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RU2017122014A - Антитела к c10orf54 и их применения - Google Patents

Антитела к c10orf54 и их применения Download PDF

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RU2017122014A
RU2017122014A RU2017122014A RU2017122014A RU2017122014A RU 2017122014 A RU2017122014 A RU 2017122014A RU 2017122014 A RU2017122014 A RU 2017122014A RU 2017122014 A RU2017122014 A RU 2017122014A RU 2017122014 A RU2017122014 A RU 2017122014A
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seq
sequence
cdr
antibody
imgt
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RU2017122014A
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RU2714232C2 (ru
RU2017122014A3 (ru
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Джон ЛИППИНКОТТ
Эдвард Тейн Хтун ВАН ДЕР ХОРСТ
Сунь Юн КИМ
Леонард Г. ПРЕСТА
Ян-Виллем ТЁНИССЕН
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Пьер Фабр Медикамент
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Claims (63)

1. Выделенное антитело или его антигенсвязывающий фрагмент, которое(ый) связывается с первой группой белков или химерных белков C10orf54 (белков, кодируемых геном из открытой рамки считывания 54 на хромосоме 10), обозначенных как СС1 (SEQ ID NO: 1079), СС4 (SEQ ID NO: 1245), CC5 (SEQ ID NO: 1246), CC8 (SEQ ID NO: 1249) и CC10 (SEQ ID NO: 1251), и не связывается со второй группой белков или химерных белков C10orf54, обозначенных как СС2 (SEQ ID NO: 1243), СС3 (SEQ ID NO: 1244), CC6 (SEQ ID NO: 1247), CC7 (SEQ ID NO: 1248) и CC9 (SEQ ID NO: 1250).
2. Антитело по п. 1 или его антигенсвязывающий фрагмент, где указанное антитело представляет собой моноклональное антитело.
3. Антитело по любому из пп. 1 или 2 или его антигенсвязывающий фрагмент, где указанное антитело выбрано из группы, состоящей из:
(a) антитела 5В, содержащего:
- тяжелую цепь (Н), содержащую следующие три CDR (определяющих комплементарность участка), которые определены согласно IMGT (ImMunoGeneTics; база данных по иммуногенетике), соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1292, CDR-H2, имеющий последовательность с SEQ ID NO: 1337, и CDR-H3, имеющий последовательность с SEQ ID NO: 1386; и
- легкую цепь (L), содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1426, CDR-L2, имеющий последовательность с SEQ ID NO: 1474, и CDR-L3, имеющий последовательность с SEQ ID NO: 1493;
(b) антитела 46А, содержащего:
тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1292, CDR-H2, имеющий последовательность с SEQ ID NO: 1342, и CDR-H3, имеющий последовательность с SEQ ID NO: 1390; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1426, CDR-L2, имеющий последовательность с SEQ ID NO: 1474, и CDR-L3, имеющий последовательность с SEQ ID NO: 1496;
(c) антитела 128А, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1292, CDR-H2, имеющий последовательность с SEQ ID NO: 1337, и CDR-H3, имеющий последовательность с SEQ ID NO: 1386; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1426, CDR-L2, имеющий последовательность с SEQ ID NO: 1474, и CDR-L3, имеющий последовательность с SEQ ID NO: 1493;
(d) антитела 146С, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1292, CDR-H2, имеющий последовательность с SEQ ID NO: 1337, и CDR-H3, имеющий последовательность с SEQ ID NO: 1386; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1426, CDR-L2, имеющий последовательность с SEQ ID NO: 1474, и CDR-L3, имеющий последовательность с SEQ ID NO: 1493;
(e) антитела 208А, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1292, CDR-H2, имеющий последовательность с SEQ ID NO: 1337, и CDR-H3, имеющий последовательность с SEQ ID NO: 1386; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1426, CDR-L2, имеющий последовательность с SEQ ID NO: 1474, и CDR-L3, имеющий последовательность с SEQ ID NO: 1493;
(f) антитела 26А, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1297, CDR-H2, имеющий последовательность с SEQ ID NO: 1355, и CDR-H3, имеющий последовательность с SEQ ID NO: 1394; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1432, CDR-L2, имеющий последовательность с SEQ ID NO: 1477, и CDR-L3, имеющий последовательность с SEQ ID NO: 1499;
(g) антитела 164А, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1099, CDR-H2, имеющий последовательность с SEQ ID NO: 1360, и CDR-H3, имеющий последовательность с SEQ ID NO: 1398; и
- легкую цепь, содержащую:
Figure 00000001
следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1438, CDR-L2, имеющий последовательность с SEQ ID NO: 1527, и CDR-L3, имеющий последовательность с SEQ ID NO: 1523; или
Figure 00000001
следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1452, CDR-L2, имеющий последовательность с SEQ ID NO: 1480, и CDR-L3, имеющий последовательность с SEQ ID NO: 1502;
(h) антитела 230А, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1302, CDR-H2, имеющий последовательность с SEQ ID NO: 1365, и CDR-H3, имеющий последовательность с SEQ ID NO: 1402; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1455, CDR-L2, имеющий
