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RU2010149611A - Ациламинозамещенные производные конденсированных циклопентанкарбоновых кислот и их применение в качестве фармацевтических средств - Google Patents

Ациламинозамещенные производные конденсированных циклопентанкарбоновых кислот и их применение в качестве фармацевтических средств Download PDF

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RU2010149611A
RU2010149611A RU2010149611/04A RU2010149611A RU2010149611A RU 2010149611 A RU2010149611 A RU 2010149611A RU 2010149611/04 A RU2010149611/04 A RU 2010149611/04A RU 2010149611 A RU2010149611 A RU 2010149611A RU 2010149611 A RU2010149611 A RU 2010149611A
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Russia
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alkyl
ring
hydrogen
carboxylic acid
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RU2010149611/04A
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RU2529484C2 (ru
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Маттиас ШЕФЕР (DE)
Маттиас ШЕФЕР
Йозеф ПЕРНЕРШТОРФЕР (DE)
Йозеф ПЕРНЕРШТОРФЕР
Дитер КАДЕРАЙТ (DE)
Дитер КАДЕРАЙТ
Хартмут ШТРОБЕЛЬ (DE)
Хартмут Штробель
Вернгард ЧЕХТИЗКИЙ (DE)
Вернгард ЧЕХТИЗКИЙ
Л. Чарли ЧЭНЬ (US)
Л. Чарли ЧЭНЬ
Алена САФАРОВА (US)
Алена САФАРОВА
Александра ВАЙХЗЕЛЬ (US)
Александра ВАЙХЗЕЛЬ
Марсель ПАТЕК (US)
Марсель Патек
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Санофи-Авентис (Fr)
Санофи-Авентис
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Abstract

1. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении, или его физиологически приемлемая соль, или физиологически приемлемый сольват любого из них ! ! где кольцо A является циклоалкановым кольцом с числом членов от 3 до 7, бензольным кольцом или моноциклическим 5-членным или 6-членным ароматическим гетероциклическим кольцом, содержащим 1 или 2 одинаковых или разных гетерочленов кольца, выбранных из группы, содержащей N, N(R0), O и S, причем циклоалкановое кольцо может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей фтор и (C1-C4)-алкил, а бензольное и гетероциклическое кольца могут необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R1, HO-, R1-O-, R1-C(O)-O-, R1-S(O)2-O-, R1-S(O)m-, H2N-, R1-NH-, R1-N(R1)-, R1-C(O)-NH-, R1-C(O)-N(R71)-, R1-S(O)2-NH-, R1-S(O)2-N(R71)-, R1-C(O)-, HO-C(O)-, R1-O-C(O)-, H2N-C(O)-, R1-NH-C(O)-, R1-N(R1)-C(O)-, H2N-S(O)2-, R1-NH-S(O)2-, R1-N(R1)-S(O)2-, NC-, O2N-, фенил и Het; ! Y выбирают из группы, содержащей N(R10), S, O, C(R12)=C(R13), N=C(R14) и C(R15)=N; ! Z выбирают из группы, содержащей N и C(R16); ! R0 выбирают из группы, содержащей водород и R2; ! R1, R2, R11, R30, R33, R35, R54, R55, R57 и R58, независимо от каждой другой группы R1, R2, R11, R30, R33, R35, R54, R55, R57 и R58, выбирают из группы, содержащей (C1-C6)-алкил, (C2-C6)-алкенил, (C2-C6)-алкинил, (C3-C7)-циклоалкил и (C3-C7)-циклоалкил-(C1-C4)-алкил-, причем все они могут необязательно иметь один или более одинаковых или разных заместителей R70; ! R3 и R5 выбирают, независимо друг от друга, из группы, содержащей водород, (C1-C4)-алкил, фенил-(C1-C4)-алкил-, фенил и гидрокси; ! R4 и R6 выбирают, независимо друг от друга, из группы, содержащей водород и (C1-C4)-алкил; ! R10 выбирают из групп

Claims (13)

1. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении, или его физиологически приемлемая соль, или физиологически приемлемый сольват любого из них
Figure 00000001
где кольцо A является циклоалкановым кольцом с числом членов от 3 до 7, бензольным кольцом или моноциклическим 5-членным или 6-членным ароматическим гетероциклическим кольцом, содержащим 1 или 2 одинаковых или разных гетерочленов кольца, выбранных из группы, содержащей N, N(R0), O и S, причем циклоалкановое кольцо может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей фтор и (C1-C4)-алкил, а бензольное и гетероциклическое кольца могут необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R1, HO-, R1-O-, R1-C(O)-O-, R1-S(O)2-O-, R1-S(O)m-, H2N-, R1-NH-, R1-N(R1)-, R1-C(O)-NH-, R1-C(O)-N(R71)-, R1-S(O)2-NH-, R1-S(O)2-N(R71)-, R1-C(O)-, HO-C(O)-, R1-O-C(O)-, H2N-C(O)-, R1-NH-C(O)-, R1-N(R1)-C(O)-, H2N-S(O)2-, R1-NH-S(O)2-, R1-N(R1)-S(O)2-, NC-, O2N-, фенил и Het;
