RU2015129771A - Микроматрица для доставки терапевтического средства и способы использования - Google Patents
Микроматрица для доставки терапевтического средства и способы использования Download PDFInfo
- Publication number
- RU2015129771A RU2015129771A RU2015129771A RU2015129771A RU2015129771A RU 2015129771 A RU2015129771 A RU 2015129771A RU 2015129771 A RU2015129771 A RU 2015129771A RU 2015129771 A RU2015129771 A RU 2015129771A RU 2015129771 A RU2015129771 A RU 2015129771A
- Authority
- RU
- Russia
- Prior art keywords
- microstructural
- polymer
- distal layer
- matrix
- distal
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229920000642 polymer Polymers 0.000 claims 24
- 239000003814 drug Substances 0.000 claims 12
- 239000011159 matrix material Substances 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 239000000725 suspension Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 229920001600 hydrophobic polymer Polymers 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 238000005266 casting Methods 0.000 claims 3
- 230000009477 glass transition Effects 0.000 claims 3
- 229920001477 hydrophilic polymer Polymers 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 238000001035 drying Methods 0.000 claims 2
- 239000002313 adhesive film Substances 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
- B29C43/02—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles
- B29C43/021—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles characterised by the shape of the surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/68—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts by incorporating or moulding on preformed parts, e.g. inserts or layers, e.g. foam blocks
- B29C70/78—Moulding material on one side only of the preformed part
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00349—Creating layers of material on a substrate
- B81C1/00357—Creating layers of material on a substrate involving bonding one or several substrates on a non-temporary support, e.g. another substrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
- B29C43/02—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles
- B29C43/021—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles characterised by the shape of the surface
- B29C2043/023—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles characterised by the shape of the surface having a plurality of grooves
- B29C2043/025—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles characterised by the shape of the surface having a plurality of grooves forming a microstructure, i.e. fine patterning
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Mechanical Engineering (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Manufacturing & Machinery (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Composite Materials (AREA)
- Molecular Biology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Claims (48)
1. Микроструктурный аппарат, содержащий:
задник, который имеет первую поверхность и вторую поверхность, противоположную ей;
матрицу микроструктур, которая содержит множество микроструктур, проходящих наружу от первой поверхности задника;
микроструктуры, которые содержат биоразрушаемый дистальный слой и по меньшей мере один проксимальный слой, расположенный между дистальным слоем и первой поверхностью задника;
дистальный слой, состоящий из по меньшей мере одного терапевтического средства и по меньшей мере одного полимера (i) выбранного из (a) гидрофобного полимера и (b) полимера с температурой стеклования, равной приблизительно 20-25°C или выше нее; или (ii) в концентрации в полимерном литейном растворе, используемом для формирования дистального слоя микроструктур, которая равна его концентрации переплетения (CE) или ниже ее, причем выбор полимера является таким, что по меньшей мере часть дистального слоя открепляется от микроструктур, когда матрицу вставляют в кожу.
2. Микроструктурный аппарат по п. 1, в котором по меньшей мере один полимер дистального слоя содержит по меньшей мере один гидрофобный полимер и приблизительно 0-99% по меньшей мере одного гидрофильного полимера.
3. Микроструктурный аппарат по п. 1, в котором по меньшей мере один полимер дистального слоя содержит по меньшей мере один гидрофобный полимер и приблизительно 0-50% гидрофильного полимера.
4. Микроструктурный аппарат по п. 1, в котором по меньшей мере один полимер дистального слоя содержит по меньшей мере один гидрофобный полимер и приблизительно 0-20% гидрофильного полимера.
5. Микроструктурный аппарат по п. 1, в котором по меньшей мере одно терапевтическое средство представляет собой низкомолекулярное лекарственное средство, по меньшей мере частично растворимое с по меньшей мере одним полимером в растворителе или сорастворителе.
6. Микроструктурный аппарат по п. 5, в котором дистальный слой содержит приблизительно 1-99% низкомолекулярного лекарственного средства.
7. Микроструктурный аппарат по п. 5, в котором дистальный слой содержит приблизительно 1-50% низкомолекулярного лекарственного средства.
8. Микроструктурный аппарат по п. 5, в котором дистальный слой содержит приблизительно 6-40% низкомолекулярного лекарственного средства.
9. Микроструктурный аппарат по п. 5, в котором дистальный слой содержит приблизительно 10-30% низкомолекулярного лекарственного средства.
10. Микроструктурный аппарат по п. 1, в котором по меньшей мере одно терапевтическое средство диспергируют в дистальном слое.
11. Микроструктурный аппарат по п. 10, в котором дистальный слой содержит приблизительно 1-90% диспергированного средства.
12. Микроструктурный аппарат по п. 10, в котором дистальный слой содержит приблизительно 1-50% диспергированного средства.
13. Микроструктурный аппарат по п. 10, в котором дистальный слой содержит приблизительно 10-40% диспергированного средства.
14. Микроструктурный аппарат по п. 10, в котором дистальный слой содержит приблизительно 20-30% диспергированного средства.
15. Микроструктурный аппарат по п. 1, в котором по меньшей мере один полимер имеет температуру стеклования (Tg) выше приблизительно температуры тела.
16. Микроструктурный аппарат по п. 1, в котором приблизительно по меньшей мере 10% дистального слоя легко открепляется, когда матрицу вставляют в кожу.
17. Микроструктурный аппарат по п. 1, в котором приблизительно по меньшей мере 50% дистального слоя легко открепляется, когда матрицу вставляют в кожу.
18. Микроструктурный аппарат по п. 1, в котором приблизительно по меньшей мере 70% дистального слоя легко открепляется, когда матрицу вставляют в кожу.
19. Микроструктурный аппарат по п. 1, в котором приблизительно по меньшей мере 90% дистального слоя легко открепляется, когда матрицу вставляют в кожу.
20. Микроструктурный аппарат по п. 1, в котором приблизительно 100% дистального слоя легко открепляется, когда матрицу вставляют в кожу.
21. Микроструктурный аппарат по п. 1, в котором по меньшей мере часть микроструктур имеет первый диаметр в поперечных размерах, который больше, чем второй диаметр в поперечных размерах.
22. Микроструктурный аппарат по п. 21, в котором по меньшей мере часть микроструктур имеет геометрическую форму в поперечных размерах, выбранную из группы, состоящей из ромба, прямоугольника и овала.
23. Микроструктурный аппарат по п. 21 или 22, в котором по меньшей мере часть микроструктур имеет асимметричную геометрическую форму поперечных размеров.
24. Микроструктурный аппарат по п. 1, в котором концентрация по меньшей мере одного полимера в полимерном литейном растворе, используемом для формирования микроструктуры, равна CE для этого полимера.
25. Микроструктурный аппарат по п. 1, в котором по меньшей мере часть проксимального и/или дистального слоев имеет воронкообразную форму.
26. Микроструктурный аппарат по п. 1, в котором микроструктуру прикрепляют к первой поверхности задника.
27. Микроструктурный аппарат по п. 1, в котором по меньшей мере часть задника образует проксимальный слой.
28. Микроструктурный аппарат по п. 1, дополнительно содержащий подложку, которая имеет первую поверхность и вторую поверхность, противоположную ей, причем вторую поверхность задника прикреплена к первой поверхности подложки.
29. Микроструктурный аппарат по п. 1, в котором дистальный слой состоит по меньшей мере из одного полимера и приблизительно 1-90% по меньшей мере одного терапевтического средства.
30. Микроструктурный аппарат по п. 1, в котором по меньшей мере один из по меньшей мере одного полимера имеет молекулярную массу приблизительно между 1-100 кДа.
31. Микроструктурный аппарат по п. 21, в котором дистальный слой имеет первый диаметр в поперечных размерах, больший, чем второй диаметр в поперечных размерах.
32. Способ получения микроструктурного аппарата, включающий в себя этапы, на которых:
растворяют или суспендируют терапевтическое средство в растворителе для формирования раствора или суспензии терапевтического средства;
растворяют, по меньшей мере, один полимер в растворителе для формирования полимерного раствора, в котором полимер (i) выбирают из (a) гидрофобного полимера и (b) полимера с температурой стеклования, равной приблизительно 20-25°C или выше нее; или (ii) в концентрации в полимерном литейном растворе, используемом для формирования дистального слоя микроструктуры, которая равна его концентрации переплетения (CE) или ниже нее;
смешивают раствор или суспензию терапевтического средства и полимерного раствора или суспензии для формирования раствора или суспензии полимерной матрицы;
распределяют раствор или суспензию полимерной матрицы на форму, которая имеет набор полостей микроструктур; после чего следует повышение давления;
удаляют избыток раствора или суспензии полимерной матрицы на поверхности формы; и сушат матрицу; и
распределяют подстилающей или поддерживающий слой на поверхности формы; и
сушат подстилающий или поддерживающий слой;
причем полимер выбирают так, что, по меньшей мере, часть дистального слоя открепляется от микроструктур при вставлении микроструктурного аппарата.
33. Способ по п. 32, дополнительно включающий этап, на котором:
прикрепляют подстилающий или поддерживающий слой к подложке.
