RU2009114589A - Композиции для ухода за полостью рта, содержащие комбинации антибактериальных агентов и агентов, изменяющих реакцию организма-носителя - Google Patents
Композиции для ухода за полостью рта, содержащие комбинации антибактериальных агентов и агентов, изменяющих реакцию организма-носителя Download PDFInfo
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- RU2009114589A RU2009114589A RU2009114589/15A RU2009114589A RU2009114589A RU 2009114589 A RU2009114589 A RU 2009114589A RU 2009114589/15 A RU2009114589/15 A RU 2009114589/15A RU 2009114589 A RU2009114589 A RU 2009114589A RU 2009114589 A RU2009114589 A RU 2009114589A
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- oral cavity
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- Medicinal Preparation (AREA)
Abstract
1. Композиция для местного применения в полости рта, содержащая в орально-приемлемом носителе комбинацию: ! (a) одного или нескольких из первых активных агентов, обладающих ингибирующей активностью по отношению к по меньшей мере одному из противовоспалительных факторов организма-носителя, выбранных из металлопротеиназ матрикса (ММР), циклооксигеназ (СОХ), PGE2, интерлейкина 1 (IL-1), IL-1β-конвертирующего фермента (ICE), трансформирующего фактора роста β1 (TGF-β1), индуцируемой синтазы оксида азота (iNOS), гиалуронидазы, катепсинов, ядерного фактора каппа В (NF-κВ) и ассоциированной с рецептором IL-1 киназы (IRAK), и ! (b) одного или нескольких из вторых активных агентов, обладающих ингибирующей активностью по отношению к по меньшей мере одному из бактериальных факторов вирулентности, выбранных из образования биопленки, прилипания биопленки и ферментов, выбранных из гингипаинов, МЕТазы и цистализина, ! в которой комбинация присутствует в количестве, эффективно обеспечивающем повышенную эффективность лечения и профилактики медиируемых бактериями состояний полости рта. ! 2. Композиция для местного применения в полости рта по п.1, в которой первый активный агент, обладающий противовоспалительной активностью, выбран из рибофлавина, рибофлавинфосфата, куркумина, эвгенола, дигидроэвгенола, тимола, карвакрола, коричного альдегида, антоцианидина, байкалеина, дубильной кислоты, кверцитина, фолиевой кислоты, гексамидина, эпигаллокатехина, эпигаллокатехингаллата (EGCG), берберина и их смесей. ! 3. Композиция для местного применения в полости рта по п.1, в которой второй активный агент, обладающий антибактериальной активностью, выбран из цетил�
Claims (8)
1. Композиция для местного применения в полости рта, содержащая в орально-приемлемом носителе комбинацию:
(a) одного или нескольких из первых активных агентов, обладающих ингибирующей активностью по отношению к по меньшей мере одному из противовоспалительных факторов организма-носителя, выбранных из металлопротеиназ матрикса (ММР), циклооксигеназ (СОХ), PGE2, интерлейкина 1 (IL-1), IL-1β-конвертирующего фермента (ICE), трансформирующего фактора роста β1 (TGF-β1), индуцируемой синтазы оксида азота (iNOS), гиалуронидазы, катепсинов, ядерного фактора каппа В (NF-κВ) и ассоциированной с рецептором IL-1 киназы (IRAK), и
(b) одного или нескольких из вторых активных агентов, обладающих ингибирующей активностью по отношению к по меньшей мере одному из бактериальных факторов вирулентности, выбранных из образования биопленки, прилипания биопленки и ферментов, выбранных из гингипаинов, МЕТазы и цистализина,
в которой комбинация присутствует в количестве, эффективно обеспечивающем повышенную эффективность лечения и профилактики медиируемых бактериями состояний полости рта.
2. Композиция для местного применения в полости рта по п.1, в которой первый активный агент, обладающий противовоспалительной активностью, выбран из рибофлавина, рибофлавинфосфата, куркумина, эвгенола, дигидроэвгенола, тимола, карвакрола, коричного альдегида, антоцианидина, байкалеина, дубильной кислоты, кверцитина, фолиевой кислоты, гексамидина, эпигаллокатехина, эпигаллокатехингаллата (EGCG), берберина и их смесей.
