3A patent/EP2379734B1/en active Active
- 2009-12-17 CA CA2743710A patent/CA2743710C/en active Active
- 2009-12-17 PL PL09795862T patent/PL2379734T3/pl unknown
- 2009-12-17 RU RU2011128564/10A patent/RU2511404C2/ru active
- 2009-12-17 CN CN200980150879.5A patent/CN102257155B/zh active Active
- 2009-12-17 PT PT97958623T patent/PT2379734T/pt unknown
- 2009-12-17 US US12/640,769 patent/US8795689B2/en active Active
- 2009-12-17 BR BRPI0922981-7 patent/BRPI0922981A8/pt not_active Application Discontinuation
-
2011
- 2011-05-26 IL IL213169A patent/IL213169A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2379734B1 (en) | 2018-03-21 |
| ES2666698T3 (es) | 2018-05-07 |
| KR101593770B1 (ko) | 2016-02-15 |
| PT2379734T (pt) | 2018-04-27 |
| WO2010080486A3 (en) | 2010-11-04 |
| US20100158953A1 (en) | 2010-06-24 |
| HK1163750A1 (zh) | 2012-09-14 |
| KR20110091546A (ko) | 2011-08-11 |
| CA2743710C (en) | 2017-01-24 |
| AU2009335826A1 (en) | 2010-07-15 |
| KR20130136011A (ko) | 2013-12-11 |
| JP2012512660A (ja) | 2012-06-07 |
| WO2010080486A2 (en) | 2010-07-15 |
| CN102257155A (zh) | 2011-11-23 |
| PL2379734T3 (pl) | 2018-08-31 |
| IL213169A0 (en) | 2011-07-31 |
| EP2379734A2 (en) | 2011-10-26 |
| IL213169A (en) | 2015-02-26 |
| BRPI0922981A2 (pt) | 2015-08-25 |
| BRPI0922981A8 (pt) | 2019-11-26 |
| DK2379734T3 (en) | 2018-04-23 |
| SI2379734T1 (en) | 2018-05-31 |
| CA2743710A1 (en) | 2010-07-15 |
| JP5843612B2 (ja) | 2016-01-13 |
| AU2009335826B2 (en) | 2013-10-31 |
| RU2011128564A (ru) | 2013-01-27 |
| RU2511404C2 (ru) | 2014-04-10 |
| CN102257155B (zh) | 2016-03-02 |
| US8795689B2 (en) | 2014-08-05 |
| HUE037465T2 (hu) | 2018-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |