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FR17C1020I2 - Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6 - Google Patents

Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6

Info

Publication number
FR17C1020I2
FR17C1020I2 FR17C1020C FR17C1020C FR17C1020I2 FR 17C1020 I2 FR17C1020 I2 FR 17C1020I2 FR 17C1020 C FR17C1020 C FR 17C1020C FR 17C1020 C FR17C1020 C FR 17C1020C FR 17C1020 I2 FR17C1020 I2 FR 17C1020I2
Authority
FR
France
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR17C1020C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Ferring BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR17C1020(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring BV filed Critical Ferring BV
Application granted granted Critical
Publication of FR17C1020I2 publication Critical patent/FR17C1020I2/fr
Publication of FR17C1020I1 publication Critical patent/FR17C1020I1/fr
Active legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR17C1020C 2008-04-16 2017-06-06 Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6 Active FR17C1020I2 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
EP13193214.7A EP2722339A1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP09733497.3A EP2268666B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation
EP14178729.1A EP2808340B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (2)

Publication Number Publication Date
FR17C1020I2 true FR17C1020I2 (fr) 2020-04-10
FR17C1020I1 FR17C1020I1 (ru) 2020-04-10

Family

ID=39717519

Family Applications (3)

Application Number Title Priority Date Filing Date
FR17C1020C Active FR17C1020I2 (fr) 2008-04-16 2017-06-06 Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6
FR25C1003C Active FR25C1003I1 (fr) 2008-04-16 2025-01-16 Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6
FR25C1025C Active FR25C1025I1 (fr) 2008-04-16 2025-07-02 Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR25C1003C Active FR25C1003I1 (fr) 2008-04-16 2025-01-16 Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6
FR25C1025C Active FR25C1025I1 (fr) 2008-04-16 2025-07-02 Fsh recombinante comprenant la sialylation alpha 2,3 et alpha 2,6

Country Status (29)

Country Link
US (6) US8951967B2 (ru)
EP (7) EP2722339A1 (ru)
JP (7) JP2011519359A (ru)
KR (5) KR101622944B1 (ru)
CN (3) CN105906702A (ru)
AR (1) AR071479A1 (ru)
AU (5) AU2009237479B2 (ru)
BR (1) BRPI0910461B8 (ru)
CA (1) CA2725257A1 (ru)
CY (1) CY1115413T1 (ru)
DK (6) DK3098234T3 (ru)
ES (5) ES2610277T3 (ru)
FI (4) FI3098234T3 (ru)
FR (3) FR17C1020I2 (ru)
HR (5) HRP20250313T1 (ru)
HU (9) HUE030652T4 (ru)
IL (2) IL208538A (ru)
LT (8) LT3098234T (ru)
MX (3) MX355457B (ru)
NO (4) NO2017025I1 (ru)
NZ (1) NZ588381A (ru)
PL (6) PL3098234T3 (ru)
PT (6) PT3144318T (ru)
RU (3) RU2537268C2 (ru)
SA (1) SA109300228B1 (ru)
SI (6) SI3098234T1 (ru)
TW (1) TWI488640B (ru)
WO (1) WO2009127826A1 (ru)
ZA (1) ZA201007373B (ru)

Families Citing this family (29)

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TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
PT2621517E (pt) 2010-09-29 2015-10-16 Ferring Bv Composição para uso no tratamento da infertilidade
JP5918697B2 (ja) 2010-10-15 2016-05-18 Jcrファーマ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
CA3163525A1 (en) * 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) * 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Jcrファーマ株式会社 新規な発現ベクター
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) * 2014-05-31 2020-02-19 Jcrファーマ株式会社 ウリジンとn−アセチル−d−マンノサミンとを含有する培地
JP2018500934A (ja) * 2014-12-22 2018-01-18 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Cmp依存性シアリダーゼ活性
SI3283097T1 (sl) 2015-04-17 2020-06-30 Ferring B.V. FSH za zdravljenje neplodnosti
MY179524A (en) 2015-06-26 2020-11-10 Ferring Bv Methods of purification and/or viral inactivation
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
RS62810B1 (sr) 2017-09-01 2022-02-28 Ferring Bv Kompozicija za kontrolisanu stimulaciju jajnika
HUE071268T2 (hu) 2018-04-30 2025-08-28 Ferring Bv Készítmény szabályozott petefészek-stimuláláshoz
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
AU2022451605A1 (en) 2022-04-01 2024-09-26 Ferring B.V. Mixed protocol for treatment of infertility
US20250333466A1 (en) 2022-05-26 2025-10-30 Ferring B.V. Compositions and methods for treatment of infertility in males
WO2024008971A1 (en) 2022-07-08 2024-01-11 Ferring B.V. Compositions and methods for intrauterine insemination (iui)
AR133300A1 (es) 2023-07-20 2025-09-17 Ferring Bv Micropartículas cargadas con fármaco de liberación prolongada

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US5541083A (en) 1989-10-24 1996-07-30 The Regents Of The University Of California Method for producing secretable glycosyltransferases and other golgi processing enzymes
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ES2350298T3 (es) 2004-02-04 2011-01-20 Centre National De La Recherche Scientifique Procedimiento para el cribado de anticuerpos específicos de glicoforma.
CN103627670B (zh) 2004-02-13 2016-12-21 格莱克托普有限公司 高活性糖蛋白加工条件及其有效生产方法
TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016575A1 (en) 2010-08-03 2012-02-09 King Saud University Stoma coat
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
PT2621517E (pt) 2010-09-29 2015-10-16 Ferring Bv Composição para uso no tratamento da infertilidade
CA3163525A1 (en) 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
SG11201608132UA (en) 2014-04-18 2016-11-29 Glycotope Gmbh Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone

