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PE20120631A1 - Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion - Google Patents

Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion

Info

Publication number
PE20120631A1
PE20120631A1 PE2012000084A PE2012000084A PE20120631A1 PE 20120631 A1 PE20120631 A1 PE 20120631A1 PE 2012000084 A PE2012000084 A PE 2012000084A PE 2012000084 A PE2012000084 A PE 2012000084A PE 20120631 A1 PE20120631 A1 PE 20120631A1
Authority
PE
Peru
Prior art keywords
acid
dosage form
opioid
opioids
oxidation
Prior art date
Application number
PE2012000084A
Other languages
English (en)
Inventor
Johannes Bartholomaus
Anja Geissler
Ulrike Bertram
Kornelia Griessmann
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41263602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120631(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20120631A1 publication Critical patent/PE20120631A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Wrappers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A UNA FORMA DE DOSIICACION FARMACEUTICA TERMOFORMADA QUE COMPRENDE: a) UN OPIOIDE TAL COMO OXIMORFONA, OXICODONA, HIDROMORFONA Y SALES DE LOS MISMOS, b) UN ACIDO LIBRE TAL COMO ACIDO MALEICO, ACIDO FUMARICO, ACIDO GLUTARICO, ACIDO MALONICO Y ACIDO CITRICO, EN UNA CANTIDAD ENTRE 0,001% Y 5,0% EN PESO BASADO EN EL PESO TOTAL DE LA FORMA DE DOSIFICACION FARMACEUTICA Y c) UN OXIDO DE POLIALQUENO. TAMBIEN PUEDE CONTENER UN ANTIOXIDANTE TAL COMO ALFA-TOCOFEROL. EL OPIOIDE SE INCLUYE EN UNA MATRIZ QUE COMPRENDE AL OXIDO DE POLIALQUENO CONTROLANDO DICHA MATRIZ LA LIBERACION DEL OPIOIDE. DICHA FORMULACION ES RESISTENTE A LA ROTURA
PE2012000084A 2009-07-22 2010-07-21 Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion PE20120631A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09009480 2009-07-22

Publications (1)

Publication Number Publication Date
PE20120631A1 true PE20120631A1 (es) 2012-06-06

Family

ID=41263602

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2012000084A PE20120631A1 (es) 2009-07-22 2010-07-21 Forma de dosificacion resistente a la manipulacion para opioides sensibles a la oxidacion
PE2012000083A PE20120572A1 (es) 2009-07-22 2010-07-21 Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2012000083A PE20120572A1 (es) 2009-07-22 2010-07-21 Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion

Country Status (26)

Country Link
US (7) US20110020451A1 (es)
EP (4) EP2997965B1 (es)
JP (2) JP2012533586A (es)
KR (2) KR101747156B1 (es)
CN (2) CN102573806B (es)
AR (1) AR077420A1 (es)
AU (2) AU2010275755B2 (es)
BR (2) BR112012001244A2 (es)
CA (2) CA2766172C (es)
CL (2) CL2011002969A1 (es)
CO (2) CO6470798A2 (es)
EC (2) ECSP12011590A (es)
ES (3) ES2718688T3 (es)
HK (1) HK1216296A1 (es)
HU (1) HUE042987T2 (es)
IL (3) IL216522A (es)
MX (2) MX2012000644A (es)
NZ (2) NZ596666A (es)
PE (2) PE20120631A1 (es)
PL (2) PL2997965T3 (es)
PT (1) PT2456424E (es)
RU (3) RU2567723C2 (es)
SI (1) SI2456424T1 (es)
TW (1) TWI473628B (es)
WO (2) WO2011009603A1 (es)
ZA (2) ZA201109447B (es)

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RU2012106166A (ru) 2013-08-27
US20150366809A1 (en) 2015-12-24
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CN102639118B (zh) 2015-07-29
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US20120136021A1 (en) 2012-05-31
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AU2010275755B2 (en) 2014-04-24
BR112012001466A2 (pt) 2020-08-11
PE20120572A1 (es) 2012-06-06
US9925146B2 (en) 2018-03-27
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CO6480912A2 (es) 2012-07-16
PL2997965T3 (pl) 2019-06-28
US20140194455A1 (en) 2014-07-10
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HUE042987T2 (hu) 2019-07-29
CN102639118A (zh) 2012-08-15
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CL2011002969A1 (es) 2012-05-18
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AU2010275755A1 (en) 2011-12-15
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IL216522A (en) 2016-11-30
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CL2011002970A1 (es) 2012-05-18
US20200038329A1 (en) 2020-02-06
CA2767888C (en) 2017-09-12
US20180177732A1 (en) 2018-06-28
RU2555531C2 (ru) 2015-07-10
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RU2567723C2 (ru) 2015-11-10
ZA201109447B (en) 2012-08-29
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PL2456424T3 (pl) 2013-12-31

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