SE8107702L - Forfarande for framstellning av indenettiksyror - Google Patents
Forfarande for framstellning av indenettiksyrorInfo
- Publication number
- SE8107702L SE8107702L SE8107702A SE8107702A SE8107702L SE 8107702 L SE8107702 L SE 8107702L SE 8107702 A SE8107702 A SE 8107702A SE 8107702 A SE8107702 A SE 8107702A SE 8107702 L SE8107702 L SE 8107702L
- Authority
- SE
- Sweden
- Prior art keywords
- methyl
- halogen
- fluoro
- indenetic
- acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 3
- 150000007513 acids Chemical class 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229910052736 halogen Chemical group 0.000 claims 4
- 150000002367 halogens Chemical group 0.000 claims 4
- -1 butyryl halide Chemical class 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- HMJXQEIMQBPTHN-UHFFFAOYSA-N 5-fluoro-2-methyl-2,3-dihydroinden-1-one Chemical compound FC1=CC=C2C(=O)C(C)CC2=C1 HMJXQEIMQBPTHN-UHFFFAOYSA-N 0.000 claims 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/75—Reactions with formaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (2)
1. Firfarande fbr framstallning ay 5-fluor-2-mety1-1-(R1- bensyl)-inden, van i Ri betecknar p-netyltio eller p-metylsulfinyl, kannetecknat darav, att en syrahalid med funnels: A 0 In G -C-C- Z earl A betecknar metyl eller tillsammans med G bildar metyliden, B betecknar vate, metyl eller halogen, G betecknar metyl, CH2R eller tillsammans med A bildar metyliden, varvid R betecknar halogen, hydroxi, dess etrar eller estrar eller -N-(C1_-alky1)2, Z betecknar halogen och varvid (1) nar A och G tillsammans betecknar metyl,, B betecknar halogen och varvid (3) ar A betecknar metyl och I betecknar mate, G betecknar CH2R, bringas att reagera med fluorbensen under Friedel-Crafts-betingelser fir bildning av 5- fluor-2-mety1-1-indanon och att denna -fluor-2-mety1-1-indanon bringas att reagera med en Iybensylforening, van i Ri bar oven an-given getydelse, under Grignard- eller Wittig-betingelser.
2. Firfarande enligt krav 1, kannetecknat darav, att syrahalid'r en o-halog,)butyrylhalid, foretrades- vis a-bromisobutyrylb,,mid.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US426864A US3870753A (en) | 1973-12-20 | 1973-12-20 | Process for preparing indenyl acetic acids |
| US05/486,031 US3970693A (en) | 1974-07-05 | 1974-07-05 | Process for preparing indene acetic acids |
| US05/509,602 US3944600A (en) | 1973-12-20 | 1974-09-30 | Indenylidene-3-acetic acid process for preparing indene acetic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8107702L true SE8107702L (sv) | 1981-12-22 |
| SE440774B SE440774B (sv) | 1985-08-19 |
Family
ID=27411527
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7415063A SE426818B (sv) | 1973-12-20 | 1974-12-02 | Forfarande for framstellning av 5-fluor-2-metyl-1-(p-metylsulfinylbesyliden)-inden-3-ettiksyra eller dess syraadditionssalt |
| SE8107702A SE440774B (sv) | 1973-12-20 | 1981-12-22 | Forfarande for framstellning av 5-fluor-2-metyl-1-(r-bensyl)-inden, vari r?711 betecknar p-metyltio eller p-metylsulfinyl |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7415063A SE426818B (sv) | 1973-12-20 | 1974-12-02 | Forfarande for framstellning av 5-fluor-2-metyl-1-(p-metylsulfinylbesyliden)-inden-3-ettiksyra eller dess syraadditionssalt |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5331153B2 (sv) |
| AR (2) | AR210484A1 (sv) |
| CA (1) | CA1044255A (sv) |
| CH (1) | CH616152A5 (sv) |
| DD (1) | DD116819A5 (sv) |
| DE (1) | DE2462380C2 (sv) |
| DK (1) | DK140835B (sv) |
| ES (2) | ES432921A1 (sv) |
| FI (1) | FI62287C (sv) |
| FR (1) | FR2255060B1 (sv) |
| GB (1) | GB1479519A (sv) |
| IE (1) | IE41529B1 (sv) |
| NL (1) | NL170534C (sv) |
| NO (2) | NO140857C (sv) |
| SE (2) | SE426818B (sv) |
| YU (2) | YU41017B (sv) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732292A (en) * | 1970-05-01 | 1973-05-08 | Merck & Co Inc | Indenyl compounds |
