RU2008152367A - Соединения для лечения периодонтального заболевания - Google Patents
Соединения для лечения периодонтального заболевания Download PDFInfo
- Publication number
- RU2008152367A RU2008152367A RU2008152367/15A RU2008152367A RU2008152367A RU 2008152367 A RU2008152367 A RU 2008152367A RU 2008152367/15 A RU2008152367/15 A RU 2008152367/15A RU 2008152367 A RU2008152367 A RU 2008152367A RU 2008152367 A RU2008152367 A RU 2008152367A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- oral composition
- independently selected
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 12
- 208000028169 periodontal disease Diseases 0.000 title claims 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 25
- 239000000203 mixture Substances 0.000 claims abstract 16
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 13
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 12
- 229910052736 halogen Inorganic materials 0.000 claims abstract 11
- -1 2- (morpholino) ethoxy Chemical group 0.000 claims abstract 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 8
- 150000002367 halogens Chemical class 0.000 claims abstract 8
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 8
- 239000001301 oxygen Substances 0.000 claims abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims abstract 4
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 4
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 4
- 229910052796 boron Inorganic materials 0.000 claims abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 150000002431 hydrogen Chemical class 0.000 claims abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract 3
- 239000000551 dentifrice Substances 0.000 claims abstract 3
- 239000007844 bleaching agent Substances 0.000 claims abstract 2
- 229940112822 chewing gum Drugs 0.000 claims abstract 2
- 235000015218 chewing gum Nutrition 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims abstract 2
- 239000002324 mouth wash Substances 0.000 claims abstract 2
- 229940051866 mouthwash Drugs 0.000 claims abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 6
- 244000005700 microbiome Species 0.000 claims 5
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 241000191992 Peptostreptococcus Species 0.000 claims 2
- 241000605894 Porphyromonas Species 0.000 claims 2
- 241001135235 Tannerella forsythia Species 0.000 claims 2
- 201000001245 periodontitis Diseases 0.000 claims 2
- 241000606750 Actinobacillus Species 0.000 claims 1
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 claims 1
- 208000010266 Aggressive Periodontitis Diseases 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241000249959 Bulleidia Species 0.000 claims 1
- 241000249957 Bulleidia extructa Species 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241000190890 Capnocytophaga Species 0.000 claims 1
- 241000190885 Capnocytophaga ochracea Species 0.000 claims 1
- 241000588877 Eikenella Species 0.000 claims 1
- 241000186394 Eubacterium Species 0.000 claims 1
- 241001516614 Exema Species 0.000 claims 1
- 241000628997 Flos Species 0.000 claims 1
- 241000605909 Fusobacterium Species 0.000 claims 1
- 241000605986 Fusobacterium nucleatum Species 0.000 claims 1
- 241001670212 Mogibacterium Species 0.000 claims 1
- 241001494429 Mogibacterium timidum Species 0.000 claims 1
- 241001135211 Porphyromonas asaccharolytica Species 0.000 claims 1
- 241000605862 Porphyromonas gingivalis Species 0.000 claims 1
- 241000605861 Prevotella Species 0.000 claims 1
- 241001135221 Prevotella intermedia Species 0.000 claims 1
- 241001657520 Slackia Species 0.000 claims 1
- 241001470488 Tannerella Species 0.000 claims 1
- 241000589886 Treponema Species 0.000 claims 1