34. Способ по п. 33, дополнительно включающий этап, на котором:
применяют нетканую или пористую пленку с двойным покрытием адгезивом для прикрепления подстилающего или поддерживающего слоя к подложке.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745513P | 2012-12-21 | 2012-12-21 | |
| US61/745,513 | 2012-12-21 | ||
| PCT/US2013/077281 WO2014100750A1 (en) | 2012-12-21 | 2013-12-20 | Microarray for delivery of therapeutic agent and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015129771A true RU2015129771A (ru) | 2017-01-30 |
| RU2698095C2 RU2698095C2 (ru) | 2019-08-22 |
Family
ID=49943595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015129771A RU2698095C2 (ru) | 2012-12-21 | 2013-12-20 | Микроматрица для доставки терапевтического средства и способы использования |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11052231B2 (ru) |
| EP (1) | EP2934660B1 (ru) |
| JP (3) | JP6865524B2 (ru) |
| KR (1) | KR102265808B1 (ru) |
| CN (1) | CN105073178B (ru) |
| AU (1) | AU2013364053B2 (ru) |
| BR (1) | BR112015014969B1 (ru) |
| CA (1) | CA2896188C (ru) |
| ES (1) | ES2743404T3 (ru) |
| IL (1) | IL239557B (ru) |
| MX (1) | MX375307B (ru) |
| RU (1) | RU2698095C2 (ru) |
| WO (1) | WO2014100750A1 (ru) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008241470B2 (en) | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| AU2011248108B2 (en) | 2010-05-04 | 2016-05-26 | Corium Pharma Solutions, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| CA2896188C (en) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| ES2921481T3 (es) | 2013-03-12 | 2022-08-26 | Corium Inc | Aplicadores para microproyecciones |
| WO2014144973A1 (en) | 2013-03-15 | 2014-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| CA2903763C (en) | 2013-03-15 | 2021-11-16 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| WO2014204176A1 (ko) * | 2013-06-17 | 2014-12-24 | 연세대학교 산학협력단 | 무고통 및 무패치의 슈팅 마이크로구조체 |
| EP4218724A3 (en) * | 2014-08-29 | 2023-08-16 | Corium Pharma Solutions, Inc. | Microstructure array for delivery of active agents |
| EP3188714A1 (en) * | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| JP6906885B2 (ja) * | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
| KR102203633B1 (ko) * | 2015-04-14 | 2021-01-15 | 주식회사 엘지생활건강 | 칼슘채널 차단제 전달용 용해성 미세바늘 |
| CN107427474A (zh) | 2015-04-13 | 2017-12-01 | 株式会社Lg生活健康 | 含有调节神经递质释放的成分的可溶性微针 |
| EP4205793A1 (en) * | 2015-04-17 | 2023-07-05 | Georgia Tech Research Corporation | Drug delivery devices having separable microneedles |
| KR102493996B1 (ko) * | 2015-04-29 | 2023-01-31 | 주식회사 엘지생활건강 | 항염 효과의 성분을 포함하는 저자극 용해성 미세바늘 패치 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| WO2017011320A1 (en) * | 2015-07-10 | 2017-01-19 | The University Of North Carolina At Chapel Hill | Rapidly dissolvable microneedles for the transdermal delivery of therapeutics |
| JP2017023511A (ja) * | 2015-07-24 | 2017-02-02 | 凸版印刷株式会社 | 針状体 |
| KR102494065B1 (ko) * | 2015-09-15 | 2023-01-31 | 주식회사 엘지생활건강 | 항바이러스 효과를 가지는 용해성 미세바늘 패치 |
| KR102494543B1 (ko) * | 2015-09-15 | 2023-02-02 | 주식회사 엘지생활건강 | Ｈｐｖ 백신 전달용 용해성 미세바늘 패치 |
| KR102494064B1 (ko) * | 2015-09-15 | 2023-01-31 | 주식회사 엘지생활건강 | 항염 효과를 가지는 용해성 미세바늘 패치 |
| KR102494066B1 (ko) * | 2015-09-15 | 2023-01-31 | 주식회사 엘지생활건강 | Ａ형 간염 예방 접종을 위한 용해성 미세바늘 패치 |
| KR102494544B1 (ko) * | 2015-09-15 | 2023-02-02 | 주식회사 엘지생활건강 | 소아마비 백신 전달용 용해성 미세바늘 패치 |
| KR102494067B1 (ko) * | 2015-09-15 | 2023-01-31 | 주식회사 엘지생활건강 | 홍역 백신을 포함하는 용해성 미세바늘 패치 |
| KR102494542B1 (ko) * | 2015-10-20 | 2023-02-02 | 주식회사 엘지생활건강 | 아토피 피부염에서 가려움증 치료제를 함유한 용해성 미세바늘 패치 |
| JP6541128B2 (ja) * | 2015-12-15 | 2019-07-10 | 株式会社ラボ・ジュヴェルサ | マイクロニードルパッチ、及びその製造方法並びにマイクロニードルアレイ製造装置 |
| PH12018501256B1 (en) * | 2015-12-28 | 2024-03-27 | Endoderma Co Ltd | Microstructure for percutaneous absorption, and method for preparing same |
| KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
| JP6736337B2 (ja) * | 2016-04-15 | 2020-08-05 | 富士フイルム株式会社 | マイクロニードルアレイ |
| WO2017217818A1 (ko) * | 2016-06-16 | 2017-12-21 | 주식회사 엔도더마 | 용해 특성이 우수한 히알루론산 마이크로구조체 |
| KR101692266B1 (ko) * | 2016-08-01 | 2017-01-03 | 부산대학교 산학협력단 | 마이크로니들 패치 및 이의 제조 방법 |
| AU2018222745B2 (en) * | 2017-02-17 | 2021-02-18 | Allergan, Inc. | Microneedle array with active ingredient |
| CN108785286A (zh) * | 2017-04-28 | 2018-11-13 | 日东电工株式会社 | 透皮吸收制剂 |
| TWI645870B (zh) * | 2017-06-27 | 2019-01-01 | 韓商安道德瑪股份有限公司 | 經皮吸收用微結構體及其製造方法 |
| KR102036921B1 (ko) * | 2017-07-27 | 2019-10-28 | 주식회사 쿼드메디슨 | 마이크로 니들 제조방법 |
| JP7096880B2 (ja) | 2017-09-12 | 2022-07-06 | ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド | 医療装置用の回転可能ストラットを持つ基材 |
| EP3694487B1 (en) * | 2017-10-11 | 2025-12-31 | Georgia Tech Research Corporation | Separable microneedle arrays for prolonged drug release |
| KR102076394B1 (ko) * | 2017-10-30 | 2020-02-11 | 장은주 | 생체흡수 및 생체분해 소재의 주입기 |
| KR102232199B1 (ko) * | 2017-12-04 | 2021-03-26 | 한국화학연구원 | 단일층 그래핀을 포함하는 템플릿을 이용하는 금속 초박막의 제조방법 |
| JP6681378B2 (ja) * | 2017-12-08 | 2020-04-15 | 株式会社ジオテクノロジー | マイクロニードルとその製造方法 |
| WO2019136033A2 (en) * | 2018-01-02 | 2019-07-11 | Evonik Corporation | Microneedle delivery system with anchor |
| WO2020005973A1 (en) | 2018-06-25 | 2020-01-02 | Corium, Inc. | Hybrid method of forming microstructure array molds, methods of making microstructure arrays, and methods of use |
| EP3845266A4 (en) | 2018-08-28 | 2022-06-15 | Industry-Academic Cooperation Foundation, Yonsei University | Perforated plate microstructure module |
| TWI687247B (zh) * | 2019-05-15 | 2020-03-11 | 微邦科技股份有限公司 | 微針結構及其生物可降解微針 |
| CN110772376A (zh) * | 2019-11-20 | 2020-02-11 | 韩熠 | 一种用于婴幼儿及儿童的医用眼贴及其制备方法 |
| EP4117768A4 (en) * | 2020-04-09 | 2024-04-24 | Carnegie Mellon University | HYBRID MICRONEEDLE ARRANGEMENTS |
| CN113827544B (zh) * | 2020-06-04 | 2024-08-09 | 中国科学院理化技术研究所 | 一种耐热型可植入式聚合物微针及其制备方法和应用 |
| JP7606202B2 (ja) * | 2020-07-06 | 2024-12-25 | 国立大学法人東北大学 | マイクロニードル、マイクロニードルアレイ、パッチ、方法 |
| WO2022174040A1 (en) | 2021-02-11 | 2022-08-18 | 10X Technology Llc | Method and apparatus for fabricating brittle microneedle |
| JP6972409B1 (ja) * | 2021-03-30 | 2021-11-24 | リンテック株式会社 | マイクロニードルの製造方法およびマイクロニードルの製造装置 |
| KR102567995B1 (ko) * | 2021-11-29 | 2023-08-18 | 주식회사 쿼드메디슨 | 다층 구조 마이크로 니들 |
| US20250170379A1 (en) * | 2022-02-28 | 2025-05-29 | Georgia Tech Research Corporation | Melting Microneedle Patches and Methods of Manufacturing Thereof |
| KR20250056504A (ko) | 2023-10-19 | 2025-04-28 | 연세대학교 산학협력단 | 분리 수율이 높은 마이크로니들 구조체, 이를 포함하는 장치 및 이의 제조 방법 |
| WO2025217557A1 (en) * | 2024-04-12 | 2025-10-16 | Mott Corporation | Drug delivery assembly including a microprojection for extended drug delivery |
Family Cites Families (457)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1554510A (en) | 1924-04-23 | 1925-09-22 | Elsie W Kirby | Massaging device |
| US1770632A (en) | 1928-07-02 | 1930-07-15 | Arthur E Smith | Ampul syringe |
| US2046240A (en) | 1932-07-01 | 1936-06-30 | Thomas W Bayley | Abrasive article |
| US2434407A (en) | 1946-01-05 | 1948-01-13 | Hofe George Douglas | Depilatory device |
| NL92403C (ru) | 1954-10-04 | |||
| JPS4637758Y1 (ru) | 1967-12-13 | 1971-12-27 | ||
| US3675766A (en) | 1970-02-04 | 1972-07-11 | Sol Roy Rosenthal | Multiple puncture injector device |
| US3704194A (en) | 1970-07-02 | 1972-11-28 | Gen Electric | Perforated reinforced plastic member and method for making |
| US3873255A (en) | 1971-01-27 | 1975-03-25 | Johnson & Johnson | Apparatus for producing nonwoven fabric |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| BE795384A (fr) | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
| DE2319591C2 (de) | 1973-04-18 | 1982-02-25 | Kirchner & Wilhelm, 7000 Stuttgart | Medizinischer Apparat |
| FR2232331B1 (ru) | 1973-06-06 | 1978-03-24 | Guerin A Ets | |
| AT347283B (de) | 1975-03-07 | 1978-12-27 | Collo Gmbh | Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl. |
| US4151240A (en) | 1976-10-19 | 1979-04-24 | The Procter & Gamble Company | Method for debossing and perforating a running ribbon of thermoplastic film |
| US4180232A (en) | 1977-01-13 | 1979-12-25 | Hardigg James S | Truss panel mold |
| US4117841A (en) | 1977-02-07 | 1978-10-03 | Anthony Perrotta | Medicated bandage pocket |
