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IT1274879B - Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo. - Google Patents

Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.

Info

Publication number
IT1274879B
IT1274879B ITBO940379A ITBO940379A IT1274879B IT 1274879 B IT1274879 B IT 1274879B IT BO940379 A ITBO940379 A IT BO940379A IT BO940379 A ITBO940379 A IT BO940379A IT 1274879 B IT1274879 B IT 1274879B
Authority
IT
Italy
Prior art keywords
active ingredient
controlled release
preparing solid
solid pharmaceutical
pharmaceutical forms
Prior art date
Application number
ITBO940379A
Other languages
English (en)
Inventor
Lorenzo Rodriguez
Maurizio Cini
Cristina Cavallari
Giuseppe Motta
Original Assignee
Saitec Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saitec Srl filed Critical Saitec Srl
Publication of ITBO940379A0 publication Critical patent/ITBO940379A0/it
Priority to ITBO940379A priority Critical patent/IT1274879B/it
Priority to DK95913940T priority patent/DK0726765T3/da
Priority to KR1019960701827A priority patent/KR100348935B1/ko
Priority to CA002173221A priority patent/CA2173221A1/en
Priority to CNB951908510A priority patent/CN1213735C/zh
Priority to DE69521406T priority patent/DE69521406T2/de
Priority to US08/624,475 priority patent/US5707636A/en
Priority to PCT/IT1995/000048 priority patent/WO1996003979A1/en
Priority to PT95913940T priority patent/PT726765E/pt
Priority to EP95913940A priority patent/EP0726765B1/en
Priority to ES95913940T priority patent/ES2159632T3/es
Priority to JP8506370A priority patent/JPH09503441A/ja
Priority to RU96112192A priority patent/RU2142792C1/ru
Priority to AU21137/95A priority patent/AU693539B2/en
Priority to AT95913940T priority patent/ATE202279T1/de
Priority to BR9506305A priority patent/BR9506305A/pt
Priority to TW084107653A priority patent/TW343149B/zh
Publication of ITBO940379A1 publication Critical patent/ITBO940379A1/it
Priority to MX9601279A priority patent/MX9601279A/es
Application granted granted Critical
Publication of IT1274879B publication Critical patent/IT1274879B/it
Priority to GR20010401401T priority patent/GR3036548T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nozzles (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
ITBO940379A 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo. IT1274879B (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.
ES95913940T ES2159632T3 (es) 1994-08-03 1995-04-06 Aparato y metodo para la preparacion de formas solidas con liberacion controlada del ingrediente activo.
RU96112192A RU2142792C1 (ru) 1994-08-03 1995-04-06 Устройство и способ для приготовления твердых форм с регулируемым высвобождением активного ингредиента
CA002173221A CA2173221A1 (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient
CNB951908510A CN1213735C (zh) 1994-08-03 1995-04-06 制备活性组分控释的固体剂型的装置和方法
DE69521406T DE69521406T2 (de) 1994-08-03 1995-04-06 Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs
US08/624,475 US5707636A (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient
PCT/IT1995/000048 WO1996003979A1 (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient
PT95913940T PT726765E (pt) 1994-08-03 1995-04-06 Dispositivo e metodo para a preparacao de formas solidas com libertacao controlada do ingrediente activo
EP95913940A EP0726765B1 (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient
DK95913940T DK0726765T3 (da) 1994-08-03 1995-04-06 Apparat og fremgangsmåde til fremstilling af faste former med styret frigivelse af den aktive bestanddel
JP8506370A JPH09503441A (ja) 1994-08-03 1995-04-06 有効成分を制御しながら開放する固体成形物の調製のための装置および方法
KR1019960701827A KR100348935B1 (ko) 1994-08-03 1995-04-06 활성성분의조절된방출을갖는고체형태제조용장치및방법
AU21137/95A AU693539B2 (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient
AT95913940T ATE202279T1 (de) 1994-08-03 1995-04-06 Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs
BR9506305A BR9506305A (pt) 1994-08-03 1995-04-06 Aparelho e processo para preparação de formas sólidas com desprendimento controlado do ingrediente ativo
TW084107653A TW343149B (en) 1994-08-03 1995-07-24 Apparatus and method for preparing solid forms with controlled release of the active ingredient
MX9601279A MX9601279A (es) 1994-08-03 1996-04-02 Aparato y metodo para preparar formas solidas con liberacion controlada de ingrediente activo.
GR20010401401T GR3036548T3 (en) 1994-08-03 2001-09-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.