Y выбирают из группы, содержащей N(R10), S, O, C(R12)=C(R13), N=C(R14) и C(R15)=N;
Z выбирают из группы, содержащей N и C(R16);
R0 выбирают из группы, содержащей водород и R2;
R1, R2, R11, R30, R33, R35, R54, R55, R57 и R58, независимо от каждой другой группы R1, R2, R11, R30, R33, R35, R54, R55, R57 и R58, выбирают из группы, содержащей (C1-C6)-алкил, (C2-C6)-алкенил, (C2-C6)-алкинил, (C3-C7)-циклоалкил и (C3-C7)-циклоалкил-(C1-C4)-алкил-, причем все они могут необязательно иметь один или более одинаковых или разных заместителей R70;
R3 и R5 выбирают, независимо друг от друга, из группы, содержащей водород, (C1-C4)-алкил, фенил-(C1-C4)-алкил-, фенил и гидрокси;
R4 и R6 выбирают, независимо друг от друга, из группы, содержащей водород и (C1-C4)-алкил;
R10 выбирают из группы, содержащей водород и R11;
R12, R13, R14, R15 и R16 выбирают, независимо друг от друга, из группы, содержащей водород, галоген, (C1-C4)-алкил, HO-(C1-C4)-алкил-, (C1-C4)-алкил-O-, (C1-C4)-алкил-S(O)m-, H2N-, (C1-C4)-алкил-NH-, (C1-C4)-алкил-N((C1-C4)-алкил)-, (C1-C4)-алкил-C(O)-, NC- и O2N-;
R20 выбирают из группы, содержащей водород и (C1-C4)-алкил;
одна из групп R21 и R22 является группой формулы II
Figure 00000002
а другую из групп R21 и R22 выбирают из группы, содержащей водород, галоген, R30, HO-, R30-O-, R30-C(O)-O-, R30-S(O)2-O-, R30-S(O)m-, H2N-, R30-NH-, R30-N(R30)-, R30-C(O)-NH-, R30-C(O)-N(R71)-, R30-S(O)2-NH-, R30-S(O)2-N(R71)-, R30-C(O)-, HO-C(O)-, R30-O-C(O)-, H2N-C(O)-, R30-NH-C(O)-, R30-N(R30)-C(O)-, H2N-S(O)2-, R30-NH-S(O)2-, R30-N(R30)-S(O)2-, NC-, O2N- и Het1;
R23 является прямой связью или цепью, содержащей от 1 до 5 членов цепи, из которых 0, 1 и или 2 члена цепи являются одинаковыми или разными гетерочленами цепи, выбранными из группы, содержащей N(R25), O, S, S(O) и S(O)2, но два гетерочлена цепи могут находиться в соседних позициях, только при условии, что один из них выбирают из группы, содержащей S(O) и S(O)2, а другой выбирают из группы, содержащей N(R25), O и S, тогда как другие члены цепи являются одинаковыми или разными группами C(R26)(R26), где две соседние группы C(R26)(R26) могут соединяться друг с другом двойной или тройной связью;
R24 выбирают из группы, содержащей водород, R31, HO-, R31-O-, R31-C(O)-O-, R31-S(O)m-, H2N-, R31-NH-, R31-N(R31)-, R31-C(O)-NH-, R31-C(O)-N(R71)-, R31-S(O)2-NH-, R31-S(O)2-N(R71)-, R31-C(O)-, HO-C(O)-, R31-O-C(O)-, H2N-C(O)-, R31-NH-C(O)-, R31-N(R31)-C(O)-, H2N-S(O)2-, R31-NH-S(O)2-, R31-N(R31)-S(O)2-, NC- и моноциклическое, бициклическое или трициклическое кольцо с числом членов от 3-х до 10-и, которое является насыщенным или ненасыщенным и содержит 0, 1, 2 или 3 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R32), O, S, S(O) и S(O)2, причем кольцо может необязательно иметь на атомах углерода кольца один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R33, HO-, R33-O-, R33-C(O)-O-, R33-S(O)2-O-, R33-S(O)m-, H2N-, R33-NH-, R33-N(R33)-, R33-C(O)-NH-, R33-C(O)-N(R71)-, R33-S(O)2-NH-, R33-S(O)2-N(R71)-, H2N-S(O)2-NH-, R33-NH-S(O)2-NH-, R33-N(R33)-S(O)2-NH-, H2N-S(O)2-N(R71)-, R33-NH-S(O)2-N(R71)-, R33-N(R33)-S(O)2-N(R71)-, R33-C(O)-, HO-C(O)-, R33-O-C(O)-, H2N-C(O)-, R33-NH-C(O)-, R33-N(R33)-C(O)-, H2N-S(O)2-, R33-NH-S(O)2-, R33-N(R33)-S(O)2-, NC-, O2N-, оксо, фенил и Het;
при условии, что общее число атомов C, N, O и S, присутствующих в двух группах R23 и R24, составляет не менее 5;
R25 выбирают из группы, содержащей водород и (C1-C4)-алкил;
