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LT4015527T - Rekombinantinis fsh, įskaitant alfa 2,3-, ir alfa 2,6-sialilinimas - Google Patents

Rekombinantinis fsh, įskaitant alfa 2,3-, ir alfa 2,6-sialilinimas

Info

Publication number
LT4015527T
LT4015527T LTEP21212873.0T LT21212873T LT4015527T LT 4015527 T LT4015527 T LT 4015527T LT 21212873 T LT21212873 T LT 21212873T LT 4015527 T LT4015527 T LT 4015527T
Authority
LT
Lithuania
Prior art keywords
alpha
sialylation
recombinant fsh
including alpha
fsh
Prior art date
Application number
LTEP21212873.0T
Other languages
English (en)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4015527(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of LT4015527T publication Critical patent/LT4015527T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1081Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/99Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTEP21212873.0T 2008-04-16 2009-04-16 Rekombinantinis fsh, įskaitant alfa 2,3-, ir alfa 2,6-sialilinimas LT4015527T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25

Publications (1)

Publication Number Publication Date
LT4015527T true LT4015527T (lt) 2025-04-10

Family

ID=39717519

Family Applications (8)

Application Number Title Priority Date Filing Date
LTEP16158141.8T LT3045471T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTEP14178729.1T LT2808340T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTEP16179121.5T LT3098234T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, apimantis alfa 2,3- ir alfa 2,6-sialilinimą
LTEP21212873.0T LT4015527T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, įskaitant alfa 2,3-, ir alfa 2,6-sialilinimas
LTPA2017018C LTPA2017018I1 (lt) 2008-04-16 2017-06-05 Rekombinantinis FSH, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTPA2017029C LTPA2017029I1 (lt) 2008-04-16 2017-09-27 Rekombinantinis FSH, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTPA2025505C LTPA2025505I1 (lt) 2008-04-16 2025-01-24
LTPA2025525C LTPA2025525I1 (lt) 2008-04-16 2025-07-07

Family Applications Before (3)

Application Number Title Priority Date Filing Date
LTEP16158141.8T LT3045471T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTEP14178729.1T LT2808340T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTEP16179121.5T LT3098234T (lt) 2008-04-16 2009-04-16 Rekombinantinis fsh, apimantis alfa 2,3- ir alfa 2,6-sialilinimą

Family Applications After (4)

Application Number Title Priority Date Filing Date
LTPA2017018C LTPA2017018I1 (lt) 2008-04-16 2017-06-05 Rekombinantinis FSH, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTPA2017029C LTPA2017029I1 (lt) 2008-04-16 2017-09-27 Rekombinantinis FSH, įskaitant alfa 2,3- ir alfa 2,6-sialilinimą
LTPA2025505C LTPA2025505I1 (lt) 2008-04-16 2025-01-24
LTPA2025525C LTPA2025525I1 (lt) 2008-04-16 2025-07-07

Country Status (29)

Country Link
US (6) US8951967B2 (lt)
EP (7) EP4015527B1 (lt)
JP (7) JP2011519359A (lt)
KR (5) KR20160056960A (lt)
CN (3) CN105906702A (lt)
AR (1) AR071479A1 (lt)
AU (5) AU2009237479B2 (lt)
BR (1) BRPI0910461B8 (lt)
CA (1) CA2725257A1 (lt)
CY (1) CY1115413T1 (lt)
DK (6) DK3045471T3 (lt)
ES (5) ES2610277T3 (lt)
FI (4) FI4015527T3 (lt)
FR (3) FR17C1020I2 (lt)
HR (5) HRP20241187T1 (lt)
HU (9) HUE068565T2 (lt)
IL (2) IL208538A (lt)
LT (8) LT3045471T (lt)
MX (3) MX2010011343A (lt)
NO (4) NO2017025I1 (lt)
NZ (1) NZ588381A (lt)
PL (6) PL4015527T3 (lt)
PT (6) PT2268666E (lt)
RU (3) RU2682270C2 (lt)
SA (1) SA109300228B1 (lt)
SI (6) SI3098234T1 (lt)
TW (1) TWI488640B (lt)
WO (1) WO2009127826A1 (lt)
ZA (1) ZA201007373B (lt)

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TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
TWI532495B (zh) * 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
WO2012016576A1 (en) * 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HUE025514T2 (en) 2010-09-29 2016-02-29 Ferring Bv Preparation for use in treating infertility
WO2012050175A1 (ja) 2010-10-15 2012-04-19 日本ケミカルリサーチ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
WO2012131306A1 (en) 2011-03-31 2012-10-04 Ferring B.V. Pharmaceutical preparation
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2013093760A2 (en) * 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
WO2013161958A1 (ja) * 2012-04-27 2013-10-31 日本ケミカルリサーチ株式会社 新規な発現ベクター
EP2824176A1 (en) * 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
JP6652334B2 (ja) * 2014-05-31 2020-02-19 Jcrファーマ株式会社 ウリジンとn−アセチル−d−マンノサミンとを含有する培地
WO2016102436A1 (en) * 2014-12-22 2016-06-30 F. Hoffmann-La Roche Ag Cmp-dependent sialidase activity
KR20170137041A (ko) 2015-04-17 2017-12-12 훼링 비.브이. 불임 치료용 조성물
CN115028675A (zh) 2015-06-26 2022-09-09 辉凌公司 纯化和/或病毒灭活的方法
EP3205719A1 (en) * 2016-02-15 2017-08-16 CEVEC Pharmaceuticals GmbH Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins
GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
HRP20211802T1 (hr) 2017-09-01 2022-03-04 Ferring B.V. Pripravak za kontroliranu stimulaciju jajnika
PL3787667T3 (pl) 2018-04-30 2025-07-28 Ferring B.V. Kompozycja do kontrolowanej stymulacji jajników
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
US20220380785A1 (en) * 2019-11-01 2022-12-01 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
US20250241993A1 (en) 2022-04-01 2025-07-31 Ferring B.V. Mixed protocol for treatment of infertility
AU2023275943A1 (en) 2022-05-26 2024-10-17 Ferring B.V. Compositions and methods for treatment of infertility in males
CN119486751A (zh) 2022-07-08 2025-02-18 辉凌公司 用于宫腔内人工授精(iui)的组合物和方法
WO2025017533A1 (en) 2023-07-20 2025-01-23 Ferring B.V. Extended release drug-loaded microparticles

