AR071479A1 - Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6 - Google Patents
Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6Info
- Publication number
- AR071479A1 AR071479A1 ARP090101333A ARP090101333A AR071479A1 AR 071479 A1 AR071479 A1 AR 071479A1 AR P090101333 A ARP090101333 A AR P090101333A AR P090101333 A ARP090101333 A AR P090101333A AR 071479 A1 AR071479 A1 AR 071479A1
- Authority
- AR
- Argentina
- Prior art keywords
- rfsh
- sialic acid
- recombinant
- hormone
- folicle
- Prior art date
Links
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title abstract 4
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title abstract 4
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
- 102000003838 Sialyltransferases Human genes 0.000 abstract 2
- 108090000141 Sialyltransferases Proteins 0.000 abstract 2
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002611 ovarian Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La hormona folículo estimulante recombinante (rFSH) con union de ácido siálico en alfa2,3 y alfa2,6 se obtuvo por ingeniería genética en una línea celular humana, de modo de expresar tanto rFSH como la sialiltransferasa alfa2,3. La FSH expresada lleva ácido siálico en alfa2,3 y alfa2,6, siendo esta ultima union el resultado de la actividad sialiltransferasa endogena. La hormona folículo estimulante recombinante presenta un alto contenido de ácido siálico y un perfil fisicoquímico y fármaco cinético semejante a la FSH natural. Se proveen composiciones farmacéuticas que incluyen la rFSH, siendo las mismas de utilidad en la estimulacion ovárica controlada y en técnicas de fecundacion asistida.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4542408P | 2008-04-16 | 2008-04-16 | |
| EP08251528 | 2008-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071479A1 true AR071479A1 (es) | 2010-06-23 |
Family
ID=39717519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101333A AR071479A1 (es) | 2008-04-16 | 2009-04-16 | Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US8951967B2 (es) |
| EP (7) | EP3045471B1 (es) |
| JP (7) | JP2011519359A (es) |
| KR (5) | KR20180095140A (es) |
| CN (3) | CN105906702A (es) |
| AR (1) | AR071479A1 (es) |
| AU (5) | AU2009237479B2 (es) |
| BR (1) | BRPI0910461B8 (es) |
| CA (1) | CA2725257A1 (es) |
| CY (1) | CY1115413T1 (es) |
| DK (6) | DK3144318T3 (es) |
| ES (5) | ES2468318T3 (es) |
| FI (4) | FI4015527T3 (es) |
| FR (3) | FR17C1020I2 (es) |
| HR (5) | HRP20250313T1 (es) |
| HU (9) | HUE068565T2 (es) |
| IL (2) | IL208538A (es) |
| LT (8) | LT3045471T (es) |
| MX (3) | MX355457B (es) |
| NO (4) | NO2017025I1 (es) |
| NZ (1) | NZ588381A (es) |
| PL (6) | PL2268666T3 (es) |
| PT (6) | PT4015527T (es) |
| RU (3) | RU2682270C2 (es) |
| SA (1) | SA109300228B1 (es) |
| SI (6) | SI3098234T1 (es) |
| TW (1) | TWI488640B (es) |
| WO (1) | WO2009127826A1 (es) |
| ZA (1) | ZA201007373B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| TWI532495B (zh) * | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| PL2621517T5 (pl) | 2010-09-29 | 2024-01-29 | Ferring B.V. | Kompozycja do stosowania w leczeniu niepłodności |
| JP5918697B2 (ja) | 2010-10-15 | 2016-05-18 | Ｊｃｒファーマ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
| EP2691119B1 (en) | 2011-03-31 | 2018-08-01 | Ferring B.V. | Pharmaceutical preparation |
| WO2012168680A1 (en) | 2011-06-06 | 2012-12-13 | Ferring B.V. | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| WO2013093760A2 (en) * | 2011-12-19 | 2013-06-27 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| EP2848687B1 (en) * | 2012-04-27 | 2017-09-13 | JCR Pharmaceuticals Co., Ltd. | Novel expression vector |