R26, независимо от каждой другой группы R26, выбирают из группы, содержащей водород, фтор, (C1-C4)-алкил и HO-, или две группы R26, связанные с одним атомом углерода, представляют собой оксо, или две группы R26 или одна группа R25 и одна группа R26, вместе с входящими в них членами цепи, образуют моноциклическое кольцо с числом членов от 3 до 7, которое является насыщенным и содержит 0, 1 или 2 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R34), O, S, S(O) и S(O)2, причем кольцо может необязательно иметь на атомах углерода кольца один или более одинаковых или разных заместителей, выбранных из группы, содержащей фтор и (C1-C4)-алкил;
R31 выбирают из группы, содержащей (C1-C6)-алкил, (C2-C6)-алкенил и (C2-C6)-алкинил, причем все они могут необязательно иметь один или более одинаковых или разных заместителей R70;
R32 и R34 выбирают, независимо друг от друга, из группы, содержащей водород, R35, R35-S(O)2-, R35-C(O)-, R35-O-C(O)-, фенил и Het;
R50 выбирают из группы, содержащей R51-O- и R52-N(R53)-;
R51 выбирают из группы, содержащей водород и R54;
R52 выбирают из группы, содержащей водород, R55, NC- и R56-S(O)2-;
R53 выбирают из группы, содержащей водород и R57;
R56 выбирают из группы, содержащей R58 и фенил;
R60, независимо от каждой другой группы R60, выбирают из группы, содержащей водород и (C1-C4)-алкил;
R70 выбирают из группы, содержащей HO-, R71-O-, R71-C(O)-O-, R71-S(O)m-, H2N-, R71-NH-, R71-N(R71)-, R71-C(O)-NH-, R71-C(O)-N(R71)-, R71-S(O)2-NH-, R71-S(O)2-N(R71)-, HO-C(O)-, R71-O-C(O)-, H2N-C(O)-, R71-NH-C(O)-, R71-N(R17)-C(O)-, H2N-S(O)2-, R71-NH-S(O)2-, R71-N(R71)-S(O)2-, NC-, оксо, фенил и Het2;
R71, независимо от каждой другой группы R71, выбирают из группы, содержащей (C1-C4)-алкил, (C3-C4)-циклоалкил и (C3-C4)-циклоалкил-(C1-C2)-алкил-;
Het независимо от каждой другой группы Het является моноциклическим гетероциклическим кольцом с числом членов от 4 до 7, которое содержит 1, 2 или 3 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R60), O, S, S(O) и S(O)2, причем кольцо является насыщенным или ненасыщенным и необязательно замещенным одним или более одинаковыми или разными заместителями, выбранными из группы, содержащей галоген, (C1-C4)-алкил и R70;
Het1 является моноциклическим гетероциклическим кольцом с числом членов от 4 до 7, которое содержит 1 или 2 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R60), O, S, S(O) и S(O)2, причем кольцо является насыщенным и необязательно замещенным одним или более одинаковыми или разными заместителями, выбранными из группы, содержащей фтор и (C1-C4)-алкил;
Het2 является моноциклическим гетероциклическим кольцом с числом членов 5 или 6, которое содержит 1, 2 или 3 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R60), O и S, причем кольцо является ароматическим и необязательно замещенным одним или более одинаковыми или разными заместителями, выбранными из группы, содержащей галоген, (C1-C4)-алкил, (C1-C4)-алкил-O- и NC-;
m независимо от каждого другого числа m является целым числом, выбранным из группы, содержащей 0, 1 и 2;
фенил независимо от каждой другой группы фенила может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, (C1-C4)-алкил, (C1-C4)-алкил-O- и NC-, если не указано иное;
циклоалкил независимо от каждой другой группы циклоалкила и независимо от других заместителей на циклоалкиле может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей фтор и (C1-C4)-алкил;
алкил, алкенил и алкинил независимо от каждой другой группы алкила, алкенила и алкинила и независимо от других заместителей на алкиле, алкениле, алкиниле может необязательно иметь один или более фтор-заместителей;
при условии, что соединение формулы I не является 2-[(6,2',4'-трихлорбифенил-3-карбонил)амино]индан-2-карбоновой кислотой, 2-[6-хлор-[1,1',4',1'']терфенил-3-карбонил)амино]индан-2-карбоновой кислотой, 2-(4-хлор-3-фенилэтинилбензоиламино)-индан-2-карбоновой кислотой, 5-(4-хлорфенил)-2-[4-(2-метил-1H-бензоимидазол-1-илметил)-бензоиламино]-индан-2-карбоновой кислотой или этиловым эфиром 5-(4-хлорфенил)-2-[4-(2-метил-1H-бензоимидазол-1-илметил)-бензоиламино]-индан-2-карбоновой кислоты.
2. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, где
R3 и R5 выбирают независимо друг от друга из группы, содержащей водород, (C1-C4)-алкил, фенил-(C1-C4)-алкил и фенил.
3. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по любому из пп.1 или 2, где
кольцо A является циклогексановым кольцом, бензольным кольцом, пиридиновым кольцом, пиридазиновым кольцом или тиофеновым кольцом, причем циклогексановое кольцо может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей фтор и (C1-C4)-алкил, а бензольное, пиридиновое, пиридазиновое и тиофеновое кольца могут необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R1, HO-, R1-O-, R1-C(O)-O-, R1-S(O)2-O-, R1-S(O)m-, H2N-, R1-NH-, R1-N(R1)-, R1-C(O)-NH-, R1-C(O)-N(R71)-, R1-S(O)2-NH-, R1-S(O)2-N(R71)-, R1-C(O)-, HO-C(O)-, R1-O-C(O)-, H2N-C(O)-, R1-NH-C(O)-, R1-N(R1)-C(O)-, H2N-S(O)2-, R1-NH-S(O)2-, R1-N(R1)-S(O)2-, NC- и O2N-;
Y выбирают из группы, содержащей S, C(R12)=C(R13) и C(R15)=N;
Z является C(R16).
4. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, где
кольцо A является бензольным кольцом, пиридиновым кольцом, пиразиновым кольцом или тиофеновым кольцом, которые могут необязательно иметь один или два одинаковых или разных заместителей, выбранных из группы, содержащей галоген, (C1-C4)-алкил и (C1-C4)-алкил-O-;
Y выбирают из группы, содержащей S, C(R12)=C(R13) и C(R15)=N;
Z является C(R16);
R3 и R5 выбирают независимо друг от друга из группы, содержащей водород и (C1-C4)-алкил;
R4 и R6 представляют собой водород;
R12, R13, R15 и R16 выбирают независимо друг от друга из группы, содержащей водород, галоген, (C1-C4)-алкил, (C1-C4)-алкил-O- и NC-;
R20 -водород.
5. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, где
R21 выбирают из группы, содержащей водород, галоген, (C1-C4)-алкил, HO-(C1-C4)-алкил-, (C1-C4)-алкил-O-, (C1-C4)-алкил-S(O)m-, H2N-, (C1-C4)-алкил-NH-, ди((C1-C4)-алкил)N-,(C1-C4)-алкил-C(O)- и NC-;
R22 является группой формулы II
Figure 00000002
R23 представляет собой прямую связь или цепь, содержащую 2, 3 или 4 члена цепи, из которых 0 или 1 член цепи является гетерочленом цепи, выбранным из группы, содержащей N(R25), O, S, S(O) и S(O)2, и другие члены цепи являются одинаковыми или разными группами C(R26)(R26), где две соседние группы C(R26)(R26) могут соединяться друг с другом двойной или тройной связью.
6. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, где
R24 - моноциклическое кольцо с числом членов от 3 до 7 или бициклическое кольцо с числом членов от 7 до 10, которое является насыщенным или ненасыщенным и содержит 0, 1 или 2 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R32), O, S, S(O) и S(O)2, причем эти кольца могут необязательно иметь на атомах углерода кольца один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R33, HO-, R33-O-, R33-S(O)m-, H2N-, R33-NH-, R33-N(R33)-, R33-C(O)-NH-, R33-C(O)-N(R71)-, R33-S(O)2-NH-, R33-S(O)2-N(R71)-, H2N-S(O)2-NH-, R33-NH-S(O)2-NH-, R33-N(R33)-S(O)2-NH-, H2N-S(O)2-N(R71)-, R33-NH-S(O)2-N(R71)-, R33-N(R33)-S(O)2-N(R71)-, HO-C(O)-, R33-O-C(O)-, H2N-C(O)-, R33-NH-C(O)-, R33-N(R33)-C(O)-, NC-, оксо, фенил и Het;
R32 выбирают из группы, содержащей водород, R35, R35-C(O)-, R35-O-C(O)- и фенил.
7. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, где
кольцо A является бензольным кольцом, пиридиновым кольцом, пиразиновым кольцом или тиофеновым кольцом, которые могут необязательно иметь один или два одинаковых или разных заместителей, выбранных из группы, содержащей галоген, (C1-C4)-алкил и (C1-C4)-алкил-O-;
Y выбирают из группы, содержащей S, C(R12)=C(R13) и C(R15)=N;
Z является C(R16);
R3 и R5 выбирают независимо друг от друга из группы, содержащей водород и (C1-C4)-алкил;
R4 и R6 представляют собой водород;
R12, R13, R15 и R16 выбирают независимо друг от друга из группы, содержащей водород, галоген, (C1-C4)-алкил, (C1-C4)-алкил-O- и NC-;
R20 - водород;
R21 выбирают из группы, содержащей водород, галоген, (C1-C4)-алкил, HO-(C1-C4)-алкил-, (C1-C4)-алкил-O-, (C1-C4)-алкил-S(O)m-, H2N-, (C1-C4)-алкил-NH-, ди((C1-C4)-алкил)N-,(C1-C4)-алкил-C(O)- и NC-;
R22 является группой формулы II
Figure 00000002
R23 представляет собой прямую связь или цепь, содержащую 2, 3 или 4 члена цепи, из которых 0 или 1 член цепи являются гетерочленами цепи, выбранными из группы, содержащей N(R25), O, S, S(O) и S(O)2, и другие члены цепи являются одинаковыми или разными группами C(R26)(R26), где две соседние группы C(R26)(R26) могут соединяться друг с другом двойной или тройной связью;
R24 - моноциклическое кольцо с числом членов от 3 до 7 или бициклическое кольцо с числом членов от 7 до 10, которое является насыщенным или ненасыщенным и содержит 0, 1 или 2 одинаковых или разных гетерочлена кольца, выбранных из группы, содержащей N, N(R32), O, S, S(O) и S(O)2, причем кольца могут необязательно иметь на атомах углерода кольца один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R33, HO-, R33-O-, R33-S(O)m-, H2N-, R33-NH-, R33-N(R33)-, R33-C(O)-NH-, R33-C(O)-N(R71)-, R33-S(O)2-NH-, R33-S(O)2-N(R71)-, HO-C(O)-, R33-O-C(O)-, H2N-C(O)-, R33-NH-C(O)-, R33-N(R33)-C(O)-, NC-, оксо, фенил и Het;
R32 выбирают из группы, содержащей водород, R35, R35-C(O)-, R35-O-C(O)- и фенил.
8. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, где
кольцо A является бензольным кольцом, которое может необязательно иметь необязательно один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, (C1-C4)-алкил и (C1-C4)-алкил-O-;
Y представляет собой C(R12)=C(R13);
Z является C(R16);
R3, R4, R5 и R6 представляет собой водород;
R12, R13 и R16 выбирают независимо друг от друга из группы, содержащей водород, галоген, (C1-C4)-алкил, (C1-C4)-алкил-O- и NC-;
R20 является водородом;
R21 выбирают из группы, содержащей водород, галоген, (C1-C4)-алкил, HO-(C1-C4)-алкил-, (C1-C4)-алкил-O-, (C1-C4)-алкил-S(O)m-, (C1-C4)-алкил-C(O)- и NC-;
R22 является группой формулы II
Figure 00000002
R23 представляет собой прямую связь или цепь, содержащую 2, 3 или 4 члена цепи, из которых 0 или 1 член цепи являются гетерочленами цепи, выбранными из группы, содержащей N(R25), O, S, S(O) и S(O)2, и другие члены цепи являются одинаковыми или разными группами C(R26)(R26);
R24 является бензольным кольцом, которое может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей галоген, R33, HO-, R33-O-, R33-S(O)m-, H2N-, R33-NH-, R33-N(R33)-, R33-C(O)-NH-, R33-S(O)2-NH-, HO-C(O)-, R33-O-C(O)-, H2N-C(O)-, R33-NH-C(O)-, R33-N(R33)-C(O)- и NC-;
при условии, что общее число атомов C, N, O и S, присутствующих в двух группах R23 и R24, составляет не менее 5;
R25 выбирают из группы, содержащей водород и (C1-C4)-алкил;
R26 независимо от каждой другой группы R26 выбирают из группы, содержащей водород, фтор, (C1-C4)-алкил и HO-, или две группы R26, присоединенные к одному и тому же атому углерода в цепи, вместе с содержащим их атомом углерода, образуют циклопропановое кольцо;
R33 выбирают независимо от каждой другой группы R33 из группы, содержащей (C1-C4)-алкил, (C3-C7)-циклоалкил и (C3-C7)-циклоалкил-(C1-C2)-алкил-, причем все они могут необязательно иметь один или более одинаковых или разных заместителей R70;
R50 выбирают из группы, содержащей R51-O- и R52-N(R53)-;
R51 выбирают из группы, содержащей водород и (C1-C4)-алкил;
R52 выбирают из группы, содержащей водород и (C1-C4)-алкил;
R53 выбирают из группы, содержащей водород и (C1-C4)-алкил;
R70 выбирают из группы, содержащей HO- и R71-O-;
R71 - (C1-C4)-алкил;
m независимо от каждого другого числа m является целым числом, выбранным из группы, содержащей 0 и 2;
циклоалкил независимо от каждой другой группы циклоалкила и независимо от других заместителей при циклоалкиле может необязательно иметь один или более одинаковых или разных заместителей, выбранных из группы, содержащей фтор и (C1-C4)-алкил;
алкил независимо от каждой другой группы алкила и независимо от других заместителей при алкиле может необязательно иметь один или более фтор-заместителей.