последовательность с SEQ ID NO: 1103, и CDR-L3, имеющий последовательность с SEQ ID NO: 1505;
(i) антитела 33А, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1312, CDR-H2, имеющий последовательность с SEQ ID NO: 1082, и CDR-H3, имеющий последовательность с SEQ ID NO: 1410; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1102, CDR-L2, имеющий последовательность с SEQ ID NO: 1103, и CDR-L3, имеющий последовательность с SEQ ID NO: 1511;
(j) антитела 321D, содержащего:
- тяжелую цепь, содержащую следующие три CDR, которые определены согласно IMGT, соответственно, CDR-H1, имеющий последовательность с SEQ ID NO: 1322, CDR-H2, имеющий последовательность с SEQ ID NO: 1082, и CDR-H3, имеющий последовательность с SEQ ID NO: 1083; и
- легкую цепь, содержащую: следующие три CDR, которые определены согласно IMGT, соответственно, CDR-L1, имеющий последовательность с SEQ ID NO: 1102, CDR-L2, имеющий последовательность с SEQ ID NO: 1103, и CDR-L3, имеющий последовательность с SEQ ID NO: 1514.
4. Антитело по любому из пп. 1-3 или его антигенсвязывающий фрагмент, где указанное антитело является гуманизированным.
5. Антитело по п. 4 или его антигенсвязывающий фрагмент, причем указанное антитело выбрано из группы, состоящей из:
(а) антитела 26А, содержащего вариабельный домен тяжелой цепи с последовательностью, выбранной среди аминокислотных последовательностей с SEQ ID NO: 1529, SEQ ID NO: 1530 и SEQ ID NO: 1531, и вариабельный домен легкой цепи с последовательностью, выбранной среди аминокислотных последовательностей с SEQ ID NO: 1532, SEQ ID NO: 1533 и SEQ ID NO: 1534;
(b) антитела 128A, содержащего вариабельный домен тяжелой цепи с последовательностью, выбранной среди аминокислотных последовательностей с SEQ ID NO: 1535, SEQ ID NO: 1536 и SEQ ID NO: 1537, и вариабельный домен легкой цепи с последовательностью, выбранной среди аминокислотных последовательностей с SEQ ID NO: 1538, SEQ ID NO: 1539 и SEQ ID NO: 1540.
6. Антитело по любому из пп. 1-5, где антитело представляет собой Fab фрагмент, F(ab')2 фрагмент, одноцепочечный Fv (sFv), диатело, триотело или миниантитело.
7. Конъюгат антитело-лекарственное средство, содержащий антитело по любому из пп. 1-6, конъюгированное с цитотоксическим агентом.
8. Полинуклеотид, содержащий нуклеотидную последовательность, кодирующую антитело по любому из пп. 1-6.
9. Экспрессирующий вектор, содержащий полинуклеотид по п. 8.
10. Клетка-хозяин, содержащая экспрессирующий вектор по п. 9.
11. Способ получения антитела или его антигенсвязывающего фрагмента по любому из пп. 1-6, включающий стадию культивирования клетки хозяина по п. 10 в условиях, которые способствуют продуцированию данного антитела.
12. Фармацевтическая композиция, содержащая антитело по любому из пп. 1-6 или конъюгат антитело-лекарственное средство по п. 7 и фармацевтически приемлемый разбавитель, носитель или эксципиент.
13. Способ лечения, предупреждения или облегчения одного или более симптомов рака, включающий введение субъекту терапевтически эффективного количества композиции по п. 12, в результате чего осуществляется лечение, предупреждение или облегчение одного или более симптомов рака.
14. Способ по п. 13, где рак представляет собой лейкоз, предпочтительно острый миелоидный лейкоз (AML), рак мочевого пузыря, рак кожи, рак толстой кишки, рак молочной железы, рак печени, рак почки, рак легкого, рак желудка, рак поджелудочной железы, рак пищевода или фибросаркому.
15. Способ ингибирования роста опухоли с воспалением у субъекта, включающий введение субъекту эффективного количества композиции по п. 12.
16. Способ ингибирования роста клетки, экспрессирующей C10orf54 на своей поверхности, включающий приведение в контакт данной клетки с эффективным количеством композиции по п. 12.
17. Способ по п. 16, где клетка представляет собой регуляторную Т-клетку.
18. Способ по п. любому из пп. 16 или 17, где данная клетка представляет собой раковую или предраковую клетку.
19. Способ модулирования иммунного ответа у субъекта, включающий введение субъекту эффективного количества композиции по п. 12.
20. Способ по п. 19, где модулирование включает:
(a) усиление активации Т-клеток;
(b) усиление пролиферации Т-клеток; или
(c) усиление продуцирования цитокинов.
21. Способ лечения рака, включающий введение субъекту терапевтически эффективного количества антитела по любому из пп. 1-6 или конъюгата антитело-лекарственное средство по п. 7.
22. Способ уничтожения опухолевой клетки, включающий приведение в контакт C10orf54-экспрессирующей опухолевой клетки с количеством антитела по любому из пп. 1-6 или конъюгата антитело-лекарственное средство по п. 7, эффективным для уничтожения данной опухолевой клетки.
23. Способ детекции C10orf54 в образце, включающий приведение в контакт данного образца с антителом по любому из пп. 1-6.
24. Набор, содержащий антитело по любому из пп. 1-6.
25. Набор по п. 24, где указанное антитело конъюгировано с детектируемым субстратом.
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