| EP2824176A1 (en) * | 2013-07-11 | 2015-01-14 | Siamed'xpress | Methods for producing sialylated therapeutic proteins |
| JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Ｊｃｒファーマ株式会社 | ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地 |
| JP2018500934A (ja) * | 2014-12-22 | 2018-01-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｍｐ依存性シアリダーゼ活性 |
| PL3283097T3 (pl) | 2015-04-17 | 2020-10-19 | Ferring B.V. | FSH do leczenia niepłodności |
| MX381279B (es) | 2015-06-26 | 2025-03-12 | Ferring Bv | Métodos de purificación y/o inactivación viral. |
| EP3205719A1 (en) * | 2016-02-15 | 2017-08-16 | CEVEC Pharmaceuticals GmbH | Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins |
| GB201603280D0 (en) | 2016-02-24 | 2016-04-13 | Ferring Bv | Stable liquid gonadotropin formulation |
| EP3382014A1 (en) | 2017-03-29 | 2018-10-03 | CEVEC Pharmaceuticals GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| EP3441471A1 (en) | 2017-08-08 | 2019-02-13 | CEVEC Pharmaceuticals GmbH | Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines |
| PT3973982T (pt) | 2017-09-01 | 2024-09-16 | Ferring Bv | Composição para estimulação ovariana controlada |
| EP4534145A3 (en) | 2018-04-30 | 2025-07-02 | Ferring B.V. | Composition for controlled ovarian stimulation |
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| US20220380785A1 (en) * | 2019-11-01 | 2022-12-01 | The University Of British Columbia | Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins |
| TW202237173A (zh) | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
| AU2022451605A1 (en) | 2022-04-01 | 2024-09-26 | Ferring B.V. | Mixed protocol for treatment of infertility |
| WO2023227761A1 (en) | 2022-05-26 | 2023-11-30 | Ferring B.V. | Compositions and methods for treatment of infertility in males |
| JP2025521461A (ja) | 2022-07-08 | 2025-07-10 | フェリング ベスローテン フェンノートシャップ | 子宮内授精（ｉｕｉ）のための組成物及び方法 |
| WO2025017533A1 (en) | 2023-07-20 | 2025-01-23 | Ferring B.V. | Extended release drug-loaded microparticles |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| US5541083A (en) | 1989-10-24 | 1996-07-30 | The Regents Of The University Of California | Method for producing secretable glycosyltransferases and other golgi processing enzymes |
| ATE278794T1 (de) | 1995-06-15 | 2004-10-15 | Crucell Holland Bv | Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie |
| JP3559652B2 (ja) * | 1996-06-25 | 2004-09-02 | グローリー工業株式会社 | 売上精算システムの管理装置 |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| CA2278178C (en) | 1997-01-16 | 2012-09-25 | Cytel Corporation | Practical in vitro sialylation of recombinant glycoproteins |
| JPH1111665A (ja) | 1997-06-28 | 1999-01-19 | Shibuya Kogyo Co Ltd | 無菌エア搬送コンベヤ装置 |
| TWI235158B (en) * | 1997-09-01 | 2005-07-01 | Kirin Brewery | Human thrombopoietin produced by human established cell lines, processes foe preparing the same, and pharmaceutical composition comprising the same |
| US7304031B2 (en) | 2001-10-29 | 2007-12-04 | Crucell Holland B.V. | Methods and means for producing proteins with predetermined post-translational modifications |
| WO2000067778A1 (en) | 1999-05-07 | 2000-11-16 | Applied Research Systems Ars Holding N.V. | Gonadotrophins |
| JP2002011665A (ja) | 2000-06-28 | 2002-01-15 | Sintokogio Ltd | ショットブラスト装置モニタシステム |
| IL140110A0 (en) | 2000-12-05 | 2002-02-10 | Applied Research Systems | Improvement of homogeneity and secretion of recombinant proteins in mammalian systems |
| ATE329930T1 (de) * | 2001-10-22 | 2006-07-15 | Applied Research Systems | Fsh-zusammensetzungen mit hohem sialylierungsgrad und deren verwendung zur herstellung von arzneimitteln |
| EP1465987B1 (en) | 2001-12-07 | 2008-01-23 | Crucell Holland B.V. | Production of viruses, viral isolates and vaccines |