9. Соединение формулы I в любой из его стереоизомерных форм или сочетании стереоизомерных форм в любом соотношении или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них по п.1, выбранное из
2-[4-метилсульфанил-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-ацетил-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-этил-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-этокси-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-метокси-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-{4-метокси-3-[2-(3-трифторметилсульфанилфенил)-этокси]-бензоиламино}-индан-2-карбоновой кислоты,
2-[4-метокси-3-(1-м-толилциклопропилметокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-{3-[2-(3-цианофенил)-этокси]-4-метокс-бензоиламино}-индан-2-карбоновой кислоты,
5-[4-метокси-3-(2-м-толилэтокси)-бензоиламино]-5,6-дигидро-4H-циклопента[c]тиофен-5-карбоновой кислоты,
5-[4-метокси-3-(2-м-толилэтокси)-бензоиламино]-5,6-дигидро-4H-циклопента[b]тиофен-5-карбоновой кислоты,
2-{[5-ацетил-4-(2-м-толилэтокси)-тиофен-2-карбонил]-амино}-индан-2-карбоновой кислоты,
2-[3-фтор-4-метокси-5-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-метокси-3-(2-м-толилоксиэтил)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-метокси-3-(3-м-толилпропил)-бензоиламино]-индан-2-карбоновой кислоты,
5-фтор-2-[4-метокси-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-метокси-3-(2-м-толилэтокси)-бензоиламино]-5,6-диметилиндан-2-карбоновой кислоты,
2-[4-циано-3-(2-м-толилэтокси)-бензоиламино]-индан-2-карбоновой кислоты,
2-[4-метокси-3-(2-м-толилэтиламино)-бензоиламино]-индан-2-карбоновой кислоты,
2-{3-[2-(3-хлорфенил)-этокси]-4-метилбензоиламино}-индан-2-карбоновой кислоты,
2-[4-метокси-3-(2-м-толилэтилсульфанил)-бензоиламино]-индан-2-карбоновой кислоты,
2-[3-(2-м-толилэтокси)-4-трифторметилбензоиламино]-индан-2-карбоновой кислоты,
2-{3-[2-(2-фтор-5-метилфенил)-этокси]-4-трифторметилбензоиламино}-индан-2-карбоновой кислоты,
2-(3-{2-[3-(2-гидроксиэтил)-фенил]-этокси}-4-метоксибензоиламино}-индан-2-карбоновой кислоты,
2-{[6-метокси-5-(2-м-толилэтокси)-пиридин-3-карбонил]-амино}-индан-2-карбоновой кислоты,
2-[(3'-метансульфониламино-6-метоксибифенил-3-карбонил)-амино]-индан-2-карбоновой кислоты,
2-[(3'-диметиламиносульфониламино-6-метоксибифенил-3-карбонил)-амино]-индан-2-карбоновой кислоты,
2-[(6-метокси-3'-трифторметоксибифенил-3-карбонил)-амино]-индан-2-карбоновой кислоты,
2-[(3'-цианометил-6-метоксибифенил-3-карбонил)-амино]-индан-2-карбоновой кислоты,
2-[(3'-изопропил-6-метоксибифенил-3-карбонил)-амино]-индан-2-карбоновой кислоты,
2-[(3'-хлор-6-метокси-2'-метилбифенил-3-карбонил)-амино]-индан-2-карбоновой кислоты,
2-{[5-(3-хлорфенил)-6-метоксипиридин-3-карбонил]-амино}-индан-2-карбоновой кислоты, и
2-[3-(2,2-дифтор-2-фенилэтокси]-4-метоксибензоиламино}-индан-2-карбоновая кислоты.
10. Способ получения соединения формулы I или его физиологически приемлемой соли или физиологически приемлемого сольвата любого из них по одному или более пп.1-9, включающий реакцию соединения формулы III с соединением формулы IV
Figure 00000003
где кольцо A и группы Y, Z, R3 по R6, R20 по R22 и R50 в соединениях формул III и IV определены как в соединениях формулы I, а также могут присутствовать функциональные группы в защищенной форме или в форме группы-предшественника, и группа G в соединении формулы IV представляет HO-, (C1-C4)-алкил-O- или галоген.
11. Соединение формулы I по п.1, или его физиологически приемлемая соль или физиологически приемлемый сольват любого из них для применения в качестве фармацевтического средства.
12. Фармацевтическая композиция, содержащая не менее одного соединения формулы I по одному или более пп.1-9, или его физиологически приемлемую соль или физиологически приемлемый сольват любого из них и физиологически приемлемый носитель.