| JPS5428369A (en) | 1977-08-03 | 1979-03-02 | Yamakawa Tsuneko | Method of forming needleelike projection of thermoplastic resin on sheet |
| US4342314A (en) | 1979-03-05 | 1982-08-03 | The Procter & Gamble Company | Resilient plastic web exhibiting fiber-like properties |
| US4402696A (en) | 1979-10-15 | 1983-09-06 | Gulko Bruce N | Folded applicator |
| US4381963A (en) | 1980-07-30 | 1983-05-03 | The University Of Rochester | Micro fabrication molding process |
| US4395215A (en) | 1981-02-02 | 1983-07-26 | The Procter & Gamble Company | Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its construction |
| US4509908A (en) | 1981-02-02 | 1985-04-09 | The Procter & Gamble Company | Apparatus for uniformly debossing and aperturing a resilient plastic web |
| US4463045A (en) | 1981-03-02 | 1984-07-31 | The Procter & Gamble Company | Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impression |
| US4460370A (en) | 1981-10-29 | 1984-07-17 | Almedco, Inc. | Trans-dermal medication application cell |
| US4460368A (en) | 1981-10-29 | 1984-07-17 | Almedco, Inc. | Trans-dermal medication system |
| US4585991A (en) | 1982-06-03 | 1986-04-29 | Texas Instruments Incorporated | Solid state multiprobe testing apparatus |
| FR2535602B1 (fr) | 1982-11-05 | 1986-06-13 | Stallergenes Lab | Dispositif scarificateur |
| US4556441A (en) | 1983-01-24 | 1985-12-03 | Faasse Jr Adrian L | Pharmaceutical packaging method |
| US4515168A (en) | 1983-07-22 | 1985-05-07 | Chester Martin H | Clamp-on nerve stimulator and locator |
| US5591123A (en) | 1983-08-18 | 1997-01-07 | Drug Delivery Systems Inc. | Programmable control mounting system for transdermal drug applicator |
| US4708716A (en) | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
| US4695422A (en) | 1984-02-16 | 1987-09-22 | The Procter & Gamble Company | Production of formed material by solid-state formation with a high-pressure liquid stream |
| US4583982A (en) | 1984-08-24 | 1986-04-22 | Vlock D G | Fluid dispenser |
| US5569469A (en) | 1984-10-16 | 1996-10-29 | Vectorpharma International, S.P.A. | Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate |
| US5135477A (en) | 1984-10-29 | 1992-08-04 | Medtronic, Inc. | Iontophoretic drug delivery |
| US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| EP0213180B1 (en) | 1985-02-26 | 1992-10-07 | The Johns Hopkins University | Neovascularization inhibitors and methods for their production and use |
| US4904475A (en) | 1985-05-03 | 1990-02-27 | Alza Corporation | Transdermal delivery of drugs from an aqueous reservoir |
| US4609518A (en) | 1985-05-31 | 1986-09-02 | The Procter & Gamble Company | Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimensional forming structures |
| US4630603A (en) | 1986-02-13 | 1986-12-23 | The Kendall Company | Wound dressing |
| US4743249A (en) | 1986-02-14 | 1988-05-10 | Ciba-Geigy Corp. | Dermal and transdermal patches having a discontinuous pattern adhesive layer |
| AU597890B2 (en) | 1986-03-14 | 1990-06-14 | Drug Delivery Systems Inc. | Transdermal drug applicator and electrodes therefor |
| US4660721A (en) | 1986-04-07 | 1987-04-28 | Cvp Systems, Inc. | Sterilization package |
| US4784737A (en) | 1986-04-18 | 1988-11-15 | The United States Department Of Energy | Electromicroinjection of particles into living cells |
| US4837049A (en) | 1986-06-17 | 1989-06-06 | Alfred E. Mann Foundation For Scientific Research | Method of making an electrode array |
| US4743234A (en) | 1987-05-18 | 1988-05-10 | The Cloverline, Inc. | Syringe magnifier |
| US4842794A (en) | 1987-07-30 | 1989-06-27 | Applied Extrusion Technologies, Inc. | Method of making apertured films and net like fabrics |
| US5061258A (en) | 1987-08-07 | 1991-10-29 | Martz Joel D | Vapor permeable dressing with releasable medication |
| US4846821A (en) | 1987-08-24 | 1989-07-11 | The Procter & Gamble Company | Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement |
| DE3880763T2 (de) | 1987-08-24 | 1993-12-02 | Procter & Gamble | Im wesentlichen flüssigkeitsundurchlässige polymere Warenbahn mit Mikrobläschen und Verfahren und Vorrichtung für deren Herstellung. |
| US4812305A (en) | 1987-11-09 | 1989-03-14 | Vocal Rodolfo S | Well medicine strip |
| SU1641346A1 (ru) | 1987-12-08 | 1991-04-15 | Мгту Им.Н.Э.Баумана | Устройство дл электростимул ции |
| DK157899C (da) | 1987-12-15 | 1990-09-03 | Coloplast As | Hudpladeprodukt |
| FR2625937B1 (fr) | 1988-01-19 | 1993-04-30 | Vuillaume Andre | Procede et dispositif pour perforer un produit en feuille, et produit perfore ainsi obtenu |
| US5362307A (en) | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| US5198192A (en) | 1988-05-18 | 1993-03-30 | Inax Corporation | Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility |
| US4894054A (en) | 1988-06-20 | 1990-01-16 | Miskinyar Shir A | Preloaded automatic disposable syringe |
| JP2608921B2 (ja) | 1988-06-27 | 1997-05-14 | ティーディーケイ株式会社 | 高誘電率セラミックス組成物 |
| GB2221394B (en) | 1988-08-05 | 1992-03-04 | Eilert Eilertsen | An injection device |
| DE3844247A1 (de) | 1988-12-29 | 1990-07-12 | Minnesota Mining & Mfg | Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments |
| SU1667864A1 (ru) | 1989-03-23 | 1991-08-07 | Опытный завод энергетического машиностроения | Электростимул тор |
| US5134079A (en) | 1989-03-27 | 1992-07-28 | International Technidyne Corp. | Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling |
| US5788983A (en) | 1989-04-03 | 1998-08-04 | Rutgers, The State University Of New Jersey | Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes |
| US5531675A (en) | 1989-05-10 | 1996-07-02 | Yoo; Tae W. | Micro-acupuncture needle for a finger of a hand |
| CA2016900A1 (en) | 1989-07-06 | 1991-01-06 | Ronald J. Filipski | Tines structure in clinical applicator |
| EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
| US5215088A (en) | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
| JP2646766B2 (ja) | 1989-11-08 | 1997-08-27 | 日本電気株式会社 | 皮膚角層の除去器具 |
| US5190558A (en) | 1989-11-08 | 1993-03-02 | Nec Corporation | Method of eliminating stratum corneum from the skin and an instrument to be used therefor |
| US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| US5244711A (en) | 1990-03-12 | 1993-09-14 | Mcneil-Ppc, Inc. | Apertured non-woven fabric |
| US5162043A (en) | 1990-03-30 | 1992-11-10 | Alza Corporation | Iontophoretic delivery device |
| US5139029A (en) | 1990-04-06 | 1992-08-18 | Henry Fishman | Allergy testing apparatus and method |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| ES2082052T3 (es) | 1990-07-19 | 1996-03-16 | Nardino Righi | Jeringuilla de seguridad, de un solo uso. |
| US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| TW279133B (ru) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| US5156591A (en) | 1990-12-13 | 1992-10-20 | S. I. Scientific Innovations Ltd. | Skin electrode construction and transdermal drug delivery device utilizing same |
| US5158073A (en) | 1990-12-18 | 1992-10-27 | Bukowski Voytek Z | Acupressure foot massage mat |
| US5252279A (en) | 1991-01-17 | 1993-10-12 | Reinhold Industries | Method for making perforated articles |
| US5312456A (en) | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
| US5160315A (en) | 1991-04-05 | 1992-11-03 | Minnesota Mining And Manufacturing Company | Combined adhesive strip and transparent dressing delivery system |
| TW273531B (en) | 1991-08-14 | 1996-04-01 | Chicopee | Textile-like apertured plastic films |
| JP3189337B2 (ja) | 1991-11-08 | 2001-07-16 | 日本電気株式会社 | 皮膚角層の除去器具および除去方法 |
| JPH05162076A (ja) | 1991-12-13 | 1993-06-29 | Sony Corp | 遊離微粒子噴射加工装置 |
| DE69230408T2 (de) | 1992-02-18 | 2000-06-08 | Mcneil-Ppc, Inc. | Textilähnliche, gelochte plastikfolie |
| US5256360A (en) | 1992-03-25 | 1993-10-26 | Panasonic Technologies, Inc. | Method of manufacturing a precision micro-filter |
| US5756117A (en) | 1992-04-08 | 1998-05-26 | International Medical Asscociates, Inc. | Multidose transdermal drug delivery system |
| IE930532A1 (en) | 1993-07-19 | 1995-01-25 | Elan Med Tech | Liquid material dispenser and valve |
| US5318557A (en) | 1992-07-13 | 1994-06-07 | Elan Medical Technologies Limited | Medication administering device |
| US5308625A (en) | 1992-09-02 | 1994-05-03 | Cygnus Therapeutic Systems | Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters |
| US5462743A (en) | 1992-10-30 | 1995-10-31 | Medipro Sciences Limited | Substance transfer system for topical application |
| US5250067A (en) | 1992-11-30 | 1993-10-05 | Ala Gelfer | Body treatment pad having a multiple number of sharpened skin-penetration protuberances |
| US5383512A (en) | 1993-01-27 | 1995-01-24 | Midwest Research Institute | Method for fabricating a substrate having spaced apart microcapillaries thereon |
| JPH06238644A (ja) | 1993-02-15 | 1994-08-30 | Taiyo Yuden Co Ltd | セラミックグリーンシートの加工方法 |
| US6685682B1 (en) | 1993-03-22 | 2004-02-03 | 3M Innovative Properties Company | Carrier delivered dressing and method of manufacture |
| KR100355857B1 (ko) | 1993-03-22 | 2003-03-31 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 접착성합성체드레싱및그제조방법 |
| GB9305930D0 (en) | 1993-03-22 | 1993-05-12 | Moran Peter L | Electrical circuit board |
| IE68890B1 (en) | 1993-04-08 | 1996-07-24 | Elan Med Tech | Intradermal delivery device |
| AU667766B2 (en) | 1993-05-27 | 1996-04-04 | Paul Hartmann Ag | Hydrogel wound dressing product |
| US5330452A (en) | 1993-06-01 | 1994-07-19 | Zook Gerald P | Topical medicating device |
| US5728089A (en) | 1993-06-04 | 1998-03-17 | The Regents Of The University Of California | Microfabricated structure to be used in surgery |
| US5320600A (en) | 1993-06-14 | 1994-06-14 | Lambert Wm S | Plural content container for simultaneous ejection |
| CA2132277C (en) | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
| JP3590805B2 (ja) | 1993-11-10 | 2004-11-17 | 株式会社ニコン | 採血装置 |
| US5962011A (en) | 1993-12-06 | 1999-10-05 | Schering-Plough Healthcare Products, Inc. | Device for delivery of dermatological ingredients |
| WO1995022612A2 (en) | 1994-02-22 | 1995-08-24 | Board Of Trustees Of The University Of Illinois | Genes and genetic elements associated with sensitivity to platinum-based drugs |
| US5457041A (en) | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| US5536263A (en) | 1994-03-30 | 1996-07-16 | Lectec Corporation | Non-occulusive adhesive patch for applying medication to the skin |
| US5503843A (en) | 1994-04-22 | 1996-04-02 | Flora Inc. | Transdermal delivery of alpha adrenoceptor blocking agents |
| KR0134151B1 (ko) | 1994-05-23 | 1998-04-14 | 이형도 | 인슐린 패치 |
| CA2149836C (en) | 1994-05-23 | 1999-07-06 | Sang Bae Choi | Perforating device for dermal administration |
| FR2720003B1 (fr) | 1994-05-23 | 1998-06-26 | Samsung Electro Mech | Dispositif servant à inciser la peau pour une médication transcutanée. |
| KR0134152B1 (ko) | 1994-05-23 | 1998-04-14 | 이형도 | 의약품 투여용 피부흠집 형성장치 |
| US5851549A (en) | 1994-05-25 | 1998-12-22 | Becton Dickinson And Company | Patch, with system and apparatus for manufacture |
| US5512219A (en) | 1994-06-03 | 1996-04-30 | Reflexite Corporation | Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold |
| US5591139A (en) | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
| US5487726A (en) | 1994-06-16 | 1996-01-30 | Ryder International Corporation | Vaccine applicator system |
| US5771890A (en) | 1994-06-24 | 1998-06-30 | Cygnus, Inc. | Device and method for sampling of substances using alternating polarity |
| US5496304A (en) | 1994-07-20 | 1996-03-05 | University Of Utah Research Foundation | Surgical marking pen |
| US5498235A (en) | 1994-09-30 | 1996-03-12 | Becton Dickinson And Company | Iontophoresis assembly including patch/controller attachment |
| US5551953A (en) | 1994-10-31 | 1996-09-03 | Alza Corporation | Electrotransport system with remote telemetry link |
| IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
| US6120488A (en) | 1994-11-28 | 2000-09-19 | The Procter & Gamble Company | Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon |
| CA2205444A1 (en) | 1994-12-09 | 1996-06-13 | Novartis Ag | Transdermal system |
| WO1996037256A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical patch for enhancing the delivery of compounds through the skin |
| WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
| US5869079A (en) | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| DE19525607A1 (de) | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| US5780050A (en) | 1995-07-20 | 1998-07-14 | Theratech, Inc. | Drug delivery compositions for improved stability of steroids |
| JP2713255B2 (ja) | 1995-08-11 | 1998-02-16 | 日本電気株式会社 | 浸出液吸引装置 |
| IE77523B1 (en) | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
| US5735273A (en) | 1995-09-12 | 1998-04-07 | Cygnus, Inc. | Chemical signal-impermeable mask |
| JP2718408B2 (ja) | 1995-09-20 | 1998-02-25 | 日本電気株式会社 | 浸出液吸引装置 |
| US5645977A (en) | 1995-09-22 | 1997-07-08 | Industrial Technology Research Institute | Method of making molds for manufacturing multiple-lead microstructures |
| US5658515A (en) | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
| US5776103A (en) | 1995-10-11 | 1998-07-07 | Science Incorporated | Fluid delivery device with bolus injection site |
| US5662127A (en) | 1996-01-17 | 1997-09-02 | Bio-Plas, Inc. | Self-contained blood withdrawal apparatus and method |
| US5730721A (en) | 1996-01-25 | 1998-03-24 | Vesture Corporation | Medical applicator and method |
| JP3430771B2 (ja) | 1996-02-05 | 2003-07-28 | 株式会社デンソー | 半導体力学量センサの製造方法 |
| JPH09215755A (ja) | 1996-02-09 | 1997-08-19 | Poritoronikusu:Kk | 皮接治療具 |
| US5948488A (en) | 1996-04-30 | 1999-09-07 | 3M Innovative Properties Company | Glittering cube-corner article |
| DE69719761T2 (de) | 1996-06-18 | 2003-12-18 | Alza Corp., Palo Alto | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
| DE19624578A1 (de) | 1996-06-20 | 1998-01-08 | Nancy L Divers | Vorrichtung zur Hautpflege |
| AU3880697A (en) | 1996-07-03 | 1998-01-21 | Altea Technologies, Inc. | Multiple mechanical microporation of skin or mucosa |
| US6512010B1 (en) | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US5983136A (en) | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
| DE19649100A1 (de) | 1996-11-27 | 1998-06-04 | Lohmann Therapie Syst Lts | Verfahren zur verlustarmen Herstellung wirkstoffhaltiger scheibenförmiger Formkörper und diese enthaltende transdermale therapeutische Systeme |
| WO1998028307A1 (en) | 1996-12-23 | 1998-07-02 | Sartomer Company, Inc. | Free radically polymerizable silane monomers and oligomers and the method for making them |
| US5873849A (en) | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| JP3097600B2 (ja) | 1997-05-30 | 2000-10-10 | 日本電気株式会社 | 角質層穿刺装置 |
| US5904712A (en) | 1997-06-12 | 1999-05-18 | Axelgaard Manufacturing Co., Ltd. | Current-controlling electrode |
| US5928207A (en) | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6047208A (en) | 1997-08-27 | 2000-04-04 | Becton, Dickinson And Company | Iontophoretic controller |
| US20010023324A1 (en) | 1997-11-03 | 2001-09-20 | Allan Pronovost | Glucose detector and method for diagnosing diabetes |
| US5868244A (en) | 1997-12-01 | 1999-02-09 | Ethicon, Inc. | Microbial barrier vented package for sterile medical devices and method of packaging |
| US5938684A (en) | 1997-12-09 | 1999-08-17 | Sierra Self Healing Products, Inc. | Accupressure device for therapeutic relief |
| US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
| KR100572539B1 (ko) | 1997-12-11 | 2006-04-24 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
| WO1999029365A1 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
| KR100557261B1 (ko) | 1997-12-11 | 2006-03-07 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
| US6778853B1 (en) | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
| US6135990A (en) | 1997-12-17 | 2000-10-24 | University Of South Florida | Electroporation device and method |
| US6024553A (en) | 1997-12-22 | 2000-02-15 | Mcneil-Ppc, Inc. | Apparatus for supporting a starting web during formation of the apertured web |
| EP1041975B1 (en) | 1997-12-22 | 2002-09-04 | Alza Corporation | Rate controlling membranes for controlled drug delivery devices |
| CA2312919C (en) | 1997-12-31 | 2004-12-14 | Minimed, Inc. | Insertion device for an insertion set and method of using the same |
| JPH11230707A (ja) | 1998-02-10 | 1999-08-27 | Mitsutoyo Corp | マイクロセンサデバイスの製造方法 |