| US20040248784A1 (en) * | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| US20080015142A1 (en) * | 2003-12-03 | 2008-01-17 | Defrees Shawn | Glycopegylated Follicle Stimulating Hormone |
| WO2005076013A2 (en) | 2004-02-04 | 2005-08-18 | Centre National De La Recherche Scientifique | Process for screening glycoform-specific antibodies |
| CN1926242B (zh) | 2004-02-13 | 2013-01-16 | 格莱克托普有限公司 | 高活性糖蛋白加工条件及其有效生产方法 |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| US8790322B2 (en) | 2010-08-03 | 2014-07-29 | King Saud University | Stoma coat |
| WO2012016576A1 (en) | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| PL2621517T5 (pl) | 2010-09-29 | 2024-01-29 | Ferring B.V. | Kompozycja do stosowania w leczeniu niepłodności |
| EP2691119B1 (en) | 2011-03-31 | 2018-08-01 | Ferring B.V. | Pharmaceutical preparation |
| WO2012168680A1 (en) | 2011-06-06 | 2012-12-13 | Ferring B.V. | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| MX2016013449A (es) | 2014-04-18 | 2017-05-04 | Glycotope Gmbh | Hiperestimulacion ovarica controlada con la hormona estimuladora folicular humana recombinante mejorada. |
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2009
- 2009-04-15 TW TW098112483A patent/TWI488640B/zh active
- 2009-04-16 PL PL09733497T patent/PL2268666T3/pl unknown
- 2009-04-16 HU HUE16179121A patent/HUE068565T2/hu unknown
- 2009-04-16 WO PCT/GB2009/000978 patent/WO2009127826A1/en not_active Ceased
- 2009-04-16 PT PT212128730T patent/PT4015527T/pt unknown
- 2009-04-16 CN CN201510933782.9A patent/CN105906702A/zh active Pending
- 2009-04-16 EP EP16158141.8A patent/EP3045471B1/en not_active Revoked
- 2009-04-16 KR KR1020187023820A patent/KR20180095140A/ko not_active Ceased
- 2009-04-16 PT PT161791215T patent/PT3098234T/pt unknown
- 2009-04-16 HU HUE16158141A patent/HUE033830T2/en unknown
- 2009-04-16 ES ES09733497.3T patent/ES2468318T3/es active Active
- 2009-04-16 PL PL16158141T patent/PL3045471T3/pl unknown
- 2009-04-16 KR KR1020197022294A patent/KR102108377B1/ko active Active
- 2009-04-16 HR HRP20250313TT patent/HRP20250313T1/hr unknown
- 2009-04-16 AU AU2009237479A patent/AU2009237479B2/en active Active
- 2009-04-16 LT LTEP16158141.8T patent/LT3045471T/lt unknown
- 2009-04-16 PT PT97334973T patent/PT2268666E/pt unknown
- 2009-04-16 EP EP16179121.5A patent/EP3098234B1/en active Active
- 2009-04-16 MX MX2017007881A patent/MX355457B/es unknown
- 2009-04-16 DK DK16194925.0T patent/DK3144318T3/da active
- 2009-04-16 EP EP21212873.0A patent/EP4015527B1/en active Active
- 2009-04-16 EP EP13193214.7A patent/EP2722339A1/en active Pending
- 2009-04-16 PL PL16179121.5T patent/PL3098234T3/pl unknown
- 2009-04-16 PL PL21212873.0T patent/PL4015527T3/pl unknown
- 2009-04-16 JP JP2011504527A patent/JP2011519359A/ja active Pending
- 2009-04-16 LT LTEP14178729.1T patent/LT2808340T/lt unknown
- 2009-04-16 HR HRP20241187TT patent/HRP20241187T1/hr unknown
- 2009-04-16 NZ NZ588381A patent/NZ588381A/en unknown
- 2009-04-16 ES ES14178729.1T patent/ES2610277T3/es active Active
- 2009-04-16 PL PL16194925T patent/PL3144318T3/pl unknown
- 2009-04-16 ES ES21212873T patent/ES3023526T3/es active Active
- 2009-04-16 PT PT141787291T patent/PT2808340T/pt unknown
- 2009-04-16 SI SI200932205T patent/SI3098234T1/sl unknown
- 2009-04-16 KR KR1020167012148A patent/KR20160056960A/ko not_active Ceased
- 2009-04-16 DK DK09733497.3T patent/DK2268666T3/da active
- 2009-04-16 SI SI200931670A patent/SI3045471T1/sl unknown
- 2009-04-16 EP EP16194925.0A patent/EP3144318B1/en active Active
- 2009-04-16 DK DK16179121.5T patent/DK3098234T3/da active
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