13. Применение соединения формулы I по одному или более пп.1-9 или его физиологически приемлемой соли, или физиологически приемлемого сольвата любого из них, для получения лекарственного средства для лечения сердечно-сосудистых заболеваний, сердечной недостаточности, кардиомиопатии, инфаркта миокарда, ремоделирования миокарда, ремоделирования сосудов, гипертензии, атеросклероза, окклюзионного периферического поражения артерий, рестеноза, тромбоза, нарушений проницаемости сосудов, воспалительных заболеваний, ревматоидного артрита, остеоартрита, заболеваний почек, медуллярного некроза почки, почечной недостаточности, легочных заболеваний, хронического обструктивного заболевания легких, астмы, синдрома острой дыхательной недостаточности, иммунологических заболеваний, аллергических заболеваний, роста опухоли, метастазирования, метаболических заболеваний, фиброзных заболеваний, легочного фиброза, кардиофиброза, сосудистого фиброза, периваскулярного фиброза, почечного фиброза, фиброза печени, фиброзных заболеваний кожи, псориаза, боли, прурита, ретинального повреждения при ишемии/реперфузии, дегенерации желтого пятна, психических расстройств, нейродегенеративных заболеваний, нарушений мозгового нерва, расстройств периферической нервной системы, эндокринных растройств, гипертиреоза, избыточного рубцевания или нарушения заживления ран или в качестве кардиопротектора или ренопротектора.
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ581610A (en) * 2007-06-05 2012-02-24 Sanofi Aventis Substituted benzoylamino-indan-2-carboxylic acids and related compounds
MX2010011754A (es) * 2008-05-05 2010-12-06 Sanofi Aventis Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino y su uso como productos farmaceuticos.
MX2011003191A (es) * 2008-10-14 2011-04-27 Actelion Pharmaceuticals Ltd Derivados de fenetilamida y sus analogos heterociclicos.
WO2010068775A2 (en) 2008-12-11 2010-06-17 Amira Pharmaceuticals, Inc. Alkyne antagonists of lysophosphatidic acid receptors
GB2466121B (en) 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
CA2766643C (en) 2009-07-08 2017-01-03 Dermira (Canada), Inc. Tofa analogs useful in treating dermatological disorders or conditions
JP2013501064A (ja) 2009-08-04 2013-01-10 アミラ ファーマシューティカルス，インコーポレーテッド リゾホスファチジン酸受容体アンタゴニストとしての化合物
GB2474120B (en) 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
AR079022A1 (es) 2009-11-02 2011-12-21 Sanofi Aventis Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion
WO2011159635A1 (en) * 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonist for the treatment of dermal conditions
JP6039559B2 (ja) 2010-09-02 2016-12-07 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｌｐａ受容体アンタゴニストとしてのピラゾロピリジノン誘導体
EP2694496A1 (en) 2011-04-05 2014-02-12 Amira Pharmaceuticals, Inc. 3- or 5 - bi phenyl - 4 - ylisoxazole - based compounds useful for the treatment of fibrosis, pain, cancer and respiratory, allergic, nervous system or cardiovascular disorders
WO2013025733A1 (en) 2011-08-15 2013-02-21 Intermune, Inc. Lysophosphatidic acid receptor antagonists
WO2013070879A1 (en) 2011-11-10 2013-05-16 Bristol-Myers Squibb Company Methods for treating spinal cord injury with lpa receptor antagonists
EP3302465A1 (en) 2015-06-05 2018-04-11 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
WO2017093903A1 (en) * 2015-11-30 2017-06-08 Laurus Labs Private Limited An improved process for the preparation of macitentan
RU2631649C1 (ru) * 2016-07-11 2017-09-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Этиловый эфир 2-(((z)-амино((z)-2,4-диоксо-5-(2-оксо-2-фенилэтилиден)пирролидин-3-илиден)метил)амино)-4,5,6,7-тетрагидробензо[b]тиофенкарбоновой кислоты, обладающий анальгетической активностью
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
CN106831524B (zh) * 2017-01-04 2019-08-09 哈尔滨三联药业股份有限公司 一种手性吡咯烷酮乙酰胺衍生物及其制备方法和用途
GB201801355D0 (en) 2018-01-26 2018-03-14 Enterprise Therapeutics Ltd Compounds
SMT202200134T1 (it) 2018-03-08 2022-05-12 Incyte Corp Composti di amminopirazindiolo come inibitori di pi3k-y
HRP20230243T1 (hr) 2018-06-07 2023-04-14 Idorsia Pharmaceuticals Ltd Alkoksi supstituirani derivati piridinila kao antagonisti receptora lpa1 i njihova uporaba u liječenju fibroze
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
AR119162A1 (es) 2019-06-18 2021-12-01 Idorsia Pharmaceuticals Ltd Derivados de piridin-3-ilo
EP4037676A4 (en) * 2019-10-02 2023-02-22 Canopy Growth Corporation CANNABINOID DERIVATIVES