- 241000589892 Treponema denticola Species 0.000 claims 1
- 241001494431 [Eubacterium] nodatum Species 0.000 claims 1
- 201000009329 acute pericementitis Diseases 0.000 claims 1
- 208000033608 aggressive 1 periodontitis Diseases 0.000 claims 1
- 230000001680 brushing effect Effects 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000606 toothpaste Substances 0.000 claims 1
- 229940034610 toothpaste Drugs 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 2
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 0 *B(C=*)OC(Cc1c(*)ccc(*)n1)=O Chemical compound *B(C=*)OC(Cc1c(*)ccc(*)n1)=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80450406P | 2006-06-12 | 2006-06-12 | |
| US60/804,504 | 2006-06-12 | ||
| US82389306P | 2006-08-29 | 2006-08-29 | |
| US60/823,893 | 2006-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008152367A true RU2008152367A (ru) | 2010-07-20 |
Family
ID=38832802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008152367/15A RU2008152367A (ru) | 2006-06-12 | 2007-06-12 | Соединения для лечения периодонтального заболевания |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2044091A4 (es) |
| KR (1) | KR20090029797A (es) |
| AU (1) | AU2007257689A1 (es) |
| BR (1) | BRPI0713010A2 (es) |
| CA (1) | CA2654449A1 (es) |
| IL (1) | IL195571A0 (es) |
| MX (1) | MX2008015918A (es) |
| RU (1) | RU2008152367A (es) |
| WO (1) | WO2007146965A2 (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1853251T3 (pl) | 2005-02-16 | 2013-09-30 | Anacor Pharmaceuticals Inc | Halogenopodstawione boronoftalidy do leczenia infekcji |
| CN106008583A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| EP2719388B1 (en) * | 2006-02-16 | 2019-04-10 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| RU2015109165A (ru) | 2008-03-06 | 2015-11-10 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных агентов |
| PE20091838A1 (es) * | 2008-04-09 | 2009-12-18 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso |
| WO2010018837A2 (ja) * | 2008-08-11 | 2010-02-18 | 独立行政法人科学技術振興機構 | 蛋白質架橋阻害剤 |
| EP2348863A4 (en) | 2008-09-04 | 2012-03-07 | Anacor Pharmaceuticals Inc | BORN SMALL MOLECULES |
| WO2010028005A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010045503A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| EA201190034A1 (ru) | 2008-12-17 | 2012-02-28 | Анакор Фармасьютикалс, Инк. | Полиморфы (s)-3-аминометил-7-(3-гидроксипропокси)-3н-бензо[c][1,2]оксаборол-1-ола |
| JP2012523425A (ja) | 2009-04-07 | 2012-10-04 | インフイニトイ プハルマセウトイカルス インコーポレイテッド | 脂肪酸アミドヒドロラーゼの阻害薬 |
| CA2757679A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| TW201109022A (en) * | 2009-06-03 | 2011-03-16 | Colgate Palmolive Co | Borinic compositions |
| KR20130031233A (ko) | 2009-07-28 | 2013-03-28 | 아나코르 파마슈티칼스 인코포레이티드 | 삼치환된 붕소 함유 분자 |
| AP4039A (en) | 2009-08-14 | 2017-02-28 | Daitao Chen | Boron-containing small molecules as antiprotozoal agents |
| US9346834B2 (en) | 2009-10-20 | 2016-05-24 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| US20110212918A1 (en) | 2009-11-11 | 2011-09-01 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011063293A1 (en) * | 2009-11-20 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antihelminth agents |
| RU2414210C1 (ru) * | 2009-12-28 | 2011-03-20 | Общество С Ограниченной Ответственностью "Сплат-Косметика" (Ооо "Сплат-Косметика") | Средство для удаления табачных смол и композиции на его основе |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| RU2569061C2 (ru) | 2010-02-03 | 2015-11-20 | Инфинити Фармасьютикалз, Инк. | Ингибиторы амид-гидролазы жирных кислот |