| US6106751A (en) | 1998-03-18 | 2000-08-22 | The Regents Of The University Of California | Method for fabricating needles via conformal deposition in two-piece molds |
| US6136008A (en) | 1998-03-19 | 2000-10-24 | 3M Innovative Properties Company | Skin abrader for biomedical electrode |
| US5902800A (en) | 1998-03-27 | 1999-05-11 | Glenpharma | Dextran formulations and method for treatment of inflammatory joint disorders |
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| US6120792A (en) | 1998-04-29 | 2000-09-19 | Juni; Jack E. | Medicated skin patch and method for its use |
| US6290679B1 (en) | 1999-05-14 | 2001-09-18 | Disetronic Licensing Ag | Device for metered administration of an injectable product |
| EP1190229B1 (en) | 1998-05-22 | 2011-10-26 | California Institute Of Technology | Microfabricated cell sorter |
| JP2002517300A (ja) | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| GB9815820D0 (en) | 1998-07-22 | 1998-09-16 | Secr Defence | Improvements relating to micro-machining |
| GB9815819D0 (en) | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
| WO2000012173A1 (en) | 1998-08-31 | 2000-03-09 | Johnson & Johnson Consumer Companies, Inc. | Electrotransport device comprising blades |
| JP2000146777A (ja) | 1998-09-08 | 2000-05-26 | Matsushita Electric Ind Co Ltd | 検体採取方法、検体採取装置、検体採取用容器、検体測定方法、検体測定装置および検体測定用容器 |
| US7048723B1 (en) | 1998-09-18 | 2006-05-23 | The University Of Utah Research Foundation | Surface micromachined microneedles |
| US6036659A (en) | 1998-10-09 | 2000-03-14 | Flexsite Diagnostics, Inc. | Collection device for biological samples and methods of use |
| US6038465A (en) | 1998-10-13 | 2000-03-14 | Agilent Technologies, Inc. | Telemedicine patient platform |
| US6611706B2 (en) | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
| EP1003078A3 (en) | 1998-11-17 | 2001-11-07 | Corning Incorporated | Replicating a nanoscale pattern |
| JP4214584B2 (ja) | 1998-11-27 | 2009-01-28 | 株式会社デンソー | 半導体力学量センサおよびその製造方法 |
| JP2002532165A (ja) | 1998-12-18 | 2002-10-02 | メドトロニック ミニメド インコーポレイテッド | 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法 |
| JP2000194142A (ja) | 1998-12-25 | 2000-07-14 | Fujitsu Ltd | パタ―ン形成方法及び半導体装置の製造方法 |
| JP2000232095A (ja) | 1999-02-12 | 2000-08-22 | Nippon Telegr & Teleph Corp <Ntt> | 半導体表面の微細パターン形成方法 |
| JP2000232971A (ja) | 1999-02-15 | 2000-08-29 | Arkray Inc | 吸引浸出液採取方法および装置 |
| US5997549A (en) | 1999-02-16 | 1999-12-07 | Sauceda; Charles J. | Wart removing tool |
| US6132449A (en) | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
| US6183770B1 (en) | 1999-04-15 | 2001-02-06 | Acutek International | Carrier patch for the delivery of agents to the skin |
| US6689103B1 (en) | 1999-05-07 | 2004-02-10 | Scimed Life System, Inc. | Injection array apparatus and method |
| JP2000323461A (ja) | 1999-05-11 | 2000-11-24 | Nec Corp | 微細パターン形成装置、その製造方法、および形成方法 |
| NO311797B1 (no) | 1999-05-12 | 2002-01-28 | Thin Film Electronics Asa | Fremgangsmåter til mönstring av polymerfilmer og anvendelse av fremgangsmåtene |
| JP4114761B2 (ja) | 1999-05-14 | 2008-07-09 | 国立大学法人群馬大学 | 情報記録ディスク用スタンパー、その製造方法、情報記録ディスク、および情報記録ディスク製造方法 |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| EP1187653B1 (en) | 1999-06-04 | 2010-03-31 | Georgia Tech Research Corporation | Devices for enhanced microneedle penetration of biological barriers |
| US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
| US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| DE19927359A1 (de) | 1999-06-16 | 2000-12-21 | Creavis Tech & Innovation Gmbh | Elektrophoretische Displays aus lichtstreuenden Trägermaterialien |
| JP3654059B2 (ja) | 1999-06-25 | 2005-06-02 | 松下電工株式会社 | 赤外線センサーの製造方法 |
| JP4948726B2 (ja) | 1999-07-21 | 2012-06-06 | イー インク コーポレイション | 電子ディスプレイを制御するための電子回路素子を作製する好適な方法 |
| JP3387897B2 (ja) | 1999-08-30 | 2003-03-17 | キヤノン株式会社 | 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス |
| US6623457B1 (en) | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
| US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| US20030093089A1 (en) | 1999-10-20 | 2003-05-15 | Greenberg Ronald Allan | Apparatus for variable micro abrasion of human tissue and/or hides using different size and types of abrasive particles |
| US6355054B1 (en) | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
| EP1235611B1 (en) | 1999-11-15 | 2005-09-07 | Velcro Industries B.V. | Skin attachment member |
| WO2001036321A1 (en) | 1999-11-17 | 2001-05-25 | The Regents Of The University Of California | Apparatus and method for forming a membrane with nanometer scale pores |
| US6511463B1 (en) | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
| WO2001039675A1 (en) | 1999-12-01 | 2001-06-07 | Aesthetic Technologies, Inc. | Skin abrasion system and method |
| ES2253278T3 (es) | 1999-12-10 | 2006-06-01 | Alza Corporation | Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias. |
| EP1239917B1 (en) | 1999-12-10 | 2005-05-11 | ALZA Corporation | Skin treatment apparatus for sustained transdermal drug delivery |
| AU2088301A (en) | 1999-12-16 | 2001-06-25 | Alza Corporation | Device for enhancing transdermal flux of sampled agents |
| US6406638B1 (en) | 2000-01-06 | 2002-06-18 | The Regents Of The University Of California | Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby |
| US6248120B1 (en) | 2000-01-10 | 2001-06-19 | P. Z. “HTL” Spolka Akcyjna | Puncturing device |
| US6375627B1 (en) | 2000-03-02 | 2002-04-23 | Agilent Technologies, Inc. | Physiological fluid extraction with rapid analysis |
| US6558361B1 (en) | 2000-03-09 | 2003-05-06 | Nanopass Ltd. | Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems |
| US6629949B1 (en) | 2000-05-08 | 2003-10-07 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
| US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
| JP4001311B2 (ja) | 2000-06-01 | 2007-10-31 | 株式会社リコー | 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ |
| US6537242B1 (en) | 2000-06-06 | 2003-03-25 | Becton, Dickinson And Company | Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance |
| US6607513B1 (en) | 2000-06-08 | 2003-08-19 | Becton, Dickinson And Company | Device for withdrawing or administering a substance and method of manufacturing a device |
| JP2002000728A (ja) | 2000-06-19 | 2002-01-08 | Terumo Corp | 微小針を備えた噴射式の薬液注入装置 |
| US6494830B1 (en) | 2000-06-22 | 2002-12-17 | Guidance Interactive Technologies, Inc. | Handheld controller for monitoring/using medical parameters |
| US6589202B1 (en) | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
| US6603987B2 (en) | 2000-07-11 | 2003-08-05 | Bayer Corporation | Hollow microneedle patch |
| US6440096B1 (en) | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| US20080164638A1 (en) | 2006-11-28 | 2008-07-10 | Wei Zhang | Method and apparatus for rapid imprint lithography |
| GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| WO2002007543A1 (en) | 2000-07-25 | 2002-01-31 | Dickinson Legg Limited | Lamina separator |
| US6533949B1 (en) | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
| JP2002079499A (ja) | 2000-09-08 | 2002-03-19 | Terumo Corp | 針形状物の作製方法および作製された針 |
| CA2357386C (en) | 2000-09-15 | 2009-03-24 | Timberjack Inc. | High rotation felling head mechanism |
| AU2001293460A1 (en) | 2000-10-05 | 2002-04-15 | Thomas Marsoner | Medical injection device |
| KR20030068136A (ko) | 2000-10-13 | 2003-08-19 | 알자 코포레이션 | 미세 돌기부로 피부를 천공하기 위한 장치 및 방법 |
| MXPA03003303A (es) | 2000-10-13 | 2004-12-13 | Johnson & Johnson | Retenedor del miembro de microprotrusion para aplicador de impacto. |
| CZ20031035A3 (cs) | 2000-10-13 | 2004-02-18 | Alza Corporation | Nárazový aplikátor opatřený množinou mikročepelek |
| US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
| US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| WO2002094368A1 (en) | 2000-10-26 | 2002-11-28 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
| US6533884B1 (en) | 2000-11-03 | 2003-03-18 | Printpack Illinois, Inc. | Method and system for extrusion embossing |
| JP3525177B2 (ja) | 2000-11-14 | 2004-05-10 | 関西ティー・エル・オー株式会社 | Ｘ線を用いた材料の加工方法 |
| US6591133B1 (en) | 2000-11-27 | 2003-07-08 | Microlin Llc | Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices |
| WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| US6508947B2 (en) | 2001-01-24 | 2003-01-21 | Xerox Corporation | Method for fabricating a micro-electro-mechanical fluid ejector |