Also Published As

Publication number Publication date
ES2468318T3 (es) 2014-06-16
ES2629392T3 (es) 2017-08-09
HUS1700024I1 (hu) 2017-06-28
US8951967B2 (en) 2015-02-10
AU2017225020B2 (en) 2019-11-14
TW200948378A (en) 2009-12-01
PL2808340T3 (pl) 2017-02-28
DK2268666T3 (da) 2014-05-12
DK3098234T3 (da) 2024-10-21
AR071479A1 (es) 2010-06-23
PT4015527T (pt) 2025-04-10
PT2268666E (pt) 2014-06-25
IL230571A (en) 2015-11-30
HRP20170958T1 (hr) 2017-09-22
SI2808340T1 (sl) 2016-12-30
LTPA2025525I1 (ru) 2025-07-25
NO2017025I1 (no) 2017-06-06
NO2025032I1 (no) 2025-07-14
PL2268666T3 (pl) 2014-08-29
SI3144318T1 (sl) 2020-12-31
EP2268666A1 (en) 2011-01-05
US9771407B2 (en) 2017-09-26
RU2745557C3 (ru) 2021-12-10
PT3144318T (pt) 2020-11-04
SI3045471T1 (sl) 2017-07-31
AU2017225020A1 (en) 2017-09-28
NO2025006I1 (no) 2025-01-16
HRP20161520T1 (hr) 2016-12-30
LT2808340T (lt) 2016-11-10
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
US20180079794A1 (en) 2018-03-22
EP3144318A1 (en) 2017-03-22
US9546204B2 (en) 2017-01-17
RU2537268C2 (ru) 2014-12-27
DK2808340T3 (en) 2016-12-05
AU2009237479A1 (en) 2009-10-22
ES3023526T3 (en) 2025-06-02
JP2020040956A (ja) 2020-03-19
JP7316905B2 (ja) 2023-07-28
FI3098234T3 (fi) 2024-10-31
JP2022031652A (ja) 2022-02-22
ZA201007373B (en) 2011-06-29
MX355457B (es) 2018-04-19
CN105906702A (zh) 2016-08-31
US20210332099A1 (en) 2021-10-28
LT3045471T (lt) 2017-07-10
BRPI0910461B1 (pt) 2021-02-23
AU2014203277A1 (en) 2014-07-24
KR20160056960A (ko) 2016-05-20
CN102066414A (zh) 2011-05-18
HUS2500008I1 (hu) 2025-02-28
IL208538A0 (en) 2010-12-30
HUS2500029I1 (hu) 2025-07-28
AU2017204258A1 (en) 2017-07-20
FI4015527T3 (fi) 2025-04-29
HUE030652T2 (en) 2017-05-29
ES2989729T3 (es) 2024-11-27
IL208538A (en) 2014-03-31
KR20110005863A (ko) 2011-01-19
KR102108377B1 (ko) 2020-05-08
EP3045471B1 (en) 2017-03-29
EP3045471A1 (en) 2016-07-20
HRP20250313T1 (hr) 2025-05-09
PT3098234T (pt) 2024-10-21
LTPA2025505I1 (ru) 2025-02-10
CY1115413T1 (el) 2017-01-04
AU2009237479B2 (en) 2014-05-15
PL3144318T3 (pl) 2021-02-08
FR25C1025I1 (fr) 2025-09-19
JP2024038000A (ja) 2024-03-19
LTPA2017029I1 (lt) 2017-10-10
AU2014203277B2 (en) 2017-04-06
EP3098234A1 (en) 2016-11-30
AU2017204259B2 (en) 2017-08-17
US20160347811A1 (en) 2016-12-01
RU2014141994A3 (ru) 2018-05-28
JP2011519359A (ja) 2011-07-07
FIC20250003I1 (fi) 2025-01-15
PL3098234T3 (pl) 2025-01-07
FR17C1020I1 (ru) 2020-04-10
HUE033830T2 (en) 2018-01-29
HUS1700036I1 (hu) 2017-10-30
EP4015527A1 (en) 2022-06-22
JP2018021037A (ja) 2018-02-08
MX348622B (es) 2017-06-22
AU2014203277C1 (en) 2017-07-27
KR20170110741A (ko) 2017-10-11
AU2017204259A1 (en) 2017-07-20
HUE030652T4 (en) 2017-09-28
JP2015120696A (ja) 2015-07-02
US12516094B2 (en) 2026-01-06
EP4015527B1 (en) 2025-01-22
LTPA2017018I1 (lt) 2017-06-26
HUE068565T2 (hu) 2025-01-28
EP2722339A1 (en) 2014-04-23
HRP20241187T1 (hr) 2024-12-06
US20240327487A1 (en) 2024-10-03
EP3144318B1 (en) 2020-09-23
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RU2682270C2 (ru) 2019-03-18
PT3045471T (pt) 2017-06-14
DK3144318T3 (da) 2020-12-07
SA109300228B1 (ar) 2014-04-08
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SI2268666T1 (sl) 2014-07-31
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BRPI0910461A8 (pt) 2018-10-16
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JP6486310B2 (ja) 2019-03-20
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FR25C1003I1 (fr) 2025-02-28
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EP3098234B1 (en) 2024-07-31
KR20180095140A (ko) 2018-08-24
HUS1700025I1 (hu) 2017-06-28
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AU2017204258B2 (en) 2017-08-17
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BRPI0910461A2 (pt) 2018-03-27

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