| US3822310A (en) * | 1971-01-21 | 1974-07-02 | Merck & Co Inc | Substituted indenyl acetic acids |
| NL7200058A (sv) * | 1971-01-21 | 1972-07-25 |
-
1974
- 1974-12-02 FI FI3489/74A patent/FI62287C/fi active
- 1974-12-02 NL NLAANVRAGE7415701,A patent/NL170534C/xx not_active IP Right Cessation
- 1974-12-02 SE SE7415063A patent/SE426818B/sv not_active IP Right Cessation
- 1974-12-04 DK DK629674AA patent/DK140835B/da not_active IP Right Cessation
- 1974-12-05 NO NO744395A patent/NO140857C/no unknown
- 1974-12-10 CA CA215,636A patent/CA1044255A/en not_active Expired
- 1974-12-12 IE IE2557/74A patent/IE41529B1/en unknown
- 1974-12-13 YU YU3316/74A patent/YU41017B/xx unknown
- 1974-12-13 ES ES432921A patent/ES432921A1/es not_active Expired
- 1974-12-14 DD DD183051A patent/DD116819A5/xx unknown
- 1974-12-16 GB GB54320/74A patent/GB1479519A/en not_active Expired
- 1974-12-17 FR FR7441519A patent/FR2255060B1/fr not_active Expired
- 1974-12-18 CH CH1682474A patent/CH616152A5/de not_active IP Right Cessation
- 1974-12-19 DE DE2462380A patent/DE2462380C2/de not_active Expired
- 1974-12-20 JP JP14580474A patent/JPS5331153B2/ja not_active Expired
-
1976
- 1976-01-30 AR AR262084A patent/AR210484A1/es active
- 1976-07-15 AR AR20633476D patent/AR206334A1/es active
-
1977
- 1977-01-25 ES ES455333A patent/ES455333A1/es not_active Expired
-
1979
- 1979-02-05 NO NO790360A patent/NO141892C/no unknown
-
1981
- 1981-03-05 YU YU00559/81A patent/YU55981A/xx unknown
- 1981-12-22 SE SE8107702A patent/SE440774B/sv not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE8107702L (sv) | Forfarande for framstellning av indenettiksyror | |
| WO1989005303A1 (fr) | Procede de fabrication de composes d'alkyles metalliques | |
| GB1508869A (en) | Phenyl ethers and process for their manufacture | |
| ES433533A1 (es) | Procedimiento para la preparacion de abonos granulados a base de fosfatos calcinados que contienen metales alcali- nos. | |
| IE40501L (en) | Alkyl derivatives of prostanoic acids | |
| CA1045131A (en) | Derivatives of 9-hydroxy-13-trans-prostenoic acid | |
| US3651116A (en) | Silylated prostaglandin f a acids and esters | |
| GB1268699A (en) | New water-soluble reactive monoazo dyestuffs and process for their manufacture | |
| SU375293A1 (ru) | Способ получения триметилгаллия или триметилиндия | |
| GB1421129A (en) | Process for preparing heptadec-16-en-1,2,4-triol derivatives | |
| JPS5254087A (en) | Production prostaglandins | |
| JPS56161348A (en) | Preparation of delta-keto-acid | |
| JPS58210096A (ja) | ホスホン酸の製造法 | |
| JPS53105459A (en) | Preparation of 3-(2-cyclopentenyl)ketones | |
| SE7904739L (sv) | Forfarande for framstellning av n-tritylimidazolforeningar | |
| FR2326184A1 (fr) | Analogues de prostaglandines et leur preparation | |
| GB1309331A (en) | Process for preparing methyl and ethyl-10-epoxy-7-preparing methyl and ethyl-10-epoxy-7-ethyl-3,11-dimethyl-2,6-tridecadienoate | |
| JPS5936658A (ja) | プロスタグランジンｅ↓１類の製造法 | |
| GB1496716A (en) | (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids | |
| GB1470342A (en) | Benzanthrone derivatives and process for preparing them | |
| JPS5490178A (en) | 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation | |
| DE3165346D1 (en) | Dihydro-as-triazino(5,6-c)quinoline derivatives, process for their preparation and pharmaceutical compositions containing these compounds | |
| JPS5476555A (en) | Production of intermediate for prostaglandin analog | |
| SU591453A1 (ru) | Способ получени сложных эфиров 3-оксапентанола | |
| GB1142760A (en) | Process for the preparation of phenthiazine derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8107702-6 Effective date: 19950110 Format of ref document f/p: F |
|
| NUG | Patent has lapsed |
Ref document number: 8107702-6 Format of ref document f/p: F |