| WO2002062202A2 (en) | 2001-02-05 | 2002-08-15 | Becton, Dickinson And Company | Microprotrusion array and methods of making a microprotrusion |
| JP3696513B2 (ja) | 2001-02-19 | 2005-09-21 | 住友精密工業株式会社 | 針状体の製造方法 |
| US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| ATE444773T1 (de) | 2001-04-20 | 2009-10-15 | Alza Corp | Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält |
| US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
| US6585742B2 (en) | 2001-05-08 | 2003-07-01 | Dowling B. Stough | Wart removal method and device |
| US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
| US6921410B2 (en) | 2001-05-29 | 2005-07-26 | Scimed Life Systems, Inc. | Injection molded vaso-occlusive elements |
| US20020188310A1 (en) | 2001-06-08 | 2002-12-12 | Seward Kirk Partick | Microfabricated surgical device |
| AU2002312380A1 (en) | 2001-06-08 | 2002-12-23 | Becton, Dickinson And Company | Device for manipulating a needle or abrader array |
| US6767341B2 (en) | 2001-06-13 | 2004-07-27 | Abbott Laboratories | Microneedles for minimally invasive drug delivery |
| US6991809B2 (en) | 2001-06-23 | 2006-01-31 | Lyotropic Therapeutics, Inc. | Particles with improved solubilization capacity |
| US20040204669A1 (en) | 2001-07-05 | 2004-10-14 | Hofmann Gunter A. | Apparatus for electroporation mediated delivery for drugs and genes |
| US6749792B2 (en) | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
| JP5055672B2 (ja) | 2001-07-31 | 2012-10-24 | 大日本印刷株式会社 | 薄膜パターン形成用スタンプ |
| JP4919446B2 (ja) | 2001-08-09 | 2012-04-18 | 学校法人東京電機大学 | 微細溝加工方法及びその装置 |
| US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| US20040087992A1 (en) | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| WO2003024290A1 (en) | 2001-09-14 | 2003-03-27 | The Procter & Gamble Company | Method of exfoliation of skin using closely-packed microstructures and apparatus therefor |
| JP2005503210A (ja) | 2001-09-14 | 2005-02-03 | ザ プロクター アンド ギャンブル カンパニー | 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造 |
| AU2002327675A1 (en) | 2001-09-19 | 2003-04-01 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
| CA2500453A1 (en) | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Microneedle with membrane |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US20030093028A1 (en) | 2001-11-09 | 2003-05-15 | Michael Spiegel | Appararus and method for magnetic induction of therapeutic electric fields |
| EP1485317A2 (en) | 2001-11-30 | 2004-12-15 | Alza Corporation | Methods and apparatuses for forming microprojection arrays |
| MXPA04007389A (es) | 2002-02-04 | 2004-10-11 | Becton Dickinson Co | Dispositivo y metodo para entregar o retirar una substancia a traves de la piel. |
| US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
| US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
| US7713214B2 (en) | 2002-04-19 | 2010-05-11 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing |
| KR101061975B1 (ko) | 2002-06-25 | 2011-09-05 | 권성윤 | 약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 |
| US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
| KR20050054483A (ko) | 2002-06-28 | 2005-06-10 | 알자 코포레이션 | 코팅된 미세돌출부를 갖는 경피용 약물 전달 장치 |
| KR101323980B1 (ko) | 2002-07-19 | 2013-10-30 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법 |
| US20060127378A1 (en) | 2002-07-22 | 2006-06-15 | Kenji Yasuda | Composition for promoting the proliferation of lactobacillus casei subsp. casei |
| JP2004065775A (ja) | 2002-08-08 | 2004-03-04 | Sanwa Kagaku Kenkyusho Co Ltd | 針状構造体を備えたデバイス |
| AR040819A1 (es) | 2002-08-08 | 2005-04-20 | Alza Corp | Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas |
| AU2003270011B8 (en) | 2002-08-29 | 2009-03-05 | Becton, Dickinson And Company | Substance delivery via rotating microabrading surface |
| US8062573B2 (en) | 2002-09-16 | 2011-11-22 | Theraject, Inc. | Solid micro-perforators and methods of use |
| US7148211B2 (en) | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| DE10244503A1 (de) | 2002-09-25 | 2004-04-08 | Capsulution Nanoscience Ag | Methode zur Herstellung und Stabilisierung von Mikro- und Nanosuspensionen mit Amphiphilen und Polyelektrolyten |
| WO2004033021A1 (en) | 2002-10-07 | 2004-04-22 | Biovalve Technologies, Inc. | Microneedle array patch |
| GB0226401D0 (en) | 2002-11-12 | 2002-12-18 | Koninkl Philips Electronics Nv | Electroluminescent devices and their manufacture |
| US7578954B2 (en) | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| US6926694B2 (en) | 2003-05-09 | 2005-08-09 | Medsolve Technologies, Llc | Apparatus and method for delivery of therapeutic and/or diagnostic agents |
| US7572405B2 (en) | 2003-06-02 | 2009-08-11 | Corium International Inc. | Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation |
| PL1638468T3 (pl) | 2003-06-30 | 2008-01-31 | Alza Corp | Sposób powlekania mikrowystępów do przekłuwania skóry |
| TW200513280A (en) | 2003-07-02 | 2005-04-16 | Alza Corp | Microprojection array immunization patch and method |
| JP2007501071A (ja) | 2003-08-04 | 2007-01-25 | アルザ・コーポレーシヨン | 経皮作用剤流率を向上させる方法および装置 |
| US8353861B2 (en) * | 2003-09-18 | 2013-01-15 | Texmac, Inc. | Applicator for applying functional substances into human skin |
| JP2007508914A (ja) | 2003-10-24 | 2007-04-12 | アルザ・コーポレーシヨン | 経皮薬剤送達を促進するための装置及び方法 |
| WO2005044333A2 (en) | 2003-10-31 | 2005-05-19 | Alza Corporation | Self-actuating applicator for microprojection array |
| WO2005046769A2 (en) | 2003-11-12 | 2005-05-26 | Vidacare Corporation | Reusable intraosseous device and method for accessing bone marrow in the sternum |
| CA2552385C (en) | 2003-12-29 | 2013-07-23 | 3M Innovative Properties Company | Medical devices and kits including same |
| EP1711159B1 (en) | 2003-12-30 | 2013-03-20 | Durect Corporation | Solid implants containing a block copolymer for controlled release of a gnrh compound |
| AT500095B8 (de) | 2004-01-23 | 2007-02-15 | Braun Werner Mag | Transdermales abgabesystem |
| WO2005082593A1 (en) | 2004-02-17 | 2005-09-09 | Avery Dennison Corporation | Method of making microneedles |
| JP2007523771A (ja) | 2004-02-23 | 2007-08-23 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの成形方法 |
| US20050203575A1 (en) | 2004-03-15 | 2005-09-15 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin microactivation system and method |
| WO2005094526A2 (en) | 2004-03-24 | 2005-10-13 | Corium International, Inc. | Transdermal delivery device |
| AU2005232541A1 (en) | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
| JP2007537783A (ja) | 2004-04-13 | 2007-12-27 | アルザ コーポレイション | 複数のワクチンを経皮送達するための装置及び方法 |
| JP5007427B2 (ja) | 2004-05-13 | 2012-08-22 | アルザ コーポレイション | 副甲状腺ホルモン剤の経皮送達のための装置および方法 |
| EP3329960A1 (en) | 2004-06-10 | 2018-06-06 | 3M Innovative Properties Company | Patch application device and kit |
| WO2006015299A2 (en) | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| AR054300A1 (es) | 2004-08-10 | 2007-06-20 | Alza Corp | Aparato y sistema de microproyeccion con escaso potencial infeccioso |
| GB2417462A (en) | 2004-08-31 | 2006-03-01 | Eastman Chem Co | Moulding of thermoplastic polyesters |
| KR20070057954A (ko) | 2004-09-28 | 2007-06-07 | 알자 코포레이션 | 알룸-애주번트가 있는 면역 활성제의 안정화 |
| JP2008520367A (ja) | 2004-11-18 | 2008-06-19 | スリーエム イノベイティブ プロパティズ カンパニー | 皮膚非接触型のマイクロニードルアレイアプリケータ |
| CN101060883B (zh) | 2004-11-18 | 2010-06-23 | 3M创新有限公司 | 低轮廓微针阵列施放器 |
| DE602005027397D1 (de) | 2004-11-18 | 2011-05-19 | 3M Innovative Properties Co | Mikronadelanordungsapplikator und halter |
| AU2005306426B2 (en) | 2004-11-18 | 2011-04-28 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| CA2589730C (en) * | 2004-12-10 | 2014-03-25 | 3M Innovative Properties Company | Medical device |
| US20060134188A1 (en) | 2004-12-20 | 2006-06-22 | Hans-Peter Podhaisky | Transdermal pharmaceutical preparation with a progesterone A-specific ligand (PRASL) as active ingredient |
| JP4913030B2 (ja) | 2005-01-31 | 2012-04-11 | 株式会社バイオセレンタック | 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具 |
| US20070043320A1 (en) | 2005-02-09 | 2007-02-22 | Kenany Saad A | Microstream injector |
| WO2006101459A1 (en) * | 2005-03-23 | 2006-09-28 | Agency For Science, Technology And Research | Microneedles |