| AP2012006482A0 (en) | 2010-03-19 | 2012-10-31 | Anacor Pharmacueticals Inc | Boron-containing small molecules as anti-protozoalagent |
| LT3251678T (lt) | 2010-09-07 | 2021-12-10 | Anacor Pharmaceuticals, Inc. | Benzoksaborolo dariniai, skirti bakterinių infekcijų gydymui |
| AR088668A1 (es) * | 2011-11-21 | 2014-06-25 | Lilly Co Eli | Moleculas pequeñas que contienen boro |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| AU2014212576B2 (en) | 2013-01-30 | 2015-08-13 | Agrofresh Inc. | Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| TW201625649A (zh) | 2014-07-01 | 2016-07-16 | 第一三共股份有限公司 | 作爲抗菌劑的三環化合物 |
| NZ745681A (en) | 2016-03-07 | 2022-05-27 | Agrofresh Inc | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| WO2017193914A1 (zh) * | 2016-05-09 | 2017-11-16 | 苏州科睿思制药有限公司 | 克立硼罗游离形式的晶型及其制备方法和用途 |
| US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
| CN107759625B (zh) * | 2016-08-22 | 2020-12-29 | 药源药物化学（上海）有限公司 | 4-(1-羟基-1,3-二氢苯并[c][1,2]氧杂硼杂环戊二烯-5-基氧基)苯氰的制备方法 |
| EP3609504A4 (en) | 2017-03-01 | 2021-03-03 | Anacor Pharmaceuticals, Inc. | NEW OXABOROLE ANALOGUES AND USES OF THE LATEST |
| CA3054138A1 (en) * | 2017-03-09 | 2018-09-13 | The Penn State Research Foundation | Boron-containing small molecules for inhibiting activity of a receptor-like protein tyrosine phosphatase |
| CN110183477B (zh) * | 2019-07-03 | 2022-03-04 | 石家庄诚志永华显示材料有限公司 | 有机电致发光化合物及其应用 |
| WO2022043936A1 (en) | 2020-08-31 | 2022-03-03 | Pfizer Inc. | Methods of protecting rna |
| KR102638321B1 (ko) * | 2022-01-27 | 2024-02-19 | 마이크로바이오헬스케어 주식회사 | 바이오필름 형성 억제 활성을 갖는 신규 화합물 및 이의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4716035A (en) * | 1985-05-24 | 1987-12-29 | The Procter & Gamble Company | Oral compositions and methods for treating gingivitis |
| WO2000044387A1 (fr) * | 1999-01-29 | 2000-08-03 | Nitto Kasei Co., Ltd. | Composes organobores presentant une activite de coccidiostats |
| US7390806B2 (en) * | 2002-12-18 | 2008-06-24 | Anacor Pharmaceuticals, Inc. | Antibiotics containing borinic acid complexes and methods of use |
| US20040224923A1 (en) * | 2002-12-18 | 2004-11-11 | Ving Lee | Antibiotics containing borinic acid complexes and methods of use |
| US20070155698A1 (en) * | 2003-09-02 | 2007-07-05 | Doron Steinberg | Oxazaborolidines as bacteria effectors |
| AR049915A1 (es) * | 2004-06-14 | 2006-09-13 | Anacor Pharmaceuticals Inc | Compuestos con contenido de boro y metodos de uso de los mismos |
| AR049916A1 (es) * | 2004-06-14 | 2006-09-13 | Anacor Pharmaceuticals Inc | Usos anti-parasitarios de complejos de acido borinico |
-
2007
- 2007-06-12 AU AU2007257689A patent/AU2007257689A1/en not_active Abandoned
- 2007-06-12 RU RU2008152367/15A patent/RU2008152367A/ru not_active Application Discontinuation
- 2007-06-12 EP EP07812123A patent/EP2044091A4/en not_active Withdrawn
- 2007-06-12 KR KR1020097000565A patent/KR20090029797A/ko not_active Withdrawn
- 2007-06-12 CA CA002654449A patent/CA2654449A1/en not_active Abandoned
- 2007-06-12 WO PCT/US2007/071049 patent/WO2007146965A2/en not_active Ceased
- 2007-06-12 MX MX2008015918A patent/MX2008015918A/es unknown
- 2007-06-12 BR BRPI0713010-4A patent/BRPI0713010A2/pt not_active IP Right Cessation
-
2008
- 2008-11-27 IL IL195571A patent/IL195571A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007146965A3 (en) | 2008-12-04 |
| IL195571A0 (en) | 2009-09-01 |
| BRPI0713010A2 (pt) | 2012-10-09 |
| AU2007257689A1 (en) | 2007-12-21 |
| CA2654449A1 (en) | 2007-12-21 |
| WO2007146965A2 (en) | 2007-12-21 |
| EP2044091A2 (en) | 2009-04-08 |
| KR20090029797A (ko) | 2009-03-23 |
| MX2008015918A (es) | 2009-01-14 |
| EP2044091A4 (en) | 2010-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20101223 |