RU2010135200A - Лекарственная форма - Google Patents
Лекарственная форма Download PDFInfo
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- RU2010135200A RU2010135200A RU2010135200/15A RU2010135200A RU2010135200A RU 2010135200 A RU2010135200 A RU 2010135200A RU 2010135200/15 A RU2010135200/15 A RU 2010135200/15A RU 2010135200 A RU2010135200 A RU 2010135200A RU 2010135200 A RU2010135200 A RU 2010135200A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. Лекарственная форма с контролированным высвобождением фармакологически активного состава (А), содержащегося там, причем лекарственная форма имеет предел прочности на разрыв B1 по крайней мере 500 Н в направлении растяжения Е1 и имеет предел прочности на разрыв B2 меньше, чем 500 Н в направлении растяжения E2. ! 2. Лекарственная форма по п.1, где общая поверхность S лекарственной формы в мм2 удовлетворяет следующим требованиям: ! , ! где А представляет собой 4,5 и ! W является общей массой лекарственной формы в мг. ! 3. Лекарственная форма по п.2, где А представляет собой 6,2. ! 4. Лекарственная форма по п.1, которая содержит полимер (С). !5. Лекарственная форма по п.4, где полимер (С) имеет среднемассовый молекулярный вес по крайней мере 100000 г/моль-1. ! 6. Лекарственная форма по п.4, где полимер (С) является гидрофильным. ! 7. Лекарственная форма по п.4, где полимер (С) включает полиалкиленоксид и/или по крайней мере одно производное эфира целлюлозы. ! 8. Лекарственная форма по п.7, где производное эфира целлюлозы выбрано из группы, состоящей из гидроксипропилметилцеллюлозы и/или гидроксипропилцеллюлозы. ! 9. Лекарственная форма по п.7, где полиалкиленоксид представляет собой полиэтиленоксид. ! 10. Лекарственная форма по п.9, где полиэтиленоксид имеет молекулярный вес в пределах от приблизительно 500000 г/моль до приблизительно 15000000 г/моль. ! 11. Лекарственная форма по п.4, которая дополнительно включает полиалкиленгликоль. ! 12. Лекарственная форма по п.11, где полиалкиленгликоль представляет собой полиэтиленгликоль. ! 13. Лекарственная форма по п.1, которая является устойчивой против злоупотреблений и где фармакологически активный состав (А) имеет пот
Claims (20)
1. Лекарственная форма с контролированным высвобождением фармакологически активного состава (А), содержащегося там, причем лекарственная форма имеет предел прочности на разрыв B1 по крайней мере 500 Н в направлении растяжения Е1 и имеет предел прочности на разрыв B2 меньше, чем 500 Н в направлении растяжения E2.
2. Лекарственная форма по п.1, где общая поверхность S лекарственной формы в мм2 удовлетворяет следующим требованиям:
где А представляет собой 4,5 и
W является общей массой лекарственной формы в мг.
3. Лекарственная форма по п.2, где А представляет собой 6,2.
4. Лекарственная форма по п.1, которая содержит полимер (С).
5. Лекарственная форма по п.4, где полимер (С) имеет среднемассовый молекулярный вес по крайней мере 100000 г/моль-1.
6. Лекарственная форма по п.4, где полимер (С) является гидрофильным.
7. Лекарственная форма по п.4, где полимер (С) включает полиалкиленоксид и/или по крайней мере одно производное эфира целлюлозы.
8. Лекарственная форма по п.7, где производное эфира целлюлозы выбрано из группы, состоящей из гидроксипропилметилцеллюлозы и/или гидроксипропилцеллюлозы.
9. Лекарственная форма по п.7, где полиалкиленоксид представляет собой полиэтиленоксид.
10. Лекарственная форма по п.9, где полиэтиленоксид имеет молекулярный вес в пределах от приблизительно 500000 г/моль до приблизительно 15000000 г/моль.
11. Лекарственная форма по п.4, которая дополнительно включает полиалкиленгликоль.
12. Лекарственная форма по п.11, где полиалкиленгликоль представляет собой полиэтиленгликоль.
13. Лекарственная форма по п.1, которая является устойчивой против злоупотреблений и где фармакологически активный состав (А) имеет потенциал для злоупотребления.
14. Лекарственная форма по п.13, где фармакологически активный состав (А), который является потенциальным для злоупотребления, представляет собой опиоид или производное опиоида.
15. Лекарственная форма по п.14, где фармакологически активный состав (А) представляет собой тапентадол.
16. Лекарственная форма по п.1, где часть ее поверхности является выпуклой, другая часть ее поверхности является вогнутой.
17. Лекарственная форма по п.1, которая включает по крайней мере один фармакологически активный состав (А) и имеет форму, содержащую продольную ось и две противоположные продольные кромки, поперечную ось, перпендикулярную к продольной оси, и две противоположные поперечные кромки, переднюю поверхность, противоположную заднюю поверхность и окружающий ободок между указанной передней и задней поверхностью, где передняя поверхность и/или задняя поверхность содержит поверхность основания, и где передняя поверхность и/или задняя поверхность содержит по крайней мере одну выпуклость, которая простирается выше указанной поверхности основания по крайней мере одна указанная выпуклость, имеющаяся на и/или расположена рядом по крайней мере с участком одной или двух продольных кромок и/или на и/или расположена рядом по крайней мере с участком одной или двух поперечных кромок и/или как между продольными кромками, так и между поперечными кромками.