| JP2006271781A (ja) | 2005-03-30 | 2006-10-12 | Toppan Printing Co Ltd | 医療品用滅菌包装袋の製造方法 |
| US10035008B2 (en) | 2005-04-07 | 2018-07-31 | 3M Innovative Properties Company | System and method for tool feedback sensing |
| US20060253078A1 (en) | 2005-04-25 | 2006-11-09 | Wu Jeffrey M | Method of treating skin disorders with stratum corneum piercing device |
| JP2006341089A (ja) | 2005-05-13 | 2006-12-21 | Fujikura Ltd | 医薬物運搬用器具およびその製造方法 |
| WO2007002523A2 (en) | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
| JP5144510B2 (ja) | 2005-06-27 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイ適用装置 |
| CA2613114C (en) | 2005-06-27 | 2015-02-24 | 3M Innovative Properties Company | Microneedle cartridge assembly and method of applying |
| CN101227940A (zh) * | 2005-07-25 | 2008-07-23 | 纳米技术维多利亚有限公司 | 微阵列装置 |
| JP5161776B2 (ja) | 2005-09-06 | 2013-03-13 | セラジェクト， インコーポレイテッド | 薬物粒子および／または薬物を吸着した粒子を含む、固溶体穿孔器 |
| US8697087B2 (en) | 2005-11-04 | 2014-04-15 | Novartis Ag | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| JP2007130030A (ja) | 2005-11-08 | 2007-05-31 | Toray Ind Inc | マイクロニードル、マイクロニードル集合体及びその製造方法 |
| CA2629193C (en) | 2005-11-18 | 2016-03-29 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
| US7842008B2 (en) | 2005-11-21 | 2010-11-30 | Becton, Dickinson And Company | Intradermal delivery device |
| US20080275400A1 (en) | 2005-12-23 | 2008-11-06 | Ferguson Dennis E | Manufacturing Microneedle Arrays |
| US7658728B2 (en) | 2006-01-10 | 2010-02-09 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
| JP2007190112A (ja) | 2006-01-18 | 2007-08-02 | Toray Ind Inc | マイクロニードル |
| CN101400320A (zh) | 2006-03-10 | 2009-04-01 | 阿尔扎公司 | 采用高防渗定位器的微突起阵列应用 |
| US9119945B2 (en) | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| AU2007288442A1 (en) | 2006-05-09 | 2008-02-28 | Apogee Technology, Inc. | Nanofiber structures on asperities for sequestering, carrying and transferring substances |
| US20080063866A1 (en) | 2006-05-26 | 2008-03-13 | Georgia Tech Research Corporation | Method for Making Electrically Conductive Three-Dimensional Structures |
| JP2008006178A (ja) | 2006-06-30 | 2008-01-17 | Fujifilm Corp | マイクロニードルシートの製造方法及び製造装置 |
| US20090182306A1 (en) | 2006-07-21 | 2009-07-16 | Georgia Tech Research Corporation | Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal |
| WO2008011625A2 (en) | 2006-07-21 | 2008-01-24 | Georgia Tech Researh Corporation | Microneedle devices and methods of drug delivery or fluid withdrawal |
| EP2789363B1 (en) | 2006-07-27 | 2016-11-02 | Toppan Printing Co., Ltd. | Method of manufacturing microneedle |
| ITMI20061538A1 (it) | 2006-08-02 | 2008-02-03 | Mediolanum Pharmaceuticals Ltd | Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo |
| JPWO2008020632A1 (ja) | 2006-08-18 | 2010-01-07 | 凸版印刷株式会社 | マイクロニードル及びマイクロニードルパッチ |
| EP2054109B1 (en) | 2006-08-24 | 2017-12-13 | F. Hoffmann-La Roche AG | Insertion device for insertion heads, in particular for infusion sets |
| JP4925039B2 (ja) | 2006-09-21 | 2012-04-25 | 日東電工株式会社 | 糖材料の調製方法ならびに糖材料、糖材料を含むマイクロニードルおよびマイクロニードルをそなえてなる経皮製剤 |
| US20110165236A1 (en) | 2006-09-22 | 2011-07-07 | Biokey, Inc. | Controlled release hydrogel formulation |
| EP2090331A4 (en) | 2006-11-22 | 2012-04-18 | Toppan Printing Co Ltd | MICRONADEL ARRANGEMENT AND MANUFACTURING METHOD THEREFOR |
| US7785301B2 (en) | 2006-11-28 | 2010-08-31 | Vadim V Yuzhakov | Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection |
| JP2008142183A (ja) | 2006-12-07 | 2008-06-26 | Fujifilm Corp | マイクロニードルシート及びその製造方法 |
| US20080214987A1 (en) | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
| WO2008091602A2 (en) | 2007-01-22 | 2008-07-31 | Corium International, Inc. | Applicators for microneedle arrays |
| CN101594905A (zh) | 2007-01-29 | 2009-12-02 | 株式会社医药处方 | 生产热敏物质微针的方法 |
| JP4959363B2 (ja) | 2007-02-14 | 2012-06-20 | 凸版印刷株式会社 | 針状体の製造方法 |
| AU2008241470B2 (en) * | 2007-04-16 | 2013-11-07 | Corium Pharma Solutions, Inc. | Solvent-cast microneedle arrays containing active |
| US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
| US7578985B2 (en) | 2007-04-18 | 2009-08-25 | Gas Technology Institute | Method for direct oxidation of hydrogen sulfide to elemental sulfur at low temperatures |
| JP2008284318A (ja) | 2007-05-15 | 2008-11-27 | Kosumedei Seiyaku Kk | 生体由来物質からなる投薬用微細針 |
| WO2008139648A1 (ja) | 2007-05-15 | 2008-11-20 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードルのコーティング方法 |
| WO2008150970A2 (en) * | 2007-05-30 | 2008-12-11 | Dow Global Technologies Inc. | High-output solvent-based electrospinning |
| EP2173431A4 (en) | 2007-07-09 | 2013-06-12 | Apogee Technology Inc | IMMUNOSTIMULATING POLYPHOSPHAZEN COMPOUNDS FOR INTRADERMAL IMMUNIZATION |
| US20090017210A1 (en) | 2007-07-09 | 2009-01-15 | Andrianov Alexander K | Methods and systems for coating a microneedle with a dosage of a biologically active compound |
| WO2009021048A2 (en) | 2007-08-06 | 2009-02-12 | Transderm, Inc. | Microneedle arrays formed from polymer films |
| US20120150023A1 (en) | 2007-08-06 | 2012-06-14 | Kaspar Roger L | Microneedle arrays for active agent delivery |
| AU2008302516B2 (en) | 2007-09-17 | 2013-09-19 | Tecpharma Licensing Ag | Insertion devices for infusion devices |
| JP4885816B2 (ja) | 2007-09-27 | 2012-02-29 | 富士フイルム株式会社 | 機能性膜の製造方法および製造装置 |
| JP2009082206A (ja) | 2007-09-27 | 2009-04-23 | Fujifilm Corp | 機能性膜の製造方法 |
| CN101808588B (zh) | 2007-09-28 | 2012-12-19 | 贝尔法斯特女王大学 | 递送装置及方法 |
| US20090117158A1 (en) | 2007-10-23 | 2009-05-07 | Mahmoud Ameri | Transdermal sustained release drug delivery |
| CA2706404C (en) | 2007-11-21 | 2017-04-11 | Bioserentach Co., Ltd. | Preparation for body surface application and preparation for body surface application-holding sheet |
| CA2745339C (en) | 2007-12-24 | 2016-06-28 | The University Of Queensland | Coating method |
| JP5267910B2 (ja) | 2008-02-28 | 2013-08-21 | コスメディ製薬株式会社 | マイクロニードルアレイ |
| CN102105108B (zh) | 2008-05-21 | 2013-12-04 | 谢拉杰克特股份有限公司 | 制作固体溶液穿孔器贴剂的方法及其使用 |
| CA2760680A1 (en) | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection by microneedle patch with analyte selective reagents |
| JP2010069270A (ja) * | 2008-09-17 | 2010-04-02 | Yoshiichi Tobinaga | 機能剤投与デバイス、その製造方法及び製造装置 |
| KR20100037389A (ko) | 2008-10-01 | 2010-04-09 | 연세대학교 산학협력단 | 다중 약물방출조절이 가능한 솔리드 마이크로구조체 및 이의 제조방법 |
| DK2346563T3 (da) | 2008-10-07 | 2019-01-02 | Tuo Jin | Polymere faseovergangsmikronåle |
| CN102333565A (zh) | 2008-10-16 | 2012-01-25 | 昆士兰大学 | 用于涂布帖剂组件上的突起物的方法和相关的装置 |
| KR20100064669A (ko) | 2008-12-05 | 2010-06-15 | 폴 곽 | 마이크로 니들 피부 미용기 |
| CA2760573A1 (en) | 2008-12-22 | 2010-07-01 | The University Of Queensland | Patch production |
| JP5902390B2 (ja) | 2008-12-26 | 2016-04-13 | 久光製薬株式会社 | マイクロニードルデバイス |
| JP2010233673A (ja) | 2009-03-30 | 2010-10-21 | Fujifilm Corp | 経皮吸収シート及びその製造方法 |
| JP2010233674A (ja) * | 2009-03-30 | 2010-10-21 | Fujifilm Corp | マイクロニードルシート及びその使用方法並びに製造方法 |
| ES2634667T3 (es) | 2009-04-24 | 2017-09-28 | Corium International, Inc. | Métodos para fabricar conjuntos de microproyección |
| JP2011012050A (ja) | 2009-06-03 | 2011-01-20 | Bioserentack Co Ltd | 多孔性基盤を用いたマイクロニードル・アレイとその製造方法 |
| JP5615814B2 (ja) | 2009-06-10 | 2014-10-29 | 久光製薬株式会社 | マイクロニードルデバイス |
| RU2414255C1 (ru) | 2009-07-01 | 2011-03-20 | Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) | Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления |
| JP5620911B2 (ja) | 2009-07-23 | 2014-11-05 | 久光製薬株式会社 | マイクロニードルアレイ |
| BR112012001685B8 (pt) | 2009-07-31 | 2021-06-22 | 3M Innovative Properties Co | conjuntos de microagulhas ocas |
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| ATE553800T1 (de) | 2009-11-26 | 2012-05-15 | Hoffmann La Roche | Extern auslösbare kanülenanordnung |
| EP2338557A1 (en) * | 2009-12-23 | 2011-06-29 | Debiotech S.A. | Soluble microneedle |
| US8911422B2 (en) | 2010-02-24 | 2014-12-16 | Hisamitsu Pharmaceutical Co., Inc. | Micro-needle device |
| WO2011116388A1 (en) | 2010-03-19 | 2011-09-22 | Nanostar Health Corporation | Body fluid sampling/fluid delivery device |
| US9415159B2 (en) | 2010-03-30 | 2016-08-16 | Unomedical A/S | Medical device |
| CA2796965C (en) | 2010-04-28 | 2019-04-16 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