Publications (3)

Publication Number Publication Date
ITBO940379A0 ITBO940379A0 (it) 1994-08-03
ITBO940379A1 ITBO940379A1 (it) 1996-02-03
IT1274879B true IT1274879B (it) 1997-07-25

Family

ID=11339983

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.

Country Status (19)

Country Link
US (1) US5707636A (it)
EP (1) EP0726765B1 (it)
JP (1) JPH09503441A (it)
KR (1) KR100348935B1 (it)
CN (1) CN1213735C (it)
AT (1) ATE202279T1 (it)
AU (1) AU693539B2 (it)
BR (1) BR9506305A (it)
CA (1) CA2173221A1 (it)
DE (1) DE69521406T2 (it)
DK (1) DK0726765T3 (it)
ES (1) ES2159632T3 (it)
GR (1) GR3036548T3 (it)
IT (1) IT1274879B (it)
MX (1) MX9601279A (it)
PT (1) PT726765E (it)
RU (1) RU2142792C1 (it)
TW (1) TW343149B (it)
WO (1) WO1996003979A1 (it)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9819272D0 (en) * 1998-09-03 1998-10-28 Andaris Ltd Microparticles
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
DE10009996B4 (de) * 2000-03-02 2005-10-13 Cognis Ip Management Gmbh Feststoffgranulate mit monodisperser Korngrößenverteilung, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
FR2809011B1 (fr) * 2000-05-22 2002-11-15 Sederma Sa Utilisation du beurre de karite incorpore dans les microcapsules fixees sur tout textile pour augmenter l'hydratation cutanee
DE20019711U1 (de) * 2000-11-20 2002-04-04 Söring GmbH, 25451 Quickborn Ultraschall-Gerät zur Behandlung septischer Wunden
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8545463B2 (en) * 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
ATE501766T1 (de) * 2003-05-20 2011-04-15 James F Collins Ophthalmisches arzneimittelabgabesystem
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) * 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE502004004205D1 (de) * 2003-08-06 2007-08-09 Gruenenthal Gmbh Gegen missbrauch gesicherte darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US7413690B1 (en) 2003-10-29 2008-08-19 The University Of Mississippi Process and apparatus for producing spherical pellets using molten solid matrices
AU2004294817B2 (en) * 2003-12-04 2007-01-25 Pfizer Products Inc. Method for making pharmaceutical multiparticulates
DE102004032049A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004032103A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20080075811A1 (en) * 2006-09-23 2008-03-27 Peter Horlacher Coated particles and their use
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
EP2022557A1 (en) * 2007-08-06 2009-02-11 Laboratories Development LLC A process for the preparation of granular frozen powder
WO2009053885A2 (en) * 2007-10-23 2009-04-30 Koninklijke Philips Electronics N.V. Methods for preparing polymer microparticles
EP2101131A1 (en) 2007-12-31 2009-09-16 Terruzzi Fercalx S.p.A. Lyophilization method and system therefor
CA2713128C (en) 2008-01-25 2016-04-05 Gruenenthal Gmbh Pharmaceutical dosage form
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
PT2273983T (pt) * 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
PE20120572A1 (es) * 2009-07-22 2012-06-06 Gruenenthal Chemie Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
EP2531176B1 (en) 2010-02-03 2016-09-07 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of an extruder
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
JP5964826B2 (ja) 2010-07-15 2016-08-03 アイノビア，インコーポレイティド 滴生成デバイス
CA2805425C (en) 2010-07-15 2019-07-23 Corinthian Ophthalmic, Inc. Ophthalmic drug delivery
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
MX2013002377A (es) 2010-09-02 2013-04-29 Gruenenthal Gmbh Forma de dosificacion resistente a manipulacion que comprende una sal inorganica.
AU2011297892B2 (en) 2010-09-02 2014-05-29 Grunenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