18. Применение лекарственной формы по любому из пп.1-17 в качестве лекарственной формы для перорального применения с немедленным высвобождением или ретардированным высвобождением.
19. Применение лекарственной формы по любому из пп.1-17 в качестве стойкой против злоупотреблений или стойкой к разрыву лекарственной формы для перорального применения с ретардированым высвобождением.
20. Способ лечения боли у пациента, нуждающегося в таком лечении, включающий введение указанному пациенту лекарственной формы по любому из пп.1-17, где фармакологически активный состав (А) выбран из группы, состоящей из болеутоляющих.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08001416.0 | 2008-01-25 | ||
| EP08001416 | 2008-01-25 | ||
| EP08001415.2 | 2008-01-25 | ||
| EP08001415 | 2008-01-25 | ||
| EP08018221.5 | 2008-10-17 | ||
| EP08018221 | 2008-10-17 | ||
| PCT/EP2009/000438 WO2009092601A1 (en) | 2008-01-25 | 2009-01-23 | Pharmaceutical dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010135200A true RU2010135200A (ru) | 2012-02-27 |
| RU2493830C2 RU2493830C2 (ru) | 2013-09-27 |
Family
ID=40511977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010135200/15A RU2493830C2 (ru) | 2008-01-25 | 2009-01-23 | Лекарственная форма |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8383152B2 (ru) |
| EP (1) | EP2249811A1 (ru) |
| JP (1) | JP5774853B2 (ru) |
| KR (1) | KR101616246B1 (ru) |
| CN (1) | CN102014877B (ru) |
| AU (1) | AU2009207796B2 (ru) |
| BR (1) | BRPI0906467C1 (ru) |
| CA (1) | CA2713128C (ru) |
| CO (1) | CO6280466A2 (ru) |
| EC (1) | ECSP10010416A (ru) |
| IL (1) | IL207128A (ru) |
| MX (1) | MX2010008138A (ru) |
| NZ (1) | NZ586792A (ru) |
| RU (1) | RU2493830C2 (ru) |
| TW (1) | TWI454288B (ru) |
| WO (1) | WO2009092601A1 (ru) |
| ZA (1) | ZA201006029B (ru) |
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| ES2360102T3 (es) | 2003-03-26 | 2011-05-31 | Egalet A/S | Sistema para la liberación controlada de morfina. |
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| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
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- 2009-01-23 JP JP2010543436A patent/JP5774853B2/ja active Active
- 2009-01-23 NZ NZ586792A patent/NZ586792A/xx not_active IP Right Cessation
- 2009-01-23 BR BRPI0906467A patent/BRPI0906467C1/pt not_active IP Right Cessation
- 2009-01-23 CA CA2713128A patent/CA2713128C/en active Active
- 2009-01-23 KR KR1020107018922A patent/KR101616246B1/ko active Active
- 2009-01-23 WO PCT/EP2009/000438 patent/WO2009092601A1/en not_active Ceased
- 2009-01-23 CN CN200980112528.5A patent/CN102014877B/zh active Active
- 2009-01-23 TW TW098102817A patent/TWI454288B/zh active
- 2009-01-23 US US12/358,415 patent/US8383152B2/en active Active
- 2009-01-23 RU RU2010135200/15A patent/RU2493830C2/ru not_active IP Right Cessation
- 2009-01-23 EP EP09704933A patent/EP2249811A1/en not_active Withdrawn
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2010
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- 2010-08-24 ZA ZA2010/06029A patent/ZA201006029B/en unknown
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2013
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2014
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| CN102014877B (zh) | 2017-06-06 |
| US9750701B2 (en) | 2017-09-05 |
| TWI454288B (zh) | 2014-10-01 |
| IL207128A (en) | 2015-01-29 |
| AU2009207796B2 (en) | 2014-03-27 |
| EP2249811A1 (en) | 2010-11-17 |
| ZA201006029B (en) | 2011-05-25 |
| CO6280466A2 (es) | 2011-05-20 |
| MX2010008138A (es) | 2010-08-10 |
| BRPI0906467A2 (pt) | 2016-04-26 |
| IL207128A0 (en) | 2010-12-30 |
| US8383152B2 (en) | 2013-02-26 |
| AU2009207796A1 (en) | 2009-07-30 |
| US20160199305A1 (en) | 2016-07-14 |
| JP2011510034A (ja) | 2011-03-31 |
| WO2009092601A1 (en) | 2009-07-30 |
| US20130251759A1 (en) | 2013-09-26 |
| KR101616246B1 (ko) | 2016-05-02 |
| ECSP10010416A (es) | 2010-09-30 |
| CN102014877A (zh) | 2011-04-13 |
| BRPI0906467C1 (pt) | 2021-05-25 |
| NZ586792A (en) | 2012-09-28 |
| BRPI0906467B1 (pt) | 2019-12-24 |
| TW200944247A (en) | 2009-11-01 |
| KR20100111303A (ko) | 2010-10-14 |
| US20140322323A1 (en) | 2014-10-30 |
| CA2713128C (en) | 2016-04-05 |
| CA2713128A1 (en) | 2009-07-30 |
| US20090202634A1 (en) | 2009-08-13 |
| RU2493830C2 (ru) | 2013-09-27 |
| JP5774853B2 (ja) | 2015-09-09 |
| BRPI0906467B8 (pt) | 2021-01-05 |
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