3. Композиция для местного применения в полости рта по п.1, в которой второй активный агент, обладающий антибактериальной активностью, выбран из цетилпиридиний хлорида (СРС), агента, содержащего ион олова(2), агента, содержащего ион цинка, агента, содержащего ион меди, агента, содержащего ион железа, аскорбилстеарата, олеоилсаркозина, алкилсульфата, диоктилсульфосукцината и их смесей.
4. Композиция для местного применения в полости рта по п.2, дополнительно содержащая противовоспалительный агент, выбранный из аспирина, кеторолака, флурбипрофена, ибупрофена, напроксена, индометацина, аспирина, кетопрофена, пироксикама, меклофенамовой кислоты, нордигидрогваяретовой кислоты и их смесей.
5. Композиция для местного применения в полости рта по п.1, в которой указанная композиция находится в форме, выбранной из зубного эликсира, зубной пасты, геля для ухода за зубами, зубного порошка, неабразивного геля, мусса, пены, жевательной резинки, спрея для рта, пастилок, таблеток для полости рта, приспособления для обработки зубов и продукта для ухода за домашними животными.
6. Композиция для местного применения в полости рта по п.1, дополнительно содержащая изменяющий реакцию организма-носителя агент, который представляет собой модификатор окислительно-восстановительного статуса клеток, выбранный из группы, состоящей из кофермента Q10, PQQ, витамина С, витамина Е, витамина А, анетолдитиотиона и их смесей.
7. Композиция для местного применения в полости рта по п.1, в которой указанная композиция содержит дополнительное терапевтическое активное вещество, выбранное из антимикробных агентов/агентов против образования зубного налета, агентов, ингибирующих образование биопленки, антибиотиков; анальгетиков; местных анестезирующих агентов; агентов, десенсибилизирующих дентин; агентов, маскирующих запахи; и их смесей.
8. Использование агента, обладающего ингибирующей активностью по отношению к одному или нескольким из провоспалительных факторов организма-носителя, выбранных из металлопротеиназ матрикса (ММР), циклооксигеназ (СОХ), PGE2, интерлейкина 1 (IL-1), IL-1β-конвертирующего фермента (ICE), трансформирующего фактора роста β1 (TGF-β1), индуцируемой синтазы оксида азота (iNOS), гиалуронидазы, катепсинов, ядерного фактора каппа В (NF-κВ) и ассоциирований с рецептором IL-1 киназы (IRAK), в производстве композиции для местного применения в полости рта, предназначенной для лечения и профилактики бактериальных инфекций полости рта и ингибирования системных заболеваний, медиируемых указанными бактериальными инфекциями полости рта, у субъектов, имеющих указанные бактериальные инфекции и системные заболевания, или с риском их развития, причем композиция дополнительно предусматривает местное применение в полости рта указанных субъектов композиции, содержащей активный агент, эффективный против одного или нескольких бактериальных факторов вирулентности, выбранных из образования биопленки, прилипания биопленки и ферментов, выбранных из гингипаинов, МЕТазы и цистализина, и орально приемлемый носитель.
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| US11/595,530 US8283135B2 (en) | 2000-06-30 | 2006-11-10 | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| US11/595,530 | 2006-11-10 |
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| RU2009114589A true RU2009114589A (ru) | 2010-12-20 |
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| CN (2) | CN101534823A (ru) |
| AU (1) | AU2007318251B2 (ru) |
| BR (1) | BRPI0718699A2 (ru) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2669019C (en) | 2014-01-14 |
| AU2007318251A1 (en) | 2008-05-15 |
| JP2010508346A (ja) | 2010-03-18 |
| EP2415473B1 (en) | 2014-09-17 |
| BRPI0718699A2 (pt) | 2013-01-15 |
| EP2079468A1 (en) | 2009-07-22 |
| CN104958187A (zh) | 2015-10-07 |
| WO2008057136A1 (en) | 2008-05-15 |
| EP2415473A1 (en) | 2012-02-08 |
| ES2395854T3 (es) | 2013-02-15 |
| MY157928A (en) | 2016-08-15 |
| MX2009004973A (es) | 2009-05-19 |
| CN101534823A (zh) | 2009-09-16 |
| RU2448711C2 (ru) | 2012-04-27 |
| US8283135B2 (en) | 2012-10-09 |
| CA2669019A1 (en) | 2008-05-15 |
| AU2007318251B2 (en) | 2013-05-02 |
| JP5280366B2 (ja) | 2013-09-04 |
| EP2079468B1 (en) | 2012-09-19 |
| US20070053849A1 (en) | 2007-03-08 |
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