KR102775995B1 (ko) 2019-11-15 2025-03-11 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도
WO2021110805A1 (en) 2019-12-04 2021-06-10 Idorsia Pharmaceuticals Ltd Combination of an azetidine lpa1 receptor antagonist with pirfenidone and/or nintedanib for use in the treatment of fibrotic diseases
KR20220161476A (ko) * 2020-04-02 2022-12-06 호라이즌 테라퓨틱스 아일랜드 디에이씨 전신 경화증의 치료 방법
CA3185689A1 (en) 2020-06-03 2021-12-09 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
TWI843503B (zh) 2020-06-03 2024-05-21 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
CN116529234A (zh) * 2020-08-31 2023-08-01 赛诺菲 结晶edg-2受体拮抗剂及制备方法
TW202227390A (zh) * 2020-08-31 2022-07-16 法商賽諾菲公司 結晶型edg-2受體拮抗劑及製造方法
AU2022273631B2 (en) 2021-05-11 2025-04-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
WO2022241023A1 (en) 2021-05-13 2022-11-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
CN118541360A (zh) 2021-12-08 2024-08-23 吉利德科学公司 Lpa受体拮抗剂及其用途
CA3249794A1 (en) 2022-03-02 2023-09-07 Horizon Therapeutics Ireland Dac TREATMENT OF SYSTEMIC SCLEROSIS AND IDIOPATHIC PULMONARY FIBROSIS
CA3251849A1 (en) 2022-03-02 2023-09-07 Horizon Therapeutics Ireland Dac METHOD FOR MANUFACTURING A CRYSTALLINE EDG-2 RECEPTOR ANTAGONIST

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3602016A1 (de) 1985-12-05 1987-06-11 Bayer Ag Pyri(mi)dyl-oxy- und thio-benzoesaeure-derivate
DE69430747T2 (de) 1993-07-28 2003-03-06 Aventis Pharma Ltd., West Malling Verbindungen als pde iv und tnf inhibitoren
US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
KR20010082515A (ko) 1998-02-17 2001-08-30 우에노 도시오 아미디노 유도체 및 그 유도체를 유효 성분으로서함유하는 약제
EP1063982B1 (en) 1998-03-27 2007-02-14 Genentech, Inc. Antagonists for treatment of cd11/cd18 adhesion receptor mediated disorders
ES2320320T3 (es) * 2000-02-18 2009-05-21 Kyowa Hakko Kirin Co., Ltd. Nuevos compuestos de isoxazol y tiazol y uso de los mismos como farmacos.
DE10033353A1 (de) 2000-07-08 2002-01-24 Aventis Pharma Gmbh Breit einsetzbares Verfahren zur Identifizierung von Modulatoren von G-Protein gekoppelten Rezeptoren
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
EP1361872A4 (en) 2000-10-03 2004-05-19 Univ Virginia NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS
JP2005519915A (ja) 2002-01-18 2005-07-07 セレテック・リミテッド・ライアビリティ・カンパニー Ｅｄｇ受容体に関連する症状の処置方法
US7285680B2 (en) 2002-05-28 2007-10-23 Ono Pharmaceutical Co., Ltd. β-alanine derivatives and the use thereof
KR100962972B1 (ko) 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
US20060122184A1 (en) 2002-12-05 2006-06-08 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
CA2532800C (en) 2003-07-23 2013-06-18 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
KR20060119871A (ko) 2003-08-21 2006-11-24 오에스아이 파마슈티컬스, 인코포레이티드 Ｎ３―치환된 이미다조피리딘 ｃ―ｋｉｔ 억제제
TW200521108A (en) 2003-12-19 2005-07-01 Ono Pharmaceutical Co Compounds having lysophosphatidic acid receptor(LPA)-antagonizing effect and their use
US7820703B2 (en) 2004-05-06 2010-10-26 University Of Virginia Patent Foundation Lysophosphatidic acid receptor selective antagonists
US7683097B2 (en) * 2004-05-27 2010-03-23 Propharmacon Inc. Topoisomerase inhibitors
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
MX2007004217A (es) 2004-10-15 2007-06-11 Bayer Pharmaceuticals Corp Preparacion y uso de derivados de acido bifenil-4-il-carbonilamino para el tratamiento de obesidad.
JP2008516989A (ja) * 2004-10-19 2008-05-22 コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー 組成物及び抗腫瘍剤としてのその使用
MX2007005590A (es) * 2004-11-09 2007-05-24 Smithkline Beecham Corp Compuestos del inhibidor glicogeno fosforilasa y sus composiciones farmaceuticas.
EP1849465A4 (en) * 2005-02-18 2008-12-24 Takeda Pharmaceutical AGENS TO CONTROL THE FUNCTION OF THE GPR34 RECEPTOR
WO2006128184A2 (en) 2005-05-20 2006-11-30 Alantos-Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法
WO2007095495A2 (en) * 2006-02-13 2007-08-23 Pharmacopeia, Inc. Benzodiazepine gcnf modulators for stem cell modulation
KR20090023645A (ko) 2006-06-28 2009-03-05 사노피-아벤티스 신규한 ｃｘｃｒ2 억제제
NZ581610A (en) * 2007-06-05 2012-02-24 Sanofi Aventis Substituted benzoylamino-indan-2-carboxylic acids and related compounds
MX2010011754A (es) 2008-05-05 2010-12-06 Sanofi Aventis Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino y su uso como productos farmaceuticos.

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