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
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WO2012016576A1 (en) 2010-08-04 2012-02-09 Glycotope Gmbh Improved recombinant human follicle-stimulating hormone
HUE025514T2 (en) 2010-09-29 2016-02-29 Ferring Bv Preparation for use in treating infertility
WO2012131306A1 (en) 2011-03-31 2012-10-04 Ferring B.V. Pharmaceutical preparation
AR090095A1 (es) 2011-06-06 2014-10-22 Ferring Bv Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
WO2015158875A1 (en) 2014-04-18 2015-10-22 Glycotope Gmbh Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone

Also Published As

Publication number Publication date
CA2725257A1 (en) 2009-10-22
FI3098234T3 (fi) 2024-10-31
NZ588381A (en) 2012-05-25
HRP20241187T1 (hr) 2024-12-06
EP3144318B1 (en) 2020-09-23
US12516094B2 (en) 2026-01-06
ES3023526T3 (en) 2025-06-02
EP3098234A1 (en) 2016-11-30
AU2014203277C1 (en) 2017-07-27
KR20160056960A (ko) 2016-05-20
TWI488640B (zh) 2015-06-21
AU2014203277A1 (en) 2014-07-24
ES2468318T3 (es) 2014-06-16
AU2017225020B2 (en) 2019-11-14
US8951967B2 (en) 2015-02-10
AU2009237479B2 (en) 2014-05-15
LTPA2025505I1 (lt) 2025-02-10
LTPA2017029I1 (lt) 2017-10-10
PL3045471T3 (pl) 2017-10-31
HUE068565T2 (hu) 2025-01-28
HUE030652T4 (en) 2017-09-28
AU2009237479A1 (en) 2009-10-22
HK1199039A1 (en) 2015-06-19
EP3045471A1 (en) 2016-07-20
HUS1700025I1 (hu) 2017-06-28
RU2682270C2 (ru) 2019-03-18
JP6486310B2 (ja) 2019-03-20
FR25C1025I1 (fr) 2025-09-19
PT3144318T (pt) 2020-11-04
SA109300228B1 (ar) 2014-04-08
MX2010011343A (es) 2011-01-20
PL4015527T3 (pl) 2025-05-26
EP4015527B1 (en) 2025-01-22
NO2017050I1 (no) 2017-09-28
MX348622B (es) 2017-06-22
PT2268666E (pt) 2014-06-25
SI2268666T1 (sl) 2014-07-31
PL3144318T3 (pl) 2021-02-08
AR071479A1 (es) 2010-06-23
SI3098234T1 (sl) 2024-10-30
HRP20170958T1 (hr) 2017-09-22
FI4015527T3 (fi) 2025-04-29
HRP20250313T1 (hr) 2025-05-09
RU2745557C1 (ru) 2021-03-29
ES2989729T3 (es) 2024-11-27
HUE030652T2 (en) 2017-05-29
PT3098234T (pt) 2024-10-21
DK3144318T3 (da) 2020-12-07
DK2808340T3 (en) 2016-12-05
BRPI0910461A8 (pt) 2018-10-16
EP3098234B1 (en) 2024-07-31
SI3045471T1 (sl) 2017-07-31
KR20190092608A (ko) 2019-08-07
LT3098234T (lt) 2024-09-10
HUS2500008I1 (hu) 2025-02-28
KR20180095140A (ko) 2018-08-24
ES2629392T3 (es) 2017-08-09
HRP20161520T1 (hr) 2016-12-30
ZA201007373B (en) 2011-06-29
AU2014203277B2 (en) 2017-04-06
BRPI0910461A2 (pt) 2018-03-27
US20150065695A1 (en) 2015-03-05
IL208538A0 (en) 2010-12-30
LTPA2025525I1 (lt) 2025-07-25
RU2745557C3 (ru) 2021-12-10
PT3045471T (pt) 2017-06-14
AU2017204258B2 (en) 2017-08-17
FIC20250025I1 (fi) 2025-07-11
EP4015527A1 (en) 2022-06-22
AU2017225020A1 (en) 2017-09-28
LT2808340T (lt) 2016-11-10
PT4015527T (pt) 2025-04-10
CN105906702A (zh) 2016-08-31
EP2808340A1 (en) 2014-12-03
RU2010141908A (ru) 2012-05-27
HUS2500029I1 (hu) 2025-07-28
AU2017204259B2 (en) 2017-08-17
RU2537268C2 (ru) 2014-12-27
EP2268666A1 (en) 2011-01-05
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