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PT4249073T - Pirimidinas para degradação da tirosina cinase de bruton - Google Patents

Pirimidinas para degradação da tirosina cinase de bruton

Info

Publication number
PT4249073T
PT4249073T PT231627316T PT23162731T PT4249073T PT 4249073 T PT4249073 T PT 4249073T PT 231627316 T PT231627316 T PT 231627316T PT 23162731 T PT23162731 T PT 23162731T PT 4249073 T PT4249073 T PT 4249073T
Authority
PT
Portugal
Prior art keywords
bruton
pyrimidines
degrading
tyrosine kinase
tyrosine
Prior art date
Application number
PT231627316T
Other languages
English (en)
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PT4249073T publication Critical patent/PT4249073T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT231627316T 2022-03-22 2023-03-17 Pirimidinas para degradação da tirosina cinase de bruton PT4249073T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202263322505P 2022-03-22 2022-03-22

Publications (1)

Publication Number Publication Date
PT4249073T true PT4249073T (pt) 2025-01-06

Family

ID=85776045

Family Applications (1)

Application Number Title Priority Date Filing Date
PT231627316T PT4249073T (pt) 2022-03-22 2023-03-17 Pirimidinas para degradação da tirosina cinase de bruton

Country Status (22)

Country Link
US (2) US12172992B2 (pt)
EP (2) EP4480482A3 (pt)
JP (1) JP7805983B2 (pt)
KR (1) KR20240163634A (pt)
CN (1) CN119072475A (pt)
AR (1) AR128842A1 (pt)
AU (1) AU2023237882A1 (pt)
CO (1) CO2024012427A2 (pt)
DK (1) DK4249073T3 (pt)
ES (1) ES3014292T3 (pt)
FI (1) FI4249073T3 (pt)
HR (1) HRP20241722T1 (pt)
HU (1) HUE070665T2 (pt)
IL (1) IL314260A (pt)
LT (1) LT4249073T (pt)
MX (1) MX2024011120A (pt)
PL (1) PL4249073T3 (pt)
PT (1) PT4249073T (pt)
RS (1) RS66349B1 (pt)
SI (1) SI4249073T1 (pt)
TW (1) TW202346287A (pt)
WO (1) WO2023183811A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025501082A (ja) * 2021-12-30 2025-01-17 ベイジーン スウィッツァーランド ゲーエムベーハー ブルトン型チロシンキナーゼ(btk)阻害剤をe3リガーゼリガンドにコンジュゲートすることによるbtkの分解及び使用方法
WO2026021570A1 (en) * 2024-07-26 2026-01-29 Ascentage Pharma (Suzhou) Co., Ltd. Btk degrader and use thereof

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JP2025501082A (ja) 2021-12-30 2025-01-17 ベイジーン スウィッツァーランド ゲーエムベーハー ブルトン型チロシンキナーゼ(btk)阻害剤をe3リガーゼリガンドにコンジュゲートすることによるbtkの分解及び使用方法

Also Published As

Publication number Publication date
EP4249073B1 (en) 2024-12-11
ES3014292T3 (en) 2025-04-21
US12172992B2 (en) 2024-12-24
HRP20241722T1 (hr) 2025-02-28
LT4249073T (lt) 2025-01-27
MX2024011120A (es) 2024-09-18
US20250304568A1 (en) 2025-10-02
FI4249073T3 (fi) 2025-02-03
SI4249073T1 (sl) 2025-02-28
HUE070665T2 (hu) 2025-06-28
TW202346287A (zh) 2023-12-01
EP4249073A1 (en) 2023-09-27
WO2023183811A1 (en) 2023-09-28
JP2023140319A (ja) 2023-10-04
KR20240163634A (ko) 2024-11-19
EP4480482A3 (en) 2025-03-26
IL314260A (en) 2024-09-01
JP7805983B2 (ja) 2026-01-26
CO2024012427A2 (es) 2024-09-30
AU2023237882A1 (en) 2024-08-01
PL4249073T3 (pl) 2025-03-17
US20240109877A1 (en) 2024-04-04
RS66349B1 (sr) 2025-01-31
AR128842A1 (es) 2024-06-19
EP4480482A2 (en) 2024-12-25
CN119072475A (zh) 2024-12-03
DK4249073T3 (da) 2025-01-02

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