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AR128842A1 - Pirimidinas para degradar la tirosina quinasa de bruton - Google Patents

Pirimidinas para degradar la tirosina quinasa de bruton

Info

Publication number
AR128842A1
AR128842A1 ARP230100693A ARP230100693A AR128842A1 AR 128842 A1 AR128842 A1 AR 128842A1 AR P230100693 A ARP230100693 A AR P230100693A AR P230100693 A ARP230100693 A AR P230100693A AR 128842 A1 AR128842 A1 AR 128842A1
Authority
AR
Argentina
Prior art keywords
bruton
pyrimidines
degrade
tyrosine kinase
cll
Prior art date
Application number
ARP230100693A
Other languages
English (en)
Inventor
Zhiguo Bian
Jason P Burke
Zhaozhong J Jia
Xingyu Jiang
Matthew H Katcher
Venkat Reddy Mali
Violeta L Marin
Elizabeth L Noey
Akinori Okano
Alexey A Rivkin
Spencer O Scholz
Kevin R Woller
Xianrui Zhao
Ashley M Adams
Berenger Biannic
Shahab Mortezaei
Joshua N Payette
Jeffery A Zablocki
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of AR128842A1 publication Critical patent/AR128842A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona compuestos de la fórmula (1) en donde R¹, R², R³, R⁴ᵃ, R⁴ᵇ, y R⁵, son como se define en la presente descripción, y sales farmacéuticamente aceptables de estos, que son útiles como agentes en el tratamiento de la CLL.
ARP230100693A 2022-03-22 2023-03-22 Pirimidinas para degradar la tirosina quinasa de bruton AR128842A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202263322505P 2022-03-22 2022-03-22

Publications (1)

Publication Number Publication Date
AR128842A1 true AR128842A1 (es) 2024-06-19

Family

ID=85776045

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230100693A AR128842A1 (es) 2022-03-22 2023-03-22 Pirimidinas para degradar la tirosina quinasa de bruton

Country Status (22)

Country Link
US (2) US12172992B2 (es)
EP (2) EP4480482A3 (es)
JP (1) JP7805983B2 (es)
KR (1) KR20240163634A (es)
CN (1) CN119072475A (es)
AR (1) AR128842A1 (es)
AU (1) AU2023237882A1 (es)
CO (1) CO2024012427A2 (es)
DK (1) DK4249073T3 (es)
ES (1) ES3014292T3 (es)
FI (1) FI4249073T3 (es)
HR (1) HRP20241722T1 (es)
HU (1) HUE070665T2 (es)
IL (1) IL314260A (es)
LT (1) LT4249073T (es)
MX (1) MX2024011120A (es)
PL (1) PL4249073T3 (es)
PT (1) PT4249073T (es)
RS (1) RS66349B1 (es)
SI (1) SI4249073T1 (es)
TW (1) TW202346287A (es)
WO (1) WO2023183811A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118475571A (zh) * 2021-12-30 2024-08-09 百济神州有限公司 通过使布鲁顿酪氨酸激酶(btk)抑制剂与e3连接酶配体缀合来降解btk及使用方法

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Also Published As

Publication number Publication date
RS66349B1 (sr) 2025-01-31
MX2024011120A (es) 2024-09-18
HUE070665T2 (hu) 2025-06-28
PT4249073T (pt) 2025-01-06
FI4249073T3 (fi) 2025-02-03
EP4249073A1 (en) 2023-09-27
PL4249073T3 (pl) 2025-03-17
ES3014292T3 (en) 2025-04-21
CN119072475A (zh) 2024-12-03
JP2023140319A (ja) 2023-10-04
IL314260A (en) 2024-09-01
EP4480482A2 (en) 2024-12-25
US12172992B2 (en) 2024-12-24
WO2023183811A1 (en) 2023-09-28
US20250304568A1 (en) 2025-10-02
US20240109877A1 (en) 2024-04-04
HRP20241722T1 (hr) 2025-02-28
TW202346287A (zh) 2023-12-01
JP7805983B2 (ja) 2026-01-26
SI4249073T1 (sl) 2025-02-28
DK4249073T3 (da) 2025-01-02
CO2024012427A2 (es) 2024-09-30
AU2023237882A1 (en) 2024-08-01
KR20240163634A (ko) 2024-11-19
EP4480482A3 (en) 2025-03-26
EP4249073B1 (en) 2024-12-11
LT4249073T (lt) 2025-01-27

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