RU2449777C1 (ru) * 2010-12-20 2012-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ получения высокодисперсного парацетамола
NO2736495T3 (it) 2011-07-29 2018-01-20
MX348054B (es) 2011-07-29 2017-05-25 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco.
US20130172830A1 (en) 2011-12-12 2013-07-04 Corinthian Ophthalmic, Inc. Ejector mechanism, ejector device, and methods of use
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PT2838512T (pt) 2012-04-18 2018-11-09 Gruenenthal Gmbh Forma farmacêutica resistente à adulteração e resistente à libertação inesperada de alta quantidade (dose-dumping)
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
WO2014191397A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
US9452271B2 (en) 2013-05-29 2016-09-27 General Electric Company Nebulizer systems and methods
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
CN106572980A (zh) 2014-05-12 2017-04-19 格吕伦塔尔有限公司 包含他喷他多的防篡改即释胶囊制剂
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
WO2016169795A1 (en) * 2015-04-21 2016-10-27 Basf Se Method for producing particles comprising a hydrocarbon wax in a continuous phase and a pesticide dispersed in the continuous phase by generating droplets with a vibrating nozzle
AU2016251854A1 (en) 2015-04-24 2017-10-19 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
CN108623724A (zh) * 2017-03-17 2018-10-09 江苏华昌织物有限公司 用于信息素缓释的高分子微球的制备方法
SG11201911895XA (en) 2017-06-10 2020-01-30 Eyenovia Inc Methods and devices for handling a fluid and delivering the fluid to the eye
JP2023506781A (ja) 2019-12-11 2023-02-20 アイノビア・インコーポレイテッド 眼に流体を送達するためのシステム及び装置並びに使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2828206A (en) * 1954-02-24 1958-03-25 Roseuberg Adolf Stabilized fat-soluble vitamins and methods of making same
US3078216A (en) * 1961-04-11 1963-02-19 American Cyanamid Co Prolonged release oral pharmaceutical preparations
ES297425A1 (es) * 1963-03-04 1964-06-01 Merck & Company Incorporated Procedimiento para preparar composiciones farmaceúticas en forma de tabletas de acción diferida
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
DE2725849C3 (de) * 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
US4657543A (en) * 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4779806A (en) * 1984-07-23 1988-10-25 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
FR2571980A1 (fr) * 1984-10-22 1986-04-25 Extramet Sa Procede et dispositif de fabrication de micro-billes calibrees et micro-billes obtenues.
DE3669103D1 (de) * 1986-11-14 1990-04-05 Puetter Medice Chem Pharm Ibuprofen enthaltendes arzneimittel.
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
FR2664851B1 (fr) * 1990-07-20 1992-10-16 Oreal Procede de compactage d'un melange pulverulent permettant d'obtenir un produit compact absorbant ou partiellement delitable et produit obtenu par ce procede.

Also Published As

Publication number Publication date
ITBO940379A0 (it) 1994-08-03
DE69521406T2 (de) 2002-05-02
MX9601279A (es) 1998-11-30
PT726765E (pt) 2001-12-28
CA2173221A1 (en) 1996-02-15
JPH09503441A (ja) 1997-04-08
RU2142792C1 (ru) 1999-12-20
US5707636A (en) 1998-01-13
KR100348935B1 (ko) 2002-12-28
EP0726765A1 (en) 1996-08-21
KR960704529A (ko) 1996-10-09
TW343149B (en) 1998-10-21
CN1213735C (zh) 2005-08-10
ES2159632T3 (es) 2001-10-16
AU693539B2 (en) 1998-07-02
ATE202279T1 (de) 2001-07-15
BR9506305A (pt) 1997-08-05
WO1996003979A1 (en) 1996-02-15
DE69521406D1 (de) 2001-07-26
AU2113795A (en) 1996-03-04
EP0726765B1 (en) 2001-06-20
GR3036548T3 (en) 2001-12-31
DK0726765T3 (da) 2001-10-15
CN1135175A (zh) 1996-11-06
ITBO940379A1 (it) 1996-02-03

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