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MX2024011120A - Pirimidinas para degradar la tirosina cinasa de bruton. - Google Patents

Pirimidinas para degradar la tirosina cinasa de bruton.

Info

Publication number
MX2024011120A
MX2024011120A MX2024011120A MX2024011120A MX2024011120A MX 2024011120 A MX2024011120 A MX 2024011120A MX 2024011120 A MX2024011120 A MX 2024011120A MX 2024011120 A MX2024011120 A MX 2024011120A MX 2024011120 A MX2024011120 A MX 2024011120A
Authority
MX
Mexico
Prior art keywords
sup
bruton
pyrimidines
degrading
tyrosine kinase
Prior art date
Application number
MX2024011120A
Other languages
English (en)
Inventor
Zhaozhong J Jia
Kevin R Woller
Venkat Reddy Mali
Xianrui Zhao
Violeta L Marin
Akinori Okano
Spencer O Scholz
Zhiguo Bian
Jason P Burke
Xingyu Jiang
Matthew H Katcher
Elizabeth L Noey
Alexey A Rivkin
Ashley M Adams
Berenger Biannic
Shahab Mortezaei
Joshua N Payette
Jeffery A Zablocki
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2024011120A publication Critical patent/MX2024011120A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona compuestos de la Fórmula (I) (ver Fórmula) (I); en donde R1, R2, R3, R4A, R4b, y R5, son como se definen en la presente descripción, y sales farmacéuticamente aceptables de estos, que son útiles como agentes en el tratamiento de la CLL.
MX2024011120A 2022-03-22 2023-03-21 Pirimidinas para degradar la tirosina cinasa de bruton. MX2024011120A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263322505P 2022-03-22 2022-03-22
PCT/US2023/064775 WO2023183811A1 (en) 2022-03-22 2023-03-21 Pyrimidines for degrading bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
MX2024011120A true MX2024011120A (es) 2024-09-18

Family

ID=85776045

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2024011120A MX2024011120A (es) 2022-03-22 2023-03-21 Pirimidinas para degradar la tirosina cinasa de bruton.

Country Status (22)

Country Link
US (2) US12172992B2 (es)
EP (2) EP4480482A3 (es)
JP (1) JP7805983B2 (es)
KR (1) KR20240163634A (es)
CN (1) CN119072475A (es)
AR (1) AR128842A1 (es)
AU (1) AU2023237882A1 (es)
CO (1) CO2024012427A2 (es)
DK (1) DK4249073T3 (es)
ES (1) ES3014292T3 (es)
FI (1) FI4249073T3 (es)
HR (1) HRP20241722T1 (es)
HU (1) HUE070665T2 (es)
IL (1) IL314260A (es)
LT (1) LT4249073T (es)
MX (1) MX2024011120A (es)
PL (1) PL4249073T3 (es)
PT (1) PT4249073T (es)
RS (1) RS66349B1 (es)
SI (1) SI4249073T1 (es)
TW (1) TW202346287A (es)
WO (1) WO2023183811A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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EP4249073B1 (en) 2024-12-11
ES3014292T3 (en) 2025-04-21
US12172992B2 (en) 2024-12-24
HRP20241722T1 (hr) 2025-02-28
LT4249073T (lt) 2025-01-27
US20250304568A1 (en) 2025-10-02
FI4249073T3 (fi) 2025-02-03
SI4249073T1 (sl) 2025-02-28
HUE070665T2 (hu) 2025-06-28
TW202346287A (zh) 2023-12-01
EP4249073A1 (en) 2023-09-27
WO2023183811A1 (en) 2023-09-28
JP2023140319A (ja) 2023-10-04
KR20240163634A (ko) 2024-11-19
EP4480482A3 (en) 2025-03-26
IL314260A (en) 2024-09-01
PT4249073T (pt) 2025-01-06
JP7805983B2 (ja) 2026-01-26
CO2024012427A2 (es) 2024-09-30
AU2023237882A1 (en) 2024-08-01
PL4249073T3 (pl) 2025-03-17
US20240109877A1 (en) 2024-04-04
RS66349B1 (sr) 2025-01-31
AR128842A1 (es) 2024-06-19
EP4480482A2 (en) 2024-12-25
CN119072475A (zh) 2024-12-03
DK4249073T3 (da) 2025-01-02

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