| AU2011248108B2 (en) | 2010-05-04 | 2016-05-26 | Corium Pharma Solutions, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| CN105662530B (zh) * | 2010-05-04 | 2018-07-20 | 考里安国际公司 | 微针施加器 |
| KR101848225B1 (ko) | 2010-05-14 | 2018-04-12 | 애브비 인코포레이티드 | Ｉｌ－１ 결합 단백질 |
| EP2399624B1 (en) | 2010-06-21 | 2015-10-07 | F.Hoffmann-La Roche Ag | Device for inserting a soft member into the tissue of the body of a patient |
| CA2808965C (en) | 2010-08-20 | 2020-01-07 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
| US8703727B2 (en) | 2010-08-24 | 2014-04-22 | Aphios Corporation | Nanotechnology formulation of poorly soluble compounds |
| JP5770055B2 (ja) * | 2010-09-29 | 2015-08-26 | 富士フイルム株式会社 | 針状アレイ経皮吸収シートの製造方法 |
| US10933173B2 (en) | 2010-10-19 | 2021-03-02 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
| EP2992827B1 (en) | 2010-11-09 | 2017-04-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
| CN102000020B (zh) | 2010-11-17 | 2012-10-10 | 河南羚锐制药股份有限公司北京药物研究院 | 新型可降解聚合物微针贴剂及其制备方法 |
| JP5663278B2 (ja) | 2010-11-19 | 2015-02-04 | ルネサスエレクトロニクス株式会社 | 半導体装置 |
| WO2012088154A1 (en) | 2010-12-22 | 2012-06-28 | Valeritas, Inc. | Microneedle patch applicator |
| CA2825016C (en) | 2011-01-24 | 2021-02-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Nanoparticles for dermal and systemic delivery of drugs |
| DK2683359T3 (en) | 2011-03-07 | 2015-07-20 | 3M Innovative Properties Co | MICROWAVE DEVICES AND METHODS |
| GB2486748B (en) | 2011-03-24 | 2013-04-10 | Owen Mumford Ltd | Autoinjector devices |
| GB201107642D0 (en) | 2011-05-09 | 2011-06-22 | Univ Cork | Method |
| US11179553B2 (en) | 2011-10-12 | 2021-11-23 | Vaxxas Pty Limited | Delivery device |
| CA2857501C (en) | 2011-11-30 | 2020-06-23 | 3M Innovative Properties Company | Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same |
| PL2791160T3 (pl) * | 2011-12-16 | 2022-06-20 | Modernatx, Inc. | Kompozycje zmodyfikowanego mrna |
| CN102580232B (zh) | 2012-02-23 | 2013-12-18 | 游学秋 | 一种丝素微针系统和丝素纳米颗粒及其制备方法 |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| MX374014B (es) | 2012-05-16 | 2020-07-24 | Mewa Singh | Composiciones farmaceuticas para la entrega de farmacos insolubles en agua. |
| US20140200508A1 (en) | 2012-06-29 | 2014-07-17 | Isaac D. Cohen | Microneedles Comprising One Or More Cosmetic Ingredients |
| CA2889500A1 (en) | 2012-11-02 | 2014-05-08 | Cosmed Pharmaceutical Co., Ltd. | Retinoic acid microneedle |
| WO2014077244A1 (ja) | 2012-11-13 | 2014-05-22 | 富士フイルム株式会社 | 経皮吸収シート及びその製造方法 |
| JP6038173B2 (ja) | 2012-11-13 | 2016-12-07 | 富士フイルム株式会社 | 経皮吸収シートの製造方法 |
| ES2744984T3 (es) | 2012-11-29 | 2020-02-27 | Massachusetts Inst Technology | Artículos adhesivos que contienen una combinación de micromodelación de superficie y química reactiva y métodos de realización y uso de los mismos |
| CA2896188C (en) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| ES2921481T3 (es) | 2013-03-12 | 2022-08-26 | Corium Inc | Aplicadores para microproyecciones |
| US10668260B2 (en) | 2013-03-12 | 2020-06-02 | Takeda Pharmaceutical Company Limited | Microneedle patch |
| CA2903763C (en) | 2013-03-15 | 2021-11-16 | Corium International, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| WO2014144973A1 (en) | 2013-03-15 | 2014-09-18 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
| CN105188569B (zh) | 2013-03-15 | 2020-11-20 | 考里安公司 | 用于递送活性剂的微结构阵列 |
| WO2015023557A1 (en) | 2013-08-12 | 2015-02-19 | Nanomedical Systems, Inc. | Device and method for sustained release of low water solubility therapeutic agent in solubilizer |
| JP6934721B2 (ja) | 2014-04-24 | 2021-09-15 | ジョージア テック リサーチ コーポレイション | マイクロニードル及びその製造方法 |
| EP4218724A3 (en) | 2014-08-29 | 2023-08-16 | Corium Pharma Solutions, Inc. | Microstructure array for delivery of active agents |
| EP3188714A1 (en) | 2014-09-04 | 2017-07-12 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
| JP5931155B2 (ja) | 2014-09-30 | 2016-06-08 | 日本写真印刷株式会社 | マイクロニードルシートの梱包体及びその製造方法 |
| AU2015342808A1 (en) | 2014-11-07 | 2017-05-25 | Corium, Inc. | Medical device packaging |
| US10792857B2 (en) | 2015-03-13 | 2020-10-06 | The University Of North Carolina At Chapel Hill | Polymeric microneedles and rapid additive manufacturing of the same |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
| PH12018501256B1 (en) | 2015-12-28 | 2024-03-27 | Endoderma Co Ltd | Microstructure for percutaneous absorption, and method for preparing same |
-
2013
- 2013-12-20 CA CA2896188A patent/CA2896188C/en active Active
- 2013-12-20 JP JP2015549839A patent/JP6865524B2/ja active Active
- 2013-12-20 RU RU2015129771A patent/RU2698095C2/ru active
- 2013-12-20 WO PCT/US2013/077281 patent/WO2014100750A1/en not_active Ceased
- 2013-12-20 ES ES13818960T patent/ES2743404T3/es active Active
- 2013-12-20 AU AU2013364053A patent/AU2013364053B2/en not_active Ceased
- 2013-12-20 EP EP13818960.0A patent/EP2934660B1/en active Active
- 2013-12-20 BR BR112015014969-3A patent/BR112015014969B1/pt active IP Right Grant
- 2013-12-20 CN CN201380073512.4A patent/CN105073178B/zh active Active
- 2013-12-20 KR KR1020157019673A patent/KR102265808B1/ko active Active
- 2013-12-20 MX MX2015008157A patent/MX375307B/es active IP Right Grant
- 2013-12-20 US US14/137,899 patent/US11052231B2/en active Active
-
2015
- 2015-06-21 IL IL239557A patent/IL239557B/en unknown
-
2018
- 2018-11-06 JP JP2018208785A patent/JP2019048107A/ja active Pending
-
2020
- 2020-11-25 JP JP2020194902A patent/JP2021041208A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US11052231B2 (en) | 2021-07-06 |
| IL239557A0 (en) | 2015-08-31 |
| MX375307B (es) | 2025-03-06 |
| MX2015008157A (es) | 2016-02-22 |
| JP2016511014A (ja) | 2016-04-14 |
| WO2014100750A1 (en) | 2014-06-26 |
| CA2896188C (en) | 2021-02-23 |
| ES2743404T3 (es) | 2020-02-19 |
| JP2019048107A (ja) | 2019-03-28 |
| IL239557B (en) | 2022-01-01 |
| RU2698095C2 (ru) | 2019-08-22 |
| BR112015014969A2 (pt) | 2017-07-11 |
| EP2934660A1 (en) | 2015-10-28 |
| CN105073178A (zh) | 2015-11-18 |
| US20140180201A1 (en) | 2014-06-26 |
| BR112015014969B1 (pt) | 2021-12-07 |
| WO2014100750A9 (en) | 2014-12-11 |
| JP2021041208A (ja) | 2021-03-18 |
| AU2013364053A1 (en) | 2015-07-16 |
| KR20150100807A (ko) | 2015-09-02 |
| KR102265808B1 (ko) | 2021-06-16 |
| CN105073178B (zh) | 2019-07-30 |
| AU2013364053B2 (en) | 2018-08-30 |
| CA2896188A1 (en) | 2014-06-26 |
| JP6865524B2 (ja) | 2021-04-28 |
| EP2934660B1 (en) | 2019-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015129771A (ru) | Микроматрица для доставки терапевтического средства и способы использования | |
| Guan et al. | Fabrication of polymeric microparticles for drug delivery by soft lithography | |
| Yu et al. | Asymmetric wettable composite wound dressing prepared by electrospinning with bioinspired micropatterning enhances diabetic wound healing | |
| KR101171888B1 (ko) | 약물 함유 나노입자를 포함하는 마이크로 니들의 제조방법 및 이에 의하여 제조된 마이크로 니들 | |
| TWI629073B (zh) | Microneedle patch manufacturing method | |
| JP6290988B2 (ja) | マイクロ構造体製造方法 | |
| JP6369026B2 (ja) | マイクロニードル、および、マイクロニードルの製造方法 | |
| CA2698632A1 (en) | Microneedle array using porous substrate and production method thereof | |
| WO2008097511A3 (en) | Medical device coatings for releasing a therapeutic agent at multiple rates | |
| RU2010150095A (ru) | Офтальмологическое устройство для контролируемого высвобождения активных препаратов | |
| JP2016514133A5 (ru) | ||
| KR102139335B1 (ko) | 니들 팁에 코팅부를 보유하는 마이크로니들을 제조하는 방법 및 장치 | |
| JP2010131123A (ja) | マイクロニードルアレイへの薬剤担持法 | |
| KR102245058B1 (ko) | 리도카인이 함유된 마이크로 니들 패치 및 그 제조방법 | |
| WO2016155082A1 (zh) | 一种溶胀型丝素蛋白微针给药系统及其制备方法 | |
| Zhong et al. | Novel biomaterials for wound healing and tissue regeneration | |
| CN107974768A (zh) | 具有可调控纤维表面微孔结构的形状记忆纤维膜的制备方法及其药物释放的应用 | |
| CN111344131B (zh) | 用于连续制造微针的装置和工艺 | |
| KR102296331B1 (ko) | 마이크로니들 연속 제조용 장치 및 공정 | |
| KR102139336B1 (ko) | 유효 성분의 흡수속도가 개선된 용해성 마이크로니들 디바이스 및 이를 포함하는 키트 | |
| JP2019006798A (ja) | 針状体 | |
| KR101264185B1 (ko) | 스트레인 제어 방식의 약물 전달 기구 | |
| KR20190085643A (ko) | 마이크로구조체 제조방법 | |
| JP2015208479A (ja) | 針状体デバイス | |
| ES2774454T3 (es) | Procedimiento para preparar películas de poli(tereftalato de etileno) (PET) tratadas con silicona |