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RU2745557C3 - Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование - Google Patents

Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование

Info

Publication number
RU2745557C3
RU2745557C3 RU2018139379A RU2018139379A RU2745557C3 RU 2745557 C3 RU2745557 C3 RU 2745557C3 RU 2018139379 A RU2018139379 A RU 2018139379A RU 2018139379 A RU2018139379 A RU 2018139379A RU 2745557 C3 RU2745557 C3 RU 2745557C3
Authority
RU
Russia
Prior art keywords
alpha
sialylation
fsh
stimulating hormone
recombinant follicle
Prior art date
Application number
RU2018139379A
Other languages
English (en)
Other versions
RU2745557C1 (ru
Original Assignee
Ферринг Интернэшнл Сентер СА
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2745557(C3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ферринг Интернэшнл Сентер СА filed Critical Ферринг Интернэшнл Сентер СА
Application granted granted Critical
Publication of RU2745557C1 publication Critical patent/RU2745557C1/ru
Publication of RU2745557C3 publication Critical patent/RU2745557C3/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (1)

  1. Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий α2,3- и α2,6-сиалирование, где от 11,5 до 15,76% общего сиалирования рекомбинантного ФСГ представляет собой α2,6-сиалирование, обеспеченное активностью эндогенной сиалилтрансферазы, экспрессированный в клеточной линии Реr.С6, которая модифицирована с использованием α2,3-сиалилтрансферазы.
RU2018139379A 2008-04-16 2018-11-08 Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование RU2745557C3 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
US61/045,424 2008-04-16
EP08251528 2008-04-25
EP08251528.9 2008-04-25

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2014141994A Division RU2682270C2 (ru) 2008-04-16 2009-04-16 Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021105626A Division RU2021105626A (ru) 2021-03-04 Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование

Publications (2)

Publication Number Publication Date
RU2745557C1 RU2745557C1 (ru) 2021-03-29
RU2745557C3 true RU2745557C3 (ru) 2021-12-10

Family

ID=39717519

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2010141908/10A RU2537268C2 (ru) 2008-04-16 2009-04-16 Рекомбинантный фолликулостимулирующий гормон (фсг), включающий альфа-2, 3- и альфа-2, 6-сиалирование
RU2014141994A RU2682270C2 (ru) 2008-04-16 2009-04-16 Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование
RU2018139379A RU2745557C3 (ru) 2008-04-16 2018-11-08 Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RU2010141908/10A RU2537268C2 (ru) 2008-04-16 2009-04-16 Рекомбинантный фолликулостимулирующий гормон (фсг), включающий альфа-2, 3- и альфа-2, 6-сиалирование
RU2014141994A RU2682270C2 (ru) 2008-04-16 2009-04-16 Рекомбинантный фолликулостимулирующий гормон (ФСГ), включающий альфа-2,3- и альфа-2,6-сиалирование

Country Status (29)

Country Link
US (6) US8951967B2 (ru)
EP (7) EP2722339A1 (ru)
JP (7) JP2011519359A (ru)
KR (5) KR101622944B1 (ru)
CN (3) CN105906702A (ru)
AR (1) AR071479A1 (ru)
AU (5) AU2009237479B2 (ru)
BR (1) BRPI0910461B8 (ru)
CA (1) CA2725257A1 (ru)
CY (1) CY1115413T1 (ru)
DK (6) DK3098234T3 (ru)
ES (5) ES2610277T3 (ru)
FI (4) FI3098234T3 (ru)
FR (3) FR17C1020I2 (ru)
HR (5) HRP20250313T1 (ru)
HU (9) HUE030652T4 (ru)
IL (2) IL208538A (ru)
LT (8) LT3098234T (ru)
MX (3) MX355457B (ru)
NO (4) NO2017025I1 (ru)
NZ (1) NZ588381A (ru)
PL (6) PL3098234T3 (ru)
PT (6) PT3144318T (ru)
RU (3) RU2537268C2 (ru)
SA (1) SA109300228B1 (ru)
SI (6) SI3098234T1 (ru)
TW (1) TWI488640B (ru)
WO (1) WO2009127826A1 (ru)
ZA (1) ZA201007373B (ru)

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Publication number Publication date
ES2468318T3 (es) 2014-06-16
ES2629392T3 (es) 2017-08-09
HUS1700024I1 (hu) 2017-06-28
US8951967B2 (en) 2015-02-10
AU2017225020B2 (en) 2019-11-14
TW200948378A (en) 2009-12-01
PL2808340T3 (pl) 2017-02-28
DK2268666T3 (da) 2014-05-12
DK3098234T3 (da) 2024-10-21
AR071479A1 (es) 2010-06-23
PT4015527T (pt) 2025-04-10
PT2268666E (pt) 2014-06-25
IL230571A (en) 2015-11-30
HRP20170958T1 (hr) 2017-09-22
SI2808340T1 (sl) 2016-12-30
LTPA2025525I1 (ru) 2025-07-25
NO2017025I1 (no) 2017-06-06
NO2025032I1 (no) 2025-07-14
PL2268666T3 (pl) 2014-08-29
SI3144318T1 (sl) 2020-12-31
EP2268666A1 (en) 2011-01-05
US9771407B2 (en) 2017-09-26
PT3144318T (pt) 2020-11-04
SI3045471T1 (sl) 2017-07-31
AU2017225020A1 (en) 2017-09-28
NO2025006I1 (no) 2025-01-16
HRP20161520T1 (hr) 2016-12-30
LT2808340T (lt) 2016-11-10
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
US20180079794A1 (en) 2018-03-22
FR17C1020I2 (fr) 2020-04-10
EP3144318A1 (en) 2017-03-22
US9546204B2 (en) 2017-01-17
RU2537268C2 (ru) 2014-12-27
DK2808340T3 (en) 2016-12-05
AU2009237479A1 (en) 2009-10-22
ES3023526T3 (en) 2025-06-02
JP2020040956A (ja) 2020-03-19
JP7316905B2 (ja) 2023-07-28
FI3098234T3 (fi) 2024-10-31
JP2022031652A (ja) 2022-02-22
ZA201007373B (en) 2011-06-29
MX355457B (es) 2018-04-19
CN105906702A (zh) 2016-08-31
US20210332099A1 (en) 2021-10-28
LT3045471T (lt) 2017-07-10
BRPI0910461B1 (pt) 2021-02-23
AU2014203277A1 (en) 2014-07-24
KR20160056960A (ko) 2016-05-20
CN102066414A (zh) 2011-05-18
HUS2500008I1 (hu) 2025-02-28
IL208538A0 (en) 2010-12-30
HUS2500029I1 (hu) 2025-07-28
AU2017204258A1 (en) 2017-07-20
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